• 디지털융복합연구
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• 제17권4호
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• pp.187-194
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• 2019

본 연구는 산업정책 및 기업전략의 개발 및 적용에 활용될 수 있는 브레인 임플란트 산업의 장기 미래 시나리오 모델개발 및 시나리오별 대응전략을 개발하는 것을 연구의 목적으로 삼았다. 뇌과학 산업은 미래 핵심 산업으로 그 가능성에 대하여서는 많은 논의가 있었지만 구체적인 산업육성정책이나 기업전략 분야는 연구가 매우 부족한 실정이다. 이는 이 분야가 아직 산업육성정책이나 기업전략을 작성하기에 필요한 정보가 축적되지 못하였기 때문이다. 이러한 한계를 극복하기 위하여 본 연구에서는 뇌과학산업의 핵심영역으로 많은 불확실성이 존재하는 브레인 임플란트 산업에 대하여 시스템 다이내믹스 모델로 미래 시나리오를 작성하고 이를 기반으로 각각의 시나리오에 적합한 전략을 제시하였다. 따라서 본 연구는 뇌과학산업 육성 정책 입안 및 개별 기업에서의 전략개발에 주요한 자료로 활용될 수 있을 것으로 기대된다. 향후 글로벌 시장 상황이 어느 시나리오로 발전하는 지를 조기에 파악할 수 있는 신호에 관한 연구의 필요성이 제기된다.

• 식품과학과 산업
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• 제55권2호
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• pp.140-153
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• 2022

The purpose of this study is to organize research trends by analyzing healing studies using emotional insects, and to suggest future research directions. As a result, only six emotional insect species were used for healing purposes, and most of the age groups of the test subjects were elementary school students and the elderly. As for the type of research, field application of the healing program was dominant at 76.5%. Effectiveness verification was mainly conducted through questionnaires before and after participating in the healing program. In some cases, stress-related salivary hormones were used as indicators or clinical tests were conducted by medical staff. Based on the results of this analysis, future strategies such as finding new emotional insect species, developing various types of healing program models, and expanding and subdividing the target subjects were suggested to promote the growth of the healing industry using emotional insects in the future.

• Korean Journal of Radiology
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• 제22권11호
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• pp.1786-1796
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• 2021

Objective: To evaluate the prognostic implications of preoperative magnetic resonance imaging (MRI) features of hepatocellular carcinoma (HCC) with a focus on those with targetoid appearance based on the Liver Imaging Reporting and Data System (LI-RADS), as well as known microvascular invasion (MVI) features. Materials and Methods: This retrospective study included 242 patients (190 male; mean age, 57.1 years) who underwent surgical resection of a single HCC (≤ 5 cm) as well as preoperative gadoxetic acid-enhanced MRI between January 2012 and March 2015. LI-RADS category was assigned, and the LR-M category was further classified into two groups according to rim arterial-phase hyperenhancement (APHE). The imaging features associated with MVI were also assessed. The overall survival (OS), recurrence-free survival (RFS), and their associated factors were evaluated. Results: Among the 242 HCCs, 190 (78.5%), 25 (10.3%), and 27 (11.2%) were classified as LR-4/5, LR-M with rim APHE, and LR-M without rim APHE, respectively. LR-M with rim APHE (vs. LR-4/5; hazard ratio [HR] for OS, 5.48 [p = 0.002]; HR for RFS, 2.09 [p = 0.042]) and tumor size (per cm increase; HR for OS, 6.04 [p = 0.009]; HR for RFS, 1.77 [p = 0.014]) but not MVI imaging features (p > 0.05) were independent factors associated with OS and RFS. Compared to the 5-year OS and RFS rates in the LR-4/5 group (93.9% and 66.8%, respectively), the LR-M with rim APHE group had significantly lower rates (68.0% and 45.8%, respectively, both p < 0.05), while the LR-M without rim APHE group did not significantly differ in the survival rates (91.3% and 80.2%, respectively, both p > 0.05). Conclusion: Further classification of LR-M according to the presence of rim APHE may help predict the postoperative prognosis of patients with a single HCC.

• IMMUNE NETWORK
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• 제20권6호
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• pp.48.1-48.11
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• 2020

Hyperprogressive disease (HPD) is a distinct pattern of progression characterized by acceleration of tumor growth after treatment with anti-PD-1/PD-L1 Abs. However, the immunological characteristics have not been fully elucidated in patients with HPD. We prospectively recruited patients with metastatic non-small cell lung cancer treated with anti-PD-1/PD-L1 Abs between April 2015 and April 2018, and collected peripheral blood before treatment and 7-days post-treatment. HPD was defined as ≥2-fold increase in both tumor growth kinetics and tumor growth rate between pre-treatment and post-treatment. Peripheral blood mononuclear cells were analyzed by multi-color flow cytometry to phenotype the immune cells. Of 115 patients, 19 (16.5%) developed HPD, 52 experienced durable clinical benefit (DCB; partial response or stable disease ≥6 months), and 44 experienced non-hyperprogressive progression (NHPD). Patients with HPD had significantly lower progression-free survival (p<0.001) and overall survival (p<0.001). When peripheral blood immune cells were examined, the pre-treatment frequency of CD39⁺ cells among CD8⁺ T cells was significantly higher in patients with HPD compared to those with NHPD, although it showed borderline significance to predict HPD. Other parameters regarding regulatory T cells or myeloid derived suppressor cells did not significantly differ among patient groups. Our findings suggest high pre-treatment frequency of CD39⁺CD8⁺ T cells might be a characteristic of HPD. Further investigations in a larger cohort are needed to confirm our results and better delineate the immune landscape of HPD.

• International journal of advanced smart convergence
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• 제1권2호
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• pp.47-51
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• 2012

In highly developed society, information and communication technologies are widely used for better medical services. These information and communication technologies should be more and more acceptable in all hospitals for exchange medical records. EMR becomes more convenient than the previously used paper charts. It will be able to record medical institutions every time and dual treatment. Each is different specifications for each medical institution to use the program or document to exchange it. The personal clinic records still does not exchange well. To solve this gap between medical alienation, this paper describes the concepts of HL7-CDA and proposes types of telemedicine system. To resolve time and space constraints, new form of treatment methods presents in future directions after described about related systems. CDA enables electronic medical records to the each medical center and gradually expanded by exchanging the patient's medical records. This paper is using XML-based CDA documents as a hierarchical for medical information exchange standards compliant HL7-CDA documents. It could be possible currently used structural variety of multimedia data. Thus It is able to send and receive HL7-CDA-based medical information and clinical information to identify the medical institutions of medical information with interchange system design and building standards, and through mutual exchange of clinical information.

• 한국의학물리학회지:의학물리
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• 제35권1호
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• pp.16-19
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• 2024

A new E_n score of the proficiency test (PT) is formulated; it is applicable when a correlation exists between the reference and participant's values. Based on the uncertainty propagation rule given in ISO/IEC Guide 98-3 (GUM:1995), the E_n score covering the correlation case is newly developed for the PT. The new E_n score will be applied in a future PT organized by the Korea Research Institute of Standards and Science (KRISS) dosimetry team. The new E_n score will enhance measurement traceability and contribute to improving the quality management system of participants in the KRISS PT by avoiding performance underestimation.

• Physical Therapy Rehabilitation Science
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• 제9권4호
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• pp.269-274
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• 2020

Objective: There are many cases of applying various taping methods to prevent muscle damage and to assist with movement. The purpose of this study was to investigate and to compare the effects of dynamic taping on joint position sense and to find out the difference in error values during various degrees of shoulder flexion. Design: Cross-sectional study. Methods: A total of 20 subjects participated in this study with a randomized cross-over design. The order of taping was adjusted by randomly proceeding with dynamic taping, sham taping, and no taping. After the taping, the proprioception of the shoulder joint was evaluated. The evaluation of proprioceptive sensation was performed by evaluating joint position sensation. The sequence was adjusted by randomly performing joint position tests at each shoulder flexion of 50, 90, and 110 degrees. All angles were repeated 3 times. Results: There was a significant difference between dynamic taping and no taping in 50 degrees of shoulder flexion. There was a significant difference between sham taping and no taping in 90 degrees of shoulder flexion (p<0.05). No significant difference was found in 110 degrees of shoulder flexion. Conclusions: In this study, it was confirmed that dynamic taping is effective in improving the joint position sense in 50 degrees of shoulder flexion. In the future, it is expected that further studies will be conducted on patients with shoulder dysfunction with decreased proprioception.

• International Journal of Knowledge Content Development & Technology
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• 제9권2호
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• pp.45-64
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• 2019

This study examined the perception and use of web 2.0 applications for academic purposes by medical students of Ambrose Alli University, Ekpoma. The objective was to investigate the medical students' perceptions of web 2.0 applications, web 2.0 tools use, extent of use, perception and purpose for using web 2.0 applications. Descriptive survey method was used for this study. The total population of this study was 3670 and the sample size was 367 representing 10% of the study. The purposive sampling technique was adopted, and the instrument used for this study was questionnaire, a total of 367 copies were administered and 321 were found useful for the study. Percentage means and standard deviation on table and chart were used to analyze the data collected using Statistical Package for the Social Sciences (SPSS) software. Findings showed that the perception of web 2.0 applications of medical students AAU was positive and few of web 2.0 applications were used for academic purposes. It was recommended in the study that medical students should be provided with the facilities in a format more familiar to them and used by most of them and institutions need to equip the learning process with the needed facilities which will be of utmost benefit even for future purposes.

• Nuclear Engineering and Technology
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• 제55권4호
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• pp.1265-1268
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• 2023

One important issue in using radiopharmaceuticals as therapeutic and imaging agents is predicting different organ absorbed dose following their injection. The present study aims at extrapolating dosimetry estimates to a female phantom from the animal data of ⁸⁹Zr radionuclide accumulation using the Sparks-Idogan relationship. The absorbed dose of ⁸⁹Zr radionuclide in different organs of the human body was calculated based on its distribution data in mice using both MIRD method and the MCNP simulation code. In this study, breasts, liver, heart wall, stomach, kidneys, lungs and spleen were considered as source and target organs. The highest and the lowest absorbed doses were respectively delivered to the liver (4.00E-02 and 3.43E-02 mGy/MBq) and the stomach (1.83E-03 and 1.66E-03 mGy/MBq). Moreover, there was a good agreement between the results obtained from both MIRD and MCNP methods. Therefore, according to the dosimetry results, [⁸⁹Zr] DFO-CR011-PET/CT seems to be a suitable for diagnostic imaging of the breast anomalies for CDX-011 targeting gpNMB in patients with TNBC in the future.

• 한국의사학회지
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• 제34권2호
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• pp.97-108
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• 2021

In this study, we examine Maeng Hwa-seop's academic activities, focusing on articles published in Uirim, JKM (Journal of Korean Medicine), and other branch journals which were affiliated with the Society of Korean Medicine. The present study charts and summarizes the papers published in the above journals. By organizing Maeng Hwa-seop's papers and making tables, we find that his research can be divided into four categories: symptoms and diseases, prescriptions, academic presentations, and translations of medical literatures. Based on this study, we hope that further researches about the academic activities of Maeng Hwa-seop can be conducted in the future.