• Proceedings of the Materials Research Society of Korea Conference
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• 2011.05a
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• pp.51.1-51.1
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• 2011

An electrospun Poly (lactice-co-glycolide acid) (PLGA) and Gelatin nanofiber tube was fabricated for potential intestinal stent application. Mechanical properties of tube were evaluated by tensile strength and burst strength tests. Physical and chemical properties were evaluated by contact angle measurement, swelling rates and porosity measurements. Biodegradability was investigated by immersion in simulated body fluid (SBF). Biocompatibility was investigated in vitro by cytotoxicity and proliferation studies by MTT assay, confocal microscopy and western blot using IEC-18 (Rat intestinal epithelial cell). After intestinal stent was implanted into rat bowel for periods from 7 to 10days, it was then analyzed using micro-computed tomography (Micro CT) and X-ray techniques. Futhermore, histological analysis was performed by hematoxylin-eosin (H&E) stain.

• Polymer(Korea)
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• v.32 no.5
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• pp.409-414
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• 2008

The fabrication of gelatin nanofibers by electro spinning has been examined using the TFE/DW co-solvent system. It has been found that no beads-on-string structure was formed for the solution containing ionic salts. The resulting fibers exhibited a uniform diameter ranging from 110 to 125 nm. As the concentration of ionic salts increases, the beads become smaller and more spindle like, due to the increase of viscosity and conductivity. The addition of ionic salts induces a higher charge density on the surface of ejected jet during spinning, leading that higher elongation forces are applied to the jet. The higher enhancement of viscosity and conductivity was observed in gelatin solutions by the use of divalent salt. However, the concentration of ionic salts scarcely affected the variation of fiber diameter. While very low crystallinity was observed from XRD pattern for the sample containing no ionic salt, which increased with increasing the concentration of ionic salts.