• BMB Reports
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• v.40 no.4
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• pp.517-524
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• 2007

There were many different families of zinc finger proteins that contained multiple cysteine and/or histidine residues and used zinc to stabilize their folds. The classical C2H2 zinc finger proteins were the founding members of this superfamily and were among the most abundant proteins in eukaryotic genomes. C2H2 proteins typically contained several C2H2 fingers that made tandem contacts along the DNA. Here we reported a novel C2H2 type zinc finger gene, ZNF438, which encoded 828 amino acids that formed five zinc finger domains. Bioinformatics analysis revealed that the ZNF438 was mapped to human chromosome 10p11.2 and shared 62% identity with rat and mouse homologues. RT-PCR analysis indicated that it was ubiquitously expressed in 18 human adult tissues. With immunofluorescence assay, it was shown that the exogenous Flag-tagged ZNF438 was located in nucleus of COS-7 cells. To further explore the function of ZNF438, we examined the transcriptional activity of ZNF438 protein by transfecting recombinant pM-ZNF438 into mammalian cells. The subsequent analysis based on the duel luciferase assay system showed that ZNF438 was a transcriptional repressor.

• Korean Journal of Oriental Medicine
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• v.18 no.2
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• pp.1-16
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• 2012

Objectives : The 10th Conference of the Parties to the Convention on Biological Diversity (COP 10) was held in Nagoya, Japan in October 2010, during which an international convention on access to genetic resources and conventional knowledge and sharing of benefits thereof was adopted. The Oriental Medicine field uses medicinal herbs based on genetic resources, as well as traditional knowledge about genetic resources. As such, if Korea, China and Japan compete over the ownership of such traditional knowledge, it will almost certainly trigger disputes over the payment of royalties among other problems. Notably, since the traditional medicine industry is closely related with China, it is highly likely this will adversely affect Korea's production of medicines using natural materials, including Korean herbal doctors' prescription, formulation and preparation of medicinal herbs. Methods : This study also analyzed the recent situation in Japan, which is the chair nation of the Nagoya Protocol and a member nation like Korea. It analyzed the Japanese people's awareness of the Nagoya Protocol and its strategies in the two years since its adoption, as well as the Guidelines for Genetic Resources, which were newly revised in 2012. Conclusions : The Nagoya Protocol requires the preparation of legislative and administrative measures and policies in order to pave the way for sharing the benefits deriving from the use of genetic resources and the relevant traditional knowledge with the providers of such resources. Thus, corresponding domestic legal measures need to be taken. Such measures include the refining of the procedure of accessing genetic resources, the designation of liaison offices, a competent agency and a supervisory agency, and the building of a system designed to issue internationally acknowledged certificates. It is also important to operate related professional consulting offices, as is the case in Japan. In addition, in the case of genetic resources, there is a need to seek multinational and bilateral cooperation including free trade agreements. Regarding traditional knowledge about genetic resources, measures need to be prepared to enable the three East Asian countries, namely, Korea, China and Japan, to commonly use ancient literature on Oriental medicine and to claim exclusive rights to such intellectual properties. Notably, with China now moving to expand the scope of traditional knowledge through the WIPO, Korea needs to prepare response measures.

• 제어로봇시스템학회:학술대회논문집
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• 2004.08a
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• pp.1028-1032
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• 2004

In order to prevent machine tool feed slide system from transient vibrations during operations, machine tool designers usually adopt some typical design solutions; box-in-box typed feed slides, optimizing moving body for minimum weight and dynamic compliance, and so on. Despite all efforts for optimizing design, a feed drive system may experience severe transient vibrations during high-speed operation if its feed rate control is unsuitable. A rough feed rate curve having discontinuity in its acceleration profile causes a serious vibration problem in the feed slides system. This paper presents a feed rate optimization of a ball screw driven machine tool feed slide system for its minimum vibration. Firstly, a ball screw feed drive system was mathematically modeled as a 6-degree-of-freedom lumped parameter system. Next, a feed rate optimization of the system was carried out for minimum vibrations. The main idea of the feed rate optimization is to find out the most appropriate smooth acceleration profile with jerk continuity. A genetic algorithm was used in this feed rate optimization

• Journal of Korean Society for Quality Management
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• v.43 no.1
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• pp.31-42
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• 2015

Purpose: System consists of a lot of units with coherent function. In design phase, various units could be considered with the same function. In this study, we consider the alternative units with the same function and redundancy allocation to maximize system reliability in multi level system. Methods: The redundancy allocation problem with the alternative units in multi level system is formulated. Memetic algorithm(MA) is proposed to optimize the redundancy allocation problem. In addition, the performance of the proposed algorithm is explained by a numerical experiment. Results: MA showed better results than genetic algorithm(GA) and the convergence of the solutions in MA was also faster than GA. In addition, we could know from experiment that system reliability is increased and the chosen unit for redundancy allocation is changed if cost limit is increased. Conclusion: The chose unit for redundancy allocation is changed as resource constraints. It means we need to consider the alternative units in system design. In the future, we need to consider various problem related to redundancy allocation in multi level system and develop the better method to enhance search performance.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.50 no.7
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• pp.324-332
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• 2001

In this paper, it is suggested that the selection method of parameter of Power System Stabilizer(PSS) with robustness in low frequency oscillation for Static VAR Compensator(SVC) using a Real Variable Elitism Genetic Algorithm(RVEGA). A SVC, one of the Flexible AC Transmission System(FACTS), constructed by a fixed capacitor(FC) and a thyristor controlled reactor(TCR), is designed and implemented to improve the damping of a synchronous generator, as well as controlling the system voltage. The proposed PSS parameters are optimized using RVEGA in order to maintain optimal operation of generator under the various operating conditions. To decrease the computational time, real variable string is adopted. To verify the robustness of the proposed method, we considered the dynamic response of generator speed deviation and generator terminal voltage by applying a power fluctuation and three-phase fault at heavy load, normal load and light load. Thus, we prove the usefulness of proposed method to improve the stability of single machine-infinite bus with SVC system.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.51 no.7
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• pp.317-326
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• 2002

In this paper, a methodology for optimal PI supplementary controller using the modified genetic algorithm has been proposed to the oscillation damping in HDVC transmission system. These study processes are summarized as the formulation for load flow calculation in HVDC transmission system with SVC, the investigations on the basic control in HVDC system, the mathematical modeling for dynamic characteristics analyses, and the optimal design of MGA based PI controller generation the supplementary control signal of SVC. Its properties were verified through a series of computer simulations including dynamic stability. It means that the application of MGA-PI controller in HVDC transmission system can contribute the propriety to the improvement of the stability in HVDC transmission system and the design of MGA-OI controller has been proved indispensible when applied to HVDC transmission system.

• International Journal of Aerospace System Engineering
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• v.2 no.2
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• pp.29-33
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• 2015

The multidisciplinary design optimization (MDO) of a launch vehicle (LV) with a hybrid rocket engine (HRE) was carried out to investigate the ability of an HRE for a single-stage LV. The non-dominated sorting genetic algorithm-II (NSGA-II) was employed to solve two design problems. The design problems were formulated as two-objective cases involving maximization of the downrange distance over the target flight altitude and minimization of the gross weight, for two target altitudes: 50.0 km and 100.0 km. Each objective function was empirically estimated. Several non-dominated solutions were obtained using the NSGA-II for each design problem, and in each case, a trade-off was observed between the two objective functions. The results for the two design problem indicate that economical performance of the LV is limited with the HRE in terms of the maximum downrange distances achievable. The LV geometries determined from the non-dominated solutions were examined.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.1278-1282
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• 2003

A new interacting multiple model (IMM) method using intelligent input estimation (IIE) is proposed to track a maneuvering target. In the proposed method, the acceleration level for each sub-model is determined by IIE-the estimation of the unknown acceleration input by a fuzzy system using the relation between maneuvering filter residual and non-maneuvering one. The genetic algorithm (GA) is utilized to optimize a fuzzy system for a sub-model within a fixed range of acceleration input. Then, multiple models are composed of these fuzzy systems, which are optimized for different ranges of acceleration input. In computer simulation for an incoming ballistic missile, the tracking performance of the proposed method is compared with those of the input estimation (IE) technique and the adaptive interacting multiple model (AIMM) method.

• Journal of the Korean Society for Precision Engineering
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• v.22 no.4
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• pp.151-158
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• 2005

An important component of a cooling tower is an axial fan, and there happens distortion in its shape which brings significant loss of efficiency. In this paper, a surface profile measuring system for large size axial fan of cooling towers is developed. A laser sensor is used as a measuring device and aluminum profiles and stepping motors are engaged into the system as frame structure and driving devices respectively. The measuring data are compared to the design data to compute the distortion of the axial fans. Two types of errors, axial and twist errors, are used to represent the precision of axial fan distortion. Genetic algorithm is used to solve the optimization problem during computing the precision. Results are displayed three dimensionally in a solid-modeler as well as 2-D drawings to help users find it with ease.

• Proceedings of the KIPE Conference
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• 2001.10a
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• pp.404-408
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• 2001

This paper deals with speed control of induction motors with a gain tuning based on simple Genetic Algorithms, which are search algorithms based on the mechanics of natual selection and genetics. Based on the designed control system structure, the indirect vector control system of induction motors is simulated. The simulation results show that the system has a strong robust to the parameter variation and is insensitive to the load disturbance. Thus, the proposed PI controller based on genetic algorithms is superior to manually tuned classical PI controller in improving the speed control performance of induction motors.