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Association of serum carotenoid, retinol, and tocopherol concentrations with the progression of Parkinson's Disease

  • Kim, Ji Hyun;Hwang, Jinah;Shim, Eugene;Chung, Eun-Jung;Jang, Sung Hee;Koh, Seong-Beom
    • Nutrition Research and Practice
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    • v.11 no.2
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    • pp.114-120
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    • 2017
  • BACKGROUND/OBJECTIVES: A pivotal role of oxidative stress has been emphasized in the pathogenesis as well as in the disease progression of Parkinson's disease (PD). We aimed at investigating serum levels of antioxidant vitamins and elucidating whether they could be associated with the pathogenesis and progression of PD. MATERIALS/METHODS: Serum levels of retinol, α- and γ-tocopherols, α- and β-carotenes, lutein, lycopene, zeaxanthin and β-cryptoxanthin were measured and compared between 104 patients with idiopathic PD and 52 healthy controls matched for age and gender. In order to examine the relationship between antioxidant vitamins and the disease progression, multiple group comparisons were performed among the early PD (Hoehn and Yahr stage I and II, N = 47), advanced PD (stage III and IV, N = 57) and control groups. Separate correlation analyses were performed between the measured antioxidant vitamins and clinical variables, such as Hoehn and Yahr stage and Unified Parkinson's Disease Rating Scale (UPDRS) motor score. RESULTS: Compared to controls, PD patients had lower levels of α- and β-carotenes and lycopene. α-carotene, β-carotene and lycopene levels were significantly reduced in advanced PD patients relative to early PD patients and were negatively correlated with Hoehn and Yahr stage and UPDRS motor score in PD patients. No significant differences were found in serum levels of retinol, α- and γ-tocopherols, and other carotenoids between PD patients and controls. No significant correlations were found between these vitamin levels and clinical variables in PD patients. CONCLUSTIONS: We found that serum levels of some carotenoids, α-carotene, β-carotene and lycopene, were lower in PD patients, and that these carotenoids inversely correlated with clinical variables representing disease progression. Our findings suggest that decreases in serum α-carotene, β-carotene and lycopene may be associated with the pathogenesis as well as progression of PD.

Study of Jindo Dog Personality Traits:Questionnaire of The 16th Korean Jindo Dog Show (진도개 성격형질연구:제16회 한국진도개품평회 설문조사)

  • Hong, Kyung-Won;Kim, Young-San;Shin, Young-Bin;Oh, Seok-Il;Kim, Jong-Seok;Choi, Hyuk;Lee, Ji-Woong;Sun, Sang-Soo;Lee, Jae-Il;Lee, Sang-Eun;Chung, Dong-Hee;Cho, Yong-Min;Im, Seok-Ki;Choi, Bong-Hwan
    • Journal of Animal Science and Technology
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    • v.50 no.2
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    • pp.273-278
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    • 2008
  • There have been studies about dog’s personality and behavior, which is helpful to breed dogs as guide or companion. In this study, a questionnaire was developed using 54 Jindo dogs, which considered ten items about aggressiveness and sociability. The scores were analyzed by principle component analysis (PCA), after accounting for four variables: age, gender, growing place, and coat-colors. Our results from the PCA indicated three principle components, which classified ‘aggressiveness’, ‘sociability’ and unknown factor. The four variables did not significantly affect aggressiveness(P>0.05). However, there was a relationship between coat-color and sociability, i.e., the Jindo dogs with fawn color were more sociable than the white ones(P<0.1).

A Study on the Changes in Digital Perception of Information Vulnerable Class After COVID-19 (코로나이후 정보취약계층의 디지털인식변화에 관한연구)

  • Kim, So-Young;Jung, Jin-Teak
    • Journal of Digital Convergence
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    • v.19 no.12
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    • pp.531-539
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    • 2021
  • Given the rapid development of information and communication technology (ICT) and the deepening of the information gap phenomenon in the context of the COVID-19 pandemic, researchers and practitioners need to understand the changing perceptions of new phenomena such as COVID-19 information gap on the existing information-vulnerable population. In this study, an empirical analysis was performed with the digital information gap survey data in 2020 to understand the potential impact of COVID-19 on the information gap according to the information-vulnerable class. This study is to verify the effect of information gap, marginalized groups, gender, and major factors of information services (contents, social relations, life services, information production, networking, social participation, non-face-to-face services) on the change in perception of digital information technology after Corona. Hierarchical regression analysis was performed. As a result of the analysis, it was found that the higher the content, social relationship, life service, networking, and digital non-face-to-face service, the higher the change in perception of digital information technology after Corona. Therefore, in light of the evolving phenomenon of COVID-19, it is considered that the government needs to provide education and training to strengthen the capabilities of the information-vulnerable class in order to resolve the digital information gap.

Study on Middle and High School Students' Use of Convenience Foods at Convenience Stores in Incheon (인천지역 일부 중학생과 고등학생의 편의점 편의식 이용 실태)

  • Lee, Seul-Ki;Choi, Mi-Kyeong;Kim, Mi-Hyun
    • Korean Journal of Community Nutrition
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    • v.24 no.2
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    • pp.137-151
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    • 2019
  • Objectives: The rapidly changing dietary environment requires a study that addresses the status of middle and high school students regarding their consumption of convenience food sold at convenience stores. Methods: This study examined adolescents' lifestyle patterns, dietary habits, and status of consuming convenience food at convenience stores. A total of 659 students (329 middle school students and 330 high school students) in Incheon participated in this questionnaire survey. Results: The mean age of the subjects was 13.7 years for the middle school students, and 16.6 years for the high school students. The gender and grade distributions in the middle and high school students were similar. The middle school students reported that they spent more time using electronic devices (p<0.001) or watching TV (p<0.001) than high school students. More than 60% of middle and high school students consumed convenience food at convenience stores without statistical difference between the two groups. The main reason for consuming convenience food from convenience stores was its convenience followed by taste in both groups. Despite the high frequency of consuming convenience food, the students rarely checked the nutrition labels at the time of purchase. On the other hand, they were still most concerned about the nutritional value of the convenience foods when they consumed convenience foods. The most frequently consumed convenience food was ramyon in both groups. Significant positive correlations were observed between the frequency of consuming convenience food at convenience stores and lifestyle factors for the middle school students, including monthly allowance, time for using electronic devices, and number of private lessons. For the high school students, however, the only monthly allowance had a significant positive correlation with the consumption. Conclusions: Adolescents are increasingly exposed to convenience foods and relevant nutritional issues are a concern. Therefore, a dietary environment that is adequately formed for the healthy development of youth as well as systematic nutrient education that is appropriately designed for both middle and high school students is required.

Factors Affecting Depression in the Elderly Over 65 Years in Korea: Using Andersen's Behavioral Model (한국 65세 이상 노인의 우울증에 영향을 미치는 요인 : 앤더슨 모형을 활용한 융합적 연구)

  • Park, Hyo-Eun;Seo, In Soon
    • Journal of the Korea Convergence Society
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    • v.10 no.8
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    • pp.83-95
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    • 2019
  • The purpose of this study was to comprehensively investigate predictive factors influencing on geriatric depression of the elderly by applying the Andersen's Behavioral Model of Health Service Use,. The research data was focused on the final analysis of 3,585 elderly population aged 65 or older among 21,724 participants in the 6th (2013-2015) Korea National Health and Nutrition Examination Survey. Hierarchical logistic regression analysis was conducted to multivariate analysis method of the variables for possible depression by the Andersen's Behavioral Model of Health Service Use. As a result of hierarchical regression analysis, there was a negative correlation of 0.49 times(0.31-0.78) for males. In addition, there was a positive correlation of pain 1.56 times(1.05-2.31), stress 0.55 times(1.10-2.19), walking exercise 1.44 times(1.03-2.00) and outpatient use 1.48 times(1.10-1.98). Therefore, differentiated support according to the gender of the community residents is necessary, and stress intervention or additional support for exercise is required.

Sensitivity analysis of missing mechanisms for the 19th Korean presidential election poll survey (19대 대선 여론조사에서 무응답 메카니즘의 민감도 분석)

  • Kim, Seongyong;Kwak, Dongho
    • The Korean Journal of Applied Statistics
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    • v.32 no.1
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    • pp.29-40
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    • 2019
  • Categorical data with non-responses are frequently observed in election poll surveys, and can be represented by incomplete contingency tables. To estimate supporting rates of candidates, the identification of the missing mechanism should be pre-determined because the estimates of non-responses can be changed depending on the assumed missing mechanism. However, it has been shown that it is not possible to identify the missing mechanism when using observed data. To overcome this problem, sensitivity analysis has been suggested. The previously proposed sensitivity analysis can be applicable only to two-way incomplete contingency tables with binary variables. The previous sensitivity analysis is inappropriate to use since more than two of the factors such as region, gender, and age are usually considered in election poll surveys. In this paper, sensitivity analysis suitable to an multi-dimensional incomplete contingency table is devised, and also applied to the 19th Korean presidential election poll survey data. As a result, the intervals of estimates from the sensitivity analysis include actual results as well as estimates from various missing mechanisms. In addition, the properties of the missing mechanism that produce estimates nearest to actual election results are investigated.

Relationship between Eating Behavior and Healthy Eating Competency of Single-Person and Multi-Person Households by Age Group (연령대별 1인 가구 및 다인 가구의 식생활 행태 및 건강한 식생활 역량과의 관계)

  • Hong, Seung-Hee;Kim, Ji-Myung
    • Korean Journal of Community Nutrition
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    • v.26 no.5
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    • pp.337-349
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    • 2021
  • Objectives: The purpose of this study was to analyse the relationship between eating behaviour and healthy dietary competency of single and multi-person households, to improve healthy eating behavior. Methods: This study was conducted on 6,355 adult household members who participated in the Food Consumption Behavior Survey 2020. The subjects were divided into age groups comprising young people in their 20s and 30s, middle-aged people in their 40s and 50s, and the elderly in their 60s and above. The eating behavior and healthy dietary competency of single-person and multi-person households were then analyzed. Results: The average age of the members in the single-person households was found to be higher. Single-person households were also found to have a lower marriage rate and lower monthly household income than multi-person households across the age groups of young, middle-aged, and elderly people (P < 0.05). Among each of the age groups, single-person households had significantly higher rates of skipping breakfast and eating breakfast, lunch, and dinner alone than multi-person households (P < 0.05). Young single-person households had lower average scores on healthy dietary competency than multi-person households (P = 0.032). When adjusted for age, gender, marriage, education, occupation, and household income, single-person households had a higher risk of delivery/take-out, eating out, or skipping meals compared to multi-person households (P < 0.05). In multi-person households, the risk of skipping meals, eating alone, eating out, or delivery/take-out decreased as healthy dietary competency improved (P < 0.05). On the other hand, in single-person households, as healthy dietary competency increased, the risk of delivery/take-out or eating alone decreased (P < 0.05). Conclusions: The results of this study suggest that healthy dietary competency and eating practices can be improved by providing customized dietary education by age group for single and multi-person households.

Health Risk Behavior and Oral Symptoms in Adolescents in Multicultural Families (다문화 가정 청소년의 건강 위험 행동과 구강 증상에 관한 연구)

  • Sim, Seon-Ju;Hong, Min-Hee
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.12
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    • pp.246-252
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    • 2020
  • This study used the raw data of the 15th (2019) Korean Youth Health Risk Behavior Survey to investigate the risk factors of the health-risk behaviors of Korean multicultural adolescents on the subjective oral symptoms. The scope of the multicultural family was limited to children of immigrant women's families married to Korean men and immigrant male families married to Korean women, and 572 were selected as the final study subjects. The sociodemographic variables were surveyed as gender, grade, economic level, and school performance. The health risk behaviors included drinking, smoking, medication, stress, sleep satisfaction, suicidal thoughts, depression, and brushing before bedtime. The oral symptoms examined were toothache, gum pain, and halitosis. As a result, toothache was related to drinking, toothbrushing before sleep, stress, sleep satisfaction, suicidal thoughts, and depression. Gum pain was associated with drug use, sleep satisfaction, suicidal thoughts, and depression. Halitosis was associated with medication, brushing before sleep, stress, suicidal thoughts, and depression. In terms of health risk factors, drinking, stress, and sleep satisfaction were risk factors for toothache. Smoking, sleep satisfaction, and suicidal thoughts were risk factors for gum pain. The presence of toothbrushing and stress were risk factors for halitosis. In conclusion, a policy system is needed to support oral health education programs nationally at times, such as after-school activities or club activities, to promote oral health for teenagers.

The Influence of Online Classes Educational Quality and Learning Emotions on Learning Outcome - Focusing on H Technical College Students - (온라인 수업의 교육의 질, 학습 정서가 학습성과에 미치는 영향 - H 전문대학 학생들을 중심으로 -)

  • Kim, Bo-Young;Hwang, Hye-Kyoung
    • Journal of Korea Entertainment Industry Association
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    • v.14 no.8
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    • pp.467-476
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    • 2020
  • The purpose of this study is as a base study for improving the quality of online classes through multilateral analysis that examines the learning outcoms of educational quality and learning emotions on non-face-to-face online classes at Technical Colleges To this study, from March 1, 2020 to August 31, 2020, a survey was conducted on 1,000 students of H Technical Colleges located in the metropolitan area. The collected data were statistically processed using the SPSS Statistics 18.0 program, t-validation were performed to reveal awareness of online class also correlation analysis and multiple regression analysis were performed to reveal the relation and influence of factors related to quality of instruction, learning emotions, learning outcomes. First, there was a statistically significant difference in perception of online classes by gender and grade. Second, there was a positive correlation between the educational quality, learning emotions, and learning outcomes for online classes. Third, among the learning outcomes, the factors that influence the achievement were the educational content and positive emotions, and the factors that influence the satisfaction among the learning outcomes were the educational content and the learning environment.

Bike Insurance Fraud Detection Model Using Balanced Randomforest Algorithm (균형 랜덤 포레스트를 이용한 이륜차 보험사기 적발 모형 개발)

  • Kim, Seunghoon;Lee, Soo Il;Kim, Tae ho
    • Journal of Digital Convergence
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    • v.20 no.2
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    • pp.241-250
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    • 2022
  • Due to the COVID-19 pandemic, with increased 'untact' services and with unstable household economy, the bike insurance fraud is expected to surge. Moreover, the fraud methodology gets complicated. However, the fraud detection model for bike insurance is absent. we deal with the issue of skewed class distribution and reflect the criterion of fraud detection expert. We utilize a balanced random-forest algorithm to develop an efficient bike insurance fraud detection model. As a result, while the predictive performance of balanced random-forest model is superior than it of non-balanced model. There is no significant difference between the variables used by the experts and the confirmatory models. The important variables to detect frauds are turned out to be age and gender of driver, correspondence between insured and driver, the amount of self-repairing claim, and the amount of bodily injury liability.