• 대한화학회지
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• 제65권5호
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• pp.313-319
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• 2021

Menthol (M) is a cyclic monoterpenode and is a major component of essential oils. Menthol, along with menthol, isomenton, etc., gives taste and odor of the mint plant, and when it comes to menthol in general, L- or (-) -menthol is usually used. Included in pharmaceuticals, cosmetics and pesticides. It has antimicrobial, antibacterial, antioxidant properties. It is also known that the licorice plant (Glycyrrhiza Glabra L.) differs from other types of plants by its medicinal properties. For many years it has been used in folk medicine. Extraction of licorice root revealed up to 25% glycyrrhizinic acid (GA). Its aglycone - glycyrrhizic acid is notable for its structural similarity to the adrenal cortex hormones. Currently, GA and glycyrrhizic acid are widely used in medicine as a remedy for colds, allergies, viral diseases, tumors. The biological activity of menthol and GA-based supramolecular compounds has been poorly studied, and their effect on the functional parameters of rat liver mitochondria has been studied little. For this purpose, in our experiments, the effect of menthol (M), glycyrrhizinic acid (GA) and their supramolecular complexes obtained in different proportions on in vitro and in vivo studies on rat liver mitochondria was studied.

• 통합자연과학논문집
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• 제15권4호
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• pp.137-144
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• 2022

This paper presents the effect of the supramolecular complex of GA (Glycyrrhizic acid) and Mt(menthol) and GA: Mt (4: 1) obtained on their basis can restore functional dysfunction of the liver mitochondria in alloxan diabetes, ie, inhibit lipid peroxidation. The hypoglycemic activity and mitochondrial membrane stabilizing properties of the supramolecular compound GA: Mt (4: 1) in alloxan diabetes were more pronounced than those of menthol, GA and its GK: Mt (2: 1) and GA: Mt (9: 1) compounds. According to the results obtained, the concentration of GA did not affect the peroxidation of lipid membranes of the liver mitochondria. However, a concentration of 15 μM of GA was found to reduce LPO (lipid peroxidation) formed by the effect of Fe²+ / ascorbate on the mitochondrial membrane by 58.0 ± 5.0% relative to control. The inhibitory effect of GA and its supramolecular compounds in different proportions with menthol on the peroxidation of lipids in rat heart and brain tissue has been studied

• 생약학회지
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• 제20권1호
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• pp.37-42
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• 1989

This study was carried out to investigate the effect of Glycyrrhizae Radix on serum corticosterone and blood histamine content by immobilization stress in mice. Corticosterone secretion and blood histamine level was significantly increased in mice by subjecting the animals to immobilization stress 1 hr. after intraperitoneal injection of Glycyrrhizae Radix extract (150 mg/kg) and glycyrrhizinic and (15 mg/kg). whereas, administration of cortisol $(7.5\;{\mu}g/kg)$ provoked a decrease in corticosterone secretion and histamine levels. These results suggested that glycyrrhizinic acid was effective on cortiosterone release provoked by immobilization stress and this release was mediated in part by histamine.

• 한국국제농업개발학회지
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• 제23권5호
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• pp.531-536
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• 2011

재배토성이 감초 생육 및 품질에 미치는 영향을 구명코자 2009년부터 2년간 시험을 수행한 결과를 요약하면 다음과 같다. 1. 재배년생별 생육중 경엽은 1년생, 포복경 2년생, 근은 2년생에서 양호한 경향을 보였으며, 토성에 따라서 경엽중은 사양토에서 무거웠고, 초장, 분지수, 경태는 사질식양토에서 우수하였다. 2. 포복경의 길이, 수, 무게 등 생육은 사질식양토 > 사양토 > 양질사토 순으로 좋았다. 3. 주근과 지근의 생육은 양질사토에서 길었으며, 주근경, 지근경은 사양토에서 굵었다. 지근수는 사질식양토에서 다소 많았다. 4. 근 수량은 주근, 지근 등에서 사양토 > 사질식양토 > 양질 사토 순으로 많으며, 1년생과 2년생 근 상품 수량은 사양토에서 양질사토 204 kg/10a 대비 57%, 2년생은 71% 각각 증수하였다. 5. 글리시리진(glycyrrhizinic acid)의 함량은 1년생은 사질식 양토에서 1.62%, 2년생은 사양토에서 1.58%로 가장 높았다.