• IMMUNE NETWORK
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• 제6권4호
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• pp.169-178
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• 2006

Background: Adipose tissues were initially introduced as energy storages, but recently they have become famous as an endocrine organ which produces and secretes various kinds of molecules to make physiologic and metabolic changes in human body. It has been studied that these molecules are secreted in abundance as the adipose tissue becomes bigger along with obesity. Furthermore, it has been found that they are mediating systemic inflammation and generation of metabolic diseases such as type 2 diabetes and atherosclerosis. On the basis of these, we studied previous papers which have been researched about the interaction between preadipocytes and macrophages, adipose tissues and lymph nodes, and adipose tissue secreting molecules. Results: Firstly, preadipocytes and macrophages are expressing similar transcriptomes and proteins, and preadipocytes can be converted to mature macrophages which have phagocytic activity. Moreover, the monocytes, which initially located in the bone marrow, are filtrated to the adipose tissue by monocyte chemotatic protein-1 and are matured to macrophages by colony stimulating factor-1. Secondly, adipose tissues and their associated lymph nodes are interacting each other in terms of energy efficiency. Lymph nodes promote lipolysis in adipose tissues, and polyunsaturated fatty acids in adipocytes become energy sources for dendritic cells. Lastly, adipose tissues produce and secrete proinflammatory molecules such as leptin, adiponectin, TNF-${\alpha}$, IL-6, and acute phase proteins, which induce the inflammation and potentially generate metabolic diseases. Conclusion: According to these, we can link adipose tissues to inflammation, but we need to affirm the actual levels and roles of adipose tissue-derived proinflammatory molecules in human body.

• Biomolecules & Therapeutics
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• 제15권4호
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• pp.252-260
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• 2007

As it is needed to assay possible feasibility of extrapolation between in vivo and in vitro systems and to develop a new in vitro method for toxicity testing, we investigated global gene expression from both animal and cell line treated with thioacetamide (TAA) and compared between in vivo and in vitro genomic profiles. For in vivo study, mice were orally treated with TAA and sacrificed at 6 and 24 h. For in vitro study, TAA was administered to a mouse hepatic cell line, BNL CL.2 and sampling was carried out at 6 and 24 h. Hepatotoxicity was assessed by analyzing hepatic enzymes and histopathological examination (in vivo) or lactate dehydrogenase (LDH) assay and morphological examination (in vitro). Global gene expression was assessed using microarray. In high dose TAA-treated group, there was centrilobular necrosis (in vivo) and cellular toxicity with an elevation of LDH (in vitro) at 24 h. Statistical analysis of global gene expression identified that there were similar numbers of altered genes found between in vivo and in vitro at each time points. Pathway analysis identified several common pathways existed between in vivo and in vitro system such as glutathione metabolism, bile acid biosynthesis, nitrogen metabolism, butanoate metabolism for hepatotoxicty caused by TAA. Our results suggest it may be feasible to develop toxicogenomics biomarkers by comparing in vivo and in vitro genomic profiles specific to TAA for application to prediction of liver toxicity.

• 통상정보연구
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• 제11권3호
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• pp.239-262
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• 2009

This study shed light on the status of Korean Kimchi industry in overseas markets and presented methods for promoting Kimchi industry of Gwangju Jeonnam metropolitan city and stimulating the export of Kimchi produced in Gwangju Jeonnam, a city that has come to the fore as the center of Kimchi industry, which aimed to explore the ways of ratcheting up competitiveness of Kimchi industry in the global market as Kimchi has become more likely to be globalized amid the recent "Korea Trend" boom and the growing consumption of fermented food. Therefore, methods for promoting Kimchi industry and stimulating the export of Kimchi should be explored to ensure the promotion of Kimchi industry and the stimulation of the export of Kimchi, ultimately restoring the status of Korea as the home of Kimchi, in consideration of the great spillover effect on the regional economy, through a series of measures such as the clusterization of Kimchi industry, expansion of cultural experience projects related to Kimchi for the globalization and the increased consumption of Kimchi, government support to increase Kimchi companies in size and achieve the modernization of Kimchi companies, introduction of Kimchi KS audit system and quality certification system, development of new product targeting global market and making Kimchi a high-end product, expansion of export, support of export market diversification, assurance of safety and price competitiveness of Kimchi, differentiated production and marketing strategy by means of technological research, and others.

• Journal of Microbiology and Biotechnology
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• 제15권6호
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• pp.1337-1345
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• 2005

Vibrio vulnificus is the causative agent of foodborne diseases such as gastroenteritis and life-threatening septicemia. Microbial pathogenicity is a complex phenomenon in which expression of numerous virulence factors is frequently controlled by a common regulatory system. In the present study, a mutant exhibiting decreased cytotoxic activity toward intestinal epithelial cells was screened from a library of V. vulnificus mutants constructed by a random transposon mutagenesis. By a transposon-tagging method, an open reading frame, fexA, a homologue of Escherichia coli areA, was identified and cloned. The nucleotide and deduced amino acid sequences of the fexA were analyzed, and the amino acid sequence of FexA from V. vulnificus was $84\%\;to\;97\%$ similar to those of AreA, an aerobic respiration control global regulator, from other Enterobacteriaceae. Functions of the FexA were assessed by the construction of an isogenic mutant, whose fexA gene was inactivated by allelic exchanges, and by evaluating its phenotype changes in vitro and in mice. The disruption of fexA resulted in a significant alteration in growth rate under aerobic as well as anaerobic conditions. When compared to the wild-type, the fexA mutant exhibited a substantial decrease in motility and cytotoxicity toward intestinal epithelial cell lines in vitro. Furthermore, the intraperitoneal $LD_{50}$ of the fexA mutant was approximately $10^{1}-10^{2}$ times higher than that of parental wild-type. Therefore, it appears that FexA is a novel global regulator controlling numerous genes and contributing to the pathogenesis as well as growth of V. vulnificus.

• 한국지역사회생활과학회지
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• 제17권3호
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• pp.55-65
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• 2006

Recent trends of global food production, processing, distribution and preparation under free trade circumstance are creating an increase in common' concerns about food safety. It is important that farmers improve agricultural products/food safety for satisfying consumer needs and health. Cognizant to the situation, this study was conducted to analyze how the Producers gather information, and determine their awareness about agricultural Products safety using a safety Questionnaire. The Questionnaire was given to 500 farmers who cultivate rice, fruit trees, vegetables, and other crops from September through October 2005. More than half of the producers felt concerns about the agricultural products/foods safety. Uneasiness of the producers was higher amongst those who were younger and earned a higher income. Pesticides and zoonosis (BSE AI, etc.) emerged as the main risk factors causing concerns among the greatest number of producers. Producers had a positive opinion of the effects and perception of food safety, but no opinion of the activity of government. The producers showed a high level of understanding of the Country of Origin Labeling System (88.2%), the quality certification system of agricultural and livestock products (71.9%), and the raising system of environment-friendly agriculture (72.7%). However, their level of understanding of the GAP (59.3%) and the Traceability System (22.8%) was still low. To effectively implement these policies, awareness of producers who are the beneficiaries of the above policies has to be enhanced. Therefore, the safety information should be provided at a more appropriate time and should be easier to understand.

• International Journal of Internet, Broadcasting and Communication
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• 제14권2호
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• pp.79-88
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• 2022

Recently, securing stable supply of fresh food is deemed as one of the important tasks. Accordingly, now the presence of cold chain along with the needs of a comfortable and healthy life is growing as the online market expands and the contactless industry grows, however, cold chain is being studied only in the aspect of ground and sea transportation. And, due to global warming and strengthening global environmental regulations, we believe that it is necessary to convert the existing road-centered logistics system into a railway-centered logistics system, a low-carbon transportation means. Therefore, in this paper we calculated the maximum energy required by the reefer container as a basic research necessary for constructing the low temperature distribution and cold chain based on the reefer container railway, and conducted a study on methods of supplying the reefer container power utilizing 1. tramline, 2. battery, 3. generator. The results of this paper can be utilized as a foundational study for building a cold chain based on a reefer container dedicated to freight trains in the future.

• 융합경영연구
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• 제8권4호
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• pp.13-25
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• 2020

Purpose - This study is aiming to provide policy makers with new insights to promote the consumption of locally-grown produces in the HMR industry by exploring what kinds of policies Japan, UK and Italy have developed. Research design - After introduction, the research starts to review the existing literature related to the promotion of local produce consumption, and then, compares the policies introduced by the above countries. Finally, the authors draw conclusions on the basis of research findings. Results - Firstly, central government has to collaborate with local authorities to promote local food consumption in the HMR industry. Secondly, countries have strengthened food label system to enhance local food consumption, in terms of country of origin. Thirdly, all of nations has highlighted food safety to protect customers. Fourthly, the government has created the business environment forcing HMR operators and retailers to follow the government's policy. Fifthly, it is necessary to support the social communities to enhance their social responsibility, from the government's point of view. Lastly, the social responsibility and the ethical administration of retailers should be sustainably strengthened by social atmosphere. Conclusions - In line with the growth of HMR products, governments have to make a considerable effort to develop innovative methods to promote local food consumption in the HMR industry.

• 식품과학과 산업
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• 제54권3호
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• pp.124-131
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• 2021

4차 산업혁명과 더불어 기술의 발전 속도는 더욱 빨라지고 있는 추세에 있다. 4차 산업혁명의 주요 핵심이 되는 기술들을 중심으로 산업구조, 사회환경과 메가트렌드가 변화하고 있다. 특히, 코로나 팬데믹의 상황은 혁신기술의 적용을 촉진하고 사회 모든 분야에 걸쳐 적용될 것을 요구하고 있다. 식품 산업은 노동집약적으로 이루어져 있고 사람 간 접촉이 불가피한 특성이 있기 때문에 코로나와 같은 상황에서는 기술의존도가 더욱 높아져 식품의 제조 및 가공에 기계 및 자동화 도입은 필수적이라고 볼 수 있다. 앞서 국내를 포함한 주요국들의 스마트 식품 안전관리 추진동향을 살펴본 결과, 인공지능이나 사물인터넷 등 사람이 아닌 스마트한 기술적 접근을 통해 사고예방 및 예측력을 강화하는 방향으로 발전해가고 있다. 빠르게 변화하고 있는 식품산업에 발맞춰 식품 안전관리에 있어서도 혁신기술을 빠르게 도입하려는 노력을 기울이고 있으므로 향후 몇 년 뒤에는 지금보다 빠른 식품사고 원인규명과 예측 및 분석능력 증대를 통해 사후관리가 아닌 사전적 대응체계로 전환해 나갈 수 있을 것으로 기대한다.

• 수산해양교육연구
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• 제26권4호
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• pp.846-858
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• 2014

The purpose of this study is to help domestic aquaculture farm by improved evaluation method. First, We analyzed evaluation method of domestic aquaculture certification, the greater retailer's supplier and global standard. Next, By using Analytic Hierarchy Process (AHP), We found priority and importance between criteria of SQF(Safety Quality Food) standard which is appled to alternative model for aquaculture evaluation. As a result is presented as follows: regarding pairwise comparison between System Element module and Good Aquaculture Practice(GAP) module, GAP is recognized to be more important than System Element. The highest priority criteria is presented 'Purchase and Use of Medications, Aquaculture Feeds and Aquaculture Chemicals.' Next, 'Management commitment', 'Attaining Food Safety', 'Location and Layout of Structures and Vessels', 'Stock Identification and Traceability are recognized high position. This study has major implications for research into development of evaluation method.

• 식품과학과 산업
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• 제54권4호
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• pp.268-277
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• 2021

A geographical indication (GI) is a sign used on products that have a specific geographical origin and possess qualities or a reputation that are due to that origin. This paper explores ways to protect Korean goods as GIs in the U.S. and EU by examining the efforts of the Colombian Coffee Federation (FNC) to protect Colombian coffee. The FNC enhanced the global awareness of Colombian coffee and increased the profits of Colombian coffee producers by registering Colombian coffee as a certification mark in the U.S. and as a GI under the EU's quality schemes. The Korean government protects kimchi under its own GI system. For kimchi products to earn the label "Korean kimchi," the three main ingredients must be produced in Korea. This has been a challenge for kimchi producers, who often rely on imported ingredients. Korea could learn from FNC's strategies to improve the current GI system for kimchi.