• 제목/요약/키워드: functional linkage

검색결과 105건 처리시간 0.026초

Identification of quantitative trait loci for the fatty acid composition in Korean native chicken

  • Jin, Shil;Park, Hee Bok;Seo, Dongwon;Choi, Nu Ri;Manjula, Prabuddha;Cahyadi, Muhammad;Jung, Samooel;Jo, Cheorun;Lee, Jun Heon
    • Asian-Australasian Journal of Animal Sciences
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    • 제31권8호
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    • pp.1134-1140
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    • 2018
  • Objective: Fatty acid composition is one of the most important meat quality traits because it can contribute to functional, sensorial, and nutritional factors. In this study, quantitative trait locus (QTL) analyses for fatty acid composition traits were investigated in thigh and breast meat of Korean native chicken (KNC). Methods: In total, 18 fatty acid composition traits were investigated from each meat sample using 83 parents, and 595 $F_1$ chicks of 20 week old. Genotype assessment was performed using 171 informative DNA markers on 26 autosomes. The KNC linkage map was constructed by CRI-MAP software, which calculated genetic distances, with map orders between markers. The half-sib and full-sib QTL analyses were performed using GridQTL and SOLAR programs, respectively. Results: In total, 30 QTLs (12 in the thigh and 18 in the breast meat) were detected by the half-sib analysis and 7 QTLs (3 in the thigh and 4 in the breast meat) were identified by the full-sib analysis. Conclusion: With further verification of the QTL regions using additional markers and positional candidate gene studies, these results can provide valuable information for determining causative mutations affecting the fatty acid composition of KNC meat. Moreover, these findings may aid in the selection of birds with favorable fatty acid composition traits.

동기침법(動氣鍼法)을 이용한 악관절(顎關節) 장애(障碍) 환자(患者)의 임상적(臨床的) 관찰(觀察) (Clinical Observations of Temporomandibular Disorder Patients used Dong-Qi Acunpuncture Treatment)

  • 왕오호;임진강;안규범;장형석;신준식
    • Journal of Acupuncture Research
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    • 제18권5호
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    • pp.109-121
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    • 2001
  • Objective : The purpose of This study is to analyze influence of functional and clinical improvement effect on temporomandibular disorders of Dong-Qi acupuncture treatment that often be used to temporomandibular disorder patients. Methods : We investigated to focus temporomandibular disorders in Jaseng oriental medicine hospital from September 8, 2000 to March 22, 2001. We compared to before and after treatment situation using temporomandibular disease & facial ache dolor pain and malignant function disorders & activation inhibition analysis from one cured Dong-Qi acupuncture treatment of outpatients-40 examples. Results : These results appeared that Sex distinction occurrence ratio was much more female than male of 1: 7. Age distinction occupied the most ratio in 20-30 generation. Jobs was mainly ranked students and companion. In cases treated before visiting our hospital, was mainly ranked our hospital first dignosis. the distribution interval of solider was mainly followed above 3 years. the distribution interval of treatment was mainly gone within 1 month and above 3 month, frequency of treatment was examined below 5 times, into 6 to 10 times, more than 11 times, respectively. Everything showed a very valuable effect except chewing and dentalgia in decrease of ache dolor pain and linkage pain related to mal-function. There are meaningful effect in Every part on Mal-function improvement. Every contents showed a very excellent effect except activation such as motivation ingestion and recreation in influence of activation. Conclusion : The above results showed a very valuable treatment effect of temporomandibular disorders on Dong-Qi acupuncture treatment. Therefore we are considered the necessity of continuous study and observation applying to other disease as well as temporomandibular disorders.

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행정정보 데이터세트 관리 개선방안 연구: 공공데이터와의 비교를 중심으로 (A Study on the Improvement of Data Set Management in Government Information Systems: A Comparison with Public Data)

  • 서지인
    • 한국기록관리학회지
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    • 제20권4호
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    • pp.41-58
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    • 2020
  • 많은 연구에서 행정정보 데이터세트의 중요성을 언급해왔으나 지금까지 실질적인 관리는 전무했다. 이런 상황에서 2020년 국가기록원은 행정정보 데이터세트 관리를 중점 추진사업으로 선정하며 본격적인 관리 작업에 착수하였다. 국가기록원의 노력에도 불구하고 업무를 수행하여야 할 기록관은 새로운 사업에 대한 우려를 보였다. 이에 이 연구에서는 공공기관에서 이미 실시하고 있는 공공데이터 사업과의 비교를 통해 행정정보 데이터세트 관리의 문제점을 확인하고, 개선방안을 찾고자 하였다. 법률, 고시, 지침, 소관 부처에서 발행한 간행물의 내용을 중심으로 대상을 분석, 비교하였다. 분석 결과를 토대로 단위기능 책정시 정부기능분류 참조, 행정정보 데이터세트 관리기준표 재구성, 유관 시스템과의 데이터 연계를 행정정보 데이터세트 관리의 개선방안으로 제안하였다.

영어 종속접속의 유형과 기능: 극소절을 포함하여 (On the Types and Functions of English Subordination including Smallest Small Clauses)

  • 홍성심
    • 문화기술의 융합
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    • 제7권1호
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    • pp.134-139
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    • 2021
  • 접속의 개념은 인간의 언어가 가진 속성 중의 하나로, 동물의 소통방식은 접속의 구조가 없다고 알려져 있다. 접속이란 문법단위들의 '연결'(connection, linkage)로 영어의 경우 종속접속절을 전치사구(PP)의 범주로 간주하거나, 보문소구 (CP)의 범주로 분류한다. 또한, 문장의 유형과 복잡성도 접속의 방식에 의해서 결정되는데, 동등접속과 달리 종속접속은 접속되는 문법단위가 대부분 절(clause)의 형태가 된다. 전통문법이나 학교문법에서는 종속접속이 그 기능에 따라 명사성 보충절, 형용성 관계절, 부사성 수식-부가절 3가지로 나뉘어 왔으나, 본 논문은 마치 소절(small clause)이 "절"로 인정되면서, 여러 가지 기능을 하는 것과 마찬가지로 무주어 무동사 종속절 (Verbless subordinate clause. V-less SC)을 종속절의 한 유형으로 보면서, 이를 극소절(smallest small clause)로 명명하고, 이들이 종속절의 일부라는 제안을 한다. 또한, 구조와 기능을 보다 세분하여 종합적으로 분석함으로서, XP라고 특정할 수 없는 절을 포함하여 분석할 수 있는 장점이 있음을 지적한다.

An Exploration of Crops Listed in Gwanhyuji, an Agricultural Book in the Joseon Dynasty for the Promotion of the Diversity of Urban Gardens

  • Hong, In-Kyoung;Chae, Young;Lee, Sang-Mi;Jung, Young-Bin
    • 인간식물환경학회지
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    • 제22권4호
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    • pp.341-354
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    • 2019
  • Urban agriculture, which promotes communication in vulnerable classes and the formation of social networks has been gaining attention with an emphasis on healthy city, elderly-friendly city, safe city and happy city as future keywords about urban life. There is a growing interest in public awareness in many areas such as health, society, economy, and ecology. As an attempt to improve the diversity of urban gardens, this study begins with collecting suitable crops for urban gardens from "Imwongyeongjeji (林園經濟志)," an encyclopedia written by Yoo-Ku Seo, a scholar in the 18-19th century. Out of those recorded in "Gwanhyuji (灌畦志)," 128 kinds of crops with linkage of the historical achievements of the realists who gave their priority to public welfare were selected and 53 crops which had traditionality, historicality, health functionality and popularity were finally selected. The properties (cold, warm, clam) of the selected crops were evenly distributed, and there was no crop that was hot and cool. In addition, the number of crops that have a sweet taste was the highest, followed by spicy and bitter, but there was no salty vegetable, which can be attributed to the fact that 12 namuls (wild vegetables) that grow in seas were excluded in this study since they were not suitable for urban gardens. Urban gardens can be transformed from those that focus on primary production and secondary consumption activities into a new resource that offers educational and traditional values by applying humanities to urban agriculture as a content resource in the era of cultural consilience and convergence. It is expected to satisfy urban residents' intellectual and participatory needs and to enhance the diversity and utility of urban gardens by applying traditional knowledge to a new model of urban agriculture. We hope that further research will be conducted to develop new types and models of urban agriculture going forward.

군소(Aplysia kurodai)에 분포하는 글루코사미노글리칸의 추출과 기능특성 2. 글루코사미노글리칸의 구조 특성 (Extraction of Glycosaminoglycan from Sea Hare, Aplysia kurodai, and Its Functional Properties 2. Structural Properties of Purified Glycosaminoglycan)

  • 윤보영;최병대;배동원;최영준
    • 한국식품영양과학회지
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    • 제39권11호
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    • pp.1647-1653
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    • 2010
  • 군소에서 추출한 다당류로부터 DEAE-Sepharose 상에서 glycosaminoglycan(GAG)을 정제하여 기능기의 분포, 구성당의 분포, 이당류의 조성과 당 구조를 조사하였다. 정제한 GAG는 기본 형태를 구성하는 이당류 단위가 전체 구성물 중 55% 이상을 차지하고 있는 다당 복합체였다. 정제한 GAG는 1648 $cm^{-1}$에서 amide I의 특징적인 띠와 1457 $cm^{-1}$에서 C-O stretch, 탄수화물 및 아미노산의 특징, 866 $cm^{-1}$에서 단당류의 특징을 보이는 것으로 나타났다. 정제한 GAG는 fucose, N-acetylgalactosamine, N-acetylglucosamine, glucose, galactose, 미량의 mannose와 xylose로 구성되어 있는 것으로 나타났고, 이중에서 N-acetylgalactosamine, N-acetylglucosamine이 70% 이상을 차지하는 다당 복합체인 heparan sulfate인 것으로 추정되었다. 군소 GAG는 단백질핵의 threonine 잔기에 O-연결된 GlyUA(2S)-GlcNS와 GlyUA-GlcNS(6S) 구조를 가지고 있는 것으로 나타났다.

CGA 제조기법을 응용한 PVA 하이드로젤의 담체 특성 (Media Characteristics of PVA-derivative Hydrogels Using a CGA Technique)

  • 윤미해;권성현;조대철
    • 한국환경과학회지
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    • 제18권3호
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    • pp.299-308
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    • 2009
  • We manufactured PVA-derived hydrogels using a foam generation technique that has been widely used to prepare colloidal gas aphrons(CGA). These gels were differentiated to the conventional gels such as for medical or pharmaceutical applications, which have tiny pores and some crystalline structure. Rather these should be used in de-pollution devices or adhesion of cells or biomolecules. The crosslinkers used in this work were amino acid, organic acid, sugars and lipids(vitamins). The structures of the gels were observed in a scanned electron microscope. Amino acids gels showed remarkably higher swelling ratios probably because their typical functional groups help constructing a highly crosslinked network along with hydrogen bonds. Boric acid and starch would catalyze dehydration while structuring to result in much lower water content and accordingly high gel content, leading to less elastic, hard gels. Bulky materials such as ascorbic acid or starch produced, in general, large pores in the matrices and also nicotinamide, having large hydrophobic patches was likely to enlarge pore size of its gels as well since the hydrophobicity would expel water molecules, thus leading to reduced swelling. Hydrophilicity(or hydrophobicity), functional groups which are involved in the reaction or physical linkage, and bulkiness of crosslinkers were found to be more critical to gel's cross linking structure and its density than molecular weights that seemed to be closely related to pore sizes. Microscopic observation revealed that pores were more or less homogeneous and their average sizes were $20{\mu}m$ for methionine, $10-15{\mu}m$ for citric acid, $50-70{\mu}m$ for L-ascorbic acid, $30-40{\mu}m$ for nicotinamide, and $70-80{\mu}m$ for starch. Also a sensory test showed that amino acid and glucose gels were more elastic meanwhile acid and nicotinamide gels turned out to be brittle or non-elastic at their high concentrations. The elasticity of a gel was reasonably correlated with its water content or swelling ratio. In addition, the PVA gel including 20% ascorbic acid showed fair ability of cell adherence as 0.257mg/g-hydrogel and completely degraded phenanthrene(10 mM) in 240 h.

CCDC26 Gene Polymorphism and Glioblastoma Risk in the Han Chinese Population

  • Wei, Xiao-Bing;Jin, Tian-Bo;Li, Gang;Geng, Ting-Ting;Zhang, Jia-Yi;Chen, Cui-Ping;Gao, Guo-Dong;Chen, Chao;Gong, Yong-Kuan
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권8호
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    • pp.3629-3633
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    • 2014
  • Background: Glioblastoma (GBM) is an immunosuppressive tumor whose median survival time is only 12-15 months, and patients with GBM have a uniformly poor prognosis. It is known that heredity contributes to formation of glioma, but there are few genetic studies concerning GBM. Materials and Methods: We genotyped six tagging SNPs (tSNP) in Han Chinese GBM and control patients. We used Microsoft Excel and SPSS 16.0 statistical package for statistical analysis and SNP Stats to test for associations between certain tSNPs and risk of GBM in five different models. ORs and 95%CIs were calculated for unconditional logistic-regression analysis with adjustment for age and gender. The SHEsis software platform was applied for analysis of linkage disequilibrium, haplotype construction, and genetic associations at polymorphism loci. Results: We found rs891835 in CCDC26 to be associated with GBM susceptibility at a level of p=0.009. The following genotypes of rs891835 were found to be associated with GBM risk in four different models of gene action: i) genotype GT (OR=2.26; 95%CI, 1.29-3.97; p=0.019) or GG (OR=1.33; 95%CI, 0.23-7.81; p=0.019) in the codominant model; ii) genotypes GT and GG (OR=2.18; 95%CI, 1.26-3.78; p=0.0061) in the dominant model; iii) GT (OR=2.24; 95%CI, 1.28-3.92; p=0.0053) in the overdominant model; iv) the allele G of rs891835 (OR=1.85; 95%CI, 1.14-3.00; p=0.015) in the additive model. In addition, "CG" and "CGGAG" were found by haplotype analysis to be associated with increased GBM risk. In contrast, genotype GG of CCDC26 rs6470745 was associated with decreased GBM risk (OR=0.34; 95%CI, 0.12-1.01; p=0.029) in the recessive model. Conclusions: Our results, combined with those from previous studies, suggest a potential genetic contribution of CCDC26 to GBM progression among Han Chinese.

How to Increase the Supply of Rental Housing through Urban Regeneration Program in Korea

  • Huh, Pil-Won;Kim, Duk-Ki;Hong, Yo-Sep;Shim, Gyo-Eon
    • 토지주택연구
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    • 제5권3호
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    • pp.137-149
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    • 2014
  • The authors derived rental housing policy measures that are appropriate for the current conditions of Korean housing supply and demand based on the confirmation of the issues of Korean rental housing system and reviewing implications from review of cases of foreign countries and these measures can be categorized into linkage with the urban regeneration and multi-functional development, acquisition of financial resources, operational management, policy and institutional aspects. For the expansion of supply of rental housing, it is essential to link the rental housing policy with urban regeneration. To pursue regeneration of underdeveloped areas and expansion of supply of rental housing in line with urban regeneration, more development sites should be added. Further, the rental home policy must be integrated into a new paradigm that includes securing commercial viability and providing various residential conveniences through multi-functional development. In addition, diversification of developers of real estates turning away from the existing framework of policy that has been focused only on the state-led housing supply so that local governments and private sector players can take part in. Next, new options for funding the supply of rental housing must be sought. First, raising financial resources sequentially through cyclical development approach could be considered. Or, various funding schemes including utilizing Tax-increment financing (TIF) based on the local tax revenues that will be accrued after the development projects and supply of rental housing. Or there should be various schemes to raise funds including utilization of TIFs that are based on the revenues that will be realized after the development projects and supply of rental housing, or utilizing REITs where funds can be provided through private sector investments. Also, getting out from the planning practice that focused only on physical expansion of supply of rental housing, continual operational management must be performed even after the development. These activities must be supported through establishment of control tower at the national level and continuous attention must be paid even after the development by developing specialized operational management companies that are led by private sector players. Finally, in addition to the hardware support that is focused on the public rental housing only, software support such as conditional provision of housing voucher or tax exemption for low-income classes should be provided, too. In other words, a shift from policies that are supplier-centric to ones that are customer-centric must take place.

홍삼박으로부터 항산화 활성 산성다당체 분리 정제 및 구조 분석 (Separation and Purification of Antioxidant Activity Acidic Polysaccharide from Red Ginseng Marc)

  • 하유진;김슬기;유성의;유선균
    • 한국응용과학기술학회지
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    • 제34권4호
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    • pp.915-923
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    • 2017
  • 홍삼 제조 부산물인 홍삼박은 항산화 등 생리활성을 보여 줌에 따라 건강기능식품 소재로의 가능성이 높아가고 잇다. 본 연구에서는 홍삼박으로 부터 조산성다당체 추출 하고 다당체중에서 항산화능을 보여주는 산성다당체를 분리 및 정제를 하였다. 계속해서 FT-IR 및 NMR을 이용하여 분자구조적 특성을 분석하였다. 산성다당체의 추출은 10%(w/v) 홍삼박 용액을 원심분리기를 이용하여 불순물을 제거하고 ethanol, methanol, propanol, acetone 및 butanol을 이용하여 최적 용매를 선정하였고, 선정된 용매 ethanol을 이용하여 홍삼박 농도별 추출을 수행하였다. 산성다당체 추출 수율(11.95%) 및 양(11.8 mg/mL) 을 비교한 결과 홍삼박 용액 농도, 10%(w/v)를 최적 농도로 선정을 하였다. 이온교한수지를 이용하여 추출된 조산성다당체로부터 가장 높은 항산화 특성을 보여주는 산성다당체는 증류수로 용출된 다당체이다. 계속해서 구조분석 결과 C-O, C-O-O-, 및 C-H 결합들과 anomeric C-6의 피크가 나타났고 C-1과 C-6의 피크들이 동일한 강도를 나타내는 것으로 보아 ($1{\rightarrow}6$) glycosidic 결합이 존재함을 보여주어 전형적인 산성다당체의 특성 보여주었다.