• Journal of Community Nutrition
• /
• 제7권2호
• /
• pp.79-84
• /
• 2005

A vitamin B-6 (B-6) intake higher than the current Recommended Dietary Allowance (RDA) has been found to provide an improvement in immune system. Seven premenopausal women consumed their usual diet with the exception of foods relatively high in vitamin B-6 for a total of 27 d. After 7 d, all subjects received a multivitamin supplement containing 2mg B-6 and 4 subjects were given an additional 50mg of B-6 supplement for 20 d. Lymphocyte response to phytohemagglutinin (PHA) was measured before and after the supplementation. To determine the effect of different forms of B-6 on lymphocyte proliferation, cell culture media supplemented with pyridoxal (PL) and PLP, as well as B-6 free media, were tested. A 50mg B-6 supplement significantly increased vitamin B-6 status. There was no further enhancement on lymphocyte proliferation when subjects were taking an additional 50mg of vitamin B-6 supplement. In general, lymphocyte proliferation in media with either PLP or PL did not show any prominent difference. These [m-dings suggest that there may be no further benefits of a B-6 dose beyond twice that of the current RDA on lymphocyte proliferation. Further studies are necessary to examine the effect of the B-6 intake level on activities of enzymes involved in cellular B-6 metabolism in lymphocytes to provide substantial insight into the mechanisms underlying the role of B-6 in the lymphocyte proliferation.

• 한국IT서비스학회지
• /
• 제11권2호
• /
• pp.169-183
• /
• 2012

Since the competition of higher education is more and more critical, the improvement of educational services is importantly considered. Despite the current situations, there are few studies addressing the relationships between education service quality and its outcomes. As educational service quality plays a key role in improving student satisfaction, universities provides a high level of educational services for students and reinforce their competitiveness through student satisfaction. This research investigates the relationships among IT service quality, business education service quality, trust, student satisfaction and student loyalty. In so doing, the current study establishes a theoretical model to test the proposed relationships. The results further suggest that the indirect effect of the IT service quality and the business education service quality enhances its impact of student satisfaction, trust, student loyalty. Finally, the authors draw conclusions and further research directions.

• Biomolecules & Therapeutics
• /
• 제13권4호
• /
• pp.199-206
• /
• 2005

Cell therapy (CT) is a group of techniques to treat human disorders by transplantation of cells which have been processed and propagated independent of the living body. Blood transfusion and bone marrow transplant have been the primary examples of cell therapy. With introduction of stem cell (SC) technologies, however, CT is perceived as the next generation of biologies to treat human diseases such as cancer, neurological diseases, and heart disease. Despite potential of cell therapy, insufficient guidelines have been implemented concerning safety test and regulation of cell therapy. This review addresses the safety issues to be resolved for the cell therapy, especially SC therapy, to be successfully utilized for clinical practice. Adequate donor cell screening must preceed to ensure safety in cell therapy. In terms of SC culture, controlled, standardized practices and procedures should be established. Further molecular studies should be done on SC development and differentiation to enhance safety level in cell therapy. Finally, animal model must be further installed to evaluate toxicity, new concepts, and proliferative potential of SC including alternative feeder layer of animal cells.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제14권2호
• /
• pp.122-129
• /
• 2011

The persistence of jaundice beyond the first 2 weeks of life require further investigation and this can be determined if the conjugated bilirubin levels are greater than 1.5 mg/dL or greater than 20% of the total bilirubin level. There is a diverse differential diagnosis for the cause of neonatal cholestasis due to hepatobiliary disease including biliary atresia, which eventually leads to liver cirrhosis if uncorrected before 60~80 days of life. Long-established initial studies include abdominal ultrasonography, hepatobiliary scintigraphy and liver biopsy, but better diagnostic methods are needed. Promising new options are described including MRCP (magnetic resonance cholangiography), ERCP (endoscopic retrograde cholangiography), and PCC (percutaneous cholecysto-cholangiography). Though no single test can differentiate biliary atresia from other neonatal cholestasis with confidence, a combination of diagnostic methods is usually consistently beneficial. By excluding biliary atresia as early as possible, the risk of unnecessary explolaparotomy with intraoperative cholangiography is decreased. Further evaluation would be required for the diagnosis of neonatal cholestasis after excluding biliary atresia.

• 펄프종이기술
• /
• 제43권5호
• /
• pp.34-42
• /
• 2011

A fiber processing method, which might be an alternative for conventional refining process, was introduced. The method consists of repetitive, gentle, mechanical impacts on fibers, followed by fiber uncurling process. This method was very effective for OCC and BCTMP for increasing WRVs (water retention value) while keeping fiber lengths from shortening. For OCC and BCTMP, gentle mechanical impacts on fibers using Hobart mixer increased breaking lengths and tear strengths simultaneously at fast drainage level, and straightening fibers using kady mill increased those strength properties further. For SwBKP and HwBKP, only mechanical impacts using the Hobart mixer were effective on increasing tensile and tear strength at fast drainage, but there were no further increase by kady mill treatment. The strength increases of BCTMP by this alternative fiber processing method were exceptionally high. An extensive engineering development should be followed to actualize this fiber processing mechanism in an energy-effect way.

• 품질경영학회지
• /
• 제41권4호
• /
• pp.673-681
• /
• 2013

Purpose: The purpose of this study is to investigate the design optimization modeling of screening procedures based on the assessment of misclassification errors. Methods: Misclassification errors due to measurement variability are derived for normally distributed quality characteristics. Further, an optimization model for ensuring the level of outgoing quality is proposed and demonstrated through an illustrative example. Results: It is shown that two types of misclassification errors (i.e., false acceptance and false rejection) may be properly compromised through an analytical assessment of measurement errors and an optimization modeling. It is also discussed that a variety of optimization modeling may be enabled based on the derivation of measurement errors. Conclusion: It may be concluded that the design of screening inspection may further be facilitated by including the effect of measurement errors on the performance of screening inspection procedure.

• Journal of Microbiology and Biotechnology
• /
• 제15권4호
• /
• pp.740-744
• /
• 2005

Bifidobacterium has been previously shown to potentiate immune function, which was mediated through the stimulation of cytokine production by macrophage. This study was performed to further characterize the effective component of Bifidobacterium by measuring the level of interleukin (IL)-6 cytokine using the RAW 264.7 murine cell line as a macrophage model. RAW 264.7 cells were cultured for 24 h in the presence of whole cells (WCs), cell walls (CWs), and cell-free extracts (CFEs) from various strains of Bifidobacterium and other lactic acid bacteria at various concentrations. The most effective component was different depending on the strains and the concentrations used. When tested with each cell fraction from Bifidobacterium sp. BGN4, heat treatment of the cell fractions lowered the production of IL-6. Synergistic effect was obtained, especially when CWs and CFEs were combined. Sonicated WCs stimulated IL-6 production more than intact WCs. The in vitro approaches employed here should be useful in further characterization of the effects of Bifidobacterium on gastrointestinal and systemic immunity.

• Journal of Computing Science and Engineering
• /
• 제2권3호
• /
• pp.221-248
• /
• 2008

Data provenance is the background knowledge that enables a piece of data to be interpreted and used correctly within context. The importance of tracking provenance is widely recognized, as witnessed by significant research in various areas including e-science, homeland security, and data warehousing and business intelligence. In order to further advance the research on data provenance, however, one must first understand the research that has been conducted to date and identify specific topics that merit further investigation. In this work, we develop a framework based on semiotics theory to assist in analyzing and comparing existing provenance research at the conceptual level. We provide a detailed review of data provenance research and compare and contrast the research based on d semiotics framework. We conclude with an identification of challenges that will drive future research in this field.

• 한국전산유체공학회:학술대회논문집
• /
• 한국전산유체공학회 2008년도 춘계학술대회논문집
• /
• pp.472-473
• /
• 2008

Flow boiling in parallel microchannels has received attention as an effective heat sink mechanism for power-densities encountered in microelectronic equipment. the bubble dynamics coupled with boiling heat transfer in microchannels is still not well understood due to the technological difficulties in obtaining detailed measurements of microscale two-phase flows. In this study, complete numerical simulation is performed to further clarify the dynamics of flow boiling in microchannels. The level set method for tracking the liquid-vapor interface is modified to include the effects of phase change and contact angle. The method is further extended to treat the no-slip and contact angle conditions on the immersed solid. Also, the reverse flow observed during flow boiling in parallel microchannels has been investigated. Based on the numerical results, the effects of channel shape and inlet area restriction on the bubble growth, reverse flow and heat transfer are quantified.

• Journal of Information Technology Applications and Management
• /
• 제19권4호
• /
• pp.213-225
• /
• 2012

The identified research result can be outlined more specifically as follows: first, informativeness of SNS was giving positive impact to some degree on the user satisfaction; second, connectivity of SNS was giving very positive impact on the user satisfaction; third, accessibility was giving very positive impact on the user satisfaction; forth, usability of SNS was giving very positive impact on the user satisfaction; fifth, amusement of SNS was giving very positive impact on the user satisfaction; the satisfaction level of SNS users gave positive impact on the further intention of SNS users. It was identified, however, that interactiveness of SNS was the factor that did not give much impact on the user satisfaction. This result comes from the analysis that SNS is convenient to actively explore and get further information that users wish to find, while they are insufficient in function to provide the information other users require or exchange information among users through the SNS.