• Title/Summary/Keyword: gel characteristics

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Drug Release Characteristics and Skin Irritancies of Topical Gels and Multiple Emulsion Creams Containing Kojic Acid (외용겔 및 다중유제크림의 코지산 방출특성과 피부자극성)

  • Yu, Sung-Un;Park, Eun-Woo;Choi, Young-Wook
    • Journal of Pharmaceutical Investigation
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    • v.28 no.2
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    • pp.87-92
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    • 1998
  • Kojic acid (KA) is an antimelanogenic agent which has been widely used in cosmetics to whiten the skin color. However, it has the drawbacks of the skin irritancy and the instability against the pH, temperature, and light. In order to overcome these problems, various topical gels and multiple emulsion creams which can control the release of active ingredient, KA, were formulated employing cream bases of mineral oil with caprylic capric triglyceride and hydrophilic polymers such as chitosan, carbopol. and pluronics. Using Franz diffusion cells mounted with a synthetic cellulose membrane (MWCO 12,000), drug release characteristics of the formulations were evaluated by the HPLC assay of KA concentration in the receptor compartment of pH 7.4 phosphate buffered saline solution. Drug release from chitosan-based gels (ChitoGel) obeyed to the first order kinetics with a rapid release especially in the initial period. However, pluronic-based gels (PluGel) and carbopol-based gels (CarboGel) revealed controlled release of drug to some extent, followed by the square root-time kinetics. Moreover, the release of KA was further controlled with the W/O/W multiple emulsion creams (MultiCream), showing the apparent zero order release kinetics by virtue of dynamic ratecontrolling membrane of the oil layer. The flux $(J,\;{\mu}g/cm^2/hr)$ of ChitoGel. CarboGel. PluGel. and MultiCream in the initial period of 6hr were 73.30, 28.67. 24.04 and 7.72, respectively. On the other hand, the skin irritancy score of ChitoGel and MultiCream were observed as 2.5 and 2.3 respectively, in the rabbit skin irritation test. Although there were insignificant differences at p<0.05 between those formulations, it was possible to conclude that the W/O/W multiple emulsion creams containing KA might be a good candidate for an antimelanogenic drug delivery system due to the controlled release of acidic drug molecules.

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Changes in Sensory and Textural Properties of Mungbean Starch Gels during Storage (보존에 따른 녹두 전분 gel의 관능적, 텍스쳐 특성변화)

  • 최은정;오명숙
    • Korean journal of food and cookery science
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    • v.15 no.5
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    • pp.539-544
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    • 1999
  • This study attempted to determine the effect of storage temperature(5$^{\circ}C$ and 25$^{\circ}C$) and time(1, 24, 48 and 72 hours) on the sensory and textural properties of mungbean starch gels. The color value, syneresis, texture and sensory properties of mungbean starch gels were measured. As the storage time increased, the lightness(L) and whiteness(W) values of mungbean starch gel increased. This trend was more apparent at the storage temperature of 5$^{\circ}C$. The syneresis of gels also increased as the storage time increased and the storage temperature was lower. As the storage time increased, the hardness of the gel increased whereas the adhesiveness and cohesiveness of the gel decreased. These results showed that mungbean starch gel lost its typical viscoelasticity during storage. This trend was also more apparent at the storage temperature of 5$^{\circ}C$. Sensory characteristics of the gel were well correlated with the mechanical characteristics. Overall quality of the gel decreased markedly at the 2nd day storage at 5$^{\circ}C$ and at the 3rd day storage at 25$^{\circ}C$.

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V-I Properties of Silicone Gel (실리콘 젤의 전압-전류 특성)

  • 송병기;최성오;신종열;이태훈;홍진웅
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1997.11a
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    • pp.377-380
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    • 1997
  • In order to investigate the electrical characteristics due to the curing condition of silicone gel for Power Semiconductor, the V-I characteristics is studied. For experiment, We have made up several samples of different curing temperature and time such as 1[H],2[H] at 150[$^{\circ}C$], 160[$^{\circ}C$], 170[$^{\circ}C$]. As a result of the V-I characteristics, it is confirmed that the properties of specimen cured at 170[$^{\circ}C$], 2[H] is stable.

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Starch Content and Its Gelatinization Characteristics in Job′s Tears (율무 품종의 전분함량 및 호화 특성)

  • Lee, Jung-Il;Ryu, Su-Noh;Hur, Han-Sun;Kim, Yul-Ho;Kim, Kwang-Ho
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.39 no.1
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    • pp.98-102
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    • 1994
  • This study was conducted to obtain basic informations on the starch quality improvement breeding of Job's tears. Starch, amylose, gel consistency and amylogram characteristics of seeds were investigated in 36 varieties of domestic and introduced Job's tears. Starch content was distributed between 50.9 and 78% with a mean of 60.5%. The variation observed in amylose content ranged from 0 to 7.2% with the average was 5.2%. Kangsanjong, Chujeonjong, Chungrijong showed medium gel consistency. However, many Job's tears tested showed soft gel consistency. Varietal differences of amylogram characteristics was also found at break down. In general, job's tear starch showed lower value of setback.

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CO Sensor Characteristics of ZnO powders by Sol-Gel methods (Sol-Gel법에 의한 ZnO 분말의 CO 센서 특성)

  • Park, Bo-Seok;Park, Jin-Seoung;Noh, Whyo-Sub
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2002.07b
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    • pp.821-825
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    • 2002
  • ZnO thick films by Sol-Gel processing were investigated electrics, optics and the sensing characteristics of CO gas. Using the znic acetate dihydrate and acetylaceton (AcAc) as a chelating agent, stable ZnO sol was synthesized. ZnO phase was crystallized through the heat-treatment at $70^{\circ}C$ for 4hrs and influenced the sensing characteristics of the electrics and CO gas by uniform particle distributions not related particle size. The samples on the alumina substrate by thick films were investigated the properties of electrics and the effect of sensing. The sensitivity was so excellent in the sample of the heat-treatment at $600^{\circ}C$ for 12hrs and good in the heat-treatment for 1hrs generally. Crystallization and volatilization of organic materials according to the change of heating treatment temperature of thick films were analyzed by TG-DTA, XRD and mirostructure of thick films were observed by SEM.

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Macroscopic Breakup Characteristics of Water Gel Simulants with Triplet Impinging Spray Jet (젤 모사 추진제 삼중 충돌 분사 제트의 거시적 분열 특성 연구)

  • Hwang, Tae-Jin;Lee, In-Chul;Koo, Ja-Ye
    • Journal of ILASS-Korea
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    • v.15 no.3
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    • pp.109-114
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    • 2010
  • The implementation of gelled propellants systems offers high performance, energy management of liquid propulsion, storability, and high density impulse of solid propulsion. The present study focused on the macroscopic spray characteristics of liquid sheets formed by triplet impinging jets of non-Newtonian liquids which are mixed by Carbopol 941 0.5%wt. The results are compared to experiments conducted on spray images which formed by triplet impinging jets concerning with airassist effect at center orifice. When gel propellants are injected by doublet impinging jets at low pressure and high pressure, closed rim pattern shape appeared by polymeric effect from molecular force and showed inactive atomization characteristics, because of extensional viscosity related by restriction of atomization process and breakup time delay of turbulence transition. As increasing mass flow rate of the air(increasing GAR), spray breakup level is also increased.

Electrical and Chemical Characteristics of the Grain Boundaries of Semiconducting $BaTiO_3$ Ceramics Prepared with Surface-Coated Powders (표면 코팅된 분말을 이용하여 제조된 반도성 $BaTiO_3$ 소결체의 입계 화학 및 전기적 특성)

  • 박명범;김정돈;조남희
    • Journal of the Korean Ceramic Society
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    • v.37 no.4
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    • pp.338-344
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    • 2000
  • Grain boundary chemistry and electrical characteristics of polycrystalline BaTiO3 ceramics, which were prepared with sol-gel surface-coated semiconducting powders, were investigated. Mn ions were coated on the powder surface by sol-gel coating-techniques. The additives coated on the surface of the powders were observed to be present near the grain boundaries of the ceramics. The ceramics exhibit the PTCR characteristics with a resistivity jump ratio(Pmax/Pmin) of about 2$\times$103. With raising the temperature from room temprature to 20$0^{\circ}C$, the oxidation state of the Mn ions varied from Mn3+ to Mn2+ in the coating layers. Near the grain boundaries an excessive negative charge layer of about 20nm was formed.

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Electrochemical Characteristics of Pseudocapacitor Using Aqueous Polymeric Gel Electrolyte (수용성 폴리머 겔 전헤액을 사용한 Pseudocapacitor의 전기화학적 특성)

  • Park, Soo-Gil
    • Journal of the Korean Electrochemical Society
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    • v.6 no.2
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    • pp.158-160
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    • 2003
  • We have reported to make nanostructured cobalt oxide electrode that have large capacitance over than 400 F/g (specific capacitance) and good cycleability. But, it had serious demerits of low voltage range under 0.5 V and low power density. Therefore, we need to increase voltage range of cobalt oxide electrode. We report here on the electrochemical properties of sol-gel-derived nanoparticulate cobalt xerogel in 1M KOH solution and aqueous polymeric gel electrolyte. In solution electrolyte, cobalt oxide electrode had over 250 F/g capacitance consisted of EDLC and pseudocapacitance. In gel electrolyte, cobalt oxide electrode had around 100 F/g capacitance. This capacitance was only electric double layer capacitance of active surface area. In solution electrolyte, potassium ion as working ion reacted with both of layers easily. However, In gel electrolyte, reacted with only surface-active layer. Itis very hard to reach resistive layer. So, we have studied on pretreatment of electrode to contain working ions easily. We'll report more details.

Electrochemical Characteristics of Aqueous Polymeric Gel Electrolyte for Supercapaictor (수퍼커패시터용 수용성 고분자 젤 전해질의 전기화학적 특성)

  • Kim, Han-Joo;Ishikawa, Masashi;Morita, Masayuki;Park, Soo-Gil
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2001.11b
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    • pp.93-96
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    • 2001
  • We have reported to make nanostructured cobalt oxide electrode that have large capacitance over than 400F/g (specific capacitance) and good cycleability. But, It had serious demerits of low voltage range under 0.5V and low power density. Therefore, we need to increase voltage range of cobalt oxide electrode. we report here on the electrochemical properties of sol-gel-derived nanoparticulate cobalt xerogel in 1M KOH solution and aqueous polymeric gel electrolyte. In solution electrolyte, cobalt oxide electrode had over than 250F/g capacitance consisted of EDLC and pseudocapacitance. In gel electrolyte, cobalt oxide electrode had around l00F/g capacitance. This capacitance was only surface EDLC. In solution electrolyte, potassium ion as working ion reacted with both of layers easily. However, In gel electrolyte, reacted with only surface-active layer. Its very hard to reach resistive layer. So, we have studied on pretreatment of electrode to contain working ions easily. We'll report more details.

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A Study on the Valve Regulated Lead-Acid Battery using Phosphoric Acid Gel Electrolyte (인산 겔 전해질을 사용한 밀폐형 납축전지에 관한 연구)

  • Ju, Chan-Hong;Park, Keun-Ho
    • Journal of the Korean Applied Science and Technology
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    • v.20 no.4
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    • pp.296-308
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    • 2003
  • The capacity and long life of gel electrolyte batteries is connected with gas recombination producting $PbO_2$ and Pb electrode. We were prepared with phosphoric acid gel electrolyte to know gel characteristics per density to assemble VRLA batteries. We studied by measuring electrolyte dispersion using Brewster-angle microscope(BAM), charge-discharge cycle and electrode structure using scanning election microscope(SEM) per electrolyte density. As a results, phosphoric acid density 1.210 was excellent gel dispersion in sol condition, electrode condition after fifty cycles in this study.