• Radiation Oncology Journal
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• v.30 no.4
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• pp.189-196
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• 2012

Purpose: To investigate the safety of high dose hypofractionated radiotherapy (RT) in patients with small hepatocellular carcinoma (HCC) in terms of liver volumetric changes and clinical liver function. Materials and Methods: We retrospectively reviewed 16 patients with small HCC who were treated with high dose hypofractionated RT between 2006 and 2009. The serial changes of the liver volumetric parameter were analyzed from pre-RT and follow-up (FU) computed tomography (CT) scans. We estimated linear time trends of whole liver volume using a linear mixed model. The serial changes of the Child-Pugh (CP) scores were also analyzed in relation to the volumetric changes. Results: Mean pre-RT volume of entire liver was 1,192.2 mL (range, 502.6 to 1,310.2 mL) and mean clinical target volume was 14.7 mL (range, 1.56 to 70.07 mL). Fourteen (87.5%) patients had 4 FU CT sets and 2 (12.5%) patients had 3 FU CT sets. Mean interval between FU CT acquisition was 2.5 months. After considering age, gender and the irradiated liver volume as a fixed effects, the mixed model analysis confirmed that the change in liver volume is not significant throughout the time course of FU periods. Majority of patients had a CP score change less than 2 except in 1 patient who had CP score change more than 3. Conclusion: The high dose hypofractionated RT for small HCC is relatively safe and feasible in terms of liver volumetric changes and clinical liver function.

• 한국가스학회:학술대회논문집
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• 2005.10a
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• pp.37-43
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• 2005

The questionnaires about the safety of the urban gas have been carried out for the end users. about 8 of 10 persons said that the urban gas Is safe to use, whereas $35\%$ of them said there exists a hazard of an accident in thier residences. There cannot be found the clear evidences that the understandings on the safety of the urban gas have no relations to their ages, sex, and monthly incomes, while the safety is less confidential to the highly educated, the accident-experienced, or the mans who are poor at the safety inspections. Most of the questioned man know the inspection knacks for the gas utilities, but only $60\%$ of them carry out it. They said that they do not feel the necessity of the inspection because they are inspected routinely by the suppliers or the inspection companies. This says that the end user does not concern the safety inspections, and in order to improve the dependency of the user for the self-inspections, the inspection staff should educate the user for the necessity and the knack of inspections to encourage the self-inspection of the gas utilities.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.15 no.4
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• pp.81-90
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• 2016

As an autonomous driving vehicle (AV) need to cope with external road conditions by itself, its perception performance for road environment should be better than that of a human driver. A vision sensor, one of AV sensors, performs lane detection function to percept road environment for performing safe vehicle steering, which relates to define vehicle heading and lane departure prevention. Performance standards for a vision sensor in an ADAS(Advanced Driver Assistance System) focus on the function of 'driver assistance', not on the perception of 'independent situation'. So the performance requirements for a vision sensor in AV may different from those in an ADAS. In assuming that an AV keep previous steering due to lane detection failure, this study calculated lane departure distances between the AV location following curved road alignment and the other one driving to the straight in a curved section. We analysed lane departure distance and time with respect to the allowance of lane detection malfunction of an AV vision sensor. With the results, we found that an AV would encounter a critical lane departure situation if a vision sensor loses lane detection over 1 second. Therefore, it is concluded that the performance standards for an AV should contain more severe lane departure situations than those of an ADAS.

• Journal of Food Hygiene and Safety
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• v.31 no.3
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• pp.141-152
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• 2016

The demand to develop more safe and efficient methods for treating allergic patient is now continuously growing due to the increasing prevalence of allergic diseases. Probiotics are endogenous microbial flora that gives health benefits within hosts. Probiotics are now considered as one of solutions to treat allergic patients since recent evidence shows that some of probiotics have immunomodulatory function. Also, the treatment of probiotics to patients is relatively safer than other anti-inflammatory agents. In this review, we summarized on immunomodulatory function of some probiotics which show preventive or therapeutic effects on major allergic diseases such as atopic dermatitis, allergic rhinitis, asthma, or food allergy. Based on previous literature, the treatment of probiotics can alleviate the symptoms of allergic diseases via balancing $Th_1/Th_2$ response or increasing the number of regulatory T ($T_{reg}$) cells.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.35 no.2
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• pp.397-405
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• 2015

In the past, expressways focused on mobility. However, the paradigm of expressways fuction today has been changed from fast expressways to safe expressways as people's quality of living and consciousness level heightened. In 2012, 3,550 traffic accidents occurred on expressways and 371 people died. The fatality rate of traffic accidents on expressways is almost twice that on general national roads. This study developed accident forecast models (safety performance functions) based on the number of traffic accidents and traffic volumes on six major lines on expressways. It is difficult to forecast safety performance functions for each expressway line because the lines and the scales of expressways are different from each other; therefore, integrated safety performance functions of six lines were determined first, and the coefficients, which can correct the traffic accidents on each line, were calculated. It is believed that this study will contribute in the safer management of expressways by being used as basic information in the establishment of traffic safety strategies for each expressway line in prevention of traffic accidents. Moreover, more studies would be required in the future, which would suggest reliable accident forecasts by calculating correction coefficients by line through integrated models by groups dependent on the characteristics of each line.

• Journal of Acupuncture Research
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• v.33 no.3
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• pp.197-205
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• 2016

Objectives : To report the clinical application and safety of Traditional Korean Medical treatment for patients with low back pain during pregnancy. Methods : Three patients who suffered from low back pain during pregnancy were treated with acupuncture, pharmacopuncture, moxibustion, and herbal medicine for 12 to 21 days. Numeric rating scale (NRS) of low back pain and Oswestry Disability Index (ODI) were checked to measure the outcome. A liver function and renal function test was carried out to identify any drug-induced liver or renal injury, and any adverse events were monitored thoroughly until delivery. Results : Low back pain reduced on NRS in all cases, and no serious adverse effects were found in the patients or infants. Conclusion : This study suggests that Traditional Korean Medical treatment is a candidate therapy for relieving low back pain during pregnancy, and also is safe for both patients and infants.

• Herbal Formula Science
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• v.16 no.2
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• pp.1-9
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• 2008

Objective : The purpose of this report was to provide the information about activity and safety of Ojeok-san by analyzing domestic/international papers about Ojeok-san. Methods : Domestic/international papers related to Ojeok-san were reviewed and analyzed. These papers were then classified by year, experimental method and subject. Results : The following results were obtained in this study. 1. The studies of Ojeok-san started from 1984 and has continuously increased. The studies were mainly focused on experimental models rather than clinical studies. 2. By subject, papers related to safety were most common with 5 papers among 20 papers. Besides there were papers related to efficacy of analgesic, anti-hyperlipidemic, anti-blood stasis and treatment for uterine myoma. 3. The papers related to safety were mainly focused on the effect of Okeok-san on liver function, renal function or metal concentration of organs such as blood, brain, liver, kidney and bone. Ojeok-san proved to be safe, but more clinical studies regarding the safety are needed hereafter. 4. Papers related to analgesic, anti-pyretic, anti-phlogistic activities of Ojeok-san were in vivo studies, and other papers were about anti-hyperlipidemic activity, apoptosis inducing activity on uterine myeloma cell line and anti blood static activity on hydrocortisone acetate induced blood statis model. 5. Case reports were about anti-lipidemia, analgesic effect for mastalgia/back pain and anxiety disorder due to climacteric changes. Conclusion : Ojeok-san is being used in various ways with analgesic, anti-pyretic, anti-phlogistic, anti-hyperlipidemic, anti-tumor or anti-blood statis activity. However, mechanism study should be conducted at the molecular biology level and more clinical studies on the efficacy of Ojeok-san are needed.

• The Korean Journal of Pesticide Science
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• v.9 no.3
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• pp.231-236
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• 2005

This study was conducted to determine the amounts of pesticide residues after treatment of criterion dose with 4 pesticides(tolclofos-m, folpet, procymidone, and triflumizole) under cultivated period and to compare the biological half-life of pesticides with 6 kinetic models(first, zero and second order kinetics, power function, elovich and parabolic model) and to establish proposed field tolerance using biological half-lives. Recovery of 4 pesticides form strawberry was ranged from 85.1 to 105.5%. For all of 4 pesticides, dissipation rate was over 73% at 5 days after application. Among 6 kinetic models, first order kinetic model (FO) was best fit to describe the relationship between residual pattern of pesticides and time. Therefore, half-lives were calculated by FO for establishing the field tolerance. These results showed that half-life should be calculated by comparative best fit kinetic model and field tolerance can help to prevent unacceptable agricultural products from marketing. It is good for both consumers and farmers having safe agricultural products and financial benefits, respectively.

• Journal of Chest Surgery
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• v.27 no.3
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• pp.177-186
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• 1994

Pentastarch is a hydroxyethyl starch similar to hetastarch, but lower average molecular weight and fewer hydroxyethyl groups which result in enhanced enzymatic hydrolysis and faster renal elimination.This report was performed to compare the clinical efficacy and safety of 10 % pentastarch[Pentaspan , group I] for plasma volume expansion after open heart surgery with that of 5% albumin[Plasmanate, group II]. There were no statistically significant differences between the group I [n=18] and group II [n:19] in the preoperative parameters [age, sex, body weight] and operative parameters[bypass time, aorta cross clamping time]. During the first 24 hours after arrival of the patient in the surgical intensive care unit, colloid solution [500--1000 ml] was infused to maintain left atrial pressure of more than 8 mmHg, or cardiac index of 2.0 L/min/M2 of more. In results, there were 3 complications of hypotension immediately after infusion of 5 % albumin solution and 2 among the 3 patients were excluded for the study. However there was no complication after infusion of 10 % pentastarch solution. Hemodynamic responses to infusion was similar for both groups, although in group I a greater increase in both left atrial pressure[mean 1.8 versus 0.7 mmHg, p< 0.05] and right atrial pressure [mean 2.2 versus 1.7 mmHg, p < 0.05] was observed during infusion of the first 500 ml. There were no significant differences in any of the measured respiratory parameters[PaO2, intrapulmonary shunt, and effective lung compliance]. Homodilution with colloid significantly reduced hemoglobin [mean 1.2 versus 0.8 gm/dl], and serum protein and albumin level[total protein;4.8$\pm$ 0.5 versus 5.2 $\pm$0.5 gm/dl, p < 0.05: albumin: 3.2 $\pm$0.4 versus 3.6 $\pm$0.6 gm/dl, p < 0.05] by 6:00 AM on 1 day postoperatively, however there were no significant differences on 7 day postoperatively. The mean serum colloid osmotic pressure and osmolarity was similar in both group.There were no abnormal findings of liver function and kidney function in all the patients. There were no significant between-group differences in bleeding time, platelets, prothrombin time, activated partial thromboplastin time and amount of chest tube output measured on 1st and 7th postoperative day. These findings demonstrated that 10% pentastarch is more effective and safe for plasma volume expension than 5 % albumin solution with no adverse effects on coagulation. Also 10 % pentastarch is less expensive than 5 % albumin and it would appeare to be a reasonable first choice for plasma volume expansion.

• Journal of the Korean Society of Hazard Mitigation
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• v.9 no.2
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• pp.23-30
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• 2009

Crash cushions are protective devices that prevent errant vehicles from impacting on fixed objects. This function is accomplished by gradually decelerating a vehicle to a safe stop in a relatively short distance. Commonly used crash cushions generally employ one of two concepts to accomplish this function. The first concept involves the absorption of the kinetic energy of a moving vehicle by crushable or plastically deformable materials and the other one involves the transfer of the momentum of a moving vehicle to an expendable mass of material located in the vehicle's path. Crash cushions using the first concept are generally referred to as compression crash cushions and crash cushions using the other concept are generally referred to as inertial crash cushion. The objective of this research is the development of a compression-type crash cushion by employing the two concepts simultaneously. To minimize the number of full-scale crash tests for the development of the crash cushion, preliminary design guide considering inertial and frictional energy absorption was constructed and computer simulation was performed. LS-DYNA program, which is most widely used to analyze roadside safety features, was used for the computer simulation. The developed crash cushion satisfied the safety evaluation criteria for various impact conditions of CC2 performance level in the Korean design guide.