• 대한수학회논문집
• /
• 제24권3호
• /
• pp.367-379
• /
• 2009

For a prime number p, let $\mathbb{Q}_p$ denote the p-adic field and let $\mathbb{Q}_p^d$ denote a vector space over $\mathbb{Q}_p$ which consists of all d-tuples of $\mathbb{Q}_p$. For a function f ${\in}L_{loc}^1(\mathbb{Q}_p^d)$, we define the Hardy-Littlewood maximal function of f on $\mathbb{Q}_p^d$ by $$M_pf(x)=sup\frac{1}{\gamma{\in}\mathbb{Z}|B_{\gamma}(x)|H}{\int}_{B\gamma(x)}|f(y)|dy$$, where |E|$_H$ denotes the Haar measure of a measurable subset E of $\mathbb{Q}_p^d$ and $B_\gamma(x)$ denotes the p-adic ball with center x ${\in}\;\mathbb{Q}_p^d$ and radius $p^\gamma$. If 1 < q $\leq\;\infty$, then we prove that $M_p$ is a bounded operator of $L^q(\mathbb{Q}_p^d)$ into $L^q(\mathbb{Q}_p^d)$; moreover, $M_p$ is of weak type (1, 1) on $L^1(\mathbb{Q}_p^d)$, that is to say, |{$x{\in}\mathbb{Q}_p^d:|M_pf(x)|$>$\lambda$}|$_H{\leq}\frac{p^d}{\lambda}||f||_{L^1(\mathbb{Q}_p^d)},\;\lambda$ > 0 for any f ${\in}L^1(\mathbb{Q}_p^d)$.

• Journal of Astronomy and Space Sciences
• /
• 제30권3호
• /
• pp.159-162
• /
• 2013

We report the detection of a quasi-sinusoidally modulated optical flux with a period of 4.6343 hour in the optical and infrared band of the Fermi source 2FGL J2339.7-0531. Comparing the multi-wavelength observations, we suggest that 2FGL J2339.7- 0531 is a ${\gamma}$-ray emitting millisecond pulsar (MSP) in a binary system with an optically visible late-type companion accreted by the pulsar, where the MSP is responsible for the ${\gamma}$-ray emission while the optical and infrared emission originate from the heated side of the companion. Based on the optical properties, the companion star is believed to be heated by the pulsar and reaches peak magnitude when the heated side faces the observer. We conclude that 2FGL J2339.7-0531 is a member of a subclass of ${\gamma}$-ray emitting pulsars -the 'black widows'- recently revealed to be evaporating their companions in the late-stage of recycling as a prominent group of these newly revealed Fermi sources.

• 한국농공학회논문집
• /
• 제46권4호
• /
• pp.25-36
• /
• 2004

This study was conducted to derive the design rainfall by the consecutive duration using the at-site frequency analysis. Using the errors, K-S tests and LH-moment ratios, Log Pearson type 3 (LP3) and Generalized Extreme Value (GEV) distributions of Gamma and Non-Gamma Family, respectively were identified as the optimal probability distributions among applied distributions. Parameters of GEV and LP3 distributions were estimated by the method of L and LH-moments and the Indirect method of moments respectively. Design rainfalls following the consecutive duration were derived by at-site frequency analysis using the observed and simulated data resulted from Monte Carlo techniques. Relative root-mean-square error (RRMSE) and relative efficiency (RE) in RRMSE for the design rainfall derived by at-site analysis in the observed and simulated data were computed and compared. It has shown that at-site frequency analysis by GEV distribution using L-moments is confirmed as more reliable than that of GEV and LP3 distributions using LH-moments and Indirect method of moments in view of relative efficiency.

• Nuclear Engineering and Technology
• /
• 제52권8호
• /
• pp.1764-1770
• /
• 2020

The present work was mainly concerned with studying the operation of RC-phase shift oscillator based on MOSFET type 2N6660 under the influence of different temperature levels ranging from room temperature (25 ℃) up-to135 ℃ and gamma-irradiation up-to 3.5 kGy. In this concern, both the static (I-V) characteristic curves of MOSFET devices and the output signal of the proposed oscillator were recorded under ascending levels of both temperature and gamma-irradiation. From which, it is clearly shown that the drain current was decreased from 0.22 A, measured at 25 ℃, down to 0.163 A, at 135 ℃. On the other hand, its value was increased up-to 0.49 A, whenever the device was exposed to gamma-rays dose of 3.5 kGy. Considering RC-phase shift oscillator, the oscillation frequency and output pk-pk voltage were decreased whenever MOSFET device exposed to gamma radiation by ratio 54.9 and 91%, respectively. While, whenever MOSFET device exposed to temperature the previously mentioned parameters were shown to be decreased by ratio 2.07 and 46.2%.

• BMB Reports
• /
• 제47권11호
• /
• pp.599-608
• /
• 2014

As the prevalence of obesity has increased explosively over the last several decades, associated metabolic disorders, including type 2 diabetes, dyslipidemia, hypertension, and cardiovascular diseases, have been also increased. Thus, new strategies for preventing and treating them are needed. The nuclear peroxisome proliferator-activated receptors (PPARs) are involved fundamentally in regulating energy homeostasis; thus, they have been considered attractive drug targets for addressing metabolic disorders. Among the PPARs, $PPAR{\gamma}$ is a master regulator of gene expression for metabolism, inflammation, and other pathways in many cell types, especially adipocytes. It is a physiological receptor of the potent anti-diabetic drugs of the thiazolidinediones (TZDs) class, including rosiglitazone (Avandia). However, TZDs have undesirable and severe side effects, such as weight gain, fluid retention, and cardiovascular dysfunction. Recently, many reports have suggested that $PPAR{\gamma}$ could be modulated by post-translational modifications (PTMs), and modulation of PTM has been considered as novel approaches for treating metabolic disorders with fewer side effects than the TZDs. In this review, we discuss how PTM of $PPAR{\gamma}$ may be regulated and issues to be considered in making novel anti-diabetic drugs that can modulate the PTM of $PPAR{\gamma}$.

• Food Science and Biotechnology
• /
• 제16권2호
• /
• pp.212-217
• /
• 2007

Fucoidan (fucan sulfate) is a fucose-containing sulfated polysaccharide from brown algae such as Fucus vesiculosus, Ecklonia kurome, and Cladosiphon okamuranus. The aim of this study was to investigate the effect of fucoidan on the expression of diabetes-related genes in mouse cell line 3T3-L1. 3T3-L1 adipocytes were cultured for 48 hr with or without fucoidan (10, 100, and 500 ppm) on a 60 mm dish. Reverse transcription polymerase chain reaction (RT-PCR) was used for measurement of peroxisome proliferators activated receptor ${\gamma}\;(PPAR{\gamma})$, CCAAT/enhancer binding protein ${\alpha}\;(C/EBP{\gamma})$, and glucose transporter 4 (GLUT4) RT-PCR analysis revealed that expression level of GLUT4, $PPAR{\gamma}$, and $C/EBP{\alpha}$ mRNAs increased with fucoidan treatment from 10 to 500 ppm in a dose-dependent manner. Fucoidan appears to enhance insulin sensitivity by increasing the expression level of diabetes-related genes in 3T3-L1 adipocytes. Therefore, fucoidan is potentially useful as a natural therapeutic material for hyperglycemia in type II diabetes patients.

• BMB Reports
• /
• 제38권3호
• /
• pp.343-349
• /
• 2005

Gamma-glutamyltransferase (GGT, EC 2.3.2.2) which hydrolyzes glutathione (GSH), is required for the maintenance of normal intracellular GSH concentration. GGT is a membrane enzyme present in leukocytes and platelets. Its activity has also been observed in human neutrophils. In this study, GGT was purified from Triton X-100 solubilized neutrophils and its kinetic parameters were determined. For kinetic analyses of transpeptidation reaction, $\gamma$-glutamyl p-nitroanilide was used as the substrate and glycylglycine as the acceptor. Apparent $K_m$ values were determined as 1.8 mM for $\gamma$-glutamyl p-nitroanilide and 16.9 mM for glycylglycine. The optimum pH of GGT activity was 8.2 and the optimum temperature was $37^{\circ}C$. It had thermal stability with 58% relative activity at $56^{\circ}C$ for 30 min incubation. L-serine, in the presence of borate, was detected as the competetive inhibitor. Bromcresol green inhibited neutrophil GGT activity as a noncompetetive inhibitor. The neutrophils seem to contain only the isoenzyme that is present in platelets. We characterized the kinetic properties and compared the type of the isoenzyme of neutrophil GGT with platelet GGT via polyacrylamide gel electrophoresis (PAGE) under a standart set of conditions.

• Molecules and Cells
• /
• 제40권1호
• /
• pp.73-81
• /
• 2017

The ${\gamma}$-secretase complex represents an evolutionarily conserved family of transmembrane aspartyl proteases that cleave numerous type-I membrane proteins, including the ${\beta}$-amyloid precursor protein (APP) and the receptor Notch. All known rare mutations in APP and the ${\gamma}$-secretase catalytic component, presenilin, which lead to increased amyloid ${\beta}$-peptide production, are responsible for early-onset familial Alzheimer's disease. ${\beta}$-amyloid protein precursor-like (APPL) is the Drosophila ortholog of human APP. Here, we created Notch- and APPL-based Drosophila reporter systems for in vivo monitoring of ${\gamma}$-secretase activity. Ectopic expression of the Notch- and APPL-based chimeric reporters in wings results in vein truncation phenotypes. Reporter-mediated vein truncation phenotypes are enhanced by the Notch gain-of-function allele and suppressed by RNAi-mediated knockdown of presenilin. Furthermore, we find that apoptosis partly contributes to the vein truncation phenotypes of the APPL-based reporter, but not to the vein truncation phenotypes of the Notch-based reporter. Taken together, these results suggest that both in vivo reporter systems provide a powerful genetic tool to identify genes that modulate ${\gamma}$-secretase activity and/or APPL metabolism.

• Nuclear Engineering and Technology
• /
• 제53권1호
• /
• pp.337-343
• /
• 2021

In this work, self-absorption correction factor related to the variation of the composition and the density of soil samples were evaluated using the p-type HPGe detector. The validated MCNP5 simulation model of this detector was used to evaluate its Full Energy Peak Efficiency (FEPE) under the variation of the composition and the density of the analysed samples. The results indicates that FEPE calculation of low gamma ray is affected by the composition and the density of soil samples. The self-absorption correction factors for different gamma-ray energies which was fitted as a function of FEPEs via density and energy and fitting parameters as polynomial function for the logarithm neper of gamma ray energy help to calculate quickly the detection efficiency of detector. Factor Analysis for the influence of the element composition in analysed samples on the FEPE indicates the FEPE distribution changes from non-metal to metal groups when the gamma ray energy increases from 92 keV to 238 keV. At energies above 238 keV, the FEPE primarily depends only on the metal elements and is significantly affected by aluminium and silicon composition in soil samples.

• 대한방사선기술학회지:방사선기술과학
• /
• 제2권1호
• /
• pp.95-99
• /
• 1979

When the ${\gamma}-ray$ of average energy 375KeV emitted by Ir-192 is exposed to each film through lead foil with various thickness, the film sensitivity will be different according to the thickness of lead foil and film type. The results on the study, different density and sensitive ratio appeared depending on exposed time and film type, but was made on the following common points. 1. The effect of film sensitivity by the front lead foil showed rapid increase up to the thickness of more or less 0.03mm, and the thicker lead foil was decreased more in the thickness of about $0.05{\sim}0.09mm$. 2. The effect of film sensitivity by the back lead foil was increased up to around of $0.03{\sim}0.08mm$ thickness, the maximum sensitivity was obtained in the thickness of more than $0.03{\sim}0.08mm$ without any change in the above effect. 3. The sensitivity of front lead foil was higher than that of back lead foil in thin lead foil with about 0.127mm thickness, but the sensitivity of back lead foil was higher than that of front lead foil when thickness became thicker.