• 한국초전도학회:학술대회논문집
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• v.14
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• pp.11-11
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• 2004

• The Plant Pathology Journal
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• v.35 no.1
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• pp.90-90
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• 2019

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.23-23
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• 2003

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and other aryl hydrocarbon (AhR) ligands suppress 17${\beta}$-estradiol (E)-induced responses in the rodent uterus and mammary tumors and in human breast cancer cells. Treatment of ZR-75, T47D and MCF-7 human breast cancer cells with TCDD induces proteasome-dependent degradation of endogenous estrogen receptor ${\alpha}$ (ER${\alpha}$).(omitted)

• BMB Reports
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• v.53 no.5
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• pp.284-289
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• 2020

Tamoxifen, a nonsteroidal estrogen receptor (ER) antagonist, is used routinely as a chemotherapeutic agent for ER-positive breast cancer. However, it is also causes side effects, including retinotoxicity. The retinal pigment epithelium (RPE) has been recognized as the primary target of tamoxifen-induced retinotoxicity. The RPE plays an essential physiological role in the normal functioning of the retina. Nonetheless, potential therapeutic agents to prevent tamoxifen-induced retinotoxicity in breast cancer patients have not been investigated. Here, we evaluated the action mechanisms of sulfasalazine against tamoxifen-induced RPE cell death. Tamoxifen induced reactive oxygen species (ROS)-mediated autophagic cell death and caspase-1-mediated pyroptosis in RPE cells. However, sulfasalazine reduced tamoxifen-induced total ROS and ROS-mediated autophagic RPE cell death. Also, mRNA levels of tamoxifen-induced pyroptosis-related genes, IL-1β, NLRP3, and procaspase-1, also decreased in the presence of sulfasalazine in RPE cells. Additionally, the mRNA levels of tamoxifen-induced AMD-related genes, such as complement factor I (CFI), complement factor H (CFH), apolipoprotein E (APOE), apolipoprotein J (APOJ), toll-like receptor 2 (TLR2) and toll-like receptor 4 (TLR4), were downregulated in RPE cells. Together, these data provide novel insight into the therapeutic effects of sulfasalazine against tamoxifen-induced RPE cell death.

• Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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• v.4
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• pp.81-107
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• 2001

Ziel dieser Arbeit ist es, die Probleme der semantischen Interpretationen der heutigen deutschen Anaphern im $oberfl\"{a}chenstrukturell$ einfachen Satz mit Hilfe von Langackers 'C-Command' und Chomskys 'Government and Binding Theorie' zu $l\"{o}sen$. Bis Anfang der 70er Jahren wurden die koreferentiellen Erscheinungen zwischen NPs meist durch den von Langacker eingefuhrten 'precede and command' Begriff $gel\"{o}st$. Aber dieser Begriff ist $h\"{o}chst\;abitr\"{a}r$ auf theoretischen $Gr\"{u}nden$ und empirisch $inad\"{a}quat$. Reinhart versuchte, einige Schwierigkeiten mit Bezug auf Koreferenz-Beziehungen zwischen NPs zu $l\"{o}sen$, indem er command durch c-command ersetzte. Mit Hilfe von 'c-command'-Relationen werden manche Probleme, die bisher theoretisch nicht $erkl\"{a}rt$ werden konnten, befriedigend $gel\"{o}st$. Chomsky schlagt 'Binding Conditions' vor, um die semantischen Interpretationen der Anaphern im einfachen Satz zu behandeln. Die von ihm vorgeschlagenen 3 Bedingungen sind: (i) Eine Anapher $mu\ss$ in ihrer 'governing' Kategorie gebunden sein, (ii) Eine pronominale NP $mu\ss$ in ihrer 'governing' Kategorie frei sein, (iii) Eine lexikalische NP $mu{\ss}\;\"{u}berall$ frei sein. Dabei versteht man Anapher unter Reflexivpronomen, die pronominale NP unter Personalpronomen, und die lexikalische NP unter Referenz- Ausdruck. Aber in der vorliegenden Arbeit fassen ein Reflexivpronomen und ein Personalpronomen zu einer Anapher zusammen. Aufgrund der 'Binding Conditions' werden viele Fragen der semantischen Interpretationen, vor allem der komplementaren Verteilungen von den im einafchen Satz erscheinenden Anaphern erschlossen.

• BMB Reports
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• v.44 no.11
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• pp.735-740
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• 2011

Tunicamycin, an endoplasmic reticulum (ER) stress inducer, specifically inhibits N-glycosylation. The cyclic AMP (cAMP) response element-binding protein H (CREBH) was previously shown to be regulated by UPR-dependent proteolytic cleavage in the liver. On the other hand, the role of CREBH in other tissues is unknown. In the present study, tunicamycin increased the level of CREBH activation (cleavage) as well as mRNA expression in osteoblast cells. Adenoviral (Ad) overexpression of CREBH suppressed BMP2-induced expression of alkaline phosphatase (ALP) and osteocalcin (OC). Interestingly, the BMP2-induced OASIS (structurally similar to CREBH, a positive regulator of osteoblast differentiation) expression was also inhibited by CREBH overexpression. In addition, inhibition of CREBH expression using siRNA reversed the tunicamycin-suppressed ALP and OC expression. These results suggest that CREBH inhibited osteoblast differentiation via suppressing BMP2-induced ALP, OC and OASIS expression in mouse calvarial derived osteoblasts.

• Journal of The Korean Society of Clinical Toxicology
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• v.6 no.2
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• pp.99-103
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• 2008

Purpose: Chlorine gas is a common irritant that usually causes mild respiratory symptoms. One severe symptom, RADS (Reactive Airway Dysfunction Syndrome), is not well known to physicians. We analyzed the clinical features of chlorine gas exposure. Methods: We prospectively collected 25 cases of chlorine gas exposure near our emergency center on January 10th, 2007, and analyzed demographic data, event-to-ER interval, symptoms, and laboratory results based on medical records. Results: Only 2 patients out of 25 were admitted because of severe symptoms, the rest were discharged without complications. Sixty percent of them visited the ER within 12 h of exposure. The most common symptoms were chest discomfort (60%), headache (40%), nausea (40%), throat irritation (26%), and cough (32%). Two out of eight dyspnea cases showed abnormal pulmonary function, but only one case was diagnosed as RADS. Conclusion: Most symptoms after chlorine gas exposure can be treated conservatively. However, patients with chlorine exposure should be followed up long term for delayed complications.

• YAKHAK HOEJI
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• v.5 no.1
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• pp.51-55
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• 1960

Some enzymatic properties of Cynthia roretzi V. Drasche (Korean:U-Rung-Shei) was studied by author and obtained the following results; 1. The optimum pH of the digestive gland proteinase ws 7.4-7.6 2. Activity of metallic ion on the Proteinase showed following order; 10$^{-3}$ M. M $n^{++}$>1-$^{-3}$ M. $Co^{++}$>10$^{-4}$ M. $Mg^{++}$\ulcorner10$^{-2}$ M.S $r^{++}$. Inhibition of metallic ion on the Proteinase showed following order: 10$^{-3}$ M. A $g^{+}$>10$^{-3}$ M. c $d^{++}$>10$^{-3}$ M. P $b^{++}$>10$^{-3}$ M. Z $n^{++}$ 3. The digestive gland enzyme inactivated at 70.deg. C, but no influence at 50.deg. C. 4. When the enzyme concentration increase 2 times, and 3 times, the enzymatic activity also increase, but not proportionally 5. The digestive gland Proteinase showed remarkably higher enzymatic activity than the intestinal Proteinase. 6. The digestive gland amylase brom the ascidion showed remarkably higher enzymatic activity than the heptaponcreatic amylase from shell fish (Turbo (Batillus) Cornutus Solander).).er).).).er).).

• Biomolecules & Therapeutics
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• v.27 no.1
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• pp.41-47
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• 2019

The apoptotic effects of shikonin (5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione) on the human colon cancer cell line SNU-407 were investigated in this study. Shikonin showed dose-dependent cytotoxic activity against SNU-407 cells, with an estimated $IC_{50}$ value of $3{\mu}M$ after 48 h of treatment. Shikonin induced apoptosis, as evidenced by apoptotic body formation, sub-G_1$ phase cells, and DNA fragmentation. Shikonin induced apoptotic cell death by activating mitogen-activated protein kinase family members, and the apoptotic process was mediated by the activation of endoplasmic reticulum (ER) stress, leading to activation of the $PERK/elF2{\alpha}/CHOP$ apoptotic pathway, and mitochondrial $Ca^{2+}$ accumulation. Shikonin increased mitochondrial membrane depolarization and altered the levels of apoptosis-related proteins, with a decrease in B cell lymphoma (Bcl)-2 and an increase in Bcl-2-associated X protein, and subsequently, increased expression of cleaved forms of caspase-9 and -3. Taken together, we suggest that these mechanisms, including MAPK signaling and the ER- and mitochondria-mediated pathways, may underlie shikonin-induced apoptosis related to its anticancer effect.

• Annual Conference of KIPS
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• 2011.11a
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• pp.1532-1533
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• 2011

본 연구에서는 SQL를 배우고자 하는 개발자들에게 SQL 문법을 학습할 수 있는 교육용 Tool을 개발한다. 개발자가 예제와 설명을 통하여 SQL 문법을 배우고 ER-Diagram을 보면서 논리적인 DB의 개념을 이용하여 쉽게 학습할 수 있다. 예제는 초급과 중급으로 나누어져 있어 사용자의 수준에 맞는 학습이 선택가능하다. TPC-H 데이터는 DSS 환경에서 사용되는 표준 데이터 모델로 Database Generater를 통해 생성하며 본 연구에서 사용자가 데이터량의 조정이 가능하도록 구성하였다.