• Title/Summary/Keyword: genetic analysis

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Genetic Variation in the Selected Populations of Hovenia dulcis var. koreana Nakai. Based on RAPD Analysis

  • Kim Sea-Hyun;Han Jin-Gyu;Chung Hun-Gwan;Cho Yoon-Jin;Park Hyung-Soon
    • Plant Resources
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    • v.8 no.3
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    • pp.293-299
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    • 2005
  • This study used RAPD markers to assume genetic diversity and variation in selected populations of Hovenia dulcis var. koreana. Ratio of polymorphic RAPD markers were 93.4% in selected populations of Hovenia dulcis Thunb., difference of genetic structure among populations and within populations showed 16.45%, 83.55%, respectively in amount of total genetic variation of 4 populations. Total gene diversity($H_T$) that show genetic diversity appeared 0.313 and coefficient of gene differentiation($G_{ST}$) that compare genetic differentiation of populations appeared 0.1645, analysis of AMOVA for variation among populations and within populations was significantly different (P<0.001). Genetic diversity of whole populations showed that 12.44% difference among population and 87.56% difference within populations. As a result, difference within populations was larger than difference among populations in genetic diversity. Nei's genetic distance and cluster analysis appeared that mean genetic distance among populations was 0.076, thus dividing two main groups and geographic relationship did not show in populations.

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A Study on the Dynamics of Genetic Algorithm Based on Stochastic Differential Equation (유전 알고리즘의 확률 미분방정식에 의한 동역학 분석에 대한 연구)

  • 석진욱;조성원
    • Proceedings of the Korean Institute of Intelligent Systems Conference
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    • 1997.10a
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    • pp.296-300
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    • 1997
  • Recently, the genetic algorithm has been applied to the various types of optimization problems and these attempts have very successfully. However, in most cases on these approaches, there is not given by investigator about to the theoritical analysis. The reason that the analysis of the dynamics for genetic algorithm is not clear, is the probablitic aspect of genetic algorithm. In this paper, we investigate the analysis of the internal dynamics for genetic algorithm using stochastic differential method. In addition, we provide a new genetic algorithm, based on the study of the convergence property for the genetic algorithm.

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Global Genetic Analysis

  • Elahi, Elahe;Kumm, Jochen;Ronaghi, Mostafa
    • BMB Reports
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    • v.37 no.1
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    • pp.11-27
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    • 2004
  • The introduction of molecular markers in genetic analysis has revolutionized medicine. These molecular markers are genetic variations associated with a predisposition to common diseases and individual variations in drug responses. Identification and genotyping a vast number of genetic polymorphisms in large populations are increasingly important for disease gene identification, pharmacogenetics and population-based studies. Among variations being analyzed, single nucleotide polymorphisms seem to be most useful in large-scale genetic analysis. This review discusses approaches for genetic analysis, use of different markers, and emerging technologies for large-scale genetic analysis where millions of genotyping need to be performed.

Program Development of Genetic Analysis for Diallel Cross Experiment

  • Kim, Seo Young;Bae, Jong Sung
    • Communications for Statistical Applications and Methods
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    • v.9 no.3
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    • pp.675-682
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    • 2002
  • In this study, we develop the statistical analysis program for genetic analysis of diallel crosses data by SAS/MACRO, SAS/IML. Genetic analysis is to estimate of genetics parameters and heredity with reciprocal cross and without reciprocal cross. Statistical analysis program solve the problem of the difficulties on the data analysis in field denetics and breeding Therefore the user whoever want to analysis of data on genetics and breeding easily conduct the work saving time and suffering.

Genetic Structure and Composition of Genetic Diversity in the Kouchi Sub-breed of the Japanese Brown Cattle Population

  • Honda, Takeshi;Fujii, Toshihide;Mukai, Fumio
    • Asian-Australasian Journal of Animal Sciences
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    • v.20 no.11
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    • pp.1631-1635
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    • 2007
  • Japanese Brown cattle, one of the four domestic beef breeds in Japan, are suffering from numerical reduction due to economic pressure from profitable breeds. In this study, all the reproductive cows in the Kouchi sub-breed of the Japanese Brown cattle that were alive in July 2005 were investigated by pedigree analysis to clarify genetic structure and composition of genetic variability. In addition, genetically important individuals for the maintenance of genetic variability of the sub-breed were also identified through the core set method. The number of cows analyzed was 1,349. Their pedigrees were traced back to ancestors born around 1940, and pedigree records of 13,157 animals were used for the analysis. Principal component analysis was performed on the relationship matrix of the cows, and their factor loadings were plotted on a three-dimensional diagram. According to their spatial positions in the diagram, all the cows were subdivided into five genetically distinctive subpopulations of 131 to 437 animals. Genetic diversity of the whole sub-breed, which is estimated to be 0.901, was decomposed into 0.856 and 0.045 of within-subpopulation and between-subpopulation components. Recalculation of genetic diversity after removal of one or several subpopulations from the five subpopulations suggested that three of them were genetically important for the maintenance of genetic variability of the sub-breed. Applying the core set method to all the cows, maximum attainable genetic diversity was estimated to be 0.949, and optimal genetic contributions assigned to each cow supported the previous results indicating relative importance of the three subpopulations as useful genetic materials.

A Study on a Hybrid Genetic Algorithm for the Analysis of Inverse Radiation (역복사 해석을 위한 혼합형 유전 알고리듬에 관한 연구)

  • Kim, Ki-Wan;Baek, Seung-Wook;Kim, Man-Young;Ryou, Hong-Sun
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.27 no.10
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    • pp.1516-1523
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    • 2003
  • An inverse radiation analysis is presented for the estimation of the boundary emissivities for an absorbing, emitting, and scattering media with diffusely emitting and reflecting opaque boundaries. The finite-volume method is employed to solve the radiative transfer equation for a two-dimensional irregular geometry. A hybrid genetic algorithm is proposed for improving the efficiency of the genetic algorithm and reducing the effects of genetic parameters on the performance of the genetic algorithm. After verifying the performance of the proposed hybrid genetic algorithm, it is applied to inverse radiation analysis in estimating the wall emissivities in a two-dimensional irregular medium when the measured temperatures are given at only four data positions. The effect of measurement errors on the estimation accuracy is examined.

Evaluating Genetic Diversity of Agaricus bisporus Accessions through Phylogenetic Analysis Using Single-Nucleotide Polymorphism (SNP) Markers

  • Oh, Youn-Lee;Choi, In-Geol;Kong, Won-Sik;Jang, Kab-Yeul;Oh, Min ji;Im, Ji-Hoon
    • Mycobiology
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    • v.49 no.1
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    • pp.61-68
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    • 2021
  • Agaricus bisporus, commonly known as the button mushroom, is widely cultivated throughout the world. To breed new strains with more desirable traits and improved adaptability, diverse germplasm, including wild accessions, is a valuable genetic resource. To better understand the genetic diversity available in A. bisporus and identify previously unknown diversity within accessions, a phylogenetic analysis of 360 Agaricus spp. accessions using single-nucleotide polymorphism genotyping was performed. Genetic relationships were compared using principal coordinate analysis (PCoA) among accessions with known origins and accessions with limited collection data. The accessions clustered into four groups based on the PCoA with regard to genetic relationships. A subset of 67 strains, which comprised a core collection where repetitive and uninformative accessions were not included, clustered into 7 groups following analysis. Two of the 170 accessions with limited collection data were identified as wild germplasm. The core collection allowed for the accurate analysis of A. bisporus genetic relationships, and accessions with an unknown pedigree were effectively grouped, allowing for origin identification, by PCoA analysis in this study.

RFLP Analysis of the mtDNA COI Region in Four Abalone Species

  • Park, Choul-Ji;Kijima, Akihiro
    • Fisheries and Aquatic Sciences
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    • v.9 no.3
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    • pp.101-106
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    • 2006
  • The cytochrome c oxidase subunit I (COI) gene region of mitochondrial DNA (mtDNA) was examined in four abalone species to estimate its utility as a genetic marker using restriction fragment length polymorphism (RFLP) analysis. The utility was evaluated in terms of genetic divergence and relationships among Haliotis discus hannai, H. rufescens, H. rubra, and H. midae in both hemispheres of the world. There was clear genetic divergence in the mtDNA COI region between all pairs of the four species. Moreover, relationships among the abalone species were reflected in their geographical distributions and morphological characteristics. Therefore, RFLP analysis of the mtDNA COI region is a suitable genetic marker for the estimation of genetic divergence and relationships among abalone species. However, it is not effective for the evaluation of genetic differences within abalone species.

Integration of a Large-Scale Genetic Analysis Workbench Increases the Accessibility of a High-Performance Pathway-Based Analysis Method

  • Lee, Sungyoung;Park, Taesung
    • Genomics & Informatics
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    • v.16 no.4
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    • pp.39.1-39.3
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    • 2018
  • The rapid increase in genetic dataset volume has demanded extensive adoption of biological knowledge to reduce the computational complexity, and the biological pathway is one well-known source of such knowledge. In this regard, we have introduced a novel statistical method that enables the pathway-based association study of large-scale genetic dataset-namely, PHARAOH. However, researcher-level application of the PHARAOH method has been limited by a lack of generally used file formats and the absence of various quality control options that are essential to practical analysis. In order to overcome these limitations, we introduce our integration of the PHARAOH method into our recently developed all-in-one workbench. The proposed new PHARAOH program not only supports various de facto standard genetic data formats but also provides many quality control measures and filters based on those measures. We expect that our updated PHARAOH provides advanced accessibility of the pathway-level analysis of large-scale genetic datasets to researchers.

Genetic Divergence and Relationship among Abalone Species by RAPD Analysis (RAPD 분석을 이용한 전복류의 유전적 차이 및 유연관계)

  • Park, Choul-Ji;Kim, Hyun-Chul;Noh, Jae-Koo;Lee, Jeong-Ho;Myeong, Jeong-In
    • Journal of Aquaculture
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    • v.21 no.4
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    • pp.346-350
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    • 2008
  • RAPD analysis was examined to estimate the availability as a genetic marker. The availability was evaluated in terms of genetic divergence and relationships among Haliotis discus hannai, H. rufescens, H. rubra and H. midae in both hemispheres of the world. In results, RAPD analysis showed a clear genetic divergence between every pair of species. However, genetic relationships among the four species estimated by RAPD analysis unreflected to geographical distribution and morphological characteristics. In conclusion, RAPD is suitable genetic markers for estimates of genetic divergence and differences among abalone species.