• YAKHAK HOEJI
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• v.34 no.6
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• pp.407-414
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• 1990

The relationships of inhibitory activities of inflammation and wound healing of flavonoids were studied in vitro and in vivo. Generally flavonoids have not only significantly anti-inflammatory activity in carrageenin-induced paw edema and Freund's complete adjuvant-induced arthritis, but also inhibitory activity of wound healing. The more inhibitory activities of wound healing flavonoids have, the more they have the anti-inflammatory activities; apigenin > guercetin > flovone > rutin > hesperidin > naringin. Their inhibitory mechanism seems to be inhibition of the inflammatory cell infiltration and fibroblast proliferation, and so they decreased the granulomatous activity and tensile strength.

• YAKHAK HOEJI
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• v.20 no.3
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• pp.149-155
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• 1976

The antiinflammatory activity of Phytolacca saponin and phytolaccagenin isolated from the roots of Phytolacca americana has been investigated. When Phytolacca saponin and phytolaccagenin were given parenterally exhibited potent inhibitory effects on acute edema in rats and in mice. while oral administrtion required 6 times more dosage in comparison with that of intrapertioneal injection. The anti-exudative and anti-granulomatous activities of the saponin showed as much as the dose of 8 times higher than that of hydrocortisone. The saponin appeared to be of no effects on adrenal, however, showed a severe thymolysis at high dose.

• Archives of Reconstructive Microsurgery
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• v.2 no.1
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• pp.77-81
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• 1993

Free tissue transplantation is commonly performed with the brilliant achievement in microsurgery and anticoagulants and antithrombotic agents have been prescribed in the procedures. However, there is no clean-cut indication as to which agents would be more effective in every steps and final consequences. Low molecular weight heparins inhibiting coagulation in plateletrich plasma and acting on the vascular endothelium have antithrombotic and fibrinolysis action. The experiment with rat groin free flap transplantation after 6-hour ischemia and injection of the low molecular weight heparin was performed and the results between the injection and non-injection group were analysed as follows, 1. Both of the 24-hour groups, vessel patency was not proportional to color change of the groin flap. 2. On the second day after anastomois, heparin-injection group showed intact intima, patent lumen without thrombus, and mild granulomatous inflammation around the suture material and control group with doubtful patency revealed intimal loss and thrombus formation. 3. On the 5th, 7th, and 9th postoperative day, heparin group was patent in anastomosis and showed acute inflammatory cells. 4. The 7th-week period, heparin-injection group showed intact flap color, patent lumen with intact intima and persistent foreign body granuloma.