• Proceedings of the Korea Water Resources Association Conference
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• 2015.05a
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• pp.216-216
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• 2015

Frequent hydro-meteorological events caused by global climate change and human exacerbate activities, make the water resource problem more complicated. The increasing speed urbanization brings a significant impact on the city flood control and security, water supply safety, water ecological security, water environment safety and the water engineering security in China, and puts forward higher requirements to urban water integrated management, undoubtedly which become the biggest obstacle for water ecological civilization construction, thus urgent requiring an advanced methods to enhance the effectiveness of the water integrated management. The other fields of smart ideas point out a development path for water resource development. The construction demand of smart water resource is expounded in the paper, combining the philosophy of modern Internet of things with the application of cloud computing technology. The concept of smart water resource is analyzed, the connotation characteristics of smart water resource is extracted, and the general model of smart water resource is refined. Then, the frame structure of smart water resource is put forward. The connotation and the overall framework of the smart water resource represent a higher level of water resource informationization development and provide a comprehensive scientific and technological support to transform water resource management from an extensive, passive, static, branch and traditional management to a fine, active, dynamic, collaborative and modern management.

• Corrosion Science and Technology
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• v.21 no.6
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• pp.514-524
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• 2022

Carbon emissions from fuel consumption have been pointed by scientists as the cause of global warming. In particular, fossil fuels are known to emit more carbon when burned than other types of fuels. In this regard, International Maritime Organization has announced a regulation plan to reduce carbon dioxide emissions. Therefore, recently, Liquefied Natural Gas propulsion ships are responding to such carbon reduction regulation. However, from a long-term perspective, it is necessary to use carbon-free fuels such as hydrogen and ammonia. Nitrogen oxides might be generated during ammonia combustion. There is a possibility that incompletely burned ammonia is discharged. Therefore, rather than being used as a direct fuel, Ammonia is only used to reduce NO_X such as urea solution in diesel vehicle Selective Catalyst Reduction. Currently, LPG vehicle fuel feed system studies have evaluated the durability of combustion injectors and fuel tanks in ammonia environment. However, few studies have been conducted to apply ammonia as a ship fuel. Therefore, this study aims to evaluate corrosion damage that might occur when ammonia is used as a propulsion fuel on ships.

• Journal of the Korean Society of Industry Convergence
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• v.26 no.4_2
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• pp.649-656
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• 2023

Recently, global warming has become severe, and regulation is established for carbon savings each field. its regulation is applied to various fields using IC engine such as automobile, ship, agricultural machine. Therefore engine block applied Common Rail Direct Injection(CRDI) technology, that carry out thermal-structure analysis to examine design. The thermal load about 900℃ by explosion was applied in cylinder. And pressure about 9 MPa(90 Bar) was applied to structure analysis. As a result, it was the highest at 185.99℃ at the top of cylinder. Static-structure analysis applied thermal load, that was shown maximum equivalent stress at 142.59 Mpa and Maximum principal stress 145.03 MPa, Minimum principal stress -149 MPa. When compare analysis results to material property, it design is safety structurally.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.23 no.4
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• pp.149-155
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• 2023

Profiling-based recommendation services provide the convenience of easily accessing specialized content for individuals on the user side and provide an important profit model on the corporate side. Despite the utility of these recommendation services, the issues such as personal information infringement and restrictions on consumer options are emerging, and certain regulatory movements for profiling recommendation services are actively underway. Under the circumstance, there are concerns that the introduction of regulations without a close review of regulatory effectiveness and side effects will weaken the competitiveness of domestic companies in the global market. This study systematically analyzed how companies providing profiling-based recommendation services perceive the corresponding regulations.

• Journal of Navigation and Port Research
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• v.48 no.2
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• pp.97-103
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• 2024

As there is growing concern about the environmental impact of greenhouse gas emissions from ships, the International Maritime Organization (IMO) has introduced several regulations targeting reductions in carbon dioxide emissions of 50% by 2050. This study pays particular attention to the carbon intensity indicator (CII) and investigates the impact of slow steaming, one of the short-term measures in the regulation, on containership operations. To this end, a dataset of 8 containerships with various ages and sizes was collected. Based on operation data in 2021, the CII ratings of the containerships were estimated in the business-as-usual scenario for the 2023-2030 period. Then, the speed reductions required to keep the minimum CII rating were calculated for individual containerships. Finally, working day losses resulting from the speed reductions were calculated. The findings in this study were threefold. First, it was found that containerships will undergo degradation in the CII rating every 3 or 4 years without slow steaming. Second, a speed reduction of 2 knots between 2023 and 2030 is required to keep the minimum CII rating. Finally, speed reductions result in the loss of as many as 6 or 7 working days per year.

• Clinical and Experimental Vaccine Research
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• v.12 no.3
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• pp.193-208
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• 2023

One of the most significant medical advancements in human history is the development of vaccines. Progress in vaccine development has always been greatly influenced by scientific human innovation. The main objective of vaccine development would be to acquire sufficient evidence of vaccine effectiveness, immunogenicity, safety, and/or quality to support requests for marketing approval. Vaccines are biological products that enhance the body's defenses against infectious diseases. From the first smallpox vaccine to the latest notable coronavirus disease 2019 nasal vaccine, India has come a long way. The development of numerous vaccines, driven by scientific innovation and advancement, combined with researcher's knowledge, has helped to reduce the global burden of disease and mortality rates. The Drugs and Cosmetics Rules of 1945 and the New Drugs and Clinical Trials Rules of 2019 specify the requirements and guidelines for CMC (chemistry, manufacturing, and controls) for all manufactured and imported vaccines, including those against coronavirus infections. This article provides an overview of the regulation pertaining to the development process, registration, and approval procedures for vaccines, particularly in India, along with their brief history.

• Journal of Ginseng Research
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• v.48 no.2
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• pp.129-139
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• 2024

Liver diseases are a significant global health burden and are among the most common diseases. Ginssennoside Rg3 (Rg3), which is one of the most abundant ginsenosides, has been found to have significant preventive and therapeutic effects against various types of diseases with minimal side effects. Numerous studies have demonstrated the significant preventive and therapeutic effects of Rg3 on various liver diseases such as viral hepatitis, acute liver injury, nonalcoholic liver diseases (NAFLD), liver fibrosis and hepatocellular carcinoma (HCC). The underlying molecular mechanism behind these effects is attributed to apoptosis, autophagy, antioxidant, anti-inflammatory activities, and the regulation of multiple signaling pathways. This review provides a comprehensive description of the potential molecular mechanisms of Rg3 in the development of liver diseases. The article focuses on the regulation of apoptosis, oxidative stress, autophagy, inflammation, and other related factors. Additionally, the review discusses combination therapy and liver targeting strategy, which can accelerate the translation of Rg3 from bench to bedside. Overall, this article serves as a valuable reference for researchers and clinicians alike.

• IMMUNE NETWORK
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• v.23 no.1
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• pp.5.1-5.28
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• 2023

Th cell lineage determination and functional specialization are tightly linked to the activation of lineage-determining transcription factors (TFs) that bind cis-regulatory elements. These lineage-determining TFs act in concert with multiple layers of transcriptional regulators to alter the epigenetic landscape, including DNA methylation, histone modification and threedimensional chromosome architecture, in order to facilitate the specific Th gene expression programs that allow for phenotypic diversification. Accumulating evidence indicates that Th cell differentiation is not as rigid as classically held; rather, extensive phenotypic plasticity is an inherent feature of T cell lineages. Recent studies have begun to uncover the epigenetic programs that mechanistically govern T cell subset specification and immunological memory. Advances in next generation sequencing technologies have allowed global transcriptomic and epigenomic interrogation of CD4+ Th cells that extends previous findings focusing on individual loci. In this review, we provide an overview of recent genome-wide insights into the transcriptional and epigenetic regulation of CD4+ T cell-mediated adaptive immunity and discuss the implications for disease as well as immunotherapies.

• Journal of Radiation Industry
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• v.18 no.2
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• pp.109-115
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• 2024

As a global effort for eco-friendly, the ship building is making great efforts to develop ships using low-carbon, eco-friendly alternative fuels. Nuclear energy, one of several eco-friendly alternative energy sources, is evaluated as an effective alternative for future ships by minimizing carbon emissions and securing economic feasibility with low power generation cost. However, although appropriate regulatory requirements are necessary for commercialization of nuclear powered ships, there are currently no regulatory requirements for nuclear powered ships in Korea. In this study, accordingly, domestic and international regulatory requirements related to nuclear powered ships were reviewed, matters to be considered in terms of safety when developing domestic marine nuclear reactor regulatory requirements were derived, and a licensing regulatory system for nuclear powered ships was derived.This study is expected to be used as basic reference data when developing regulatory requirements for nuclear powered ships.

• Journal of Power Electronics
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• v.16 no.4
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• pp.1268-1276
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• 2016

A triode for alternating current (TRIAC) dimming light emitting diode (LED) driver, which adopts a variable switched capacitor for LED dimming and LED power regulation, is proposed in this paper. The proposed LED driver is power efficient, reliable, and long lasting because of the TRIAC switch that serves as its main switch. Similar to previous TRIAC dimmers for lamps, turn-on timing of a TRIAC switch can be controlled by a volume resistor, which modulates the equivalent capacitance of the proposed variable switched capacitor. Thus, LED power regulation against source voltage variation and LED dimming control can be achieved by the proposed LED driver while meeting the global standards for power factor (PF) and total harmonic distortion (THD). The long life and high power efficiency of the proposed LED driver make it appropriate for industrial lighting applications, such as those for streets, factories, parking garages, and emergency stairs. The detailed analysis of the proposed LED driver and its design procedure are presented in this paper. A prototype of 80 W was fabricated and verified by experiments, which showed that the efficiency, PF, and THD at V_s = 220 V are 93.8%, 0.95, and 22.5%, respectively; 65 W of LED dimming control was achieved with the volume resistor, and the LED power variation was well mitigated below 3.75% for 190 V < V_s < 250 V.