• Journal of the Society of Cosmetic Scientists of Korea
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• v.27 no.2
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• pp.15-30
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• 2001

최근 인간 유전체 사업(Human Genome Project)의 완성과 DNA Microarray, Proteomics, Bioinformatics 등의 초고속, 대용량 처리 바이오기술(High Throughput Biotechnology)의 발전과 함께 생명과학 분야의 연구는 획기적인 변화의 시기를 맞이하게 되었다. 이미 의약품 분야는 이러한 기술을 활용한 연구가 보편화 되어있고 선진 외국 회사들의 화장품연구 또한 이를 활용한 연구가 본격화 되고 있다. 화장품개발에 있어서도 이러한 기술들의 활용이 불가피하게 되었다. 여기서는 이러한 새로운 바이오기술들에 관해 간단히 알아보고 향후 이러한 기술들의 효과적인 화장품개발 관련연구 활용범위와 활용방법에 대하여 알아본다.

• Proceedings of the Korean Society of Sericultural Science Conference
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• 2002.10a
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• pp.39-39
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• 2002

No Abstract, See Full Text

• Proceedings of the PSK Conference
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• 2003.10a
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• pp.21-21
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• 2003

BT(Biotechnology) is transition stage from study and technology to mass production and one of most promising part in leading industry. After early completion of genome project, many countries keep trying their best to preoccupy in this field. Korean government support BT more than 10 years. Because their eco-compatibility and cleanness, BT is very promising part. But the big issue is the morals of genetic manipulation. (omitted)

• BMB Reports
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• v.37 no.1
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• pp.35-44
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• 2004

Recently produced information on post-translational modifications makes it possible to interpret their biological regulation with new insights. Various protein modifications finely tune the cellular functions of each protein. Understanding the relationship between post-translational modifications and functional changes ("post-translatomics") is another enormous project, not unlike the human genome project. Proteomics, combined with separation technology and mass spectrometry, makes it possible to dissect and characterize the individual parts of post-translational modifications and provide a systemic analysis. Systemic analysis of post-translational modifications in various signaling pathways has been applied to illustrate the kinetics of modifications. Availability will advance new technologies that improve sensitivity and peptide coverage. The progress of "post-translatomics", novel analytical technologies that are rapidly emerging, offer a great potential for determining the details of the modification sites.

• Genomics & Informatics
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• v.12 no.4
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• pp.208-215
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• 2014

Recently, new methods have been developed for estimating the current and recent changes in effective population sizes. Based on the methods, the effective population sizes of Korean populations were estimated using data from the Korean Association Resource (KARE) project. The overall changes in the population sizes of the total populations were similar to CHB (Han Chinese in Beijing, China) and JPT (Japanese in Tokyo, Japan) of the HapMap project. There were no differences in past changes in population sizes with a comparison between an urban area and a rural area. Age-dependent current and recent effective population sizes represent the modern history of Korean populations, including the effects of World War II, the Korean War, and urbanization. The oldest age group showed that the population growth of Koreans had already been substantial at least since the end of the 19th century.

• Genomics & Informatics
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• v.11 no.2
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• pp.60-67
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• 2013

A decade-long project, led by several international research groups, called the Encyclopedia of DNA Elements (ENCODE), recently released an unprecedented amount of data. The ambitious project covers transcriptome, cistrome, epigenome, and interactome data from more than 1,600 sets of experiments in human. To make use of this valuable resource, it is important to understand the information it represents and the techniques that were used to generate these data. In this review, we introduce the data that ENCODE generated, summarize the observations from the data analysis, and revisit a computational approach that ENCODE used to predict gene expression, with a focus on the human transcriptome and its association with chromatin modifications.

• Proceedings of the Korean Information Science Society Conference
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• 2005.07b
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• pp.271-273
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• 2005

유전자 분석기술의 발전은 지놈 프로젝트(genome project)와 햅맵 프로젝트(hapmap project)를 가능하게 하였으며 이제는 맞춤형 진단 및 신약 개발 등 실제 사업의 구체화를 가져오게 하였다. 실제 사업에 적용시키기 위해서는 비용 절감의 문제를 해결해야 한다. 그래서 대용량의 유전자형(genotype)데이터를 정확하고 빠르게 일배체형(haplotype)으로 재구성해 줄 수 있는 시스템이 생물 산업 및 제약 산업에서 제기되어 지고 있다. 기존의 연구에서 비록 정확성이 높은 알고리즘들이 개발되어 있지만 기존의 방법들은 계산에 필요한 양이 크기 때문에 대용량 데이터에 대한 처리가 불가능하였다. 우리가 제안하는 시스템은 대용량 데이터를 유동적인 크기로 블록을 분할하여 대용량 데이터 처리 문제를 해결하였다. 또한 나누어진 블록에서 나타나는 모호한 이형접합체(heterozygote)의 위상(phase)의 결정 과정에 LD기반의 블록 분할 방법을 이용함으로써, 추론된 결과의 정확률을 높였다. 구현된 시스템의 성능평가는 ms로 구성한 인공데이터를 사용하여 수행하였다.

• Genomics & Informatics
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• v.14 no.4
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• pp.196-204
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• 2016

Many researchers have found that one of the most important characteristics of the structure of linkage disequilibrium is that the human genome can be divided into non-overlapping block partitions in which only a small number of haplotypes are observed. The location and distribution of haplotype blocks can be seen as a population property influenced by population genetic events such as selection, mutation, recombination and population structure. In this study, we investigate the effects of the density of markers relative to the full set of all polymorphisms in the region on the results of haplotype partitioning for five popular haplotype block partition methods: three methods in Haploview (confidence interval, four gamete test, and solid spine), MIG++ implemented in PLINK 1.9 and S-MIG++. We used several experimental datasets obtained by sampling subsets of single nucleotide polymorphism (SNP) markers of chromosome 22 region in the 1000 Genomes Project data and also the HapMap phase 3 data to compare the results of haplotype block partitions by five methods. With decreasing sampling ratio down to 20% of the original SNP markers, the total number of haplotype blocks decreases and the length of haplotype blocks increases for all algorithms. When we examined the marker-independence of the haplotype block locations constructed from the datasets of different density, the results using below 50% of the entire SNP markers were very different from the results using the entire SNP markers. We conclude that the haplotype block construction results should be used and interpreted carefully depending on the selection of markers and the purpose of the study.

• Korean Journal of Microbiology
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• v.41 no.1
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• pp.8-12
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• 2005

Some genes, which are involved in the biosynthesis of polysaccharides, could be found by the genome project of Sphingomonas chungbukensis DJ77. In this study, we identified the complete nucleotide sequence of a gene, encoding the glucosyl-isoprenyl phosphate-transferase, which catalyzes the first step in the biochemical pathway for the synthesis of the sphingan type polysaccharide. This gene, named spsB, is initiated by the ATG codon and terminated by the TGA, and its open reading frame consists of 1392 bp, encoding 463 amino acids. The predicted amino acid sequence of this enzyme indicates $50\%$ similarity to SpsB of Sphingomonas spp S88, also produces sphingan, and $48\%$ to GelB of Sphingomonas paucimobilis ATCC 31461.

• Journal of Life Science
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• v.13 no.2
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• pp.175-183
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• 2003

The chimpanzee and gorilla are classified into hominidae, catarrhini, primates. These species are originated from Africa, so called African great apes. Recently, primatologists have classified that there are 2 species 5 subspecies of the chimpanzee and gorilla, respectively. Since the human genome project has been finished, the chimpanzee genome project has been launched to understand human evolution and genetic diseases. The sequences of chimpanzee chromosome 22 homologous to human chromosome 21 were completed, and then the Y chromosome of chimpanzee is being analyzed. Comparative analysis of human, chimpanzee and gorilla could provide the key for understanding of various human diseases and human origin. By detecting human specific-functional genes or mobile genetic elements (HERV, LINE, SINE) through primate research, we could understand what is human being\ulcorner gradually, For these comparative researches, we summarized fundamental knowledge of the feature, phylogeny and evolution of African great apes including humans.