• Biomolecules & Therapeutics
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• v.24 no.6
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• pp.604-609
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• 2016

5-fluorouracil (5-FU) is a chemotherapeutic agent commonly used for treatment of solid tumors, including colorectal cancer. However, chemoresistance against 5-fluorouracil (5-FU) often limits its success for chemotherapy and, therefore, finding out appropriate adjuvant(s) that might overcome chemoresistance against 5-FU bears a significant importance. In the present study, we have found that ${\alpha}$-mangostin can sensitize 5-FU-resistant SNUC5/5-FUR colon cancer cells to apoptosis. Exposure of ${\alpha}$-mangostin induced significant DNA damages and increased the intracellular 8-hydroxyguanosine (8-OH-G) and 4-hydroxynonenal (4-HNE) levels in SNUC5 and SNUC5/5-FUR cells. Western blot analysis illustrated that ${\alpha}$-mangostin-induced apoptosis was mediated by the activation of the extrinsic and intrinsic pathways in SNUC5/5-FUR cells. In particular, we observed that Fas receptor (FasR) level was lower in SNUC5/5-FUR cells, compared with SNUC5 cells and that silencing FasR attenuated ${\alpha}$-mangostin-mediated apoptosis in SNUC5/5-FUR cells. Together, our study illustrates that ${\alpha}$-mangostin might be an efficient apoptosis sensitizer that can overcome chemoresistance against 5-FU by activating apoptosis pathway.

• Journal of Veterinary Clinics
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• v.25 no.2
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• pp.112-114
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• 2008

The fur mite is a highly contagious zoonotic mite that causes skin disorders in rabbits. In this case report, four rabbits with a fur mite infestation were treated with a single dermal application of permethrin (65%) at a dose of 0.1 ml. All the rabbits were treated successfully with permethrin without any adverse reactions at 8 weeks after treatment. This suggests that permethrin is an effective treatment for fur mite infestations in rabbits.

• Journal of the Korea Fashion and Costume Design Association
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• v.16 no.2
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• pp.177-188
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• 2014

A fur has emerged as one of fashion staples. there has been a rising interest in fur industry. Therefore, this study investigated how to estimate the amount of raw materials consumed at the production of fur clothes, and the scope of the study was limited to mink clothes. For an empirical study, in addition, Koreans' favorable mink design was chosen based on previous studies and sales of fur clothes, and its consumption was estimated. The consumption of mink clothes depends on the special feature of natural resources such as place of origin, gender and variety. Therefore the method of consumption for mink clothes is inevitably different from it of fiber clothes. Considering the procedure of mink clothe's production as collect same kind of a fur and process though pattern placement, first is outfut work for consumption. At estimation of the consumption of mink clothes, the number of minks was counted by matching the area of mink skin with that of the mink cloth patterns. Then, the usable area of the patterns was calculated after splitting them into diverse figures such as triangle, quadrangle and trapezoid. If we divide area by using the similar in shape of pattern and calculate, We can find high efficiency by reducing extra space. Specially we can expect more efficient work system when we use computers for efficient division of area.

• Proceedings of the IEEK Conference
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• 2003.07d
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• pp.1279-1282
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• 2003

Estimation of human motion states is important enabling technologies for realizing a pervasive computing environment. In this paper, an improved method fur estimating human motion state from accelerometer data is introduced. Our method fur estimating human motion state utilizes various statistics of accelerometer data, such as mean, standard variation, skewness, kurtosis, eccentricity, as features for classification, and therefore is expected to be more robust than other existing methods that rely on only a few simple statistics. A series of experiments fur testing the effectiveness of the proposed method has been performed, and its result is presented.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2005.10a
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• pp.160-161
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• 2005

• The Korean Journal of Ceramics
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• v.5 no.3
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• pp.205-210
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• 1999

The thermodynamic properties and phase diagram of the$ PbO-ZrO_2$ system have been critically assessed using the Thermo-Calc program. Excess Gibbs energies were expressed by Redlich-Kister polynomials for the solid phases, by the two-sublattice ionic liquid model for the liquid phase and by the compound energy model for the solid solution phase. All solid phases were treated as stoichimetric compounds.

• Journal of the korean society of oceanography
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• v.31 no.3
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• pp.117-122
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• 1996

Oxygen consumption by the Manila clam, Ruditapes philippinarum (Bivalvia: Veneridae) maintained in a culture tank for 7-10 weeks was measured with an automatic intermittent-flow-respirometer (AIFR). There was evidence for an endogenous tidal rhythm of 12.4 h in oxygen consumption, at irregular intervals of between about 7 and 18 hours during experiments of between 22 h 5 min and 70 h 32 min (duration) recording for fasting animals in constant darkness at constant temperatures in the absence of tidal rhythms.

• Proceedings of the Korean Society of Life Science Conference
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• 2007.10a
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• pp.69.1-69.1
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• 2007

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• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09a
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• pp.231-232
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• 2006

Aluminum Alloys with a content of 22 wt.-% $Mg_2Si$ were spray formed. This alloy features by a low density and is therefore a superior material for leightweight applications. The main problem in spray forming of this type of alloy was the occurance of high porosities. First process optimizations have been performed to decrease porosity under a certain level, so that it can be closed by an extrusion process

• Applied Microscopy
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• v.36 no.spc1
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• pp.19-24
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• 2006

The alumina-aluminum solid-liquid interfaces were directly observed at atomic scale by heating the alumina single crystal in high-voltage electron microscope (HVEM) owing to the electron beam damage processes, Atomic ordering in the first several layers of the liquid was clearly resolved adjacent to the alumina surface and its relevance to the single crystal growth was examined with the real-time observations.