• International Journal of Industrial Entomology and Biomaterials
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• v.33 no.1
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• pp.6-14
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• 2016

The mulberry silkworm, Bombyx mori has been one of the most important domestic animals which have provided with silk fibers for weaving fabrics and a food for a protein and lipid source. In addition, various health improvement effects of diverse silkworm larval powders were reported. Recently we found that steamed and freeze-dried mature silkworm larval powder (SMSP) generated using white-jade (also known as Backokjam) silkworm variety extended healthspan and increased resistance to Parkinson's disease in animal models. Because the colors of cocoons in silkworm varieties were caused by altered signal transduction pathways transporting phytochemicals from intestinal lumens to silk glands, we performed the proximate, amino acid, mineral, carbohydrates, fatty acid, and cholesterol composition analyses of SMSPs of 3 silkworm varieties which were weaving light yellow, golden, and red cocoons. Although most of nutrient compositions among 3 SMSPs were similar, there were significant differences in certain amino acids, minerals, and fatty acid compositions. Red silk silkworm (RS)-SMSP had higher contents of crude proteins and total amino acids than other SMSPs. In addition, the ratio of n-3/n-6 unsaturated fatty acids were higher than the other SMSPs. In contrast Golden silk silkworm (GS)-SMSP had higher ratio of potassium/sodium than the other SMSPs. These nutrient analysis results suggested that 3 SMSPs might have common and unique health improvement effects. Thus, further studies in the functionalities of the 3 SMSPs will reveal unknown their health improvements effects.

• Journal of Ginseng Research
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• v.40 no.1
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• pp.9-17
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• 2016

Background: Alzheimer's disease (AD) is a progressive brain disease, for which there is no effective drug therapy at present. Ginsenoside Rg1 (G-Rg1) and G-Rg2 have been reported to alleviate memory deterioration. However, the mechanism of their anti-AD effect has not yet been clearly elucidated. Methods: Ultra performance liquid chromatography tandem MS (UPLC/MS)-based metabolomics was used to identify metabolites that are differentially expressed in the brains of AD mice with or without ginsenoside treatment. The cognitive function of mice and pathological changes in the brain were also assessed using the Morris water maze (MWM) and immunohistochemistry, respectively. Results: The impaired cognitive function and increased hippocampal $A{\beta}$ deposition in AD mice were ameliorated by G-Rg1 and G-Rg2. In addition, a total of 11 potential biomarkers that are associated with the metabolism of lysophosphatidylcholines (LPCs), hypoxanthine, and sphingolipids were identified in the brains of AD mice and their levels were partly restored after treatment with G-Rg1 and G-Rg2. G-Rg1 and G-Rg2 treatment influenced the levels of hypoxanthine, dihydrosphingosine, hexadecasphinganine, LPC C 16:0, and LPC C 18:0 in AD mice. Additionally, G-Rg1 treatment also influenced the levels of phytosphingosine, LPC C 13:0, LPC C 15:0, LPC C 18:1, and LPC C 18:3 in AD mice. Conclusion: These results indicate that the improvements in cognitive function and morphological changes produced by G-Rg1 and G-Rg2 treatment are caused by regulation of related brain metabolic pathways. This will extend our understanding of the mechanisms involved in the effects of G-Rg1 and G-Rg2 on AD.

• International Journal of Industrial Entomology and Biomaterials
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• v.35 no.2
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• pp.89-96
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• 2017

Various health promoting effects of steamed and freeze-dried mature silkworm powder (SMSP) have been reported. However, it is not still clear which substances in SMSP are responsible for those health promoting effects yet. In this study, we examined and compared the quantities of phytochemicals in SMSP and freeze-dried mulberry leave powder (FMLP). To investigate the optimal solvent for extracting phytochemicals from SMSP and FMLP, we used four different solvents. Among them, 80% ethanol extracts from SMSP and FMLP contained the highest amount of five flavonoids examined. In addition, FMLP had high contents of flavonoids compared with those of SMSP. The amounts of rutin, isoquercetin, astragalin, quercetin, and kaempferol in FMLP were $5.078{\pm}0.187mg/g$, $5.162{\pm}0.083mg/g$, $2.989{\pm}0.061mg/g$, $3.317{\pm}0.236mg/g$, and $2.243{\pm}0.237mg/g$, respectively, while the amounts of rutin, isoquercetin, astragalin, quercetin, and kaempferol in SMSP were $0.171{\pm}0.024mg/g$, $0.252{\pm}0.032mg/g$, $0.374{\pm}0.031mg/g$, $0.645{\pm}0.063mg/g$, and $0.0512{\pm}0.047mg/g$, respectively. Taken together, SMSP could be a source for providing various and readily absorbable flavonoids.

• Journal of Ginseng Research
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• v.47 no.2
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• pp.228-236
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• 2023

Background: QiShen YiQi pills (QSYQ) is a Traditional Chinese Medicine (TCM) formula, which has a significant effect on the treatment of patients with myocardial infarction (MI) in clinical practice. However, the molecular mechanism of QSYQ regulation pyroptosis after MI is still not fully known. Hence, this study was designed to reveal the mechanism of the active ingredient in QSYQ. Methods: Integrated approach of network pharmacology and molecular docking, were conducted to screen active components and corresponding common target genes of QSYQ in intervening pyroptosis after MI. Subsequently, STRING and Cytoscape were applied to construct a PPI network, and obtain candidate active compounds. Molecular docking was performed to verify the binding ability of candidate components to pyroptosis proteins and oxygen-glucose deprivation (OGD) induced cardiomyocytes injuries were applied to explore the protective effect and mechanism of the candidate drug. Results: Two drug-likeness compounds were preliminarily selected, and the binding capacity between Ginsenoside Rh2 (Rh2) and key target High Mobility Group Box 1 (HMGB1)was validated in the form of hydrogen bonding. 2 μM Rh2 prevented OGD-induced H9c2 death and reduced IL-18 and IL-1β levels, possibly by decreasing the activation of the NLRP3 inflammasome, inhibiting the expression of p12-caspase1, and attenuating the level of pyroptosis executive protein GSDMD-N. Conclusions: We propose that Rh2 of QSYQ can protect myocardial cells partially by ameliorating pyroptosis, which seems to have a new insight regarding the therapeutic potential for MI.

• Clinical Nutrition Research
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• v.12 no.4
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• pp.245-256
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• 2023

A randomized, double-blind, placebo-controlled trial was conducted to confirm whether collagen peptide supplementation for 12 week has a beneficial effect on body fat control in older adults at a daily physical activity level. Participants were assigned to either the collagen group (15 g/day of collagen peptide) or the placebo group (placebo drink). Body composition was measured by bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DEXA). In total, 74 participants (collagen group, n = 37; placebo group, n = 37) were included in the final analysis. The collagen group showed a significant reduction in total body fat mass compared with the placebo group, as evidenced by both BIA (p = 0.021) and DEXA (p = 0.041) measurements. Body fat mass and percent body fat of the whole body and trunk reduced at 12 weeks compared with baseline only in the collagen group (whole body: body fat mass, p = 0.002; percent body fat, p = 0.002; trunk: body fat mass, p = 0.001; percent body fat, p = 0.000). Total fat mass change (%) (collagen group, -0.49 ± 3.39; placebo group, 2.23 ± 4.20) showed a significant difference between the two groups (p = 0.041). Physical activity, dietary intake, and biochemical parameters showed no significant difference between the groups. The results confirmed that collagen peptide supplementation had a beneficial effect on body fat reduction in older adults aged ≥ 50 years with daily physical activity level. Thus, collagen peptide supplementation has a positive effect on age-related changes.

• Journal of Korean Academy of Nursing Administration
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• v.5 no.2
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• pp.401-414
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• 1999

향후 더욱 경쟁적인 상황에 놓이게 될 보천의료 분야에 능동적으로 대처하기 위한 방안의 하나로서 보건의료 조직은 간호부서의 성과 향상을 위한 노력을 지속적으로 기울이고 있다. 이러한 성과 향상을 위한 노력은 정확한 성과의 측정이 함께 이루어질 때 가능하게 된다. 간호서비스의 성과 측정은 여러 각도에서 조명되고 측정이 이루어져야하며 간호관리자는 총괄적인 성과측정시스템에 대한 새로운 인식과 사전 준비작업으로 무장을 하여야 한다. 이러한 요구에 맞추어, 본 논문은 간호 서비스의 성과측정방법에 대한 고찰, 즉 생산성, 효율성, 간호의 질, 수익성. quality of work life에 대한 간호분야에서의 접근방법을 재정리하고, 새로운 총괄적인 성과측정방법의 개념을 제시한다.

• Journal of the Korean housing association
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• v.7 no.2
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• pp.79-89
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• 1996

In this paper, various characteristics-physiological, psychological and social peculiarities \ulcorner of the elderly are analyzed. Then planning factors of living environment are studied to grope directions on design of living spaces for the aged in the future, which is pertinent to their needs.The peculiar properties of the elderly are analyzed and planning factors of architectural spaces are studied by referring to sundry records from many branch \ulcorner gerontology, medical science, psychology, sociology, etc. \ulcorner of knowledge. In planning house for the aged, we have to consider their physiological, psychological, social characteristics and build many types of living spaces in order to meet their special needs in mind, to maintain their living styles. because their personalities, human relations, living patterns, and so forth have been formd individually for a long period of time and their present conditions are different respectively.

• Journal of Families and Better Life
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• v.25 no.1 s.85
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• pp.59-75
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• 2007

This review synthesizes research during the past 15 years on the family relations of older persons. After discussing two background issues-sociodemographic changes of later life families and the status of the elderly-the following topics are addressed; relationships between aged parents and adult children, couple relationships, grandparents' relationship with their grandchildren and sibling relationships. Family relationships are vital support systems providing emotional and instrumental support in the lives of older persons. Mutual assistance and affection among family members were found to be common characteristics. Although research on family gerontology has increased in quantify, there are feater needs to develop qualitative, longitudinal and theory grounded studies to capture the rich complexity of family life. Other challenges and suggestions for future research on older persons' family relationship are presented.

• Journal of the Korean Home Economics Association
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• v.37 no.12 s.142
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• pp.179-192
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• 1999

Thesedays, Home Economic in Korea is faced with the danger of a discord caused by the outer pressure of reorganization in the process educational reformation. The first purpose of this study was to examine the characteristics of the informatized society and the changes of families lived in the informatized society. The second was to assert to strengthen Home Economics in the informatized society. Ultimately we suggested an integrative and interdisciplinary model about Home Economics from the ecological and informative perspective. This model consist with three parts: Human development(Child studies, Gerontology, & Adolescent studies) and family studies division(Family relation studies, family resource management studies, & Consumer studies) Environmental division(Clothing and Textiles, Food and Nutrition, & Housing) and HEIS(Home Economics Information System). This classification is correspond with the one Human-Behavioral Environment and Human-Constructed Environment of Ecological theory.

• Korea Journal of Hospital Management
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• v.18 no.4
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• pp.39-53
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• 2013

This study purports to learn the lessons from the managerial innovation of Japanese public hospitals. The performance of three innovation strategies of Japanese public hospitals, such as managerial efficiency, restucturing and networking, and rearrnagement of governance and ownership, were analyzed and its implications for Korea were discussed. Based upon it, several strategies for improving the performance of Korean public hospitals, were suggested.