• 재활간호학회지
• /
• 제11권2호
• /
• pp.67-73
• /
• 2008

Purpose: The purpose of this study was to review and identify the meaning and components of the concept, Frailty. Method: We conducted literature review of studies that concluded the word of 'frail' or 'frailty between 1980 and 2008, and used MEDLINE, CINAHL database to select the articles. Results: Frailty is defined as a concept with multidomains, which are physical, cognitive, psychological, social. Critical characteristics of Frailty include multidominal deficiency, combined accumulation, diminished ability to keep up the independence of daily living, states beyond one's reserve capacity, dynamic relativity, proximity to adverse health outcome, aggregated symptoms. Frailty is caused by decreased physical activity, loss of sensory function, Chronic symptoms or signs, relationship with Caregiver, social isolation. Moreover, Frail elderly is at risk of falls and institutionalization. Conclusion: Frailty is very useful concept, because it has the potential to identify the elderly population at risk of adverse health outcomes. Based on this results, the appropriate tool for screening Korean Frail elderly and Nursing intervention for them needs to be developed.

• Clinical and Experimental Pediatrics
• /
• 제53권3호
• /
• pp.273-285
• /
• 2010

Completion of the human genome project has allowed a deeper understanding of molecular pathophysiology and has provided invaluable genomic information for the diagnosis of genetic disorders. Advent of new technologies has lead to an explosion in genetic testing. However, this overwhelming stream of genetic information often misleads physicians and patients into a misguided faith in the power of genetic testing. Moreover, genetic testing raises a number of ethical, legal, and social issues. Diagnostic genetic tests can be divided into three primary but overlapping categories: cytogenetic studies (including routine karyotyping, high-resolution karyotyping, and fluorescent in situ hybridization studies), biochemical tests, and DNA-based diagnostic tests. DNA-based testing has grown rapidly over the past decade and includes preandpostnatal testing for the diagnosis of genetic diseases, testing for carriers of genetic diseases, genetic testing for susceptibility to common non-genetic diseases, and screening for common genetic diseases in a particular population. Theoretically, once a gene's structure, function, and association with a disease are well established, the clinical application of genetic testing should be feasible. However, for routine applications in a clinical setting, such tests must satisfy a number of criteria. These criteria include an acceptable degree of clinical and analytical validity, support of a quality assurance program, possibility of modifying the course of the diagnosed disease with treatment, inclusion of pre-and postnatal genetic counseling, and determination of whether the proposed test satisfies cost-benefit criteria and should replace or complement traditional tests. In the near future, the application of genetic testing to common diseases is expected to expand and will likely be extended to include individual pharmacogenetic assessments.

• 전기학회논문지
• /
• 제59권2호
• /
• pp.232-241
• /
• 2010

This paper describes the development of robust contingency analysis program for Korean Energy Management System. The important function of contingency analysis is to determine the bus/branch model for contingency, and to calculate the state of the power network based on the network model and topology output. In the proposed method, the bus/branch models for contingencies are determined exactly using a fast linked-list method based on the application common model database. To calculate the state of the power system included contingency, the full-decoupled powerflow approach, the partial powerflow method for contingencies and the proposed contingency screening algorithm are also used to contingency analysis. To verify the performance of the developed processor, we performed a file-based test using several structured input data and online test using the database which resides on memory. The results of these comprehensive tests showed that the developed processors can accurately calculate the power system contingency state from online data and can be applied to Korea Power Exchange system.

• KSBB Journal
• /
• 제22권5호
• /
• pp.318-321
• /
• 2007

광역동요법 (photodynamic therapy, PDT)은 악성종양을 치료하기 위해 광과민제와 레이저광을 이용하는 표적지향적 항암치료법이다. 본 연구에서는 PDT에 적용할 수 있는 새로운 광과민제를 스크리닝하기 위해 4종의 phthalocyanine계 광과민제 (silver phthalocyanine, iron (III) phthalocyanine, copper (II) phthalocyanine, nickel (II) phthalocyanine)을 이용하여 폐암과 유방암 세포주에 대한 항암활성 테스트를 수행하였다. 연구결과 phthalocyanine계 광과민제들은 폐암보다 유방암에 높은 활성을 나타냈으며, 그 중 silver phthalocyanine (AgPc)는 정상세포에 대해서는 세포독성이 낮으면서도 물에 용해할 경우 청색증을 유발하지 않아 유방암에 대한 항암제로서의 개발가능성을 확인하였다.

• 대한기계학회논문집A
• /
• 제36권11호
• /
• pp.1327-1334
• /
• 2012

본 논문은 4차 동적 시스템인 구동기를 구성하는 부품들의 변량 및 공기외란의 변량으로 인해 구동기 성능에 변량이 존재할 때, 구동기의 성능을 순응도 기반으로 최적화한 설계 결과를 제시하였다. 구동기는 BLDC 모터와 평기어 및 웜기어 조립체, 카나드로 구성된다. 구동기의 성능은 시간에 따라 변화하는 카나드 각도 정보를 이용하여 평가하였다. 고차 시스템의 성능은 해석적 접근을 통해 시스템 변수들의 함수로 표현하기 어렵기 때문에 반응표면모델을 기반으로, F-검정을 수행하여 유효한 시스템 변수들을 선정한 후 성능을 유효한 시스템 변수들의 함수로 근사화하였다. 본 연구에서 변량을 가지는 구동기 성능의 규격에 대한 순응도를 확률값으로 정의하였다. 순응도를 최적화하여 구한 설계변수는 부품 및 공기외란에 변량이 존재하더라도 고려한 규격을 모두 만족시킬 수 구동기를 제공할 수 있다.

• 한국전문물리치료학회지
• /
• 제30권2호
• /
• pp.152-159
• /
• 2023

Background: The gluteus medius (Gmed) plays a critical role in maintaining frontal plane stability of the pelvis during functional activities, such as one-leg lifting. Side-lying hip abduction (SHA) has been used as a dynamic test to evaluate Gmed function. However, the abduction force of the lower leg against the floor is not controlled during SHA. Therefore, hip abduction performance with contralateral adduction in the side-lying position (HAPCA) can be proposed as an alternative method to assess performance of hip abduction. If the number of HAPCA is related to the lateral pelvic shift distance, a new quantitative measurement for hip abductor function may be presented. Objects: This study aimed to investigate the relationship between the number of successful HAPCA and the lateral pelvic shift distance during one-leg lifting. Methods: Thirty healthy participants were recruited, and lateral pelvic shift distance was measured during one-leg lifting test using two-dimensional analysis. The number of successful HAPCA was counted when participants touched both target bars at the beat of a metronome. Results: There was a negative correlation between the number of HAPCA and lateral pelvic shift distance during one-leg lifting (r = -0.630, p < 0.05). The number of HAPCA accounted for 39.7% of the variance in the lateral pelvic shift distance during one-leg lifting (F = 18.454, p < 0.001). Conclusion: The number of successful HAPCA is significantly correlated with lateral pelvic shift distance during one-leg lifting. This finding suggests that HAPCA can be proposed as a new measurement for hip abductor performance and more research is needed on its relationship with hip abductor strength.

• 한국지구물리탐사학회:학술대회논문집
• /
• 한국지구물리탐사학회 2005년도 공동학술대회 논문집
• /
• pp.273-280
• /
• 2005

MT 전달함수의 추정과정에서 로버스트 방법의 적용은 현재 전자탐사 분야에서 일반적이다. 적절하게 고안되고 적용된 로버스트 방법은 출력 채널인 전기장에 포함되어 있는 외치의 영향을 감소시킬 수 있으나, HLP(High leverage point)라 불리 우는 자기장(입력 채널)의 외치에 종종 민감하지 못하다. 이 문제를 해결하기 위해 HLP의 영향을 최소화할 수 있는 BI(Bounded Influence) 추정이 제안되었고, 전통적인 로버스트 방법보다 신뢰성 있는 전달함수를 제공하는 것으로 보고되었다. 이는 BI 추정이 M-추정을 적용함과 동시에 자기장 성분만으로 결정되는 모자행렬의 통계적인 특성을 고려하여 가중치를 부여하는 방법이기 때문이다. 본 연구에서는 전달함수 추정과정에 BI 추정을 적용하고, 이와 더불어 전처리 단계로서 전자기장의 통계적 분포를 이용해 주파수 영역에서 극단적인 전기장과 자기장 자료의 영향을 감소시키는 기법을 개발하였다. 개발된 전처리 기법은 BI 추정으로 제거될 수 없는 자료를 주파수 영역에서 효과적으로 제거하는 것으로 생각된다. 본 연구에서 개발된 기법의 효율성과 장점은 합성 자료와 현장 자료를 이용하여 도시될 것이다.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2000년도 제18회 학술발표회 논문개요집
• /
• pp.137-137
• /
• 2000

The surface collective modes of thin K films deposited on Al(111) have been investigated using frequency dependent photoyield measurements and momentum resolved inelastic electron scattering. Jellium based theoretical calculations have predicted a richer set of features in the thin films than for the surface of a semi-infinite solid because there are th interference between two interfaces (substrate-film and film-vacuum) and heavy damping on the substrate. The use of an optical probe and electron scattering has allowed us to draw a more complete picture of the dynamic screening in thin films. The number, dispersion, damping and optical activity of the collective modes of the thin films have been measured as a function of K film thickness. New overlayer-induced excitations are observed : At qII=0, they correspond to the antisymmetric slab mode and the multipole surface plasmon. At finite qII=0, these modes undergo a transition towards the K multipole and monopole surface plasmons. With increasing coverage, the overlayer excitations turn into the collective modes of semi-infinite K. For a consistent interpretation of photoyield and electron energy loss spectra it is crucial to account for the non-analytic dispersion of the overlayer modes at small parallel wave vectors and for the finite angular resolution of the detector. The observed dispersions confirm predictions based on the time-dependent density functional approach.

• 식물조직배양학회지
• /
• 제27권4호
• /
• pp.259-268
• /
• 2000

Senescence is a sequence of biochemical and physiological events that lead to death of a cell, organ, or whole organism. Senescence is now clearly regarded as a genetically determined and evolutionarilly acquired developmental process comprising the final stage of development. However, in spite of the biological and practical importance, genetic mechanism of senescence has been very limited. Through forward and reverse genetic approaches, we are trying to reveal the molecular and genetic mechanism of senescence in plants, employing leaf organs of Arabidopsis as a model system. Using forward genetic approach, we have initially isolated several delayed senescence mutants either from T-DNA insertional lines or chemical-mutagenized lines. In the case of ore 4 and ore 9 mutants, the mutated genes were identified. The recent progress on characterization of mutants and identification of the mutated genes will be reported. We are also screening mutations from other various sources of mutant pools, such as activation tagging lines and promoter trap lines. Two dominant senescence-delayed mutants were isolated from the activation tagging pool. Cloning of the genes responsible for this phenotype is in progress. For reverse genetic approach, the genes that induced during leaf senescence were first isolated by differential screening method. We are currently using PCR-based suppression subtractive hybridization, designed to enrich a cDNA library for rare differentially expressed transcripts. Using this method, we have identified over 35 new sequences that are upregulated at leaf senescence stage. We are investigating the function of these novel genes by systemically generating antisense lines.

• 대한교통학회지
• /
• 제31권4호
• /
• pp.85-94
• /
• 2013

Continuous Risk Profile(CRP)은 고속도로의 사고취약구간을 선정하는 방법론 중에서 정확성과 효율성이 뛰어난 것으로 알려져 있다. 그러나 전통적인 CRP는 데이터베이스 구축을 위한 대규모 투자를 필요로 하는 안전성능함수를 이용한다. 본 연구는 안전성능함수 대신 동질 그룹들의 평균사고건수를 규모조정계수로 이용하는 CRP를 제안하는 것을 목적으로 한다. 고속도로 구간들을 동질 그룹으로 분류하기 위하여 각 구간의 AADT와 차로 수 자료를 기반으로 하는 계층적 군집분석이 수행된다. 제안된 모형은 캘리포니아의 I-880 자료를 이용하여 다른 여러 가지 사고취약구간 선정방법들과 비교된다. 분석 결과에 따르면, 제안된 모형은 false negative를 발생시키지 않으며 false positive rate를 감소시킨다. 본 연구에서 개발된 방법론은 추가적인 복잡한 데이터베이스 없이 고속도로 사고취약구간을 선정하는 데에 활용될 수 있으며, 또한 고속도로 안전관리시스템을 개선하는 데에 기여할 수 있다.