• Proceedings of the PSK Conference
• /
• 2000.10a
• /
• pp.165.1-165.1
• /
• 2000

• Plant Resources
• /
• v.8 no.3
• /
• pp.293-299
• /
• 2005

This study used RAPD markers to assume genetic diversity and variation in selected populations of Hovenia dulcis var. koreana. Ratio of polymorphic RAPD markers were 93.4% in selected populations of Hovenia dulcis Thunb., difference of genetic structure among populations and within populations showed 16.45%, 83.55%, respectively in amount of total genetic variation of 4 populations. Total gene diversity($H_T$) that show genetic diversity appeared 0.313 and coefficient of gene differentiation($G_{ST}$) that compare genetic differentiation of populations appeared 0.1645, analysis of AMOVA for variation among populations and within populations was significantly different (P<0.001). Genetic diversity of whole populations showed that 12.44% difference among population and 87.56% difference within populations. As a result, difference within populations was larger than difference among populations in genetic diversity. Nei's genetic distance and cluster analysis appeared that mean genetic distance among populations was 0.076, thus dividing two main groups and geographic relationship did not show in populations.

• Proceedings of the Korea Environmental Mutagen Society Conference
• /
• 2001.10b
• /
• pp.191-192
• /
• 2001

• Proceedings of the Korea Environmental Mutagen Society Conference
• /
• 2002.11a
• /
• pp.196-196
• /
• 2002

• Proceedings of the PSK Conference
• /
• 2003.04a
• /
• pp.229.2-230
• /
• 2003

Among the aldehydes derived from lipid peroxidation, 4-hydroxynonenal (HNE) that can be produced from arachidonic acids. linoleic acids, or their hydroperoxides in relatively large amounts in response to oxidative insult. Therefore, HNE might be an important mediator of Oxidative stress-induced apoptosis. To study the hypothesis that HNE may induce apoptosis, we estimated cytotoxicity of HNE on YPEN-1 rat prostatic endothelial cells. (omitted)

• Proceedings of the Korea Environmental Mutagen Society Conference
• /
• 2004.11a
• /
• pp.138-138
• /
• 2004

• Korean Journal of Pharmacognosy
• /
• v.23 no.3
• /
• pp.142-145
• /
• 1992

MeOH extract of twenty medicinal herbs were screened for their effects against protein kinase C (PKC) using bleb-forming assay and PKC enzyme assay. Smilax china and Sanguisorba officinalis showed potent anti-PKC activity. Campsis grandiflora and Galla Halepensis showed moderate inhibitory effect on PKC.

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2002.11b
• /
• pp.196-196
• /
• 2002

p16INK4a tumor suppressor gene transfer in the non-small cell lung cancer cells by transduction of recombinant adenovirus (Ad5CMV-p16) resulted in significant inhibition of cancer cell growth (Anticancer Res., 1998, 18:3257-3261). As a safety concern, we have investigated gene and protein expression after transduction of adenoviral vector (Ad5CMV-p16) in human non-small cell lung cancer (A549) cells by using microarray and 2D gel electrophoresis/ MALDI-TOF.(omitted)

• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.291.2-291.2
• /
• 2002

For the safety evaluation of adenovirus-mediated gene therapy. we have investigated gene and protein expression after transduction of adenoviral vector (Ad5CMV-p16) which contains tumor suppressor gene. p161NK4$\alpha$ in human non-small cell lung cancer (A549) cells. We compared the differential gene expression level in the A549 cells treated with Ad5CMV (null type) and Ad5CMV-p16 virus. respectively. by using cDNA membrane chip and oligonucleotide chip. (omitted)

• Proceedings of the Korean Society of Developmental Biology Conference
• /
• 2001.10a
• /
• pp.53-54
• /
• 2001