• The Journal of Asian Finance, Economics and Business
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• 제8권3호
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• pp.741-750
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• 2021

The budget deficit is closely related to expansionary fiscal policy as a fiscal instrument to encourage economic growth. This study aims to apply optimal control theory in the Keynesian macroeconomic model for the economy, so that optimal growth can be found. Macroeconomic variables include GDP, consumption, investment, exports, imports, and budget deficit as control variables. This study uses secondary data in the form of time series, the time period 1990 to 2018. Performing optimal control will result in optimal fiscal policy. The optimal determination is done through simulation, for the period 2019-2023. The discrete optimal control problem is to minimize the objective function in the form of a quadratic function against the deviation of the state variable and control variable from the target value and the optimal value. Meanwhile, the constraint is Keynes' macroeconomic model. The results showed that the optimal value of macroeconomic variables has a deviation from the target values consisting of: consumption, investment, exports, imports, GDP, and budget deficit. The largest deviation from the average during the simulation occurs in GDP, followed by investment, exports, and the budget deficit. Meanwhile, the lowest average deviation is found in imports.

• 한국발생생물학회지:발생과생식
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• 제28권2호
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• pp.37-45
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• 2024

This study aimed to elucidate the potential of Homeobox A11 (HOXA11) as a therapeutic target and a diagnostic methylation marker for cervical cancer. Gene expression analysis using cDNA microarray in cervical cancer cell lines revealed significantly reduced expression of the HOXA11 gene. Subsequent investigation of HOXA11 promoter methylation in samples from normal individuals and invasive cervical cancer patients showed over 53.2% higher methylation in cancer scrapes compared to normal scrapes. Furthermore, overexpression of HOXA11, which is downregulated in cervical cancer, strongly suppressed cell growth in cervical cancer cell lines, HeLa and HT3. Additionally, we performed transferase dUTP nick end labeling assay and confirmed that the inhibition of cervical cancer cell proliferation occurred via apoptosis. Mechanistically, overexpression of HOXA11 led to mitochondrial apoptosis characterized by PARP cleavage due to increased c-Myc and enhanced cytochrome C secretion into the cytoplasm. These findings suggest that HOXA11 could potentially serve as a methylation marker for diagnosing cervical cancer and as a novel therapeutic target for its treatment.

• 한국산림과학회지
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• 제83권2호
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• pp.121-132
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• 1994

윤벌기(輪伐期)는 각 영급이 존재하는 삼림의 생산(生産)을 조절하기 위해서 설정된 삼림경영목표(森林經營目標)중 가장 중요한 인자중의 하나이다. 본 연구(硏究)에서는 특히 최적화(最適化)계산의 형태로 법정임(法正林)모델에서의 최적윤벌기(最適輪伐期)가 추정(推定)되었다. 그리고 법정림모델과의 연계하에 자연상태에서 여러가지 위험조건에 처해있는 현실임분(現實林分)에 더욱 접근시키기 위하여 목표임(目標林)모델이 간단작업급삼림(間斷作業級森林)모델(모델 1)과 연년보속작업급삼림(連年保續作業級森林)모델(모델 2)의 두가지로 나뉘어 전개되었으며 이 두 모델에 의해 최적윤벌기가 계산되었다. 동시에 법정림모델, 목표림모델 1, 2에 의해 추정된 최적윤벌기가 상호 비교되었다. 이때 강원대학교(江原大學校) 임과대학(林科大學) 부속(附屬) 연습림(演習林) 내(內) 잣나무임분이 최적윤벌기(最適輪伐期) 계산의 대상이 되었다.

• 한국컴퓨터산업학회논문지
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• 제6권3호
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• pp.509-518
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• 2005

원격 모니터링 시스템(RMS; Remote Monitoring System)은 산업의 자동화 과정에 따라 다양한 분야에 적용되고 있으며, 단순한 상태 감시기능에서 멀티미디어 인터페이스 기반의 실시간 제어 기능을 갖는 복합 응용시스템으로 발전하고 있는 추세이다. 본 연구에서는 네트워크로 연동된 원격 사이트의 타겟 시스템(target system)을 클라이언트의 웹 브라우저에서 모니터링 할 수 있는 감시기능과 특정 동작을 제어할 수 있는 제어기능을 갖는 웹 기반 모니터링 시스템을 개발하였다. 개발 시스템은 클라이언트가 웹 브라우저에서 타겟 시스템의 상태를 실시간으로 감시할 수 있는 모니터링 기능, 클라이언트가 모니터링 화면에서 특정 모듈의 값을 설정함으로써 시스템의 상태를 제어하는 출력제어 기능, 클라이언트가 웹 환경에서 타겟 시스템의 환경 변수를 직접 설정 또는 변경할 수 있는 환경설정 기능, 네트워크에 연동된 화상카메라를 이용하여 타겟 시스템 주변 환경을 비디오로 감시할 수 있는 비디오 감시기능 등으로 구성되어 있다. 본 RMS는 웹 기반의 인터페이스로 타겟 시스템에 쉽게 접근 및 관리가 가능하며, 특히, 무인 자동화 설비 및 폐쇄 공간 등에서 유용하게 활용될 수 있다.

• Asian-Australasian Journal of Animal Sciences
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• 제29권10호
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• pp.1508-1514
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• 2016

A series of antagonists specifically targeting growth hormone receptors (GHR) in different species, such as humans, rats, bovines, and mice, have been designed; however, there are currently no antagonists that target the porcine growth hormone (GH). Therefore, in this study, we developed and characterized a porcine GHR (pGHR) antibody antagonist (denoted by AN98) via the hybridoma technique. The results from enzyme-linked immunosorbent assay, fluorescence activated cell sorter, indirect immunoinfluscent assay, and competitive receptor binding analysis showed that AN98 could specifically recognize pGHR, and further experiments indicated that AN98 could effectively inhibit pGH-induced signalling in CHO-pGHR cells and porcine hepatocytes. In addition, AN98 also inhibited GH-induced insulin-like growth factor-1 (IGF-1) secretion in porcine hepatocytes. In summary, these findings indicated that AN98, as a pGHR-specific antagonist, has potential applications in pGH-pGHR-related research on domestic pigs.

• 한국환경농학회지
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• 제29권2호
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• pp.115-119
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• 2010

Zinc (Zn) is an essential element required for growth and development of plants. However, Zn can be toxic to plants when it presents excessive amount. Phytoextraction is an economic and environment-friendly technique using plants to clean-up metal-contaminated soils. However, the technique cannot be applied in highly metal-contaminated areas because plants will not normally grow in such conditions. Therefore, this research focuses on identifying chelating agents which are biodegradable and applicable to highly metalcontaminated areas. Zn as a target metal and cysteine (Cys), histidine (His), malate, citrate oxalate, succinate, and ethylenediamine (EDA) as biodegradable chelating agents were selected. Plants were grown on agar media containing various chelating agents with Zn to analyze the effect on plant growth. Malate and His slightly increased the inhibitory effect of Zn on root growth of plants, whereas Cys, citrate, oxalate, and succinate did not show significant effects. However, EDA strongly diminished the inhibitory effect of Zn on root growth. The effect of EDA is correlated with decreased Zn uptake into the plants. In conclusion, as biodegradable chelating agents, EDA is a good candidate for growth of plants in highly Zn-contaminated areas.

• 한국어병학회지
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• 제25권2호
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• pp.103-109
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• 2012

The objective of this study was to investigate the effects of exposured $Cu^{2+}$ on growth and bioaccumulation of abalone Haliotis discus hannai. Abalone were exposed to various concentration of $Cu^{2+}$ (0, 5, 10, 20, $40{\mu}g/L$). Bioaccumulation of tissues, hepatopancreas, muscles and gills were measured. hepatopancreas and gills $Cu^{2+}$ concentration of abalone increases to extent during the 4 weeks accumulation time. But muscles showed no significant changes, with respect to control. These data indicate that abalone Haliotis discus hannai hepatopancreas and gills can be considered adequate target tissues for waterborne exposured of $Cu^{2+}$. Weight growth rate of abalone exposed to $Cu^{2+}$ was significantly decreased in 20 and $40{\mu}g/L$ groups compared to control. This study revealed that high $Cu^{2+}$ concentration (${\geq}20{\mu}g/{\ell}$) reduced growth of abalone. These data indicate that excessive waterborne $Cu^{2+}$ can affect the toxicity of xenbiotics to abalone through alterations in growth rate. Thus, environmental standard of $Cu^{2+}$ $20{\mu}g/L$, should be considered a potential source of variation in toxicological studies with abalone.

• 한국발생생물학회지:발생과생식
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• 제23권1호
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• pp.35-42
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• 2019

Fish shows great difference in growth rate between individuals during larval development and early growth. This difference seriously reduces the production efficiency in fish culture. Growth hormone (GH)/Insulin-like growth factor 1 (IGF1) system is said to play some pivotal roles in fish growth. In this study, we investigated differences of GH, IGF1 and GHR gene expressions in juvenile red spotted grouper (Epinephelus akaara) with different growth performance. Red spotted groupers were reared under the same environmental condition (water temperature $24{\pm}1^{\circ}C$, natural light) for 96 days after hatching. They were divided into 3 groups by size (fast growing, middle growing and slow growing groups: FGG, MGG, and SGG, respectively). RNA was extracted from the brain, liver and muscle tissues from each group, and target gene expression was examined by real-time PCR. In the brain with pituitary gland, expression of GH gene in FGG was significantly higher than the expression in SGG, but the expression of IGF1 and GHR genes in the muscle was highest in SGG. Difference of GHR and IGF1 mRNA in the liver between groups with different growth performance was less clear than that in other tissues, although level of IGF1 mRNA was higher in SGG than in MGG. These results suggest that hormonal governing of growth is not the same in fast growing and slow growing fish, and size grading could cause a shift of hormonal state and growth pattern in this species.

• 한국결정성장학회지
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• 제30권5호
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• pp.208-213
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• 2020

본 연구에서는 유한요소 해석과 PQRSM 알고리즘 기반의 최적설계 기법을 활용하여 IGZO 산화물 타겟과 구리백플레이트가 서로 접합되어 있는 타겟 모듈에서 IGZO 산화물의 열변형을 최소화할 수 있는 방법에 대해 고찰했다. 3차원 유한요소 해석 결과 고온에서 IGZO와 구리 백플레이트의 접합 이후 냉각될 때 IGZO 산화물의 열변형은 최대 0.161 mm로 예측되었다. 유한요소 해석을 연동한 최적설계기법을 적용하기 위해 타겟 모듈을 냉각할 때 사용하는 하부받침대와 상부고정대의 위치를 설계변수화하여 목적함수인 IGZO의 열변형이 최소화되도록 최적설계를 수행했고, 그 결과 IGZO 산화물의 열변형을 최대 42 % 감소시킬 수 있었다. 이는 타겟을 구성하는 주재료와 구조 변경 없이 공정 중에 사용되는 부재료의 위치 변경만으로도 산화물의 열변형을 감소시킬 수 있어 산업계에 유용할 것으로 사료된다.

• Molecules and Cells
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• 제40권3호
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• pp.211-221
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• 2017

Transforming growth factor ${\beta}1$ $(TGF{\beta}1)/Smad4$ signaling plays a pivotal role in maintenance of the dynamic balance between bone formation and resorption. The microRNA miR-155 has been reported to exert a significant role in the differentiation of macrophage and dendritic cells. The goal of this study was to determine whether miR-155 regulates osteoclast differentiation through $TGF{\beta}1/Smad4$ signaling. Here, we present that $TGF{\beta}1$ elevated miR-155 levels during osteoclast differentiation through the stimulation of M-CSF and RANKL. Additionally, we found that silencing Smad4 attenuated the upregulation of miR-155 induced by $TGF{\beta}1$. The results of luciferase reporter experiments and ChIP assays demonstrated that $TGF{\beta}1$ promoted the binding of Smad4 to the miR-155 promoter at a site located in 454 bp from the transcription start site in vivo, further verifying that miR-155 is a transcriptional target of the $TGF{\beta}1/Smad4$ pathway. Subsequently, TRAP staining and qRT-PCR analysis revealed that silencing Smad4 impaired the $TGF{\beta}1$-mediated inhibition on osteoclast differentiation. Finally, we found that miR-155 may target SOCS1 and MITF to suppress osteoclast differentiation. Taken together, we provide the first evidence that $TGF{\beta}1/Smad4$ signaling affects osteoclast differentiation by regulation of miR-155 expression and the use of miR-155 as a potential therapeutic target for osteoclast-related diseases shows great promise.