• Journal of the Korean Chemical Society
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• v.65 no.5
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• pp.313-319
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• 2021

Menthol (M) is a cyclic monoterpenode and is a major component of essential oils. Menthol, along with menthol, isomenton, etc., gives taste and odor of the mint plant, and when it comes to menthol in general, L- or (-) -menthol is usually used. Included in pharmaceuticals, cosmetics and pesticides. It has antimicrobial, antibacterial, antioxidant properties. It is also known that the licorice plant (Glycyrrhiza Glabra L.) differs from other types of plants by its medicinal properties. For many years it has been used in folk medicine. Extraction of licorice root revealed up to 25% glycyrrhizinic acid (GA). Its aglycone - glycyrrhizic acid is notable for its structural similarity to the adrenal cortex hormones. Currently, GA and glycyrrhizic acid are widely used in medicine as a remedy for colds, allergies, viral diseases, tumors. The biological activity of menthol and GA-based supramolecular compounds has been poorly studied, and their effect on the functional parameters of rat liver mitochondria has been studied little. For this purpose, in our experiments, the effect of menthol (M), glycyrrhizinic acid (GA) and their supramolecular complexes obtained in different proportions on in vitro and in vivo studies on rat liver mitochondria was studied.

• Journal of Integrative Natural Science
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• v.15 no.4
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• pp.137-144
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• 2022

This paper presents the effect of the supramolecular complex of GA (Glycyrrhizic acid) and Mt(menthol) and GA: Mt (4: 1) obtained on their basis can restore functional dysfunction of the liver mitochondria in alloxan diabetes, ie, inhibit lipid peroxidation. The hypoglycemic activity and mitochondrial membrane stabilizing properties of the supramolecular compound GA: Mt (4: 1) in alloxan diabetes were more pronounced than those of menthol, GA and its GK: Mt (2: 1) and GA: Mt (9: 1) compounds. According to the results obtained, the concentration of GA did not affect the peroxidation of lipid membranes of the liver mitochondria. However, a concentration of 15 μM of GA was found to reduce LPO (lipid peroxidation) formed by the effect of Fe²+ / ascorbate on the mitochondrial membrane by 58.0 ± 5.0% relative to control. The inhibitory effect of GA and its supramolecular compounds in different proportions with menthol on the peroxidation of lipids in rat heart and brain tissue has been studied

• Korean Journal of Pharmacognosy
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• v.20 no.1
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• pp.37-42
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• 1989

This study was carried out to investigate the effect of Glycyrrhizae Radix on serum corticosterone and blood histamine content by immobilization stress in mice. Corticosterone secretion and blood histamine level was significantly increased in mice by subjecting the animals to immobilization stress 1 hr. after intraperitoneal injection of Glycyrrhizae Radix extract (150 mg/kg) and glycyrrhizinic and (15 mg/kg). whereas, administration of cortisol $(7.5\;{\mu}g/kg)$ provoked a decrease in corticosterone secretion and histamine levels. These results suggested that glycyrrhizinic acid was effective on cortiosterone release provoked by immobilization stress and this release was mediated in part by histamine.

• Journal of the Korean Society of International Agriculture
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• v.23 no.5
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• pp.531-536
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• 2011

This study was conducted to investigate the effects of cultural soil textures on growth and quality of Glycyrrhiza uralensis Fischer from 2009 to 2010. The obtained results from this study were summarized as follows; The growth of stem and leaf were superior to one year old G. uralensis, and surface runner and root growth tended to be better in 2 years old G. uralensis. The weight of stem and leaf were heavy in sandy loam, and plant height, branches, stem diameter in sandy clay loam were better than other soil texture. The growth characteristics, such as length, number and weight of surface runner, was better in order of sandy clay loam > sandy loam > loamy sand. The length of main and lateral root was longer in loamy sand soil than other treatments, and the diameter of main and lateral root was more thicker in sandy loam than others. The number of lateral root was higher in the sandy loam than other treatments. The yield of main and lateral root was in order of sandy loam > sandy clay loam > loamy sand soil. Marketable root yield of one year old and two year old G. uralensis were increased 57% and 71% in sandy loam compare to a loamy sand as 204 kg/10 a, respectively. The content of glycyrrhizinic acid was the hightest as 1.62% in sandy clay loam soil in one year old, and as 1.58% in sandy loam soil in two years old of G. uralensis, respectively.