• Journal of Chest Surgery
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• v.17 no.2
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• pp.212-222
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• 1984

A total of and consecutive 291 patients underwent isolated mitral valve replacement using the Ionescu-Shiley bovine pericardial xenograft valve during the 5-year period between October 1978 and June 1983. Thirty-two patients were the children under 15 years of age. There were 15 deaths within 30 days after surgery [operative mortality, 5.2%]. All early survivors except 6 children were placed on the long-term oral anticoagulation longer than postoperative 3 months. A total follow-up period extended for 398.2 patient-years, and 12 patients died [late mortality, 4.1%, or 3.0%/patient- year]. Ten patients experienced the thromboembolic complication [2.51%/patient-year], occurring in 8 patients within the first 3 postoperative months, and 4 died. Three patients had the late prosthetic valve endocarditis [0.75%/patient-year] and 2 died. The incidence of overall valve failure according to the criteria was 3.01%/patient-year, or 12 patients, and 2 had replacement of the failed bioprostheses [primary tissue failure, 0.5%/patient-year]. The long-term survival rate was 87.8%\ulcorner2.6% at 5 years postoperatively, and 84% of the late survivors were in NYHA Class I at the end of the follow- up. The probability remaining free from thromboembolism and overall valve failure was 89.8%\ulcorner6.3% and 81.2%\ulcorner.8% at 5 years respectively. These clinical results confirm the safety of mitral valve replacement. The only remaining clinical problem is the structural and functional durability of the bovine pericardial xenograft valve, and its use in young patients may be stopped in preference to the mechanical prosthetic valves.

• The Korean Journal of Physiology and Pharmacology
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• v.12 no.4
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• pp.149-153
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• 2008

Endothelin-1 (ET-1) is unequivocally elevated in the kidney with ischemic acute renal failure (ARF), whereas ET receptors ($ET_AR$ and $ET_BR$) are variably expressed. Although renal functional and structural changes are similar between ischemic and nephrotoxic ARF, there are few reports on the alteration in the ET system in nephrotoxic ARF. This study was, therefore, undertaken to investigate changes in renal expression of ET-l and its receptors in nephrotoxic ARF induced by cisplatin. Mice were intraperitoneally injected with 16 mg of cisplatin/kg at a single dose, and the expression of mRNA and protein was then quantified by real-time RT-PCR and Western blot, respectively. Immunohistochemistry was conducted for localization. Three days after treatment, ET-1 transcript in cisplatin-treated mice was thirteen times higher than that in controls, whereas ET-1 peptide was increased by 1.5-fold. Cisplatin caused a 2-fold increase in the levels of ETAR mRNA and protein. Most of the increased immunoreactive ET-1 and ETAR were localized in damaged tubules. Neither the expression of ETBR mRNA nor the abundance and immunoreactive level of ETBR protein were changed. The findings suggest that the individual components of the renal ET system are differentially regulated in cisplatin-induced nephrotoxic ARF.

• Herbal Formula Science
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• v.24 no.3
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• pp.233-242
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• 2016

Objective : Chronic renal failure(CRF) is defined as a permanent reduction in glomerular filtration rate(GFR), resulting in Structural and functional abnormalities. The purpose of this thesis is to report the improvement of a CRF stage4 on stroke patient through integrative medicine therapy.Methods : We treated the patient with herbal medication(Sibjeondaebo-tang gagambang), acupuncture and moxibustion as well as Western medication. We measured the Creatinine, BUN, eGFR in the serum and observed clinical symptoms During 4monthsResult : After treatment, the level of BUN and Creatinine was decreased and eGFR was increased. And the symptoms of CRF(edema, anorexia, general weakness) were improved.Conclusion : This study suggests that Integrative Medicine Therapy is effective in the treatment of CRF symptoms. In the future, for the effective management of CRF, It is considered necessary to build a systematic integrative medicine therapy.

• International Journal of Heart Failure
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• v.6 no.2
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• pp.70-75
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• 2024

With advancements in both pharmacologic and non-pharmacologic treatments, significant changes have occurred in heart failure (HF) management. The previous Korean HF registries, namely the Korea Heart Failure Registry (KorHF-registry) and Korean Acute Heart Failure Registry (KorAHF-registry), no longer accurately reflect contemporary acute heart failure (AHF) patients. Our objective is to assess contemporary AHF patients through a nationwide registry encompassing various aspects, such as clinical characteristics, management approaches, hospital course, and long-term outcomes of individuals hospitalized for AHF in Korea. This prospective observational multicenter cohort study (KorHF III) is organized by the Korean Society of Heart Failure. We aim to prospectively enroll 7,000 or more patients hospitalized for AHF at 47 tertiary hospitals in Korea starting from March 2018. Eligible patients exhibit signs and symptoms of HF and demonstrate either lung congestion or objective evidence of structural or functional cardiac abnormalities in echocardiography, or isolated right-sided HF. Patients will be followed up for up to 5 years after enrollment in the registry to evaluate long-term clinical outcomes. KorHF III represents the nationwide AHF registry that will elucidate the clinical characteristics, management strategies, and outcomes of contemporary AHF patients in Korea.

• Proceedings of the Korean Geotechical Society Conference
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• 1988.06c
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• pp.3-67
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• 1988

Model studies on the response of homgeneous earth embankment dams subjected to strike-slip fault movement have been penomed via centrifuge and finite element analysis. The centrifuge model tests have shown that crack development in earth embankment experiences two major patters: shear failure deep inside the embankment and tension failure near the surface. The shear rupture zone develops from the base level and propagates upward continuously in the transverse direction but allows no open leakage chnnel. The open tensile cracks develop near the surface of the embankment, but they disappear deep in the embankment. The functional relationship has been developed based on the results of the centrifuge model tests incorporating tile variables of amount of fault movement, embankment geometry, and crack propagation extent in earth des. This set of information can be used as a guide line to evaluate a "transient" safety of the duaged embankment subjected to strike-slip fault movement. The finite element analysis has supplemented the additional expluations on crack development behavior identified from the results of the centrifuge model tests. The bounding surface time-independent plasticity soil model was employed in the numerical analysis. Due to the assumption of continuum in the current version of the 3-D FEM code, the prediction of the soil structure response beyond the failure condition was not quantitatively accurate. However, the fundamental mechanism of crack development was qualitatively evaluated based on the stress analysis for the deformed soil elements of the damaged earth embankment. The tensile failure zone is identified when the minor principal stress of the deformed soil elements less than zero. The shear failure zone is identified when the stress state of the deformed soil elements is at the point where the critical state line intersects the bounding surface.g surface.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.12
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• pp.110-117
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• 2018

Recently, as weapon systems have become more complex and multi-functional, the difficulty of the operation and maintenance of weapon systems in the military have become increasingly difficult. On the other hand, the service period of operations and maintenance workers who perform operations and maintenance has been shortened, and the skill of system operation and maintenance has been lowered. This complexity and multi-functionality of equipment cause malfunctions and errors of users and maintenance personnel, and degradation of the reliability affects availability and combat readiness. In addition, life cycle costs have been gradually increasing. Therefore, I would like to suggest an improvement plan of the design of weapon systems and ILS (Integrated Logistics Support) in order to examine the implications of failure in the military. The weapon system is operated in the ROK Navy. Data from 730 cases of failure of weapon systems was collected, and analyzed. The results of the analysis are classified into failures that can be prevented in advance and failures that cannot be prevented. This shows the portion of preventable failures in weapon systems and proposes measures to minimize failures.

• Journal of the Earthquake Engineering Society of Korea
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• v.25 no.6
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• pp.261-266
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• 2021

Nuclear power plants in Korea were designed and evaluated based on the NRC's Regulatory Guide 1.60, a design response spectrum for nuclear power plants. However, it can be seen that the seismic motion characteristics are different when analyzing the Gyeongju earthquake and the Pohang earthquake that has recently occurred in Korea. Compared to the design response spectrum, seismic motion characteristics in Korea have a larger spectral acceleration in the high-frequency region. Therefore, in the case of equipment with a high natural frequency installed in a nuclear power plant, seismic performance may be reduced by reflecting the characteristics of domestic seismic motions. The failure modes of the equipment are typically structural failure and functional failure, with an anchorage failure being a representative type of structural failure. In this study, comparative analyses were performed to decide whether to consider the inelastic behavior of the anchorage or not. As a result, it was confirmed that the seismic performance of the anchorages could be increased by considering the inelastic behavior of an anchorage.

• Clinics in Shoulder and Elbow
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• v.1 no.1
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• pp.72-77
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• 1998

We treated 5 elbows with post-traumatic flexion contractures (mean contracture: 51 degrees) by arthroscopic anterior capsular release and post-operative alternative flexion and extension splint. Each elbow had been resistant to at least six months of conservative therapy. An incongruent ulno-humeral articulation was considered to be a contraindication to this procedure. All patients complained of the residual deformity and some functional deficit. All patients, after failure of non-operative therapy, desired a operative treatment. At follow-up(mean 21.8 months), there was a mean post-operative contracture of 19 degrees, which is within a functional range of motion. So we conclude that arthroscopic capsular release in selected patients is reasonable alternative to open release.

• Journal of Chest Surgery
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• v.23 no.1
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• pp.41-48
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• 1990

Thirteen patients underwent repair of atrioventricular septal defect [AVSD] from January 1980 to July 1989 at Kyungpook National University Hospital. Two patients had complete AVSD [Rastelli type A] and eleven patients had partial AVSD [ostium primum atrial septal defect and cleft of anterior mitral leaflet]. In all the patients of partial AVSD, atrial septal defect was closed with Dacron patch and the mitral cleft was approximated with interrupted simple sutures. In one patient of complete AVSD, one patch technique was used to close the atrial and ventricular septal defect, and in the other patient of complete AVSD, two patch technique was used. In six patients, there were associated anomalies; four had isolated ostium secundum ASD, two had patent foramen ovale. Postoperative complete A-V block was noted in a patient of partial AVSD, but it was returned to 1st degree A-V block 30 months later and in another case of partial AVSD, severe congestive heart failure [NYHA functional class IV] due to residual mitral insufficiency was developed postoperatively, but this patient was recovered to the state of functional class I after receiving mitral valve replacement. There was one hospital death [8 %] resulting from low cardiac output.

• Journal of Chest Surgery
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• v.28 no.9
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• pp.817-821
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• 1995

The CarboMedics Medical valve has become our mechanical valvular prosthesis of choice because of favorable hemodynamic results that associated with marked clinical improvement and low incidence of thromboembolism after it,s uses. The data for this study was collected from August 1988 to July 1993,five years period. There were total of 57 patients[female 40,male 17 in this series with 4 isolated aortic valve,26 isolated mitral valve,11 double valve and a triple valve replacement. The mean follow up time was 32 months. Postoperatively,58% of cases were in New York Heart Association[NYHA functional class I,and mild and moderate symptoms[NYHA class II were present in 36% and there were very few patients remaining in higher functional classes. In postoperative echocardiographic study, showed marked improved cardiac function. The overall early mortality was 3.5% and the late mortality was one case after triple valve replacement due to sudden death. The causes of early death were attributed to early prosthetic valve endocarditis and heart failure.