• Title/Summary/Keyword: functional interaction

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Interrelationship of Runx2 and estrogen pathway in skeletal tissues

  • Jeong, Jae-Hwan;Choi, Je-Yong
    • BMB Reports
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    • v.44 no.10
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    • pp.613-618
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    • 2011
  • Two key molecules in skeletal tissues are bone formation master transcription factor Runx2 and the steroid hormone estrogen. It is well known that these two molecules play pivotal roles in bone homeostasis; however, the functional interaction between Runx2 and estrogen synthesis in skeletal tissues is largely unknown. Recent studies have indicated that there is a positive relationship between Runx2 and the estrogen biosynthesis pathway. In this review, a possible functional link between Runx2 and estrogen synthesis pathway in skeletal tissues will be discusses as well as the biological significance of this interaction.

Interactions of Membrane and PMAP-23 Studied by $^{31}P$ solid-state NMR Spectroscopy

  • Kim, Si-Won;Kim, Suhk-Mann
    • Journal of the Korean Magnetic Resonance Society
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    • v.11 no.2
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    • pp.110-114
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    • 2007
  • [ $^{31}P$ ] powder pattern spectra were measured to investigate the aspects of the interaction between the MLV (Multilamellar vesicle) and PMAP-23, a membrane of cathelicidin family and then CSAs(chemical shift anisotropy) were calculated to indentify the extent of perturbation of phospholipid mobility by the peptides. We found that acidic phospholipid interacts strongly with PMAP-23, and the analogues which modified to increase the amphipathic property showed that larger change of CSA. The analogue which introduced positive charge showed the same effects with amphipathic property.

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Intrinsic Viscosity and Unperturbed Dimension of Poly(DL-lactic acid) Solution

  • Lee, Jae-Sung;Kim, Sung-Chul;Lee, Hwan-Kwang
    • Macromolecular Research
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    • v.16 no.7
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    • pp.631-636
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    • 2008
  • The intrinsic viscosities were determined for poly(DL-lactic acid) (PDLLA) solutions in 1,2-dialkyl phthalate at temperatures ranging from 30 to $60^{\circ}C$. A series of dialkyl phthalate, in which the alkyl group was changed from methyl to propyl, was used as the solvent to control the solvent quality systematically. The intrinsic viscosity of the PDLLA solution was higher in the better quality solvent, with a higher molecular weight of PDLLA, and at lower temperatures. The unperturbed dimensions of the PDLLA molecule and polymer-solvent interaction parameter of PDLLA in dialkyl phthalate were deduced using extrapolation methods based on the temperature-dependent intrinsic viscosities. Slight shrinkage in the unperturbed chain dimension was observed, which resulted from a change in polymer conformation with temperature. It was also observed that the polymer-solvent interaction became more favorable with the dialkyl phthalate containing a shorter alkyl chain.

Mutant and Its Functional Revertant Signal Peptides of Escherichia coli Ribose Binding Protein Show the Differences in the Interaction with Lipid Bilayer

  • Oh, Doo-Byoung;Taeho Ahn;Kim, Hyoung-Man
    • Proceedings of the Korean Biophysical Society Conference
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    • 1999.06a
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    • pp.43-43
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    • 1999
  • Signal peptides of secretary proteins interact with various membranes and non-membrane components during the translocation. We investigated the interaction of signal peptides of ribose binding protein (RBP) with Escherichia coli (E.coli) signal recognition particle (SRP), SecA and lipid bilayer. Previous studies showed that the functional signal peptides inhibit the GTPase activity of E.coli SRP which consisted of F로 and 4.5S RNA.(omitted)

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Flicker-reduced memory compression for a volume-zone liquid crystal display overdrive

  • Sasaki, Hisashi;Ishikawa, Tatsuyuki;Ishikawa, Yukio;Ichikawa, Kazuhiro;Saitou, Nobuhiko
    • Journal of Information Display
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    • v.12 no.2
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    • pp.77-83
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    • 2011
  • The memory compression algorithm CCC-LCP (color-count-controlled local color palette) reduces flicker in the liquid crystal display (LCD) overdrive. Its compression ratio is 1:5.4 for 10-bit images, with a 33 dB PSNR peak signal-to-noise ratio and with five times flicker reduction compared with the block truncation coding. The authors' two-alternative forced choice subjective tests proposed two new soundness properties, the 'CMP harmlessness' and 'OD non-lost (or OD liveliness)', to clarify the functional interaction between the overdrive functionality OD and the compression functionality CMP. The tests verified that CCC-LCP is practically applicable (at a 1.2H viewing distance threshold) for 42" 37-ppi WXGA TVs.

Fluorine-Induced Local Magnetic Moment in Graphene: A hybrid DFT study

  • Kim, Hyeon-Jung;Jo, Jun-Hyeong
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.08a
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    • pp.127.1-127.1
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    • 2013
  • Recent experimental evidence that fluorinated graphene creates local magnetic moments around F adatoms has not been supported by semilocal density-functional theory (DFT) calculations where the adsorption of an F adatom induces no magnetic moment in graphene. Here, we show that such an incorrect prediction of the nonmagnetic ground state is due to the self-interaction error inherent in semilocal exchange-correlation functionals. The present hybrid DFT calculation for an F adatom on graphene predicts not only a spin-polarized ground state with a spin moment of ${\sim}1{\mu}_B$, but also a long-range spin polarization caused by the bipartite nature of the graphene lattice as well as the induced spin polarization of the graphene states. The results provide support for the experimental observations of local magnetic moments in fluorinated graphene.

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Thermal and Electrochemical Properties of Polymannuronate-polyaniline Nanocomposites

  • Basavaraja, C.;Veeranagouda, Y.;Kim, Na-Ri;Jo, Eun-Ae;Lee, Kyoung;Huh, Do-Sung
    • Bulletin of the Korean Chemical Society
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    • v.30 no.5
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    • pp.1097-1100
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    • 2009
  • New types of conducting polyaniline-polymannuronate (PANI-PM) composites were synthesized by in situ deposition techniques in an aqueous media. By dissolving different weight percentage of polymannuronate (PM) (5, 10, 15, and 25%), the oxidative polymerization of aniline was carried out using ammonium per sulfate as an oxidant. The obtained composites were studied for their thermal stability and electrochemical behavior. The thermal stability of PANI-PM composites is lower than PANI, which supports a strong interaction between PANI and PM. However, the composites show an appreciable electrochemical behavior. Based on these observation the PANI-PM composites can be explored in different fields such as electric devices, sensors, functional coatings, etc.

Analysis of Functional Autocorrelation and Development of Functional Econometric Model through Urban Interactions - Focusing on Economic Growth of Small and Medium Sized Cities - (도시 상호작용에 따른 기능적 자기상관분석 및 기능계량경제모형 개발 - 중소도시의 경제성장을 중심으로 -)

  • Kim, Dohyeong;Woo, Myungje
    • Journal of Korea Planning Association
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    • v.54 no.3
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    • pp.63-74
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    • 2019
  • Korean government has implemented policies to strengthen the competitiveness of small and medium sized cities. However, since it is often difficult to enhance the competitiveness through individual projects, many local governments in metropolitan areas are working together to pursue local growth. On the other hand, small and medium sized cities that are not included in metropolitan areas due to their spatial limitations have difficulties in implementing effective growth policies. Given this background, the purpose of this study is to identify the functional correlation based on urban interactions and develop functional econometric model for the economic growth of small and medium sized cities. This study uses spatial econometrics models and functional weight matrix to identify the effects of functional networks on small and medium sized cities. The results show the effect of functional networks on the growth of small and medium sized cities and provide policy implications for regional spatial planning that addresses effective management of small and medium sized cities.

Functional Regulation of Dopamine D3 Receptor through Interaction with PICK1

  • Zheng, Mei;Zhang, Xiaohan;Min, Chengchun;Choi, Bo-Gil;Oh, In-Joon;Kim, Kyeong-Man
    • Biomolecules & Therapeutics
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    • v.24 no.5
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    • pp.475-481
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    • 2016
  • PICK1, a PDZ domain-containing protein, is known to increase the reuptake activities of dopamine transporters by increasing their expressions on the cell surface. Here, we report a direct and functional interaction between PICK1 and dopamine $D_3$ receptors ($D_3R$), which act as autoreceptors to negatively regulate dopaminergic neurons. PICK1 colocalized with both dopamine $D_2$ receptor ($D_2R$) and $D_3R$ in clusters but exerted different functional influences on them. The cell surface expression, agonist affinity, endocytosis, and signaling of $D_2R$ were unaffected by the coexpression of PICK1. On the other hand, the surface expression and tolerance of $D_3R$ were inhibited by the coexpression of PICK1. These findings show that PICK1 exerts multiple effects on $D_3R$ functions.

Study of the Adsorbent-Adsorbate Interactions from Cd(II) and Pb(II) Adsorption on Activated Carbon and Activated Carbon Fiber

  • Kim, Dae Ho;Kim, Doo Won;Kim, Bo-Hye;Yang, Kap Seung;Lim, Yong-Kyun;Park, Eun Nam
    • Journal of the Korean Chemical Society
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    • v.57 no.1
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    • pp.104-108
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    • 2013
  • The adsorption characteristics of Cd(II) and Pb(II) in aqueous solution using granular activated carbon (GAC), activated carbon fiber (ACF), modified ACF (NaACF), and a mixture of GAC and NaACF (GAC/NaACF) have been studied. The surface properties, such as morphology, surface functional groups, and composition of various adsorbents were determined using X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) measurements. The specific surface area, total pore volume, and pore size distribution were investigated using nitrogen adsorption, Brunauer-Emmett-Teller (BET), and Barrett-Joyner-Halenda (BJH) methods. In this study, NaACF showed a high adsorption capacity and rate for heavy metal ions due to the improvement of its ion-exchange capabilities by additional oxygen functional groups. Moreover, the GAC and NaACF mixture was used as an adsorbent to determine the adsorbent-adsorbate interaction in the presence of two competitive adsorbents.