• Title/Summary/Keyword: gastrointestinal system

Search Result 403, Processing Time 0.03 seconds

Design of Gastrointestinal Diagnosis System based on Ultrasonic Response Characteristics (초음파 응답특성 분석에 의한 위장 경화 진단시스템의 설계)

  • Lim, Do-Hyung;Kim, Eun-Geun;Lee, Gyoun-Jung;Park, Won-Pil;Kim, Han-Sung;Shin, Tae-Min;Choi, Seo-Hyung;Lee, Yong-Heum
    • Journal of Biomedical Engineering Research
    • /
    • v.28 no.2
    • /
    • pp.250-257
    • /
    • 2007
  • Functional gastrointestinal disorders affect millions of people of all age regardless of race and sex. There are, however, rare diagnostic methods for the functional gastrointestinal disorders because functional disorders show no evidence of organic and physical causes. Our research group identified recently that the gastrointestinal tract well in the patients with the functional gastrointestinal disorders becomes more rigid than healthy people when palpating the abdominal regions overlaying the gastrointestinal tract. The aim is, therefore, to develop a diagnostic method for the functional gastrointestinal disorders based on quantitative measurement of the rigidity of the gastrointestinal tract well using ultrasound technique. For this purpose, a preliminary ultrasound diagnostic system was developed and verified through phantom tests. The system consisted of transmitter, ultrasonic transducer, receiver, TGC, and CPLD, and verified via a phantom test. For the phantom test, ten soft-tissue specimens were harvested from porcine. Five of them were then treated chemically to mimic a rigid condition of gastrointestinal tract well, which was induced by functional gastrointestinal disorders. Additionally, the specimens were tested mechanically to identify if the mimic was reasonable. The customized ultrasound system was finally verified through application to human subjects with/without functional gastrointestinal disorders(Normal and Patient Groups). It was identified from the mechanical test that the chemically treated specimens were more rigid than normalspecimen. This finding was favorably compared with the result obtained from the phantom test. The phantom test also showed that ultrasound system well described the specimen geometric characteristics and detected an alteration in the specimens. The maximum amplitude of the ultrasonic reflective signal in the rigid specimens $(0.2{\pm}0.1Vp-p)$ at the interface between the fat and muscle layers was explicitly higher than that in the normal specimens $(0.1{\pm}0.0Vp-p)$ (p<0.05). Clinical tests using our customized ultrasound system for human subject showed that the maximum amplitudes of the ultrasonic reflective signals nea. to the gastrointestinal tract well for the patient group$(2.6{\pm}0.3Vp-p)$ were generally higher than those in normal group$(0.1{\pm}0.2Vp-p)$ (p<0.05). These results suggest that newly designed diagnostic system based on ultrasound technique may diagnose enough the functional gastrointestinal disorders.

Acute Pancreatitis and Gastroduodenal Intussusception Induced by an Underlying Gastric Gastrointestinal Stromal Tumor: A Case Report

  • Yildiz, Mehmet Siddik;Dogan, Ahmet;Koparan, Ibrahim Halil;Adin, Mehmet Emin
    • Journal of Gastric Cancer
    • /
    • v.16 no.1
    • /
    • pp.54-57
    • /
    • 2016
  • Gastrointestinal stromal tumors (GISTs) are rare tumors of the gastrointestinal system and comprise only 1% to 3% of all gastrointestinal tract tumors, with the majority of them arising in the stomach. In this report, we present the unique findings of a case of gastroduodenal intussusception caused by an underlying gastric GIST and complicated with severe acute pancreatitis.

Recent Achievements in Stem Cell Therapy for Pediatric Gastrointestinal Tract Disease

  • Bae, Sun Hwan
    • Pediatric Gastroenterology, Hepatology & Nutrition
    • /
    • v.16 no.1
    • /
    • pp.10-16
    • /
    • 2013
  • The field of stem cell research has been rapidly expanding. Although the clinical usefulness of research remains to be ascertained through human trials, the use of stem cells as a therapeutic option for currently disabling diseases holds fascinating potential. Many pediatric gastrointestinal tract diseases have defect in enterocytes, enteric nervous system cells, smooth muscles, and interstitial cells of Cajal. Various kinds of therapeutic trials using stem cells could be applied to these diseases. This review article focuses on the recent achievements in stem cell applications for pediatric gastrointestinal tract diseases.

Comparison Film Screen System with Digital Radiographic System in upper gastrointestinal study (Film screen system과 DR system하의 상부위장관 조영술 진단 결과의 비교 분석)

  • Lee Hee Jeong;Son Soon Yong;Kang Sung Ho;Jang Vong Cheol;Ryu Myeong Sun
    • Journal of The Korean Radiological Technologist Association
    • /
    • v.28 no.1
    • /
    • pp.55-60
    • /
    • 2002
  • Purpose : The aim of this study is to rise interest in system control for digital image of high quality by investigating diagnostic value of Digital radiographic system in upper gastrointestinal study Materials and Method : Upper gastrointestinal study wa

  • PDF

Telemetry capsule for pressure monitoring in the gastrointestinal tract (소화관 내 압력 측정을 위한 텔레메트리 캡슐 구현)

  • Yoon, Ki-Won;Woo, Sang-Hyo;Lee, Jyung-Hyun;Moon, Yeon-Kwan;Park, Hee-Joon;Won, Chul-Ho;Kim, Byung-Kyu;Choi, Hyun-Chul;Cho, Jin-Ho
    • Journal of Sensor Science and Technology
    • /
    • v.14 no.4
    • /
    • pp.211-218
    • /
    • 2005
  • As the cause and the treatment about gastrointestinal disease has been issued recently, the importance of measuring the pressure in the gastrointestinal tract has been increased. However, the conventional measurement methods of the pressure in the gastrointestinal tract cause the patients' pain and inconvenience as well as an inaccurate pressure measurement. In this paper, the pressure monitoring telemetry system has been designed and implemented for an accurate pressure measurement inside the gastrointestinal tract with minimizing pain and inconvenience. The pressure monitoring telemetry system is composed of a pressure measurement capsule and an external receiver. The capsule has been miniaturized into the same size of a vitamin tablet so that the capsule can be swallowed through the oral cavity. After the capsule acquires and encodes the pressure data in the gastrointestinal tract, the encoded pressure data are modulated by frequency shift keying (FSK) and transmitted with ultrahigh frequency (UHF) band signal to the outside of a body. The performance of the telemetry capsule for monitoring pressure in the gastrointestinal tract is demonstrated by the results of animal in-vivo experiments.

Development of Ultrasound Diagnostic System for Functional Gastrointestinal Disorders using Finite Difference Method (유한차분법을 이용한 기능성 위장 장애 진단용 초음파 시스템의 개발)

  • Park, Won-Pil;Woo, Dae-Gon;Ko, Chang-Yong;Lee, Qyoun-Jung;Lee, Yong-Heum;Choi, Seo-Hyoung;Shin, Tae-Min;Kim, Han-Sung;Lim, Do-Hyung
    • Journal of the Korean Society for Precision Engineering
    • /
    • v.24 no.9
    • /
    • pp.130-139
    • /
    • 2007
  • The disaster from functional gastrointestinal disorders (FGID) has detrimental impact on the quality of life of the affected population. There are, however, rare diagnostic methods for FGID. Our research group identified recently that the gastrointestinal tract well of the patients with FGID became more rigid than that of healthy people when palpating the abdominal regions overlaying the gastrointestinal tract. The objective of the current study is, therefore, to identify feasibility of a diagnostic system for FGID based on ultrasound technique, which can quantify the characteristics above. Two-dimensional finite difference (FD) models (one normal and two rigid models) were developed to analyze the reflective characteristic (displacement) on each soft-tissue layer responded after application of ultrasound signals. Based on the results from FD analysis, the ultrasound system for diagnosis of the FGID was developed and clinically tested via application of it to 40 human subjects with/without FGID who were assigned to Normal and Patient Groups. The results from FD analysis showed that the maximum displacement amplitude in the rigid models (0.12 and 0.16) at the interface between the fat and muscle layers was explicitly less than that in the normal model (0.29). The results from actual specimens showed that the maximum amplitude of the ultrasound reflective signal in the rigid models $(0.2{\pm}0.1Vp-p)$ at the interface between the fat and muscle layers was explicitly higher than that in the normal model $(0.1{\pm}0.0Vp-p)$. Clinical tests using our customized ultrasound system showed that the maximum amplitudes of the ultrasound reflective signals near to the gastrointestinal tract well for the patient group $(2.6{\pm}0.3Vp-p)$ were generally higher than those in normal group $(0.1{\pm}0.2Vp-p)$. These findings suggest that our customized ultrasound system using the ultrasound reflective signal may be helpful to the diagnosis of the FGID.

The Effects of Strychni Ignatii Semen on Toxicity Levels and Gastrointestinal Tract (보두(寶豆)의 수치법(修治法)에 따른 독성(毒性) 및 소화기계(消化器系)에 미치는 영향(影響))

  • Kim, Jin-Sung;Yoon, Sang-Hyub;Ryu, Bong-Ha;Ryu, Ki-Won;Cho, Yu-Kyung
    • The Journal of Internal Korean Medicine
    • /
    • v.23 no.1
    • /
    • pp.107-115
    • /
    • 2002
  • Objective : These experiments were designed to investigate the effects of Strychni Ignatii Semen on the gastrointestinal system and declining of toxicity. About experiments of acute toxicity, I investigated the quantity of Strychni $(C_{21}H_{22}N_2O_2)\;and\;LD_{50}$. In order to study the effects on gastrointestinal tract, I investigated the changes of gastric juice, discharging level of pepsin, inhibiting effects of ulceration, and transporting of intestine. Methods : Sample I : No making Strychni Ignatii Semen Sample II : Depositing for three days in water and then dry it. Sample III : Depositing for one hour in sesame oil and bum it. The results were as follows : 1. The average values of Strychnine decreased in Sample III. 2. The levels of $LD_{50}$ increased in Sample Ⅲ by about 70%. 3. In Sample III, inhibiting effects of ulceration and discharging level of pepsin were great. 4. In the level of gastric juice decreased in Sample I.II.III. 5. The transporting ability of large intestine elevated in Sample I.II.III. According to the results, making Strychni Ignatii Semen, especially Sample 3, toxicity decreased and has good effects on the gastrointestinal system.

  • PDF

Development of a Model for a National Animal Health Monitoring System in Gyeongnam III. Cost Estimates of Selected Dairy Cattle Diseases (동물(젖소) 건강 Monitoring System 모델 개발 III. 목장에서 빈발하는 질병의 비용 평가)

  • 김종수;김용환;이효종;김곤섭;김충희;박정희;하대식;최민철
    • Journal of Veterinary Clinics
    • /
    • v.16 no.2
    • /
    • pp.428-438
    • /
    • 1999
  • A study was conducted to estimate cost of major dairy cattle diseases. Forty (n=40) of the 167 dairy herds in Gyeongnam (Chinju) area were stratified and selected randomly for participation in the national animal health monitoring system. Gyeongsnag University veterinarians, Gyeongnam Livestock Promotion Institute veterinarians and clinic veterinarian visited each herd once a month for a total periods of 12 months. At a each visit data on disease, production, management, finance, treatments, preventive activities, animal events, and any other relevant events were collected. Monthly and annual cost estimates of disease treatment were in computed in each herd and stratum(including cost of prevention). Results were expressed as cost per head and given separately for cows, young stock, and calves. In cows, the most expensive seven diseases entities (from the most to the least) were : (1) clinical mastitis; (2) breeding problems; (3)gastrointestinal problems; (4) multiple system problem; (5) birth problems; (6) metabolic/nutritional disease; (7) lameness. In young stock, the most costly disease were the multiple system problems, breeding problems, respiratory disease, gastrointestinal disease, and lameness. In calves, the most costly disease problems were gastrointestinal problems, respiratory disease, integumental, multiple system problems, and metabolic/nutritional problems.

  • PDF

Helical tomotherapy for spine oligometastases from gastrointestinal malignancies

  • Choi, Yun-Seon;Kim, Jun-Won;Lee, Ik-Jae;Han, Hee-Ji;Baek, Jong-Geal;Seong, Jin-Sil
    • Radiation Oncology Journal
    • /
    • v.29 no.4
    • /
    • pp.219-227
    • /
    • 2011
  • Purpose: This study evaluated the treatment effectiveness and proper radiation dose of helical tomotherapy (HT) in spine oligometastases from gastrointestinal cancers. Materials and Methods: From 2006 to 2010, 20 gastrointestinal cancer patients were treated with HT for spine oligometastases (31 spine lesions). The gross tumor volume (GTV) was the tumor evident from magnetic resonance imaging images fused with simulation computed tomography images. Clinical target volume (CTV) encompassed involved vertebral bodies or dorsal elements. We assumed that the planning target volume was equal to the CTV. We assessed local control rate after HT for 31 spine metastases. Pain response was scored by using a numeric pain intensity scale (NPIS, from 0 to 10). Results: Spine metastatic lesions were treated with median dose of 40 Gy (range, 24 to 51 Gy) and median 5 Gy per fraction (range, 2.5 to 8 Gy) to GTV with median 8 fractions (range, 3 to 20 fraction). Median biologically equivalent dose (BED, ${\alpha}/{\beta}$ = 10 Gy) was 52 $Gy_{10}$ (range, 37.5 to 76.8 $Gy_{10}$) to GTV. Six month local control rate for spine metastasis was 90.3%. Overall infield failure rate was 15% and outfield failure rate was 75%. Most patients showed pain relief after HT (93.8%). Median local recurrence free survival was 3 months. BED over 57 $Gy_{10}$ and oligometastases were identified as prognostic factors associated with improved local progression free survival (p = 0.012, P = 0.041). Conclusion: HT was capable of delivering higher BED to metastatic lesions in close proximity of the spinal cord. Spine metastases from gastrointestinal tumors were sensitive to high dose radiation, and BED (${\alpha}/{\beta}$ = 10 Gy) higher than 57 $Gy_{10}$ could improve local control.

Gastrointestinal Stromal Tumors: Case Report, Aeromedical Assessment of Therapy (위장관기질종양)

  • Jeon, Jong Deuk
    • Korean journal of aerospace and environmental medicine
    • /
    • v.30 no.2
    • /
    • pp.80-82
    • /
    • 2020
  • Gastrointestinal Stromal Tumors (GISTs) are relatively uncommon soft tissue sarcomas that can be located in any part of the digestive system. GISTs originate in specialized nerve cells located in the walls of the digestive system. This case report is about a 53-year-old airman who was recently diagnosed as peritoneal GISTs. He got a surgical removal of the tumor and chemotherapy, including imatinib (Gleevec®). Although his GISTs have shown excellent clinical progress, he still needs ongoing treatment. This case involves an airline pilot applicant for Class-I medical certification who has had GISTs under chemotherapy.