• Genomics & Informatics
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• 제6권1호
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• pp.29-31
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• 2008

Single nucleotide polymorphisms (SNPs) in the promoter region of the IL-1B (interleukin-1) gene have been implicated in a variety of diseases that have an inflammatory component. However, there has been significant heterogeneity among study results, especially between Caucasian and Asian populations. Recently, it has been reported that SNPs in the IL-1B gene affect transcription, according to haplotype context, and genetic association studies may be more informative if functional SNP haplotypes of population are analyzed. Therefore, we estimated the distribution of IL-1B promoter haplotypes in 433 Koreans using the three major functional IL-1B promoter SNPs (IL-1B -1464, -511, and -31) and compared the results with those in Caucasians. The difference in IL-1B promoter haplotype frequency between Korean and Caucasian populations was statistically significant. The potentially more inflammatory haplotypes had higher frequencies in Koreans when compared with Caucasians. These Korean haplotype data will be useful for future association studies between IL-1B SNPs and disease risk.

• Journal of the Optical Society of Korea
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• 제16권2호
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• pp.95-100
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• 2012

We show that the minimum EOP (eye-opening penalty) obtained by tunable dispersion compensation is a function of a figure of merit for a nonlinear process, $I_0L_{eff}$, where $I_0$ is the optical intensity and $L_{eff}$ is the effective length of the interaction region. Using this rule, we do not need to conduct nonlinear simulations in all the cases of signal power and transmission length to obtain the signal distortion in dispersion-managed optical transmission. Instead, we need to conduct a simulation in only one case of a signal power and find the functional relation, and then we can obtain the values of the signal distortion in other cases using the discovered functional relation. This technique can reduce the number of nonlinear simulations to less than 10%.

• 센서학회지
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• 제32권2호
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• pp.100-104
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• 2023

In this study, a device was fabricated to check the possibility of a memory device by controlling the oxygen functional groups in graphene oxide formed with a 45-second exposure time. We discovered that graphene oxide can be formed using the ultraviolet (UV) light treatment method with different exposure times. Moreover, Raman spectroscopy measurement revealed that the oxygen functional groups can be moved by controlling the voltage. We further studied the change in the local graphene oxide region, which was found to be related to the modulation of the electrical properties of the device. Therefore, the fabricated graphene oxide device can be used as a wettability switching membrane and graphene-based ion transport device.

• 한국임상수의학회지
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• 제40권1호
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• pp.8-15
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• 2023

Atopic dermatitis (AD) is a common skin disease in animals and several therapeutic trials with various drugs have been conducted for more effective management of AD. However, these trials have not been able to properly address all the aspects of AD management because of the lack of good efficacy or due to significant side effects of the drugs being tested. Synbio-glucan functional spray is a functional skin spray using Synbio-glucan composed of β-glucan and probiotics. We designed a functional spray composed of Synbio-glucan (patent application number:10-1805863), distilled water, glycerin, solubilizer, and 40% alcohol. We tested the efficacy and safety of the functional spray on six dogs with AD. The trial was conducted with the consent of the caregivers. The spray was applied to the skin lesions, including the trunk, axillae, inguinal region, or periocular areas, thrice a day for 30 days. To evaluate the efficacy of this functional spray, we assessed the pruritus visual analog scale (PVAS) and the canine atopic dermatitis extent and severity index (CADESI)-4. At the end of one month, the results clinical scores after functional spray treatment showed a significant decrease in the PVAS (p = 0.03) and CADESI-4 (p = 0.03) in all the subject dogs with AD. This study thus confirmed that the Synbio-glucan functional spray is efficacious and safe for the treatment of AD in dogs.

• 한국농공학회지
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• 제44권3호
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• pp.8-18
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• 2002

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회.한국자기공명학회 2005년도 공동학술대회
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• pp.77-78
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• 2005

A specific FUS-MRI platform was designed for breast cancer treatment. phased array technologies, sideways FUS transmission, and spatio-temporal temperature control in the complete region of interest, were combined for a novel therapy approach with enhanced safety and afficacy. A phase I clinical trial will start soon.

• The Plant Pathology Journal
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• 제21권1호
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• pp.39-46
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• 2005

The promoter region flanking the 5’ CAZFP1 coding region was isolated from the genomic DNA of Capsicum annuum. To identify the upstream region of the CAZFP1 gene required for promoter activity, a series of CAZFP1 promoter deletion derivatives was created. Each deletion construct was analyzed by Agrobacterium-mediated transient transformation in tobacco leaves after infection by Pseudomonas syringae pv. tabaci, or treatment with methyl jasmonate (MeJA), ethylene, abscisic acid (ABA), salicylic acid (SA), cold and wounding. Promoter fragments of 685 bp or longer showed 7-fold or greater induction after P. s. pv. tabaci infection and MeJA treatment. The CAZFP1 full-length promoter (-999 bp) also showed 6-fold induction in response to ethylene. The transiently transformed tobacco leaves with the CAZFP1 full length promoter fused-GUS gene showed more than 5-fold induction in response to SA, ABA and cold. These results suggest that the CAZFP1 promoter contains responsive elements for pathogen, MeJA, ethylene, SA, ABA and cold.

• Archives of Reconstructive Microsurgery
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• 제11권2호
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• pp.162-166
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• 2002

The anterolateral thigh free flap was first reported by Song et al. in 1984 as a fasciocutaneous flap based on septocutaneous or musculocutaneous perforators of the lateral femoral circumflex vessel. It only becomes popular recently through confirmation of additional anatomy. For reconstruction of Achilles area defect, a thin flap is required to improve aesthetic and functional results. The anterolateral thigh free flap is relatively thin and can provide large skin area. It can be a useful option for reconstruction of Achilles area defect based on these characters. Since March 2002, we have successfully transferred 4 anterolateral thigh free flaps to reconstruct Achilles area defects and have attained good range of motion in this region. The anterolateral thigh free flap has many advantages and can be used for the reconstruction of Achilles tendon area defect.

• Animal cells and systems
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• 제2권2호
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• pp.287-295
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• 1998

The Saccharomyces cerevisiae MGMT gene encodes a O6-methylguanine DNA methyltransferase that protects cells from mutation or death by DNA alkylating agents. Using an in vitro transcription system, we analyzed its promoter region to find regulatory elements for transcription initiation. DNase I footprinting and a transcription assay showed that a functional TATA box, 5'-TGATATAGCA-3', is located in the region spanning from -25 to -34. We also found one upstream repressing sequence (URS), -333 to -213, by promoter deletion and competition analysis. Gel mobility shift assays and Southwestern blot analysis using URS region indicate specific complex formations. These results indicate that several cis-acting and trans-acting elements might be involved in the transcriptional regulation of the S. cerevisiae MGMT gene.

• 한국지역지리학회지
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• 제21권1호
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• pp.1-20
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• 2015

이 논문은 네트워크도시 이론의 정책적 함의와 분석적 유용성을 고찰하면서 그 한계를 보완하고, 이를 영남권 지역에 적용하여 지역 발전을 위한 전망을 제시하고자 한다. 네트워크도시는 상대적 자립성을 가진 중소도시들이 네트워크를 구축하여 상호보완성과 시너지를 확보함으로써 개별 도시와 권역의 발전을 동시에 추구한다는 점에서, 지구 지방화 과정에 대한 도시 및 지역의 적극적인 대응방안이 될 수 있다. 그러나 네트워크도시 이론과 이를 응용한 경험적 연구가 가지는 한계와 문제를 해소하기 위하여, 네트워크도시의 연계성을 경험적으로 고찰하기 위한 분석기법의 체계화, 연계성 지표의 확장, 네트워크도시에 내재된 규범성의 재확인, 네트워크도시를 위한 협력적 거버넌스 구축, 네트워크도시와 연계된 도시 내부 공동체의 발전 방안의 모색 등이 요구된다. 이 이론을 활용한 영남권 도시지역에 관한 예비적 분석에서 이 지역은 네트워크도시에 근접하고 있지만, 명확히 네트워크도시라고 판단하기는 어렵다. 그러나 규범적, 정책적 측면에서 영남권 도시지역이 네트워크도시를 지향하기 위하여, 권역 내 도시 및 지역들 간 교통통신 인프라의 확충, 경제적 상호연계성의 강화, 협력적 거버넌스의 구축, 권역 차원의 기능적 연계성의 국지적 착근화가 필요하다는 점이 제시된다.