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Analysis and Estimation for Market Share of Biologics based on Google Trends Big Data (구글 트렌드 빅데이터를 통한 바이오의약품의 시장 점유율 분석과 추정)

  • Bong, Ki Tae;Lee, Heesang
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.43 no.2
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    • pp.14-24
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    • 2020
  • Google Trends is a useful tool not only for setting search periods, but also for providing search volume to specific countries, regions, and cities. Extant research showed that the big data from Google Trends could be used for an on-line market analysis of opinion sensitive products instead of an on-site survey. This study investigated the market share of tumor necrosis factor-alpha (TNF-α) inhibitor, which is in a great demand pharmaceutical product, based on big data analysis provided by Google Trends. In this case study, the consumer interest data from Google Trends were compared to the actual product sales of Top 3 TNF-α inhibitors (Enbrel, Remicade, and Humira). A correlation analysis and relative gap were analyzed by statistical analysis between sales-based market share and interest-based market share. Besides, in the country-specific analysis, three major countries (USA, Germany, and France) were selected for market share analysis for Top 3 TNF-α inhibitors. As a result, significant correlation and similarity were identified by data analysis. In the case of Remicade's biosimilars, the consumer interest in two biosimilar products (Inflectra and Renflexis) increased after the FDA approval. The analytical data showed that Google Trends is a powerful tool for market share estimation for biosimilars. This study is the first investigation in market share analysis for pharmaceutical products using Google Trends big data, and it shows that global and regional market share analysis and estimation are applicable for the interest-sensitive products.

A Study of Cut-Out Designs in Contemporary Fashion (현대패션에 나타난 컷 아웃 디자인에 관한 연구)

  • Kim, Sun-Young
    • The Research Journal of the Costume Culture
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    • v.20 no.1
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    • pp.36-48
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    • 2012
  • This study intends to provide fundamental data to develop creative high-value designs, proving that the cut-out technique, a decorative element of fashion design, can be used to express various visual effects. The author performed a literature review of such publications as Gap Press, Fashion News, and Mode & Mode from 2001S/S to 2010S/S, referring to Internet data to empirically analyze the cut-out technique in contemporary fashion. The study found that the cut-out design is effective overall, but is best suited for one-piece designs and for partial rather than whole items of clothing. The basic motif of the cut-out is a geometrical pattern based on a line, a tear, or is shapeless. The cut-out design is mostly shown as an overall pattern or as a symmetrical shape. Analysis shows that the characteristics of the contemporary fashion utilizing the cut-out technique are as follow: First, the cut-out technique exposes the curves of a woman's body in a direct or indirect way, thereby emphasizing her sexuality and maximizing the value of female beauty. Second, through the cut-out technique, we can highlight the various types of space formed by the technique and repeated patterns; we may also elaborate on single-patterned laser-cut designs, which will show that the particular surface effect of the material can strongly impact the attractiveness of the design through emphasis and decoration. Third, damaging or destroying clothes on purpose, showing surprising concepts through optical illusions, and expressing humor by ignoring existing clothing styles show our willingness to escape from traditional or obvious design ideas, as well as demonstrating individuality and playfulness.

Finite Element Analysis of Pipe Whip Restraint Behavior Under Jet Thrust Forces (유체 분사 추진력을 받는 배관 휩 구속장치 거동에 관한 유한요소해석)

  • Sugoong Koh;Lee, Young-Shin
    • Nuclear Engineering and Technology
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    • v.25 no.3
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    • pp.353-360
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    • 1993
  • Many types of pipe whip restraints are installed to protect the structural components from the anticipated pipe whip phenomena of high energy lines in nuclear power plants. It is necessary to investigate these phenomena accurately in order to design the pipe whip restraints properly and/or to evaluate the acceptability of the pipe whip restraint design. Various research programs have been conducted in many countries to develop analytical methods and to verify the validity of the methods. In this study, various types of finite elements in ANSYS[1], the general purpose finite element computer program, was used to simulate the postulated pipe whips to obtain impact loads and the calculated results were compared with the specific experimental results from the sample pipe whip test for the U-shaped pipe whip restraints. Some calculational models, having the gap element or the spring element between the pipe whip restraint and the pipe line, give reasonably good transient responses of the restraint forces compared with the experimental results, and could be useful in evaluating the acceptability of the pipe whip restraint design.

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A Study on Common/Private Borderline and Renovation of Apartment House (공동주택의 공사구분(共私區分)과 리모델링과의 관계에 관한 연구;한국과 일본의 공동주택 표준관리규약을 중심으로)

  • Lee, Jae-Sauk;Seo, Hyeong-Wook;Nam, Hye-Won;Chun, Jae-Youl
    • Proceedings of the Korean Institute Of Construction Engineering and Management
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    • 2007.11a
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    • pp.562-566
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    • 2007
  • In apartment house renovation project, the project progress held up in perception gap or conflict of interest with residents as usual. These dispute occurs ambiguous borderline ordistinction of Common Useing) Parts and Exclusive Possessed Private Parts. The Maintenance Covenant now in force in Korea and Japan are considered in this paper about theses item. Summarizing the conclusion is as below. 1) In The Maintenance Covenantnow in force, in definition of Ownership, Utilization, Maintenance, Japan is more ostensive than Korea. 2) The Borderline of Common Using Parts with Exclusive Possessed Parts is [Inner line of Exterior Wall] in Korea and in Japan also. But in Korea it is not in unity in purpose and action or definition and description. 3) In Japan, the Subject of Ownership is defined with hierarchically, as Housing complex-residential Building-individual dwelling, But not in Korea. 4) In Japan, [Exclusively using Common Owned Parts] are defined, But not in Korea.

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A Design of Size Reduced Ring-Hybrid using Coupled Lines of Hairpin Type (헤어핀 형태의 결합 선로를 이용한 소형화된 링 하이브리드의 설계)

  • Lee, Hong-Seop;Hwang, Hee-Yong
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.18 no.5 s.120
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    • pp.547-552
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    • 2007
  • In this paper, the coupled microstrip lines of hairpin type are applied to design a compact microstrip ring hybrid. When the gap decreases, three attenuation poles are created by coupling between the lines. The proposed structure can achieve a significant reduction of size and suppression of the harmonics. And it has the same frequency responses of conventional ring hybrid at 2.55 GHz. The harmonics are suppressed to below -20 dB up to 12 GHz, including the third harmonic. The ring part size of the proposed ring hybrid is reduced to one forth of the conventional ring hybrid. The measured frequency responses agree well with simulated ones.

A Study on Electroreflectance in Si-Doped $Al_{0.33}Ga_{0.67}As$ (Si이 첨가된 $Al_{0.33}Ga_{0.67}As$에서의 Electroreflectance에 관한 연구)

  • 김근형;김동렬;김종수;김인수;배인호;한병국
    • Electrical & Electronic Materials
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    • v.10 no.7
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    • pp.692-699
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    • 1997
  • The silicon doped $Al_{0.33}$G $a_{0.67}$As were grown by molecular beam epitaxy. The electroreflectance(ER) spectra of Schottky barrier Au/n-Al/suu x/G $a_{1-x}$ As have been measured at various modulation voltage( $V_{ac}$ ) and dc bias voltage( $V_{bias}$). From the observed Franz-Keldysh oscillations(FKO) peak, the band gap energy of the $Al_{x}$G $a_{1-x}$ As is 1.91 eV which corresponds to an Al composition of 33%. The internal electric field( $E_{i}$)of this sample is 2.96$\times$10$^{5}$ V/cm. As the modulation voltage( $V_{ac}$ ) is changed, the line shape of ER signal does not change but its amplitude varies linearly. The amplitude as a function of modulation voltage has saturated at 0.8 V. The internal electric field has decreased from 6.47$\times$10$^{5}$ V/cm to 2.00$\times$10$^{5}$ V/cm as the dc bias voltage( $V_{bias}$) increases from -3.5 V to +0.8 V. The values of built-in voltage( $V_{bi}$ ) and carrier concentration(N) determined from the plot of $V_{bias}$ from the plot of $V_{bias}$ versus $E_{i}$$^{2}$ are 0.855 V and 3.83$\times$10$^{17}$ c $m^{-3}$ , respectively.ively.y.y.y.

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A Research for Removing ECG Noise and Transmitting 1-channel of 3-axis Accelerometer Signal in Wearable Sensor Node Based on WSN (무선센서네트워크 기반의 웨어러블 센서노드에서 3축 가속도 신호의 단채널 전송과 심전도 노이즈 제거에 대한 연구)

  • Lee, Seung-Chul;Chung, Wan-Young
    • Journal of Sensor Science and Technology
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    • v.20 no.2
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    • pp.137-144
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    • 2011
  • Wireless sensor network(WSN) has the potential to greatly effect many aspects of u-healthcare. By outfitting the potential with WSN, wearable sensor node can collects real-time data on physiological status and transmits through base station to server PC. However, there is a significant gap between WSN and healthcare. WSN has the limited resource about computing capability and data transmission according to bio-sensor sampling rates and channels to apply healthcare system. If a wearable node transmits ECG and accelerometer data of 4 channel sampled at 100 Hz, these data may occur high loss packets for transmitting human activity and ECG to server PC. Therefore current wearable sensor nodes have to solve above mentioned problems to be suited for u-healthcare system. Most WSN based activity and ECG monitoring system have been implemented some algorithms which are applied for signal vector magnitude(SVM) algorithm and ECG noise algorithm in server PC. In this paper, A wearable sensor node using integrated ECG and 3-axial accelerometer based on wireless sensor network is designed and developed. It can form multi-hop network with relay nodes to extend network range in WSN. Our wearable nodes can transmit 1-channel activity data processed activity classification data vector using SVM algorithm to 3-channel accelerometer data. ECG signals are contaminated with high frequency noise such as power line interference and muscle artifact. Our wearable sensor nodes can remove high frequency noise to clear original ECG signal for healthcare monitoring.

IT Industrial Policy of Western Area in China (중국 서부지역 IT 산업의 발전 동향)

  • Kwon, Oh-Heung;Choi, Young-Ji;Kim, Do-Hwan
    • Resources Recycling
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    • v.14 no.1
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    • pp.64-71
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    • 2005
  • In spite of economic slump of global IT market, China is showing growth of 25% per year. After opening economy, the economic growth of the country haven't flagged. Moreover, according to the economic plan of the President HuJinTao who took office in 2002, IT field has been developing quickly. Even through such development is enough to show off the ability of China in the wrld, it is also a fact that there are many side effects. Among them, the imbalance of development between the east and the west is disturbing the general Chinese development. So the government is making efforts to reduce the gap as a solution, "Go West campaign". While progressing the policy, the related law which restricted domestic demand market advance in 2000 has been abolished. We also have an opportunity for launching the west of China at the same line with other developed countries. Based on such realities, we are going to research the general present state and policy of Chinese IT industries and the direction in which we have to go by investigating the situation of the western area is suggested.

Design and Implementation of BPF Using a Symmetric Coupled Line (대칭형 결합선로를 이용한 BPF의 설계 및 구현)

  • Kang, Sang-Gee;Choi, Heung-Taek;Lee, Jae-Myung
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.13 no.7
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    • pp.1255-1260
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    • 2009
  • Microstrip interdigital filter is designed with the width and length of a resonator, the gap distance between resonators and the location of a tap. When designing filters, it is a benefit to design with few design parameters comparing to many design parameters. In this paper we design and implement two microstrip interdigital filters operating in the UWB(Ultra Wide-Band) frequency band, one using a fixed width of a resonator and the other using a different width of resonators. The test results of the implemented filters show that the low-band high filter with a fixed width has the insertion loss of 1.49dB, -10dB band width of 720MHz, -35.7dBattenuation at 4.8GHzand below -13dB of S11. The filter with a different width of resonators has the insertion loss of 1.6dB, -10dBbandwidth of 1.63GHz and below-8dBof S11.

Staggered Tunnel Barrier engineered Memory

  • Son, Jeong-U;Park, Gun-Ho;Jo, Won-Ju
    • Proceedings of the Korean Vacuum Society Conference
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    • 2010.02a
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    • pp.255-255
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    • 2010
  • 전하 트랩형 비휘발성 메모리는 10년 이상의 데이터 보존 능력과 빠른 쓰기/지우기 속도가 요구 된다. 그러나 두 가지 특성은 터널 산화막의 두께에 따라 서로 trade off 관계를 갖는다. 즉, 두 가지 특성을 모두 만족 시키면서 scaling down 하기는 매우 힘들다. 이것의 해결책으로 적층된 유전막을 터널 산화막으로 사용하여 쓰기/지우기 속도와 데이터 보존 특성을 만족하는 Tunnel Barrier engineered Memory (TBM)이 있다. TBM은 가운데 장벽은 높고 기판과 전극쪽의 장벽이 낮은 crested barrier type이 있으며, 이와 반대로 가운데 장벽은 낮고 기판과 전극쪽의 장벽이 높은 VARIOT barrier type이 있다. 일반적으로 유전율과 밴드갭(band gap)의 관계는 유전율이 클수록 밴드갭이 작은 특성을 갖는다. 이러한 관계로 인해 일반적으로 crested type의 터널 산화막층은 high-k/low-k/high-k의 물질로 적층되며, VARIOT type은 low-k/high-k/low-k의 물질로 적층된다. 이 형태는 밴드갭이 다른 물질을 적층했을 때 전계에 따라 터널 장벽의 변화가 민감하여 전자의 장벽 투과율이 매우 빠르게 변화하는 특징을 갖는다. 결국 전계에 민감도 향상으로 쓰기/지우기 속도가 향상되며 적층된 유전막의 물리적 두께의 증가로 인해 데이터 보존 특성 또한 향상되는 장점을 갖는다. 본 연구에서는 기존의 TBM과 다른 형태의 staggered tunnel barrier를 제안한다. staggered tunnel barrier는 heterostructure의 에너지 밴드 구조 중 하나로 밴드 line up은 두 밴드들이 같은 방향으로 shift된 형태이다. 즉, 가전자대 에너지 장벽의 minimum이 한 쪽에 생기면 전도대 에너지 장벽의 maximum은 반대쪽에 생기는 형태를 갖는다. 이러한 밴드구조를 갖는 물질을 터널 산화막층으로 하게 되면 쓰기/지우기 속도를 증가시킬 수 있으며, 데이터 보존 능력 모두 만족할 수 있어 TBM의 터널 산화막으로의 사용이 기대된다. 본 연구에서 제작한 staggered TBM소자의 터널 산화막으로는 $Si_3N_4$/HfAlO (Hf:Al=1:3)을 사용하여 I-V(current-voltage), Retention, Endurance를 측정하여 메모리 소자로서의 특성을 분석하였으며, 터널 산화막의 제 1층인 $Si_3N_4$의 두께를 1.5 nm, 3 nm일 때의 특성을 비교 분석하였다.

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