• Nutrition Research and Practice
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• 제11권5호
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• pp.365-372
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• 2017

BACKGROUND/OBJECTIVES: Owing to health concerns related to the consumption of traditional snacks high in sugars and fats, much effort has been made to develop functional snacks with low calorie content. In this study, a new recipe for Korean rice cookie, dasik, was developed and its antioxidative, lipid-lowering, and anti-inflammatory effects and related mechanisms were elucidated. The effects were compared with those of traditional rice cake dasik (RCD), the lipid-lowering effect of which is greater than that of traditional western-style cookies. MATERIALS/METHODS: Ginseng-added brown rice dasik (GBRD) was prepared with brown rice flour, fructooligosaccharide, red ginseng extract, and propolis. Mice were grouped (n = 7 per group) into those fed a normal AIN-76 diet, a high-fat diet (HFD), and HFD supplemented with RCD or GBRD. Dasik in the HFD accounted for 7% of the total calories. The lipid, reactive oxygen species, and peroxynitrite levels, and degree of lipid peroxidation in the plasma or liver were determined. The expression levels of proteins involved in lipid metabolism and inflammation, and those of antioxidant enzymes were determined by western blot analysis. RESULTS: The plasma and hepatic total cholesterol concentrations in the GBRD group were significantly decreased via downregulation of sterol regulatory element-binding protein-2 and 3-hydroxy-3-methylglutaryl-CoA reductase (P < 0.05). The hepatic peroxynitrite level was significantly lower, whereas glutathione was higher, in the GBRD group than in the RCD group. Among the antioxidant enzymes, catalase (CAT) and glutathione peroxidase (GPx) were significantly upregulated in the GBRD group (P < 0.05). In addition, nuclear factor-kappaB (NF-${\kappa}B$) expression in the GBRD group was significantly lower than that in the RCD group. CONCLUSIONS: GBRD decreases the plasma and hepatic cholesterol levels by downregulating cholesterol synthesis. This new dasik recipe also improves the antioxidative and anti-inflammatory status in HFD-fed mice via CAT and GPx upregulation and NF-${\kappa}B$ downregulation. These effects were significantly higher than those of RCD.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제41권
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• pp.33.1-33.7
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• 2019

Background: The concept of the ideal morphology for the alveolar bone form is an important element to reconstruct or restore the in maximizing esthetic profile and functional alveolar bone restoration. The purpose of this preliminary study is to evaluate the normal alveolar bone structure to provide the standard reference and guide template for use in diagnosing for implant placement, determining the correct amount of bone augmentation in actual clinical practice and producing prostheses based on three-dimensional imaging assessment of alveolar bone. Methods: This study was included 11 men and 11 women (average age, 22.6 and 24.5 years, respectively) selected from among 127 patients. The horizontal widths of alveolar bone of maxilla and mandible were measured at the crestal, mid-root, and root apex level on MDCT (multi-detector computed tomography) images reconstructed by medical imaging software. In addition, tooth dimensions of the central incisors, canines, second premolars, and first molars of maxilla and mandible, including the horizontal width of the interdental alveolar bone crest, were also measured and statistically analyzed. Results: The horizontal alveolar bone width of the palatal side of maxilla showed a distinct increment from the alveolar bone crest to the apical region in both anterior and posterior areas. The average widths of the maxillary alveolar ridge were as follows: central incisor, 7.43 mm; canine, 8.91 mm; second premolar, 9.57 mm; and first molar, 12.38 mm. The average widths of the mandibular alveolar ridge were as follows: central incisor, 6.21 mm; canine, 8.55 mm; second premolar, 8.45 mm; and first molar, 10.02 mm. In the buccal side, the alveolar bone width was not increased from the crest to the apical region. The horizontal alveolar bone width of an apical and mandibular border region was thinner than at the mid-root level. Conclusions: The results of the preliminary study are useful as a clinical guideline when determining dental implant diameter and position. And also, these measurements can also be useful during the production of prefabricated membranes and customized alveolar bone scaffolds.

• 복식
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• 제36권
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• pp.239-262
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• 1998

The pursuit of freedom by the individual--desire to be liberated from all forms of restrictions-- is one of the defining character-istic of the modern society. As costume is, in part, a product of the spirit of the times, it was only natural that this desire for freedom would find its expression in modern costume as well. Among various forms of restrictions, differentiaton by sex has placed one of the most significant binding influences on individual behavior. From early times, the dichotomous division by sex was incorporated into the disign of costume, and the traditional differestriction of costume by sex imposed a significant restriction on the background,“the modern androhynous look”was born as a by-product of the sexual liberation movement in the second half of the 20th century, based on the concept of the individual as a complete human being rather than as a member exclusively of either the male or the female sex. This paper seeks to examine the androgynous look within a coherent theoretical frame-work, and explore new design possibilities by analyzing and understanding the visual characteristics of the androgynous look. In addition, this paper seeks to define the functional aspects of the androgynous look based on the premise that costume is an embodiment of the spirit of the times. As for research methodology, both theoretical and historical methods are employed. Through a theoretical examination of historical documents, the meaning of the androgynous look is explored from various angles, and order to examine its place in modern fashion, an-drogynous styles are categorized and system atically analyzed. The main findings of the paper can be summarized as follows : 1. Androgyny is a compound word consisting of“andro-”(meaning man) and“gyn-”(meaning woman). In modern times, this word has been associated with the socio-cultural aspect of gender rather than the physical or physiological aspect with the pshchological characteristics of the male and female sexes. Androgynous styles also appear in fashion and general arts such as drama, film, dance, and music. In fashion, the androgynous look, represented by the visual superimposition of “masculine”and “faminine”elements, has emerged as a major element of the 20th-century costume, and has gained broad acceptance among those free spirits wishing to be liberated from the conventional conceptions of male clothing, and the unisex look. 3. The androgynous look in modern fashion reflects the spirit of the 20th century society and culture, and performs various functions as follows : expression of fun, change in gender roles, expression of the inner consciousness, and pursuit of the ideal human type.

• 동의신경정신과학회지
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• 제23권1호
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• pp.1-15
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• 2012

Objectives : The objective of this study is the Basic research for mind and body cure protocol construction through the Sim(心) study at Buddhism Medicine, Constitutional Medicine, and Oriental Medicine. Methods : 1. The Sim(心) in Buddhism is a target of spiritual culture and subjective awareness of An ascetic person in interior psychology. In this research, the Sim(心) has been modified within a concept of Early Buddhism and You-sic in order to have medical logicality. 2. Since the study deep into Sim(心) within Confucianism has various aspects, each Confucian's theory argument or era. We limited the significance of the Sim(心) to be associated with the category of the Sim(心) in Sasang Constitutional Medicine which is a product of practical Confucianism. 3. The criteria of debate for the Sim(心) is based on the "Hwang-je-nae-gyoung", because "Hwang-je-nae-gyoung" is founded to definite the term regarding spirit or mind in Oriental medicine Results : 1. "Hwang-je-nae-gyoung" which came from thought of You-Sic, thought of Taoism, and Early Buddhism becomes the theoretical basis for the Sim(心) in Buddhism Medicine, Sasang Constitutional Medicine, and Oriental Medicine. 2. The Sim(心) in the mind psychology of Buddhism Medicine, Sasang Constitutional Medicine, and Oriental Medicine has active aspects. but the visual thing // There are visual aspects being contrasted with 'Sim(心)' of mind psychology and aspects of activity in Buddhism medicine, Sasang constitutional Medicine and Oriental Medicine; which are 'Hrd', 'Hrdaya', 'four-large' 'five base', 'chin, chest, navel and abdomen', 'head, shoulder, waist and buttocks' consisting 'the body', and the heart and 'four interorgans' from the study of symbolical interorgans). In Buddhism Medicine, Sim(心)'s Epistemology is the most extensively understood fact about 'Sim(心)', and for Sasang Constitutional Medicine and Oriental Medicine. 'Sim(心)' is limited as an 'Element' that comprises the body. 3. The Functional area of the Sim(心) in the Buddhism Medicine, Sasang Constitutional Medicine, Oriental Medicine is composed with 'consciousness(意識)' 'manas-vij_na(末那識)', '_aya-vij_na(阿賴耶識)', 'mind greed(心欲)', 'Li(理)' and 'Sin(神)', about the interpretive area of 'Sim(心)', 'Sin(神)' of Oriental medicine is the most comprehensive concept, and on the side of the depth of 'thinking' and 'consciousness', '_aya-vij_na(阿賴耶識)' from Buddhism Medicine in the key point. 4. The Sim(心) in the Buddhism Medicine, Sasang Constitutional Medicine, has the positive and negative aspects, such as the 'Dukkha(煩惱)' and A merciful heart or Human Sim(心) and Taoism Sim(心).

• 건축역사연구
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• 제10권4호
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• pp.43-55
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• 2001

Living spaces are the results of social environment and also the reflection of the viewpoints by their residents toward human culture and society. Therefore, in studying living spaces, the true essence of the spaces could be easily distorted when cultural and symbolic motives and values are disregarded and only their apparent characteristics are looked into. Hence, it's necessary to simultaneously understand both physical dwelling spaces from architecture's view points and social ideas, simultaneously, of people who form and interact with the spaces. Hence, this paper tries to study housing religion which is one of shamanistic religions which, in turn, have been the fundamental element of ancient religions and came into existence on the basis of dwelling spaces. This study presumes that house religion may have been permeated with its creators' ideas about living and those ideas could be one of those factors which plays a role in organizing of dwelling spaces. As such, with these prior analyses, this thesis attempts to understand the meaning of various dwelling spaces via the characteristics and functionalities of various house spirits which are mentioned in a local house religion and also will find out spatial harmony of Korean traditional living spaces by way of corelations among living spaces, people, and personalized house spirits. Almost all traditional Korean houses have assigned a house spirit to their individual dwelling space. This means a traditional house was considered as a scared space in a secular world called human society and the space was actually intended to protect sacredness of dwelling places from earthliness outside. So when the hierarchy of house spirits in housing religion is projected to a Korean traditional house, it can be shown that a dwelling house as a building was personified to a respectable human status. In other words, it can be concluded that each space was synonymous with a dwelling place for each house spirit and was considered a sacred godly place. In a nutshell, not only each space in a Korean traditional house was a physical and functional space, but also it formed a scared spatial place along with the concept of house spirits intending to ward off disasters and enjoy a comfortable life through those religious symbols and meanings. Housing shamanistic religion which has long been existing with residents and their lives is seeped with the viewpoints of the residents toward life, and hence understanding the meanings and organization of Korean traditional housing can reveal commonly practiced principles of spatial organization of the traditional houses. Therefore an analysis of Korean traditional housing on the basis of humanistic social ideas will help learn Korea's traditional houses which need to be understood in various methods.

• 대한전자공학회논문지SD
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• 제37권6호
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• pp.85-96
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• 2000

Fully Differential 연산 증폭기 회로는 SCF(Switched Capacitor Filter), D/A 컴버터, A/D 컨버터, 통신 회로 등의 VLSI 설계시 외부 부하 구동에 필수적이다. 기존의 CMOS 연산 증폭기 회로는 CMOS 기술에 따른 여러 가지 단점을 갖는데 우선 큰 부하 용량에 대한 구동 능력이 양호하지 못하고, 집적도의 증가에 따른 전원 전압의 감소로 인해 입출력 전압의 동작 특성이 저하되어 전체 회로의 동특성 법위가 감소된다. 이러한 단잠들을 개선하기 위하여 출력부의 출력 스윙을 늘릴 수 있는 차동 출력 구조를 사용한 회로가 Fully Differential 연산 증폭기 회로이며, 단일 출력 구조의 연산 증폭기 보다 스윙 폭이 향상된다. Fully Differential 연산 증폭기의 구성에서 전류 미러가 그 성능을 결정하며, 따라서 큰 출력 스윙과 안정된 회로 동작을 위해서는 출력 저항이 크고, 기준 전류와의 정합이 잘 되는 전류 미러의 설계가 중요하다. 본 논문에서는 큰 출력 저항과 기준 전류와의 정합 특성이 우수한 새로운 전류 미러를 제시하였다. 출력 스윙을 키우고 전력 소모를 줄이기 위해 새로운 전류 미러를 사용하여 2단 증폭 형태의 Fully Differential 연산 증폭기를 설계하였으며, 설계한 증폭기는 레이아웃으로 구현하여 시뮬레이션 프로그램(SPICE3f)을 통하여 성능을 검증하였다.

• 벤처창업연구
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• 제15권3호
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• pp.103-119
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• 2020

본 연구는 소기업 CEO를 대상으로 기업의 성과에 영향을 미치는 창업기업가의 내적역량인 역경지수, 기업가지향성, 고객지향성간의 관계를 분석함으로서 이론적, 실무적 시사점을 도출하고자 하였다. 기존의 국내 선행연구들처럼 내적역량을 기업성과에 대한 단일 차원의 함수관계로 분석하는데서 벗어나서, 창업기업가의 내적역량들 사이의 관계를 설명하려고 하였다. 역경지수를 독립변수, 기업가지향성을 매개변수, 고객지향성을 종속변수로 설정하여 실증분석을 하였다. 분석결과는 첫째, 역경지수의 하위요소인 통제력과 주인의식은 기업가지향성과 고객지향성에 정(+)의 영향을 미치는 것으로 나타났다. 둘째, 기업가지향성은 고객지향성에 정(+)의 영향을 미치는 것으로 나타났다. 셋째, 역경지수의 주인의식만이 기업가지향성의 매개를 통해 고객지향성에 정(+)의 영향을 미치는 것으로 나타났다. 즉, 창업가의 주인의식은 기업가지향성을 통해 고객지향성에 영향을 미치는 것으로 밝혀졌다. 한편, 역경지수의 하위요소인 지속성은 기업가지향성과 고객지향성에 유의한 영향을 미치지 않는 것으로 나타났다. 이는 급변하는 뉴노멀 시대에서 창업가의 지속성은 더 이상 기업가지향성과 고객지향성에 큰 영향을 미치지 못하는 것을 의미한다. 본 연구는 창업기업가의 역량 중에서 우선 개발해야하는 역량이 무엇이고 함께 개발되어야하는 성향이 무엇인지에 대한 시사점을 준다. 나아가 정책적으로 창업지원 프로그램 설계 및 투자자의 투자기준의 가이드라인 설계 시 도움이 될 수 있을 것이다.

• 한국식품영양과학회지
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• 제34권9호
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• pp.1427-1433
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• 2005

본 연구에서는 옥수수 전분의 첨가량을 0, 10, 20, 30, $40\%$로 달리 하였을 때의 반죽의 특성과 스폰지 케이크의 물리적 및 관능적 특성을 조사하여 스폰지 케이크 제조시 옥수수전분의 첨가량에 따른 영향을 알아보고자 하였고, 그 결과는 다음과 같다. 옥수수 전분 첨가량을 달리 하여 첨가한 스폰지 케이크 반죽의 비중은 전분 첨가량이 증가할수록 감소하였고, 반죽의 점도는 전분 첨가량이 증가할수록 점도가 증가하였다. 스폰지 케 이크의 부피는 전분을 $30\%$ 첨가할 때까지는 부피가 증가하다. 그 이상 첨가할 경우 부피가 오히려 감소하는 것을 알 수 있었다. 색도를 측정한 결과 L값은 옥수수 전분의 첨가량이 증가함에 따라 높은 값을 보였고, 전분 첨가량이 증가할수록 점점 황금 갈색을 나타내었다. $30\%$ 처리구가 저장기간 동안 색의 변화가 적음을 알 수 있었다. 텍스쳐 실험 결과는 경도와 씹힘성은 옥수수 전분 첨가량이 증가할수록 낮은 값을 보였고, 저장기간이 증가함에 따라 모든 처리구의 경도는 증가하였다. 저장 기간동안 전분을 $30\%$ 첨가한 처리구의 경도 증가율이 다른 케이크에 비하여 가장 낮았다. 부착성의 경우 옥수수 전분의 첨가량이 증가할수록 높았고, 저장기간이 길어질수록 증가하였다. $30\%$ 처리구의 경우 부착성이 완만하게 증가하였다. 응집성 은 옥수수 전분첨가량이 증가할수록 감소하였고, 저장 기간이 길어질수록 다소 감소하였다. $20\%$와 $30\%$ 처리구는 완만하게 감소하여 저장 3일에도 크게 변화가 없는 것을 알 수 있었다. 관능검사결과 모든 항목에서 전분을 첨가하지 않은 $0\%$ 처리구보다 전분을 첨가한 $10\%,\;20\%$와 $30\%$ 처리구의 점수가 높았다. 반면 $40\%$ 처리구는 저장기간 동안 가장 낮은 점수를 받아 전분을 많이 첨가한 케이크는 오히려 좋아하지 않음을 알 수 있었다. 저장기간 전반에 걸쳐 $20\%$와 $30\%$의 처리구의 점수가 높아 스폰지 케이크에 옥수수 전분은 $20{\~}30\%$ 정도 첨가한 것을 가장 좋아하였다. 이상의 결과로 볼 때 스폰지 케이크를 만들 때 물리적 특성에서는 옥수수 전분을 $30\%$ 첨가할 경우 부피를 증가시키고 저장하는 동안 색과 텍스쳐를 잘 유지하여 좋은 상태의 케이크로 보관할 수 있을 것으로 보이며, 관능검사 결과에서도 전분을 $20{\~}30\%$ 첨가한 것을 선호하는 것으로 보아 스폰지 케이크 제조 시 옥수수 전분을 $30\%$ 정도 첨가할 경우 바람직한 결과를 줄 것으로 기대된다.

• Biomolecules & Therapeutics
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• 제20권1호
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• pp.27-35
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• 2012

Oroxylin A is a flavone isolated from a medicinal herb reported to be effective in reducing the inflammatory and oxidative stresses. It also modulates the production of brain derived neurotrophic factor (BDNF) in cortical neurons by the transactivation of cAMP response element-binding protein (CREB). As a neurotrophin, BDNF plays roles in neuronal development, differentiation, synaptogenesis, and neural protection from the harmful stimuli. Adenosine $A2_A$ receptor colocalized with BDNF in brain and the functional interaction between $A2_A$ receptor stimulation and BDNF action has been suggested. In this study, we investigated the possibility that oroxylin A modulates BDNF production in cortical neuron through the regulation of $A2_A$ receptor system. As expected, CGS21680 ($A2_A$ receptor agonist) induced BDNF expression and release, however, an antagonist, ZM241385, prevented oroxylin A-induced increase in BDNF production. Oroxylin A activated the PI3K-Akt-GSK-$3{\beta}$ signaling pathway, which is inhibited by ZM241385 and the blockade of the signaling pathway abolished the increase in BDNF production. The physiological roles of oroxylin A-induced BDNF production were demonstrated by the increased neurite extension as well as synapse formation from neurons. Overall, oroxylin A might regulate BDNF production in cortical neuron through $A2_A$ receptor stimulation, which promotes cellular survival, synapse formation and neurite extension.

• Biomolecules & Therapeutics
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• 제26권5호
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• pp.487-493
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• 2018

Cluster of differentiation 44 (CD44), a cell surface receptor for hyaluronic acid (HA), is involved in aggressive cancer phenotypes. Herein, we investigated the role of the CD44 standard isoform (CD44s) in hypoxia-inducible $factor-1{\alpha}$ ($HIF-1{\alpha}$) regulation using MCF7 overexpressing CD44s (pCD44s-MCF7). When pCD44s-MCF7 was incubated under hypoxia, levels of $HIF-1{\alpha}$, vascular endothelial growth factor, and the $HIF-1{\alpha}$ response element-derived luciferase activity were significantly increased compared to those in the control MCF7. Incubation of pCD44s-MCF7 cells with HA further increased $HIF-1{\alpha}$ accumulation, and the silencing of CD44s attenuated $HIF-1{\alpha}$ elevation, which verifies the role of CD44s in $HIF-1{\alpha}$ regulation. In addition, the levels of phosphorylated extracellular signal-regulated kinase (ERK) was higher in hypoxic pCD44s-MCF7 cells, and $HIF-1{\alpha}$ accumulation was diminished by the pharmacological inhibitors of ERK. CD44s-mediated $HIF-1{\alpha}$ augmentation resulted in two functional outcomes. First, pCD44s-MCF7 cells showed facilitated cell motility under hypoxia via the upregulation of proteins associated with epithelial-mesenchymal transition, such as SNAIL1 and ZEB1. Second, pCD44s-MCF7 cells exhibited higher levels of glycolytic proteins, such as glucose transporter-1, and produced higher levels of lactate under hypoxa. As a consequence of the enhanced glycolytic adaptation to hypoxia, pCD44s-MCF7 cells exhibited a higher rate of cell survival under hypoxia than that of the control MCF7, and glucose deprivation abolished these differential responses of the two cell lines. Taken together, these results suggest that CD44s activates hypoxia-inducible $HIF-1{\alpha}$ signaling via ERK pathway, and the $CD44s-ERK-HIF-1{\alpha}$ pathway is involved in facilitated cancer cell viability and motility under hypoxic conditions.