• The Korean Journal of Pharmacology
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• v.5 no.2
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• pp.141-148
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• 1969

The direct effect of isoproterenol on renal function, when given intravenously, is usually obscured by its potent hypotensive action. To obviate the latter action, isoproterenol was infused directly into one renal artery of the dog, the other kidney serving as a control for the general action. And following results were obtained. In the first series of experiments, the directic action of isoproterenol was ascertained. $1.0\;{\mu}g/kg/min$. reduced on both kidneys the urine flow, clearances of PAH and creatinine, as well as the amount of sodium excreted, but the effect was weaker on the experimental side than on contralateral side. With $0.1\;{\mu}g/kg/min$., two cases among 6 experiments showed marked diuresis, two cases no apparent effect, and another two marked antidiuresis on the experimental kidney, whereas the contralateral kidney exhibited antidiuresis in all cases. Further reducing the dose unmasked the diuretic action on the ,experimental kidney. In another series, the effects of isoproterenol on the blood flow distribution within the kidney and on sodium concentration gradient within the kidney tissue were observed. $0.05\;{\mu}g/kg/min$ isoproterenol markedly increased the medullary plasma flow and slightly increased total renal plasma flow and glomerular filtration rate, along with concomitant increase in the amount of sodium excreted and osmolar clearance, and decrease in reabsorption of free water. Sodium concentration gradient markedly decreased in the experimental kidney, reaching 2/3 of the value observed in the contralateral kidney at the papilla. It is thus concluded that isoproterenol exerts a diuretic action, when infused directly into a renal artery, and the mechanism of the action rests on its hemodynamic action, substantiated as the increase in glomerular filtration and in the medullary blood flow, resulting in washout of hyperosmolality produced by the coutercurrent multiplier system.

• Journal of Soil and Groundwater Environment
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• v.22 no.4
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• pp.9-26
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• 2017

When a warm well located downgradient is captured by cold thermal plume originated from an upgradient cold well, the warm thermal plume is pushed further downgradient in the direction of groundwater flow. If groundwater flow direction is parallel to an aquifer thermal energy storage (ATES), the warm well can no longer be utilized as a heat source during the winter season because of the reduced heat capacity of the warm groundwater. It has been found that when the specific discharge is increased by $1{\times}10^{-7}m/s$ in this situation, the performance of ATES is decreased by approximately 2.9% in the warm thermal plume, and approximately 6.5% in the cold thermal plume. An increase of the specific discharge in a permeable hydrogeothermal system with a relatively large hydraulic gradient creates serious thermal interferences between warm and cold thermal plumes. Therefore, an area comprising a permeable aquifer system with large hydraulic gradient should not be used for ATES site. In case of ATES located perpendicular to groundwater flow, when the specific discharge is increased by $1{\times}10^{-7}m/s$ in the warm thermal plume, the performance of ATES is decreased by about 2.5%. This is 13.8% less reduced performance than the parallel case, indicating that an increase of groundwater flow tends to decrease the thermal interference between cold and warm wells. The system performance of ATES that is perpendicular to groundwater flow is much better than that of parallel ATES.

• Journal of Korean Tunnelling and Underground Space Association
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• v.19 no.2
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• pp.213-229
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• 2017

Recently, in urban areas there is a tendency to construct more complex network-type tunnels including entrance and exit ramps. At the same time, various one-dimensional programs based on the network theory have been proposed for tunnel ventilation analysis. This paper aims at developing a program that can analyze the ventilation flow rate and pollutants concentration in complex network-type tunnels based on the none hardy-cross method. The flow analysis in the branch was carried out on the basis of the Gradient method, while for the concentration analysis a new logic has been developed to calculate the inflow and outflow concentration automatically in a complex network-type structure. Additionally, in the tunnel segments showing low flow rate, proper grid interval sizes were proposed to reduce numerical error. To verify the applicability of the program, flow rates predicted in the straight tunnels were compared with the classical velocity-diagram method by Stokic and the TVSDM program. The results showed that the errors were within 1%. In addition, the program was applied to the recent ventilation system adopted in the complex network-type urban tunnels.

• 한국전산유체공학회:학술대회논문집
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• 2001.10a
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• pp.44-50
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• 2001

A numerical study was made to choose the better turbulence model for the flow in the discharge flow path from a diffuser to a wall. In this study standard $\kappa-\epsilon$ model(SKE), RNG $\kappa-\epsilon$ model(RNG), and Reynolds stress model(RSM) were applied. In case of the flow with relatively high Reynolds number at a diffuser inlet, the pressure loss coefficients by RNG have a tendency to be near to those by SKE at small ratio(below about 0.35) of $h/D_o$, but to those by RSM at large ratio(above about 0.35). At large ratio RNG begins to enlarge the effects of rapid strain and streamline curvature. RNG & RSM are recommended as the appropriate turbulence models for this case. But it is noticeable that the velocity gradient pattern in RNG is same as in SKE, and also that the total pressure distribution in RNG is same as in RSM only at swirling flow area, same as in SKE only at main flow area.

• International Journal of Vascular Biomedical Engineering
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• v.2 no.1
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• pp.25-30
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• 2004

Catheters are used to measure translesional pressure gradients in the stenosed coronary arteries. Uses of catheters during coronary angioplasty cause flow obstructions. A narrowed flow cross section with catheter effectively introduced a tighter stenosis than the enlarged residual stenoses after balloon angiplasty. Catheters in blood vessels cause pressure gradient rise and blood flow drop during the measurements. In this study, three dimensional computer simulations are conducted to investigate the flow blockage effects due to the catheter obstructions during the coronary angioplasty. The computer simulation models are generated by the data, which are measured by coronary angiogram, and the blood is treated as non-Newtonian fluid. The velocity, pressure, and wall shear stress variations are observed for the estimate of damages of blood vessel. This study is also extended to investigate the effects of stenotic vessel size, and shape and catheter size and location.

• Korean Management Science Review
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• v.21 no.1
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• pp.77-86
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• 2004

In this paper, we present a methodology for solving the multicommodity network flow problems using interior point methods. In our method, the minimum cost network flow problem extracted from the given multicommodity network flow problem is solved by primal-dual barrier method in which normal equations are solved partially using preconditioned conjugate gradient method. Based on the solution of the minimum cost network flow problem, a warm-start point is obtained from which Castro's specialized interior point method for multicommodity network flow problem starts. In the computational experiments, the effectiveness of our methodology is shown.

• Transactions of the Korean Society of Automotive Engineers
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• v.5 no.3
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• pp.35-46
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• 1997

In order to satisfy customer's requirements of ride comfort and high performance, it is necessary for designers to fully understand vehicle aerodynamics and wind noise of newly produced cars because characteristics of flow and wind noise are heavily dependent on each other. In this study numerical and experimental study have been carried out to analyse the effect of flow characteristics at around of rear view mirror on wind noise and soiling on the front S/W. As a result, it's found that the spiral flow mear the front pillar is weakened and spreaded because rear view mirror obstructs the flow. It is also shown that there is abrupt change of gradient of separa- tion line, separation area, intensity of spiral flow and turbulent kinetic energy with varying shape of neck and housing of rear view mirror.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2012.05a
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• pp.324-330
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• 2012

Dual bell nozzle is one of the most promising choices among the altitude adaptation nozzles. This facilitates having a forced, steady and symmetrical separation at lower altitudes and a controlled flow separation at the wall inflection point which prevents the generation of dangerous side loads. In order to ensure the attached flow in the second bell, a clear understanding of the flow transition is required. Hence the motivation of our study is to arrive at an optimum profile for the second bell, which allows a sudden and controlled transition. In this work, we designed the first bell using the conventional MoC and the second bell using an inverse MoC, imposing a pressure gradient constraint. A CFD analysis is also carried out. It is found that the separation point is near the inflection point within one fourth of the extension length or it is near the exit.

• Journal of the Korean Geosynthetics Society
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• v.9 no.2
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• pp.11-20
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• 2010

This paper studies the discharge capacity of vertical drain boards that is controlling hydraulic gradient among many factors in the specification. The KS K 0940(2008), a testing method based on the conventional Delft type method for measuring the discharge capacity of a vertical drain, was specified in Korea Standard recently. In this test method, the variation in hydraulic gradient can result in large differences in the discharge capacity for the same vertical drain board.

• Proceedings of the Korean Vacuum Society Conference
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• 2012.02a
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• pp.524-524
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• 2012

Thermal Barrier Coating (TBC)은 미사일, 로켓발사체와 같이 고온에 노출되는 장비를 열로부터 보호하기 위한 코팅이다. 일반적인 Thermal Barrier Coating (TBC)은 모재와 코팅층간의 낮은 접합력과 높은 열충격으로 인한 박리가 많이 나타난다. 그래서 접합력을 높이고, 열충격을 줄이기 위해 모재와 코팅층 사이에 본드코팅층을 만든 Duplex - Thermal Barrier Coating (Duplex-TBC)이 개발되었다. 그러나 Duplex - Thermal Barrier Coating (Duplex-TBC)은 금속재료인 본드코팅층과 세라믹재료인 탑코팅층 사이에서 박리가 많이 발생한다. 이러한 문제점을 해결하기 위해 두 가지 분말을 동시에 코팅하여 본드코팅과 탑코팅의 경계가 없는 Functional Gradient Material - Thermal Barrier Coating (FGM-TBC)의 연구가 필요하다. 본 연구에서는 Functional Gradient Material - Thermal Barrier Coating (FGM-TBC)의 열충격 특성에 미치는 진공 플라즈마 용사 조건의 영향을 조사하였다. Functional Gradient Material - Thermal Barrier Coating (FGM-TBC)는 진공 플라즈마 용사장치를 사용하여 Cu-Cr 합금위에 코팅하였다. 거리, Carrier gas flow, 그리고 챔버 내부의 압력을 달리하여 제조하였다. 사용한 분말은 본드코팅용으로 Amdry 962와 내열 세라믹코팅을 위해 204NS를 사용하였고, 각각 분말 공급조건을 조절하여 두 분말의 비율을 달리하였다. 제조한 Functional Gradient Material - Thermal Barrier Coating (FGM-TBC) 코팅은 전기로에서 50분간 가열한 후, 수조에서 10분간 냉각하는 열충격 실험을 통해 열차폐 성능을 평가 하였다. 이러한 과정에서 진공 플라즈마 용사 조건 및 FGM 조성과 비율이 내열충격 특성에 미치는 영향을 미세조직학적 관점에서 고찰하였다.