• Investigative Magnetic Resonance Imaging
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• v.9 no.1
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• pp.16-23
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• 2005

Purpose : In order to investigate the functional brain anatomy associated with mental calculation, functional magnetic resonance imaging was performed. Materials and Methods : In six normal right handed subjects, functional MR images were obtained using a 1.57 MR scanner and the EPI BOLD technique. The study included experiment I and experiment II. Each experiment consisted of five resting and four activation periods with each period of 30 seconds. During the activation period of both experiment I and II, calculation equations[an example: $(4+5)\times8=72$] were presented and the subjects were instructed to decide true or false of them. During the resting period of experiment I, the subjects were instructed to visually fixate on a crosshair. During the resting period of experiment II, two diagrams (an example: $(\bullet,\;\blacksquare)$)were presented and the subjects were instructed to decide they are same or not. For the post-processing of images, the SPM program was used, with the threshold of significance set at p<0.00001. The activated areas during the tasks were assessed. Results : In experiment 1, the inferior frontal gyrus, prefrontal cortex, promoter area, supplementary motor area, and intraparietal sulcus including superior parietal cortex were activated bilaterally. Although these areas were also activated in experiment II, the activated signals in the right frontal and parietal lobes were lessened. Conclusion : The left inferior frontal gyrus and prefrontal cortex and bilateral intraparietal sulci were activated during mental calculation. The right frontal and parietal lobes might be related to attention and decision making.

• Journal of radiological science and technology
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• v.34 no.1
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• pp.17-25
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• 2011

In this study, we examined the impact caused by chronic exposure to Mn by investigating the degree of brain activation based on the data of recognition activities using fMRI (functional magnetic resonance imaging). A questionnaire survey, blood tests, and fMRI tests were carried out with respect to two groups. Group 1 was an exposure group consisting of 15 male workers who are 34 years old or older, and who worked for longer than 10 years in a shipbuilding factory as a welder. Group 2 was a control group consisting of 15 workers in manufacturing industries with the same gender and age. The results showed that blood Mn concentration of Group 1($1.3\;{\mu}g/dl$) was significantly higher than that of Group 2($0.8\;{\mu}g/dl$)(p < 0.001), and Pallidal Index (PI) of Group 1 was also significantly higher than that of Group 2 (p < 0.001). PI value of the group whose blood Mn concentration was $0.93\;{\mu}g/dl$ or higher was significantly higher than that of the group whose blood Mn concentration was less than $0.93 \;{\mu}g/dl$ (p < 0.001). As for brain activity area within the control group, the right and the left areas of occipital cortex showed significant activity and the left area of middle temporal cortex, the right area of superior inferior frontal cortex and inferior parietal cortex showed significant activity. Unlike the control group, the exposure group showed significant activity on the right area of superior inferior temporal cortex, the left of insula area. In the comparison of brain activity areas between the two groups, the exposure group showed significantly higher activation than the control group in such areas as the right inferior temporal cortex, the left area of superior parietal cortex and occipital cortex, and cerebellum including middle temporal cortex. However, in nowhere the control group showed more activated area than the exposure group. As the final outcome, chronic exposure to Mn increased brain activity during implementation of arithmetic task. In an identical task, activation increased in superior inferior temporal cortex, and insula area. And it was discovered that brain activity increase in temporal area and occipital area was more pronounced in the exposure group than in the control group. This result suggests that chronic exposure to Mn in the work environment affects brain activation neuro-network.

• Journal of Acupuncture Research
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• v.18 no.4
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• pp.188-200
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• 2001

Background and Objetive : Acupuncture is a valuable method of oriental medicine with broad application in many disease. It is based on the experiences of traditional oriental medicine as well as on experimentally proven biological (biochemical and neurophysiological) effects. Acupuncture theory has been explained by the meridian system that is thought to be linked with particular organs. However, in western medicine it is held that many disorders are either controlled or affected by the brain. Material and Method : In order to review the studies concerned with the mechanism related brain, we have referred to the Pubmed site and the Journal of Korean acupuncture and moxibustion Result and Conculsion : Among the 12 studies in the Journal of Korean acupuncture and moxibustion, 8 papers related neurotransmitters were done by experimental study, 4 papers related brain mapping were done by clinical study. Among the 8 studies related brain mapping in the Pubmed site, 6 clinical studies using functional magnetic resonance imaging(fMRI) were done and I clinical study using single-photon emission computed tomography(SPECT) was done, I paper was review article. By the above result, it would be needed further research on the acupuncture mechanism related brain using SPECT, fMRI, positron emission tomography(PET) etc.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2002.05a
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• pp.216-221
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• 2002

본 연구는 문자 규칙 심층성이 다른 문자체계인 한국어와 중국어의 차이가 이중언어화자의 모국어 처리와 외국어 처리에서 각각 어떤 대뇌 활성화의 차이를 가져오는지 fMRI (functional Magnetic Resonance Imaging)를 이용하여 살펴보았다. 중국어 (Ll)-한국어(L2) 이중언어화자 및 한국어(Ll)-중국어(L2) 이중언어화자를 제 2언어 습득시기에 따라 초기 및 후기 이중언어화자로 구분하여 모국어 차이와 습득시기에 따른 영향을 알아보았다. 실험 1에서는 어휘 판단 과제(lexical decision task)를 실시하였고, 실험 2에서는 의미 판단 과제(semantic decision task)를 각각 실시하였다. 어휘판단과제를 사용한 실험 1의 결과는 음운처리와 관련된 좌반구 SMG(supramarginal gyrus), 하두정소엽(inferior parietal lobule, BA 39, 40)에서 중국어-한국어 초기 및 후기이중언어화자의 경우, 한국어 조건에서 보다 많은 활성화를 보였으나, 한국어-중국어 화자의 경우 활성화가 나타나지 않았다. 철자처리에 관련된 방추상회(fusiform gyrus, BA 37, 19) 영역에서는 중국어-한국어 화자뿐만 아니라, 한국어-중국어 인중언어화자의 경우도 중국어 조건에서 보다 많은 활성화를 보였다. 실험 2에서 사용한 의미판단과제의 경우, 중국어-한국어 이중언어화자의 경우 어휘판단과제를 사용한 실험 1의 결과에서 보고된 한국어 특정적인 반응, 즉 SMG영역에서의 활성화의 증가가 실험 2에서는 나타나지 않았다. 그러나 한국어-중국어 이중언어화자의 경우, 실험 1에서 나타난 것과 같이 철자처리 혹은 의미처리와도 관련된다고 보고되는 방추상회(fusiform gyrus)등의 영역 유의미한 차이를 나타났다. 이는 어휘 판단과제와 의미판단과제가 유도하는 뇌 활성화 양상이 다름을 시사한다. 종합해 볼 때, 이중언어화자의 뇌 영상 연구에서 어휘수준에서는 거의 공통적인 활성화를 보인다는 개략적 수준의 연구 결과를 넘어, 음운처리 및 철자처리와 같은 어휘접근 수준에서는 이중언어화자들의 뇌 활성화가 다르게 일어남을 보여주고 있다. 따라서 이중언어 화자의 뇌 기전을 밝히기 위해서도 보다 개략적 수준을 넘어 언어처리의 세부적인 수준에 따른 접근이 필요함을 시사한다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.31 no.3
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• pp.121-130
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• 2020

Objectives: We investigated the differences in cognitive and emotional empathic ability between adolescents and adults, and the differences of the brain activation during cognitive and emotional empathy tasks. Methods: Adolescents (aged 13-15 years, n=14) and adults (aged 19-29 years, n=17) completed a range of empathic ability questionnaires and were scanned functional magnetic resonance imaging (fMRI) during both cognitive and emotional empathy task. Differences in empathic ability and brain activation between the groups were analyzed. Results: Both cognitive and emotional empathic ability were significantly lower in the adolescent compared to the adult group. Comparing the adolescent to the adult group showed that brain activation was significantly greater in the right transverse temporal gyrus (BA 41), right insula (BA 13), right superior parietal lobule (BA 7), right precentral gyrus (BA 4), and right thalamus whilst performing emotional empathy tasks. No brain regions showed significantly greater activation in the adolescent compared to the adult group while performing cognitive empathy task. In the adolescent group, scores of the Fantasy Subscale in the Interpersonal Reactivity Index, which reflects cognitive empathic ability, negatively correlated with activity of right superior parietal lobule during emotional empathic situations (r=-0.739, p=0.006). Conclusion: These results strongly suggest that adolescents possess lower cognitive and emotional empathic abilities than adults do and require compensatory hyperactivation of the brain regions associated with emotional empathy or embodiment in emotional empathic situation. Compensatory hyperactivation in the emotional empathy-related brain areas among adolescents are likely associated with their lower cognitive empathic ability.

• Korean Journal of Acupuncture
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• v.23 no.2
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• pp.89-103
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• 2006

Objectives: Recently, the effect of acupuncture has been approved not only in the East but also in the West, so the interest on acupuncture was greatly improved. Especially, functional magnetic resonance imaging(fMRI) was embossed as the study tool for the mechanism of acupuncture noninvasively and many studies on the mechanism of acupuncture using fMRI were carried out. We archived the fMRI study on the brain activity induced by manual acupuncture at BL62(申脈). Methods: The study was the acupuncture at BL62(申脈) and we acquired 9 fMRI results from 6 persons$(age\;20{\sim}30,\;4\;male\;and\;2\;female)$. These studies employed The block design for mapping brain activity and acupuncture was perfomed at BL62(申脈) on the left foot. Results: The brain related motor function was cerebellum, basal ganglia and cerebral cortex and thalamus connected these elements. In the result of this study, the regions of significant activation in the cerebellum was centered on the spinocerebellum in the anterior lobe, so we presumed that this result showed the input of stimulation by the acupuncture on BL62(申脈). But basal ganglia and cerebral cortex showed the regions of significant activation in the left larger than the right and regions of the cerebral cortex was the motor and sensory cortex. Such a result explained that acupuncture at BL62(申脈) could have influence the motor function and acupuncture at left BL62(申脈) could affect the right side through the activation of the left basal ganglia and cerebral cortex. Conclusions: In the theory of crossing needling at collaterals(繆刺論), it the pathogenic factor invaded in the Yang Heel channel(陽?脈) that was one of the eight Extra meridians(奇經八脈), we recognized the disease of the collateral channel and used contralateral BL62(申脈) for treatment of the Yang Heel channel(陽?脈). Moreover the result of this study could bear the construction that acupuncture at the left BL62(申脈) treats the contralateral lesion and this construction is related to the theory of crossing needling at collaterals(繆刺論).

• Investigative Magnetic Resonance Imaging
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• v.3 no.1
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• pp.41-46
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• 1999

Purpose : To investigate the difference of total activation in visual area, motor area, and cerebellum according to the stimulation paradigm. Materials and Methods : Functional MR imaging was performed in 5 healthy volunteers with visual and motor activity using EPI technique. LED and Checker-Board stimulation were performed for visual activity. Thumb motion and Finger Tapping were performed for motor and cerebellum activity. Stimulus timing was 60sec. off, 120sec. on, 60sec. off. Data processing was carried out by using the cross-correlation method for each pixel. Each pixel was then selected and assumed activated if the correlation coefficient was equal or larger than a threshold value. Time course data was obtained by calculating the total activation which was defined as the number of activated pixel x averaged pixel intensity. Results : In the case of visual activity with LED stimulation, we found increased total activity of more than 100% compared with Checker-Board stimulation. In the case of motor area and cerebellum with Finger tapping stimulation, we found increased total activity of more than 10% and 150%, respectively compared with Thumb motion stimulation.

• Investigative Magnetic Resonance Imaging
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• v.3 no.1
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• pp.78-83
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• 1999

Purpose : To evaluate the language areas activated by fMRI during different reading tasks and to assess the difference of activated areas according to each reading task. Materials and Methods : Functional maps of the language area were obtained during three reading tasks(Korean consonant letter, pseudoword, and word) in nine right-handed volunteers(7 males 2 females). MR examinations were performed at 1.5T scanner with EPI BOLD technique(gradient echo shot EPI, TR/TE 3000/60, flip angle $90^{\circ}$, matrix $64{\times}64$, 5mm thickness, no slice gap). Each task consisted of three resting periods and two activation periods and each period lasted 30 seconds. We used SPM program for the postprocessing of images and signification level was set at p<0.01. Activated areas were topographically analyzed in each stimulus. Results : Significant activated signals were demonstrated in all volunteers. Activated signals were seen in the frontal, temporal, parietal and occipital lobes during reading tasks and they were lateralized to the left hemisphere except occipital lobe. Letter and pseudoword produced stronger activated signals than word, and the activated signals were more lateralized to the left hemisphere in pseudoword reading than in letter reading. Conclusion : Activated signals were induced in the language areas by reading task of letter or wordform. Greater activation of language areas was induced when letter or pseudowords were presented than familiar words.

• Korean Journal of Radiology
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• v.23 no.10
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• pp.986-997
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• 2022

Objective: Whether metabolic redistribution occurs in patients with white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) is unknown. This study aimed 1) to propose a measure of the brain metabolic network for an individual patient and preliminarily apply it to identify impaired metabolic networks in patients with WMHs, and 2) to explore the clinical and imaging features of metabolic redistribution in patients with WMHs. Materials and Methods: This study included 50 patients with WMHs and 70 healthy controls (HCs) who underwent ¹⁸F-fluorodeoxyglucose-positron emission tomography/MRI. Various global property parameters according to graph theory and an individual parameter of brain metabolic network called "individual contribution index" were obtained. Parameter values were compared between the WMH and HC groups. The performance of the parameters in discriminating between the two groups was assessed using the area under the receiver operating characteristic curve (AUC). The correlation between the individual contribution index and Fazekas score was assessed, and the interaction between age and individual contribution index was determined. A generalized linear model was fitted with the individual contribution index as the dependent variable and the mean standardized uptake value (SUV_mean) of nodes in the whole-brain network or seven classic functional networks as independent variables to determine their association. Results: The means ± standard deviations of the individual contribution index were (0.697 ± 10.9) × 10^-3 and (0.0967 ± 0.0545) × 10^-3 in the WMH and HC groups, respectively (p < 0.001). The AUC of the individual contribution index was 0.864 (95% confidence interval, 0.785-0.943). A positive correlation was identified between the individual contribution index and the Fazekas scores in patients with WMHs (r = 0.57, p < 0.001). Age and individual contribution index demonstrated a significant interaction effect on the Fazekas score. A significant direct association was observed between the individual contribution index and the SUV_mean of the limbic network (p < 0.001). Conclusion: The individual contribution index may demonstrate the redistribution of the brain metabolic network in patients with WMHs.

• Science of Emotion and Sensibility
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• v.14 no.1
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• pp.93-100
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• 2011

Sonic branding is defined as creation and management of brand value by using sounds. Among various methods of sonic branding, sonic logo, i.e., brand’s acoustic identification element, is the most widely used form and usually combined with visual logo. Although sonic branding has become an increasingly important tool for marketers, little academic research has been done on this topic. The current study investigates neural responses to sonic branding using functional Magnetic Resonance Imaging (fMRI). Brain activity of 15 right-handed participants was monitored with 3T MRI machine, while they viewed sequentially presented pictures of brand logos (20 visual logos usually accompanied by sonic logos and 20 visual logos unaccompanied by sonic logos) without sound. Results showed that brain areas known to be associated with auditory imagery (including superior temporal gyrus, STG), showed greater activation for the visual logos usually accompanied by sonic logos compared to visual logos unaccompanied by sonic logos, although actual sound was not presented during scanning. The degree of familiarity participants have with the brand and its advertisements was correlated positively with signal strength in these areas.