• Asian Pacific Journal of Cancer Prevention
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• v.16 no.17
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• pp.7843-7846
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• 2015

Background: Some matrix metalloproteinases (MMPs) are involved in invasion and metastasis of head and neck squamous cell carcinoma (HNSCC). However, there are few studies on association between stromelysin-2 (ST-2) and invasive behavior of HNSCC. The purpose of this study was to investigate Stromelysin-2 expression by immunohistochemistry. Materials and Methods: This study was conducted on 81 specimens, including 61 HNSCC and 20 non neoplastic epithelium. Sections with 5 micron thickness were prepared and stained with immunohistochemistry technique. Then expression of ST-2 was evaluated according to percentage of stained cells and intensity of staining. Data were analyzed by SPSS (V.21) using Kruskal-Wallis and Tukey tests (P<0.05). Results: The 61 HNSCC specimens were grades I 36.1%, II 34.4% and III 29.5%. The level of ST-2 expressions were moderate (++) and intensive (+++) in 21.3% and 78.7% of tumors, respectively. The ST-2 expression level was only significant between the tumors with grade I and grade III (P=0.016). Tumors presented ST-2 expression with staining intensity of mild 6.6%, moderate 26.2% and strong 67.2%. Staining intensity of ST-2 in grade I tumors was significantly lower than grade II and grade III (P<0.05), and there was no significant difference between grades II and III (P=0.99). Conclusions: According to this study, the expression of ST-2 is associated with histopathological grade and tumor differentiation in HNSCCs.

• Journal of the Korean School Mathematics Society
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• v.14 no.3
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• pp.295-323
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• 2011

This study is based on the recognition that teacher educators have to focus their attention on developing pre-service teachers' statistical reasoning for statistics education of school mathematics. This paper investigated knowledge on pre-service teachers' statistical reasoning. Statistical Reasoning Assessment (SRA) is performed to find out pre-service teachers' statistical reasoning ability. The research findings are as follows. There was meaningful difference in the statistical area of statistical reasoning ability with significant level of 0.05. This proved that 4 grades pre-service teachers were more improve on statistical reasoning than 2 grades pre-service teachers. Even though most of the pre-service teachers ratiocinated properly on SRA, half of pre-service teachers appreciated that small size of sample is more likely to deviate from the population than the large size of sample. A few pre-service teachers have difficulties in understanding "Correctly interprets probabilities(be able to explain probability by using ratio" and "Understands the importance of large samples(A small sample is more likely to deviate from the population)".

• KSCE Journal of Civil and Environmental Engineering Research
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• v.9 no.3
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• pp.75-88
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• 1989

The state-of-art knowledge of highway performance analysis model was developed in this research and a computerized process named GUCAM(Geometric-specific User Cost Analysis Model) was established to facilitate the computational procedure. A comparison of GUCAM was made to HIAP program using a case study of widening two-lane rural highway into four-lane rural. The comparison indicated that GUCAM was more realistic and sensitive to the highway geometric features by virtue of the new methodology for the distribution of highway curves and grades. However, the model still remains insensitive to improvements at isolated locations such as specific grades or curves. Further research is required to straighten out this problem.

• Journal of Korean Neurosurgical Society
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• v.48 no.6
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• pp.480-484
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• 2010

Objective : To evaluate the role of lumbar drainage in the prevention of shunt-dependent hydrocephalus after treatment of ruptured intracranial aneurysms by coil embolization in good-grade patients. Methods : One-hundred-thirty consecutive patients with aneurysmal subarachnoid hemorrhage in good-grade patients (Hunt & Hess grades I-III), who were treated by coil embolization between August 2004 and April 2010 were retrospectively evaluated. Poor-grade patients (Hunt & Hess grades IV and V), a history of head trauma preceding the development of headache, negative angiograms, primary subarachnoid hemorrhage (SAH), and loss to follow-up were excluded from the study. We assessed the effects on lumbar drainage on the risk of shunt-dependent hydrocephalus related to coil embolization in patients with ruptured intracranial aneurysms. Results : One-hundred-twenty-six patients (96.9%) did not develop shunt-dependent hydrocephalus. The 2 patients (1.5%) who developed acute hydrocephalus treated with temporary external ventricular drainage did not require permanent shunt diversion. Overall, 4 patients (3.1%) required permanent shunt diversion; acute hydrocephalus developed in 2 patients (50%). There was no morbidity or mortality amongst the patients who underwent a permanent shunt procedure. Conclusion : Coil embolization of ruptured intracranial aneurysms may be associated with a lower risk for developing shunt-dependent hydrocephalus, possibly by active management of lumbar drainage, which may reflect less damage for cisternal anatomy than surgical clipping. Coil embolization might have an effect the long-term outcome and decision-making for ruptured intracranial aneurysms.

• Journal of The Korean Society of Grassland and Forage Science
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• v.21 no.3
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• pp.109-114
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• 2001

The object of this experiment was to evaluate nutritive value of roughage which was collected by Woosung Feed Co., Ltd. in Korea in 1999-2000. Nineteen kinds of roughage(l32 samples) were collected by Woosung Feed Co., Ltd. and their chemical composition, ADF, NDF, Ca and P. were analysed. In addition, their DMD, DMI, WV and hay grades were calculated based on analysed values. The CP content of roughage was ranged from 17.35%(alfalfa hay) to 4.00%(Italian ryegrass hay), and ten kinds of roughage under six percentages were observed. The NDF content of roughage was ranged from 47.50%(sugarcane leaf) to 78.84%(orchardgrass hay), and eight kinds of roughage above seventy percentages were observed. The DMD of roughage was ranged from 66.38%(beet pulp) to 50.95%(orchardgrass hay). The WV of roughage was ranged from 60.1 l(orchardgrass hay) to 125.07(sugarcane leaf). In hay grade of roughage, the first grade was assigned to sugarcane leaf only and the third grade and fourth grade were assigned to four kinds of roughage each. Bermudagrass straw received the fifth grade, and the nine kinds of roughage received the poor grades. As shown in the above results, nineteen kinds of roughage were mostly low in crude protein contents and dry matter digestibility, but they were high in fibrous contents. Futhermore, while only one kind of roughage was evaluated as obtaining the first grade, nine kinds of roughage were evaluated as the poor grade. Hence, we know that roughage which was collected in Korea was mostly low in their quality and that there was significant difference in their feed value among those roughage(P<0.05). Therefore, it is necessary to mark the hay quality for purpose of distributive circulation of roughage. (Key words : Roughages, Nutritive value, DMD. RFV. Hay grade)

• Korean Journal of Health Education and Promotion
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• v.20 no.4
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• pp.79-93
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• 2003

Childhood injuries are the primary cause of death and disability among children aged 5 to 14. Consistent practice of learned safety behaviors can reduce the occurrence of severe injuries among children. However, safety behavior concern is low among Korean-American children specifically and American children, in general. The objective of the study is to evaluate the impact of an unintentional injury prevention curriculum, Risk Watch among Korean-American children. A quasi-experimental design with a nonequivalent control group was used for the designed of the study. Two intervention and two control Korean schools in Atlanta participated in this study. The intervention consisted of weekly lessons in traffic, bicycle, pedestrian, and fire safety. One hundred and two students completed a pre-test and a post-test. The main outcomes were safety behaviors (seat belt use or helmet use), behavioral intentions, and safety knowledge. Analysis of covariance was used for the statistical analyses. Strong intervention effects were found for increasing knowledge of all safety topics in the intervention group. Additionally, statistically significant intervention effects were detected for increasing seat belt and helmet use, as well as behavioral intentions of wearing a seat belt and wearing a helmet, among pre-kindergarten and kindergarten students. For students in grades 1 and 2, intervention effects were found for increasing helmet use. Among students in grades 3 to 8, the intervention group showed statistically significant increases for seat belt use. Limitations of the study and recommendations for modifying and supporting unintentional injury prevention programs for school children are discussed.

• International Journal of Industrial Entomology and Biomaterials
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• v.12 no.1
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• pp.21-28
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• 2006

Peroxidase activity was measured in brown leaf spot pathogen (Myrothecium roridum) inoculated potted mulberry (Morus alba) during pre-symptomatic to various symptom development stages and compared with corresponding healthy leaf tissues. The enzyme showed a pH optimum of 7.0 and the activity was linearly increased up to 15 min of incubation. The peroxidase had a broad substrate specificity and the rates of oxidation were in the rank of pyrogallol> guaiacol> ascorbate at pH 7.0. Catechol at 10 mM inhibited 89% of guaiacol-peroxidase and 76% pyrogallol-peroxidase activities, indicated higher non-specific peroxidation in pyrogallol dependent assay system in mulberry than guaiacol. The optimum requirement for the guaiacol dependent assay was 0.2 ml (${\approx}40-60{\mu}g$ equivalent of protein) of crude enzyme source. Excepting the 8th leaf from the apex, the peroxidase activity did not vary appreciably in different leaf positions. In pre-symptomatic phases, an initial (1 to 5 min) rise of peroxidase activity was noticed in inoculated leaves, and then maintained a plateau up to 300 min. In contrary, non-infected tissue showed a slightly increased trend of enzyme level up to 420 min. In infected tissue, a sharp transient increase (3.1 fold) of peroxidase activity appeared between 300 - 420 min post infections. Afterwards, significantly different but steady maintenance of enzyme levels were observed in two treatments. On the other hand, during symptom development, a sharp increase in peroxidase activity was noticed up to 4th grade of lesion appearance (25.1 % to 50% of leaf area infection), and then declined slightly. However, in non-infected but same age healthy leaves, such huge fluctuations of enzyme level did not apparent. A high positive correlation $(R^2=0.92)$ between peroxidase activity and leaf spot development grades was also marked. The result implies that pre-symptomatic burst (between 1 - 5 and 300 - 420 min) and subsequent increased trend of guaiacol peroxidase activity may require for the symptomatic manifestation of Myrothecium leaf spot in mulberry.

• Archives of Plastic Surgery
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• v.46 no.4
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• pp.359-364
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• 2019

Background Few scales are currently available to evaluate changes in hand volume. We aimed to develop a hand grading scale for quantitative assessments of dorsal hand volume with additional consideration of changes in skin texture; to validate and prove the precision and reproducibility of the new scale; and to demonstrate the presence of clinically significant differences between grades on the scale. Methods Five experienced plastic surgeons developed the Hand Volume Rating Scale (HVRS) and rated 91 images. Another five plastic surgeons validated the scale using 50 randomly selected images. Intra- and inter-rater agreement was calculated using the weighted kappa statistic and intraclass correlation coefficients (ICCs). Paired images were also evaluated to verify whether the scale reflected clinical differences. Results The intra-rater agreement was 0.95 (95% confidence interval, 0.922-0.974). The interrater ICCs were excellent (first rating, 0.94; second rating, 0.94). Image pairs that differed by 1, 2, and 3 grades were considered to contain clinically relevant differences in 80%, 100%, and 100% of cases, respectively, while 84% of image pairs of the same grade were found not to show clinically relevant differences. This confirmed that the scale of the HVRS corresponded to clinically relevant distinctions. Conclusions The scale was proven to be precise, reproducible, and reflective of clinical differences.

• Investigative Magnetic Resonance Imaging
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• v.25 no.2
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• pp.93-100
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• 2021

Purpose: (1) To evaluate the trabecular pattern at the femoral attachment of the posterior cruciate ligament (PCL) in patients with a PCL injury; (2) to analyze bone microarchitecture by applying gray level co-occurrence matrix (GLCM)-based texture analysis; and (3) to determine if there is a significant relationship between bone microarchitecture and posterior instability. Materials and Methods: The study included 96 patients with PCL tears. Trabecular patterns were evaluated on T2-weighted MRI qualitatively, and were evaluated by GLCM texture analysis quantitatively. The grades of posterior drawer test (PDT) and the degrees of posterior displacement on stress radiographs were recorded. The 96 patients were classified into two groups: acute and chronic injury. And 27 patients with no PCL injury were enrolled for control. Pearson's correlation coefficient and one-way ANOVA with Bonferroni test were conducted for statistical analyses. This protocol was approved by the Institutional Review Board. Results: A thick and anisotropic trabecular bone pattern was apparent in normal or acute injury (n = 57/61;93.4%), but was not prominent in chronic injury and posterior instability (n = 31/35;88.6%). Grades of PDT and degrees of posterior displacement on stress radiograph were not correlated with texture parameters. However, the texture analysis parameters of chronic injury were significantly different from those of acute injury and control groups (P < 0.05). Conclusion: The trabecular pattern and texture analysis parameters are useful in predicting posterior instability in patients with PCL injury. Evaluation of the bone microarchitecture resulting from altered biomechanics could advance the understanding of PCL function and improve the detection of PCL injury.

• Journal of Korean Dental Hygiene Science
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• v.5 no.1
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• pp.39-45
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• 2022

Background: Dental hygienists undergo 3 or 4 years of college education, and dental hygienist education must receive continuous feedback through evaluation. The purpose of this study was to compare the educational performance of students from the Department of Dental Hygiene in 2018 with those from other departments in the healthcare field. Methods: We used data from the National Assessment of Student Engagement in Learning, conducted by the Korean Educational Development Institute in 2018. The survey data of 55 dental hygiene students and 60 healthcare students at K University were provided after excluding all identifying information. An independent t-test was used for comparisons between the Department of Dental Hygiene and other healthcare departments. Results: Regarding class-related activities, dental hygiene students were passive in presentations, discussions, and projects and had significantly lower grades in cooperative learning and challenging learning. Regarding extra-class activities, dental hygiene students had significantly lower global learning and external experiences, domestic experiences, club activities, and interactions with professors. Regarding learning outcomes, students had significantly lower grades in writing, speaking, critical and analytical thinking, data evaluation, understanding of data meaning, problem-solving ability, goal setting and execution, core content extraction, human and material resource utilization, creative convergence thinking, statistical understanding and analysis, information technology use, collaboration, sense of community, stress management, time management, and foreign language proficiency. Conclusions: Dental hygiene education requires innovation in educational methods and efforts of instructors to improve poor learning activities and outcomes.