• Journal of Preventive Medicine and Public Health
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• 제30권2호
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• pp.356-368
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• 1997

In effort to determine whether aircraft noise can have health effects such as hearing loss, hypertension and psychological stress, a total of 111 male professors and administrative officers working a college near a military airport in Korea(exposed group) and a total of 168 males and 112 females matched by age groups(control groups) were analyzed. Personal noise exposure and indoor and outdoor sound level of jet aircraft noise were measured at the exposed are3. And pure tone, air conduction test and measurement of blood pressure were given to the exposed(males) and matched control groups (males and females). BEPSI(Brief Encounter Psychological Instrument) and psychological response to aircraft noise were examined for the exposed group. The noise dosimetry results revealed time-weighted averages(TWAs) that ranged from 61 to 68 dBA. However the levels encountered during taking off jet airplanes reached 126 dBA for two half minutes time period. Th, audiometric, test showed that mean values of HTL(hearing threshold level) in exposed group at every frequency(500, 1,000, 2,000, 4,000, and 8,000 Hz were much lower than them of male and female control groups. And in old age groups, interaction of age and noise was observed at 8,000 Hz in both ears(p<0.05). Conclusively, aircraft noise does not appear to induce hearing loss directly in high frequency, but may decreased hearing threshold level by interaction of aging process and noise exposure. However, difference of mean values of exposed and control groups on blood pressure was not significantly. In psychological test, annoyance was the most severe psychological response to noise in exposed group, but mean value of BEPSI was not correlated with job duration in exposed group.

• Journal of Gastric Cancer
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• 제3권2호
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• pp.93-96
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• 2003

Purpose: Synthetic absorbable monofilaments offer excellent glide characteristics and cause minimal tissue trauma as a result of their smooth monofilament structure and gradual absorption within the healing tissues. For these reasons, these suture materials are commonly used in various surgical fields such as gastroenterology, urology, gynecology, and plastic surgery. The aim of this study was to evaluate the safety and usefulness of a new synthetic absorbable monofilament, Glycoside-..-caprolactone-trimethylene carbonate interpolymer (GCT), in gastrointestinal anastomosis and closure. Materials and Methods: We evaluated 55 gastrointestinal anastomoses and closures using GCT $MONOSYN^{R}$, B. Braun, Germany) in 47 patients who underwent gastric surgery between December 2001 and May 2002 at Seoul National University Hospital. Patient's characteristics, operative procedure, surgeon's opinion of handling properties of GCT, and suture-related complications were analyzed. Results: There were 34 males and 13 females (M:F= 2.6:1) with an average age of 54.2 years old. Forty-five cases of gastrointestinal anastomosis (20 gastrojejunostomies and 25 jejunojejunostomies) and 10 cases of intestinal closure (7 gastrostomy closures and 3 duodenal stump closures) were performed in 41 cases of stomach cancer, three of peptic ulcer disease, two of GIST, and one MALToma. The handling properties of GCT according to the criteria of knot breaking load, knot security, and placing property were always scored with 7 to 9 points (10=excellent, 1=very poor). Two cases of postoperative complications ($3.6\%$) were noted. One was a leak of the gastrojejunostomy site which was successfully managed conservatively, and the other was a stricture of the gastrojejunostomy site which was managed by reoperation (side-to-side jejunojejunostomy). Conclusion: GCT seems to be an applicable suture material for various gastrointestinal anastomoses and closures.

• 동의생리병리학회지
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• 제23권6호
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• pp.1247-1260
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• 2009

This dissertation aims to study the five tastes in the Yellow Emperor's Canon of Internal Medicine. Medicinals as well as Foods are classified by the five tastes: sweet, sour, bitter, salty and pungent, which can be tasted by the tongue. With the development of the theory dealing with the medicinal properties, some flavors are summarized out of clinical actions of medicinals, therefore, there is a little difference between the flavors of medicinal herbs and the tastes got by tongue. Each taste acts on or has direct influence on a specific vital organ, and each of which has different physiologic actions. Taste also has a long-term or post digestive effect on the body and its metabolism. When each taste is consumed in moderation, it benefits the corresponding organ. Over-indulgence in any taste harms the organ and creates imbalance among the five vital organ systems. The Korean medicinal herbs with same flavor mostly possess similar actions while the medicinal herbs with different flavors show different actions in the treatment, which are shown as follows. Sour has absorbing, consolidating and astringent actions and acts on the liver. Bitter has the actions of drying or resolving dampness, purging and lowering and acts on the heart. Sweet has the nourishing, harmonizing and moistening actions and acts on the spleen. Pungent has an action of dispersing and promoting circulation of gi and blood and acts on the lungs. Salty has the effects of softening hard nodes or masses and promoting defecation, etc and acts on the kidneys. The five organ systems control and support each other. Proper coordination only exists when there is no one organ stronger or weaker than the rest. Since the five tastes have direct influences on the five organs, the diet we take should have a good combination of the five tastes in order to promote internal balance and harmony. They control our well-being and create dietary balance. Excessive consumption of any of these could result in adverse effects. In a word, when the properties of the five tastes respectively are distinguished, their natures and flavors cannot be separately considered. I think the harmonization of food and medicinals should be stressed on good nutritional diet to maintain good health. The traditional belief that food and medicine share the same origin is a part of Korean medicine tradition.

• 한국의사학회지
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• 제30권1호
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• pp.23-31
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• 2017

Euibangyoochui (醫方類聚), the largest medical book in Korea, has medical and historical significance in that it had classified almost all East Asian medical accomplishments before Joseon Dynasty (1392-1910). Focusing on these values, this research investigates Yi'an (醫案), an East Asian tradition of describing clinical encounters and the therapies employed, in Euibangyoochui. By this investigation, this study expected to not only establish how the genre of Yi'an is employed for what purpose in Euibangyoochui, but also to shed a light on the appearance of Yi'an before Joseon Dynasty. At first, this study extracted Yi'an from Euibangyoochui (醫方類聚), as Yi'an does not have a standardized format. In total, the number of extracted Yi'ans is 1,025 with handwork results. Extracted Yi'ans are analyzed statically, in order to find dispersion of Yi'ans for each chapter and its references. Overall, there are 73 chapters of Euibangyoochui, which has a total of 93 chapters, containing Yi'an, while the chapter on gynecology contains the highest number of Yi'ans, 86. Judged from these result, the genre of Yi'an was used diversely and frequently, indicating various messages in Euibangyoochui. To categorize the usage and purpose of writing of Yi'ans in Euibangyoochui, this study considers some examples of Yi'ans and concludes that 3 types of Yi'ans are employed in Euibangyoochui in order to deliver the adequate medical message. One is result-centered Yi'an delivering a broader medical lesson, such as a taboo in treatment or a doctrine in medicine. The second is the concise-styled Yi'an presenting a short effective medical method. The third is multiple-information Yi'an that describes complex information of patients and medical theories, transmitting diverse lessons. Yi'ans in Euibangyoochui refer to 58 medical books. Books written by JangJaHwa (張子和; 1156-1228) are the most cited books, offering almost a quarter of total amount of Yi'ans in Euibangyoochui. This study is meaningful in that it provides basic information, such as numbers, applications, purpose of writing and references of Yi'an in Euibangyoochui. Moreover considering the historic values of Euibangyoochui, this information reflects, on the other hands, overall figures of Yi'an written before publication of Euibangyoochui.

• 한방재활의학과학회지
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• 제18권2호
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• pp.143-156
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• 2008

목적 : 갱년기 여성은 내장비만의 위험이 높으며 또한 심리적 변화를 겪는 시기이다. 갱년기 여성의 복부지방, 내장지방, 피하지방 및 이와 관련된 단순비만지표, 간울증, 스트레스, 우울, 자존감 등을 조사하여 갱년기 건강의 위협이 되는 신체 심리 인자를 알아보고자 이 연구를 시행하였다. 방법 : 병원공고를 통해 체질량지수 $23kg/m^2$ 이상 비흡연자인 만 45세 이상 55세 이하의 폐경 전후의 갱년기 여성 환자를 모집하여 2007년 8월 20일부터 24일까지 47명이 모집되었으며 이중 체질량지수 $25kg/m^2$ 이상이면서 복부 전산화 단층촬영 상 내장지방이 $100cm^2$ 이상인 20명의 단순비만지표, 체성분검사, 혈액검사, 복부 전산화 단층촬영 및 한방비만변증 (간울) 및 스트레스, 우울, 자존감 설문검사 결과의 상관성을 분석하였다. 본 연구는 경희대학교 동서신의학병원의 임상연구심사위원회의 승인을 받았다. 결과 : 1. 갱년기 비만여성에서 복부지방 면적, 피하지방 면적은 체질량지수, 체지방률, 허리둘레/신장비 등의 단순비만지표와 유의한 상관성을 보인 반면 (p < 0.01), 내장지방 면적은 단순비만지표와 상관성을 보이지 않았다. 2. 내장지방 면적은 사회 재적응 평가척도 (${\gamma}=0.577$, p < 0.01)와 유의한 상관성이 있었고, 선형회귀분석에서 유의한 결과를 나타냈다. $VAT(cm^2)=116.1+0.101{\times}(SRRS\;score)$ (${\gamma}^2=0.332$) 3. 피하지방은 식이태도 점수와, 총복부지방은 식이태도 점수 및 갱년기지수 중 혈관운동증상과 상관성이 있었다. 4. 간울증은 스트레스 반응척도, 우울지수, 갱년기지수 및 그 하부항목 중 혈관운동, 정신, 운동, 소화, 전신증상과 양의 상관성을, 자존감척도와는 음의 상관성을 나타냈으며, 내장지방과 직접적인 상관성을 보이지 않았다. 결론 : 간울증은 높은 스트레스, 우울, 갱년기 증상 및 낮은 자존감과 관련되는 것으로 나타났다. 폐경전후 비만여성에서 내장지방 면적은 간울증과 유의한 상관성을 보이지 않았으나, 생활 스트레스 사건이 많을수록 높아지는 것으로 나타나 갱년기 여성 내장비만에서 스트레스에 대한 대처가 중요할 것으로 사료된다. 추후 임상적 연계성 및 설문 보완에 대한 연구가 필요하리라 생각된다.

• Tuberculosis and Respiratory Diseases
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• 제61권5호
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• pp.490-495
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• 2006

자궁근종의 병력을 가진 51세 여자가 기침, 가래, 발열을 주소로 내원하였다. 기관지내시경하 조직 생 검상 평활근종이 발견되었고 환자의 자궁근종의 병력을 고려했을 때 양성 전이성 폐평활근종과의 감별이 필요하였다. 좌하엽 절제술과 동시에 자궁 절제술을 시행하였고 두 병변의 조직학적 소견을 비교해 보았을 때 폐의 병변은 자궁근종과는 무관한 원발성 기관지 평활근종으로 확진되었으며 이후 증상의 호전을 보여 현재 경과관찰 중이다.

• 한국산학기술학회논문지
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• 제16권2호
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• pp.1318-1327
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• 2015

본 연구는 콜센터 상담사의 인구사회학적 특성, 건강행태 및 직업관련 특성에 따른 이직의도 수준을 파악하고, 특히 직무스트레스와 이직의도 간의 관련성을 규명하고자 시도하였다. 조사 대상은 콜센터를 운영하고 있는 병원 9개소와 기업체 5개소에 근무하고 있는 콜센터 상담사 158명으로 하였으며, 자료 수집은 2013년 2월 1일부터 6월 30일까지의 기간 동안에 자기기입식 설문조사(self-administered questionnaire)에 의하였다. 연구결과, 이직의도에 관련된 요인으로는 연령, 수면시간, 업무요구도, 업무자율성이 유의한 변수로 선정되었다. 특히 직무스트레스 내용과 이직의도 간의 관련성에서는 업무요구도가 높아질수록 이직의도가 높은 반면, 업무의 자율성이 높아질수록 이직의도가 낮아지는 것으로 나타났다. 이직의도에 대한 직무스트레스의 위험비는 업무 요구도가 높은 군에서, 업무자율성이 낮은 군에서, 상사의 지지도 및 동료의 지지도가 낮은 군에서 이직의도가 높은 군에 속할 위험비가 유의하게 증가하였다. 따라서 이직의도를 감소시키기 위해서는 직무스트레스 요인의 개선을 위한 노력이 필요하다고 생각된다.

• Radiation Oncology Journal
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• 제3권1호
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• pp.51-58
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• 1985

외음부에서 발생하는 악성종양은 부인과 영역의 악성종양 중에서는 드물게 발생하는 것으로 알려져 있으며 치료에 있어서도 수술 또는 방사선치료 단독의 경우보다는 수술 후 보조적으로 방사선 치료를 시행하는 것이 더 효과적이고 치료율도 높은 것으로 알려져 있다. 이에 1971년 1월부터 1985년 4월 사이에 연세대학교 의과대학 치료방사선과에서 외음부 악성 종양으로 진단되어 방사선 치료를 받았던 15예에 대하여 후향성 분석을 시행한 바 다음과 같은 결과를 얻었기에 보고하는 바이다. 1. 15예의 외음부 종양 환자 중 4예는 수술요법 시행 후 보조적요법의 방사선 치료를 받았으며, 1예는 수술전 방사선 치료를 받았고, 나머지 10예는 근치적 목적의 방사선 치료를 받았다. 2. 방사선치료만을 시행한 군과 방사선치료 및 수술요법을 병행한 군과의 국소제어율을 비교하여 본 결과, 전 15예의 국소제어율은 $53\%(8/15)$였으며, 단지 방사선 치료만을 시행한 군에서는 $40\%$(4/10), 방사선 치료 및 수술요법을 병행한 군에서는 $80\%(4/5)$의 국소제어율을 보였다. 3. 치료 실패율은(국소적 잔존+국소재발 또는 원격전이) 단지 방사선 치료만을 시행한 군에서는 $70\%(7/10)$, 수술 후 방사선 치료를 시행한 군에서는$40\%(2/5)$의 성적을 보였으며, 치료실패 호발부위는 원발병소(외음부)였다.

• Radiation Oncology Journal
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• 제9권2호
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• pp.293-301
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• 1991

CEA 측정으로 부인과 영역 악성종양의 치료결과나 재발 여부의 조기 진단을 할 수 있나를 연구한 결과이다. 1985년 1월부터 1989년 12월까지 239명의 자궁경부암 환자를 대상으로 치료전과 치료후 CEA치를 체계적으로 측정했고 이를 비교하기 위하여 정상군으로 아무런 증상이 없는 건강한 부인 65명과 양성종양을 가진 18명의 부인을 상대로 CEA치를 측정하였다. 혈장내 CEA치는 종양의 진행정도와 기의 직접관계가 있는 것을 알 수 있고 종양의 기가 진행되면 될수록 CEA치가 비정상인 경우가 높아지고 있다. 또한 CEA치가 비정상인 경우 편평상피종 환자보다는 선세포나 선세포와 편평세포가 혼합된 경우 더욱 증가되는 것을 볼 수 있었다. 결론으로 혈장내 CEA을 체계적으로 측정함으로써 치료 끝난 후 추적검사시 재발의 조기발견 및 치료결과를 확인할 수 있는 좋은 방법이라는 결론을 얻었다.

• Parasites, Hosts and Diseases
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• 제58권4호
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• pp.393-402
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• 2020

Toxoplasma gondii is an intracellular parasite that causes severe disease when the infection occurs during pregnancy. Adenosine is a purine nucleoside involved in numerous physiological processes; however, the role of adenosine receptors in T. gondii-induced trophoblast cell function has not been investigated until now. The goal of the present study was to evaluate the intracellular signaling pathways regulated by adenosine receptors using a HTR-8/SVneo trophoblast cell model of T. gondii infection. HTR8/SVneo human extravillous trophoblast cells were infected with or without T. gondii and then evaluated for cell morphology, intracellular proliferation of the parasite, adenosine receptor expression, TNF-α production and mitogen-activated protein (MAP) kinase signaling pathways triggered by adenosine A₃ receptor (A₃AR). HTR8/SVneo cells infected with T. gondii exhibited an altered cytoskeletal changes, an increased infection rate and reduced viability in an infection time-dependent manner. T. gondii significantly promoted increased TNF-α production, A₃AR protein levels and p38, ERK1/2 and JNK phosphorylation compared to those observed in uninfected control cells. Moreover, the inhibition of A₃AR by A₃AR siRNA transfection apparently suppressed the T. gondii infection-mediated upregulation of TNF-α, A₃AR production and MAPK activation. In addition, T. gondii-promoted TNF-α secretion was dramatically attenuated by pretreatment with PD098059 or SP600125. These results indicate that A₃AR-mediated activation of ERK1/2 and JNK positively regulates TNF-α secretion in T. gondii-infected HTR8/SVneo cells.