• Title/Summary/Keyword: guk (tang)

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Experimental Study for Effect of Banhasasim-tang on Mice with Reflux Esophagitis (역류성 식도염 유발 생쥐의 반하사심탕(半夏瀉心湯)투여 효과에 대한 실험 연구)

  • Jang, Myeong-Woong;Lim, Seong-Woo
    • The Journal of Internal Korean Medicine
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    • v.34 no.4
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    • pp.362-374
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    • 2013
  • Objectives : This study was carried out to investigate the inhibitory effect of Banhasasim-tang on early reflux esophagitis by control of gastric peristalsis and the lower esophageal sphincter in mice. Methods : Experimental mice were classified into three groups. The normal group were mice with no inflammation. The control group were mice with gastroesophageal reflux elicited by alcohol. The sample group were mice administered Banhasasim-tang after gastroesophageal reflux elicitation. We observed morphological change and production of ghrelin, substance P, and inducible nitric oxide synthase (iNOS) in gastroesophageal junction mucosa. In addition, we examined change of epithelial junction in esophageal mucosa and change of lower esophageal sphincter distribution. Results : The migration of inflammation-related cells in lamina propria of gastroesophageal junction decreased more in the sample group than in the control group. The positive reaction of ghrelin, substance P, and iNOS significantly decreased more in the sample group than in the control group (p<0.05). Injury of the epithelial junction in the esophageal mucosa and outer oblique layer in the lower esophageal sphincter were significantly mitigated by Banhasasim-tang administration in the sample group (p<0.05). Conclusions : According to the above results, it is supposed that Banhasasim-tang inhibits early reflux esophagitis by controlling not only gastric peristalsis and acid secretion through ghrelin, and substance P but also the lower esophageal sphincter through iNOS.

A Case of Pyungwijiyutang-gamibang Diagnosed as Constipation due to Stagnation of Eum with Ulcerative Colitis (음결(陰結)로 변증한 궤양성 대장염 환자의 평위지유탕가미방(平胃地楡湯加味方) 치험 1례)

  • Hwang, Joo-Won;Choi, Hyo-Jae;Baik, Yun-Seon;Jeong, Sung-Hyun;Shin, Gil-Cho;Lee, Won-Chul
    • The Journal of Internal Korean Medicine
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    • v.28 no.4
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    • pp.972-977
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    • 2007
  • Objectives : To see the effect of herbal medicine on ulcerative colitis by diagnosing ulcerative colitis as constipation due to stagnation of eum. Methods : We report here on a case of a patient who had abdominal pain, rectal urgency, diarrhea and hemafecia as chief complaints in December 2004 and was diagnosed with ulcerative colitis on January 20, 2007. The patient was treated with Pyungwijiyu-tang till Hwanggi was added on March 23rd of the same year. No change was made to the prescription since then. Results : After 14 weeks of herbal treatment the chief complaints decreased favorably and had no relapse. Conclusions : In this case, we recognized that the herbal medication could be effective for the clinical symptoms of ulcerative colitis. It was effective in decreasing or maintaining the symptoms of patients and in improving quality of life.

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A Case Report of a Patient with Cranial Dystonia Diagnosed as Meige Syndrome (메이그증후군으로 진단받은 안면 근육 긴장 이상 환자 증례 보고 1례)

  • Park, Song-won;Kim, Youngji;Song, Jooyeon;Lee, Chan-sol;Hong, Seungcheol;Oh, Ji-hye;Jung, Ji-chun
    • The Journal of Internal Korean Medicine
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    • v.39 no.5
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    • pp.886-894
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    • 2018
  • Objective: Despite being the most common cause of cranial dystonia, Meige syndrome remains a rare clinical entity. It is characterized by blepharospasm and orofacial dystonia. This case study reports on the use of traditional Korean medicine for a patient who suffered from blepharospasm and oromandibular dystonia suspected to be the result of Meige syndrome. Methods: A patient was given a series of Korean medicine therapy treatments, including administration of the herbal medicine Gamiguibi-tang-gamibang, acupuncture, and cupping, over a 19 day hospitalization period. We measured the state and progress of this case using the numeric rating scale and dystonia frequency. Results: A decrease in subjective symptoms and reduction in the frequency of oromandibular dystonia was observed after Korean medicine therapy treatments. Conclusion: This case is useful for describing herbal medicine treatment for Meige syndrome, and further case reports and studies will be needed in the future.

The Administration of Jeungmiyijin-tang to Rats with Induced Gastro Reflux Esophagitis (증미이진탕(增味二陳湯) 투여가 역류성 식도염 유발 생쥐에 미치는 영향)

  • Lee, Seul-ki;Lim, Seong-woo
    • The Journal of Internal Korean Medicine
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    • v.37 no.6
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    • pp.1030-1041
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    • 2016
  • Objectives: This study investigated the administration of Jeungmiyijin-tang (JYT) to rats with reflux esophagitis (RE) induced by pylorus and forestomach ligation operations. Methods: Twenty laboratory rats were divided into three groups with 5~7 rats in each group. The control group consisted of rats with no inflammation (CON). The RE group had rats with gastroesophageal reflux elicited by pylorus and forestomach ligation operations. The JYT group had rats that were orally administered Jeungmiyijin-tang (1.5 ml/day/300 g) once a day for 14 days before reflux esophagitis was induced by the pylorus and forestomach ligation operations. Six hours after the operations, the rats were sacrificed, morphological changes were observed, and histological examinations were done in the stomach and esophagus lesion areas. If apoptosis was observed, the apoptotic cells in the esophagus lesion areas were counted. Results: The morphological and histochemical changes consisted of various injuries from hemorrhagic erosion in the RE group, while there were significantly fewer in the JYT group. The RE group marked increases of gastric mucosa erosion and infiltration of inflammatory cells in the submucosa, as well as cell division in the epithelial layer, the proliferation and degranulation of mast cells, and increases in the IL-$1{\beta}$, TNF-${\alpha}$, and MMP-9 expressions in the esophagus of the rats. The JYT group was inhibited above expression compared with the RE group. Apoptosis was statistically significantly decreased in the JYT group compared with the RE group. Conclusions: According to the above results, it appears that Jeungmiyijin-tang inhibits the expression of pro-inflammatory cytokines (TNF-${\alpha}$, IL-$1{\beta}$, and MMP-9) and apoptosis in the esophagus mucosa, thereby preventing esophageal mucosal damage from esophageal reflux.

The Effect of KangwhalSokdan-tang(Jianghuoxuduan-tang) Administration on Muscle Regeneration in Atrophied Rat Muscle Induced by Hindlimb Suspension (후지체공(後肢滯空) 유발 흰쥐의 위축 근육에 대한 강활속단탕(羌活續斷湯)의 근 재생효과)

  • Soh, Kab-Seog;Park, Young-Hoi;Oh, Jae-Keun;Lee, Myeong-Jong
    • Journal of Korean Medicine Rehabilitation
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    • v.19 no.4
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    • pp.19-35
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    • 2009
  • Objectives : This experimental study was designed to investigate the effect of KangwhalSokdan-tang(Jianghuoxuduan-tang) on the muscle regeneration of atrophied rat muscle by hindlimb suspension. Materials and methods : In this study, Sprague-Dawley rats weighing about 250g were subjected to hindlimb suspension and divided into total four groups: Normal group(n=6), Control group(n=6), Hindlimb non-treatment group(n=6), Hindlimb treatment group(n=6). Experiments were seperately tried two times. The first trial was studied by the following two groups; The first was normal group(n=6). The second was group(n=18) for hindlimb suspension during 2 weeks (control I group). The second trial after 2 weeks hindlimb suspension was studied by the following three groups; The third group(n=6) was expired immediately after 2 weeks hindlimb suspension. The forth group(n=6) was given free activity during 2 weeks after 2 weeks hindlimb suspension. The fifth group(n=6) was administrated of KST during 2 weeks after 2 weeks hindlimb suspension. In order to investigate degree of muscle atrophy, body weight and gastrocnemius muscle mass were compared. To analyze muscle regeneration factors(expression of IGF-1, Myogenin, MyoD), Western blot was used. Results : The results were analyzed by statistical process as follows, 1. In body weight, all hindlimb suspension groups were lower than normal group, but tendency of increase was shown in KST group compared to non-treatment group after 2 weeks hindlimb suspension. 2. In gastrocnemius muscle mass, KST group on both side was significantly higher than non-treatment group after 2 weeks hindlimb suspension. 3. In case of IGF-I, Type I of KST group was significantly increased than non-treatment group, but Type II was not shown significance. 4. There was no significantly difference in Myogenin. 5. In MyoD, Type I of KST group was significantly increased than control group, and Type II of KST group was significantly increased than non-treatment group. Conclusions : In summary, this study demonstrates that KST administration has an effect to prevent muscle atrophy and contribute muscle regeneration and proliferation. And also it is suggested that IGF-I and MyoD is major factors of myogenesis expression to KST adminstration after hindlimb suspension.

The Effects of Hyang-Sa-Yuk-Gun-Ja-Tang and Oh-Pe-San on The Gastric Mucosal Repair (위장관(胃腸管) 점막층(粘膜層)의 회복(恢復)에 향사육군자탕(香砂六君子湯)과 오패산(烏貝散)이 미치는 영향(影響))

  • Chang, Hen-Yel;Kang, Yoon-Ho
    • The Journal of Dong Guk Oriental Medicine
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    • v.2 no.1
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    • pp.127-137
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    • 1993
  • In order to investigate the clinical efficiency based on Oriental Medical References of Hyang-Sa-Yuk-Gun-Ja-Tang and Oh-Pe-San, histological studies have been done by using the experimental animal. The following results were obtained. 1. The Hyang-Sa-Yuk-Gun-Ja-Tang showed a significant promoting effect of repair on the epithelial layer from the basement membrane of duodenal ulcer in rats. 2. The Oh-Pe-San showed efficiencies about repair of the necrosis in epithelial layer on the acute gastritis in rats. According to above results, it is concluded that Oh-Pe-San and Hyang-Sa-Yuk-Gun-Ja-Tang were recognized to be effective on the acute gastritis and the duodenal ulcer in rats, and this study may suggest a clinical guidance to the prescriptions for the treatment of gastritis end gastric ulcer.

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Effect of Geonpye-tang(GPT) on Production and Gene Expression of Respiratory Mucin (건폐탕(健肺陽)이 호흡기 뮤신의 생성 및 유전자 발현에 미치는 영향)

  • Jung, Byeong-Jin;Kim, Ho;Seo, Un-Kyo
    • The Journal of Internal Korean Medicine
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    • v.30 no.4
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    • pp.685-695
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    • 2009
  • Objectives : In this study, the author tried to investigate whether Geonpye-tang(GPT) significantly affects PMA-, EGF- or TNF-alpha-induced MUC5AC mucin production and gene expression from human airway epithelial cells. Materials and Methods : Effects of the agent on PMA-, EGF- or TNF-alpha-induced MUC5AC mucin production and gene expression from human airway epithelial cells (NCI-H292) were investigated. Confluent NCI-H292 cells were pretreated for 30 min in the presence of GPT and treated with PMA (10ng/ml) or EGF (25ng/ml) or TNF-alpha (0.2nM), to assess both effect of the agent on PMA- or EGF- or TNF-alpha-induced MUC5AC mucin production by enzyme-linked immunosorbent assay (ELISA) and gene expression by reverse transcription-polymerase chain reaction (RT-PCR). Possible cytotoxicity of the agent was assessed by examining the rate of survival and proliferation of NCI-H292 cells after treatment with the agent over 72 hrs (SRB assay). Results : (1) GPT significantly inhibited PMA-induced and EGF-induced MUC5AC mucin production from NCI-H292 cells. However, GPT did not affect TNF-alpha-induced MUC5AC mucin production. (2) GPT significantly inhibited the expression levels of PMA-, EGF- or TNF-alpha-induced MUC5AC genes in NCI-H292 cells (3) GPT did not show significant cytotoxicity to NCI-H292 cells. Conclusion : This result suggests that GPT can affect the production and gene expression of respiratory mucin observed in diverse respiratory diseases accompanied by mucus hypersecretion. This can explain the traditional use of GPT in oriental medicine. Effects of GPT with their components should be further investigated using animal experimental models that reflect pathophysiology of airway diseases through future studies.

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A Study on Reinforcing-reducing between Five Viscera and Five Tastes - Focus on 『FuXingJue』 - (오장(五臟)과 오미(五味)의 고욕보사(苦欲補瀉)에 관한 연구 - 『보행결(輔行訣)』을 중심으로 -)

  • Yeo, Min-Kyung;Kim, Thae-Yul;Lee, Byung-Wook;Kim, Ki-Wook
    • The Journal of Korean Medical History
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    • v.28 no.1
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    • pp.53-60
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    • 2015
  • Objectives : This is what tries to study irregular pairs between five viscera and five tatstes. And than tries to make convincing explanation. Methods : We analysed "SuWen ZangQiFaShiLun素問 藏氣法時論", "YiXueQiYuan醫學啓源", "TangYeBenCao湯液本草", "BenCaoGangMu 本草綱目" and "FuXingJueZangFuYongYaoFaYao輔行訣臟腑用藥法要". We found difference and similarities between these books. Result & Conclusions : "YiXueQiYuan", "TangYeBenCao", "BenCaoGangMu" inherit pairs between five viscera and five tatstes from "ZangQiFaShiLun". "YiXueQiYuan" had added examples of herbs to "ZangQiFaShiLun". "TangYeBenCao" had added examples of priscriptions to "ZangQiFaShiLun". "BenCaoGangMu" had added examples of herbs to "ZangQiFaShiLun". But new pairs between five viscera and five tatstes had suggested in the "FuXingJueZangFuYongYaoFaYao". We think that the new pairs are more logical than the others.

A Literature Review Examining the Ingredients and Cooking Methods of the Side Dishes in "Chosunmusangsinsikyorijebub" (I);Tang (guk), Changguk, Gigimi, Chigye, Chim, Chorim.Cho, Baeksuk, Hoei, Pyunyook ("조선무쌍신식료리제법(朝鮮無雙新式料理製法)"에 수록된 부식류의 조리법에 관한 고찰 (I);탕(국), 창국, 지짐이, 찌개, 찜, 조림.초, 백숙, 회, 편육)

  • Kim, Up-Sik;Han, Myung-Joo
    • Journal of the Korean Society of Food Culture
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    • v.23 no.4
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    • pp.427-437
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    • 2008
  • This study examined the ingredients and cooking methods of side dishes in "Chosunmusangsinsikyorijebub" during the year of 1924, approximately. In the recipe for Tang (Guk), there was much use of various parts of beef, fish, shellfish, vegetables, and mushrooms, and soybean paste, hot pepper paste, and soy sauce were used as seasonings. For Chootang and Byulchootang, cinnamon powder was added at the end of cooking. In foods such as Tang (Guk), Gigimi, Chigye, Chim, and steamed dishes, which were made of beef, pork, chicken, various fish, Chinese cabbage, and over ripened cucumbers, and thickened by adding buckwheat powder or wheat powder, the taste of the food was changed by controlling the gravy content. In the recipe for Gorim-Cho, ingredients such as beef, pork, chicken, and various fish were used, which were cooked in boiling water and soy sauce. Boiling or steaming were employed as the cooking methods for Baeksuk, where beef rib Baeksuk was seasoned with salt and fermented shrimp and then boiled. For porgy and herring Baeksuk, the internal organs of the fish were first removed, and then they were steamed with pine needles. Hoei incorporated the flesh of various meats, various beef organs, pork skin, and fish as ingredients, and different dipping sauces and pine nut powder were also used.

A STUDY ON THE EFFECT OF SIB ZUN DAE BO TANG ADMINISTERED IN RABBIT WITH HEPATIC DISFUNCTION ON THE RATE OF RECOVERY (십전대보탕액(十全大補湯液)을 투여(投與)하여 가토간손상(家兎肝損傷)의 회복(回復)에 관(關)한 실험적(實驗的) 연구(硏究))

  • Kim, Han-Suk
    • The Journal of Internal Korean Medicine
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    • v.1 no.1
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    • pp.78-84
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    • 1976
  • The SIB ZUN DAE BO TANG is one of the prevailing tonics appeared at first time on TAE PYUNG HOE MIN HAW ZE GUK BANG in Song’s dynasty and have been widely used up to now. To observe the metabolic effects of Thioacetamide from the SIB ZUN DAE BO TANG, the following experiment was performed. 1. The activation of G.O.T. and G.P.T. to blood serum have been decreased when Thioacetamide was administrated into the rabbit. 2. The coefficiency of the SIB JUN DAE BO TANG appears in 3 hours after administrate and it decreases gradually along with it’s time(1st, 2nd, 3rd day) but the coefficiency of the G.P.T. was more apparent on 2nd, 3rd and 5th day. 3. When administrating Thioacetamide, the total amount of cholesterol grows rapidly up to 3rd day and it continuously grows after the 3rd day. But when administrating SIB ZUN DAE BO TANG, the cholesterol amount in blood grows up to 3rd day, but it decreases gradually after it on the other day. The conclusion of the above experiments shows that the prescription (SIB ZUN DAE BO TANG) improves the metabolic deficiency and the recovery and remedy of diseases.

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