• Journal of Animal Science and Technology
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• 제51권2호
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• pp.111-122
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• 2009

비유일수별로 변화하는 유생산기록을 305일로 보정하기 위하여, 분만 시 나이와 분만계절, 산차를 고려한 305일 보정계수를 개발하였고, 비선형적 특성에 적합하고 사용을 용이하게 하는 거듭제곱 함수 형태의 보정 공식을 개발하였다. 각각의 보정계수가 얼마나 정확하게 기록을 보정 할 수 있는 지 측정하기 위하여 실제 305일 누적 착유량 및 개체별 누적 착유량 평균과의 오차를 비교 분석 한 결과 새롭게 개발된 보정계수의 오차가 가장 적게 나타났으며, 이를 토대로 한 보정공식 역시 작은 오차를 나타냈다. 유생산량의 평균치가 최근까지 많이 증가하였음에도 불구하고 2산 이상의 개체에서 2002년에 개발된 보정계수의 오차가 낮게 나타난 것으로 보아 앞으로의 보정계수 개발에는 2002년 보정계수 개발에 사용되었던 건유효과에 대한 부분을 추가해야 더 정확하게 보정할 수 있을 것으로 사료된다. 유량에서의 보정계수 개발 및 보정식 개발 방법으로 유지방, 유단백, 무지고형분량에 대해서도 비유 일수 305일째의 누적량으로 보정할 수 있는 보정 공식을 개발하였다.

• 생물정신의학
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• 제18권4호
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• pp.181-188
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• 2011

Major depression is a devastating disorder of which lifetime prevalence rate is as high as up to 25% in general population. Although the etiology of the disorder is still poorly understood, it is generally accepted that both genetic and environmental factors are involved in the precipitation of depression. Stressful lifetime events are potent precipitating environmental factors for major depression and early-life stress is in particular an important element that predisposes individuals to major depression later in life. How environmental factors such as stress can make our neural networks susceptible to depression and how those factors leave long-lasting influences have been among the major questions in the field of depression research. Epigenetic regulations can provide a bridging mechanism between environmental factors and genetic factors so that these two factors can additively determine individual predispositions to major depression. Here we introduce epigenetic regulations as candidate mechanisms that mediate the integration of environmental adversaries with genetic predispositions, which may lead to the development of major depression, and summarize basic molecular events that underlie epigenetic regulations as well as experimental evidences that support the active role of epigenetic regulation in major depression.

• 한국독성학회:학술대회논문집
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• 한국독성학회 1998년도 국제심포지움 및 추계학술대회
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• pp.14-20
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• 1998

• Journal of Genetic Medicine
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• 제11권1호
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• pp.1-10
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• 2014

Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by selective destruction of pancreatic ${\beta}$-cells resulting in insulin deficiency. The genetic determinants of T1D susceptibility have been linked to several loci, in particular to the human leukocyte antigen (HLA) region, which accounts for 50% of the genetic risk of developing T1D. Multiple genes in the HLA region, which are in strong linkage disequilibrium, are thought to be involved. Another important locus, with a smaller effect on genetic predisposition to T1D, is the insulin gene. The advent of numerous single nucleotide polymorphism markers and genome screening has enabled the identification of dozens of new T1D susceptibility loci. Some of them appear to predispose to T1D independently of the HLA and may be important in families with T1D who lack strong HLA susceptibility. Other loci may interact with each other to cause susceptibility. The autoimmune response against ${\beta}$-cells can also be triggered by environmental factors in the presence of a predisposing genetic background. Deciphering the environmental and genetic factors involved should help to understand the origin of T1D and aid in the design of individualized prevention programs.

• Interdisciplinary Bio Central
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• 제3권2호
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• pp.6.1-6.3
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• 2011

Diabetes Mellitus (DM), often simply referred to as diabetes, has developed into a major health concern affecting more than 200 million people worldwide with approximately 4 million deaths per year attributed to the presence of the disease. Diabetes mellitus is categorized as Type 1 and Type 2, where Type 1 diabetes represents a lack of insulin production, and Type 2 diabetes is characterized by a relative lack of insulin receptor (i.e., decreased sensitivity to the effect of insulin) and cased by a complex interplay between genetic factors and environmental factors. Up to date, various studies on the pathology and mechanism in terms of genetic experiments have been conducted and approximately hundreds of genes were reported as diabetes mellitus associated genes. At this point, to support studies on the cause and mechanism of diabetes mellitus, an efficient database system to provide genetic variants related to diabetes mellitus is needed. DMBase is an integrated web-based genetic information resource for diabetes mellitus designed to service genomic variants, genes, and secondary information derived for diabetes mellitus genetics researchers. The current version of DMBase documents 754 genes with 3056 genetic variants and 66 pathways. It provides many effective search interfaces for retrieving diabetes mellitus and genetic information. A web interface for the DMBase is freely available at http://sysbio.kribb.re.kr/dmBase.

• Animal Systematics, Evolution and Diversity
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• 제32권2호
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• pp.105-111
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• 2016

The genetic structure of marine animals that inhabit the seashore is affected by numerous factors. Of these, gene flow and natural selection during recruitment have strong influences on the genetic structure of seashore-dwelling species that have larval periods. Relative contributions of these two factors to the genetic structure of marine species would be determined mainly by the duration of larval stage. The relationship between larval period and genetic structure of population has been rarely studied in Korea. In this study, genetic variations of cytochrome oxidase subunit I (COI) were analyzed in two dominant species on rocky shore habitats in the Korean peninsula: periwinkle Littorina brevicula and acorn barnacle Fistulobalanus albicostatus. Both species are not strongly structured and may have experienced recent population expansion. Unlike periwinkle, however, barnacle populations have considerable genetic variation, and show a bimodal pattern of mismatch distribution. These results suggest that barnacle populations are more affected by local adaptation rather than gene flow via larval migration. The bimodal patterns of barnacle populations observed in mismatch distribution plots imply that they may have experienced secondary contact. Further studies on seashore-dwelling species are expected to be useful in understanding the evolution of the coastal ecosystem around Korean waters.

• 대한한방소아과학회지
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• 제25권3호
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• pp.57-69
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• 2011

Objectives: Purpose of this study is to analyze and to estimate which and how much genetic and environmental factors have affected on growth. Also, a method of final height prediction can be developed from this study results. Methods: Correlation analysis and categorical regression analysis were conducted between genetic and environmental factors correlated with the final adult height, through survey from 171 male. Results: Mid parental height, neonatal body weight, intake frequency of beef, chicken, milk, fruits and coffee, sleep quantity and quality during the elementary school and sleep quantity during the middle school have affected on the final adult height. And a regression equation with 0.494 for coefficient of determination was obtained. Conclusions: Mid-parental-height has the most affected on the final adult height. Among environmental factors, food and sleep have significantly affected, but exercise doesn't. Among foods, meal, beef, and milk intake have remarkably affected on the final height, and chicken and fruit also have affected in some degree, but coffee has affected badly. Among sleep habits, sleep quantity during the elementary school has the most affected, sleep quality during the elementary school and sleep quantity during the middle school also have affected in some degree on final height. The younger the age is, the more sleep have affected and sleep quantity have more affected than sleep quality. Neonatal weight also has remarkably affected on the final height. Through this analysis, the final adult height can be predicted using regression equation which covers 49.4% of genetic and environmental factors.

• 영재교육연구
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• 제17권2호
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• pp.280-306
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• 2007

본 논문은 영재성의 중요한 요소 가운데 하나인 지력(知力)에 초점을 두어, 이에 대한 생득설과 경험설의 입장과 그에 대한 영향력에 대한 다양한 연구들을 종합 분석하고, 이와 관련된 몇 가지 논의를 함으로써 영재성을 이해하는 데에 목적을 두고 있다. 다양한 연구 내용들을 검토한 결과, 인간의 지력은 절반 정도는 타고난다는 것이 보편적인 입장이었다. 하지만 중요한 것은 그것이 평생 고정되는 것이 아니라 후천적 경험에 의해 변하고 발달한다는 점이다. 결국 지력이 중요한 요소인 영재성 자체는 잠재력으로 타고나는 것이지만, 그것은 여러 가지 환경 요인에 따라 그 발현의 여부나 정도가 결정된다는 것이다. 따라서 영재교육에 관한 오늘날의 주요 관심은 생득 요인과 후천 요인의 정도에 대한 논쟁보다는, 그 영재성을 후천적으로 어떻게 최대로 발현시킬 것인가에 있다. 영재성은 뛰어난 유전 요인과 특별한 환경 요인이 역동적으로 상호작용하여 쌍방향의 절묘한 증폭 현상이 일어날 때 비로소 촉발되고 발달한다는 점에서, 그것을 도식적으로 설명하는 데에 깊은 난관이 있음을 이해할 수 있다.

• 대한영양사협회학술지
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• 제12권3호
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• pp.225-234
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• 2006

The purpose of this study was to identify the factors that related to obesity among 6th grade elementary school girls. The study subjects were 337 girls residing in Seoul. Not only variables of nutritional environment such as eating habits, health related behavioral variables, nutritional feeding methods during infancy, and genetic factors but also sexual maturity had been included as a obesity related factors. Association between obesity and related variables were analyzed by $x^2$(Chi-square) test. The obesity prevalence of the study subjects were 16% based on Röhrer Index(RI). Fifty-three percent of the study subjects experienced menarche at the time of data collection. Result of analysis showed that not only the nutritional enviromental variables such as eating habits, specific food preferences, and habit of exercise but also genetic factors did not show any statistically significant association with obesity. Above finding may imply that more variables other than the variables included in this study might have influenced on the obesity of the children. However sexual maturity in term of breast development showed significant association with obesity.

• Clinical and Experimental Reproductive Medicine
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• 제25권2호
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• pp.135-140
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• 1998

It was reported that the etiologies of recurrent spontaneous abortion are immunologic factors, endocrinologic problems, anatomical abnormalities, genetic abnormalities, infection, and unexplained factors. Among those etiologic factors, genetic abnormalities occur in about 5% of the couples who experience recurrent spontaneous abortions, and most common parental chromosomal abnormality contributing to recurrent abortion is balanced translocation. The advent of in vitro fertilization (IVF), the development of skills associated with the handling of human embryo, and an explosion of knowledge in molecular biology have opened the possibility of early diagnosis of genetic disease in preimplantation embryos. Therefore preimplantation genetic diagnosis (PGD) is indicated for couples, infertile or not, at risk of transmitting a genetic disease. A case of successful pregnancy and term delivery by PGD using fluorescence in situ hybridization (FISH) technique in patient with recurrent spontaneous abortion due to balanced translocation is presented with brief review of literatures.