• The Korean Journal of Physiology and Pharmacology
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• v.20 no.6
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• pp.573-580
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• 2016

Caspases, a family of cysteine proteases, cleave substrates and play significant roles in apoptosis, autophagy, and development. Recently, our group identified 72 genes that interact with Death Caspase-1 (DCP-1) proteins in Drosophila by genetic screening of 15,000 EP lines. However, the cellular functions and molecular mechanisms of the screened genes, such as their involvement in apoptosis and autophagy, are poorly understood in mammalian cells. In order to study the functional characterizations of the genes in human cells, we investigated 16 full-length human genes in mammalian expression vectors and tested their effects on apoptosis and autophagy in human cell lines. Our studies revealed that ALFY, BIRC4, and TAK1 induced autophagy, while SEC61A2, N-PAC, BIRC4, WIPI1, and FALZ increased apoptotic cell death. BIRC4 was involved in both autophagy and apoptosis. Western blot analysis and luciferase reporter activity indicated that ALFY, BIRC4, PDGFA, and TAK1 act in a p53-dependent manner, whereas CPSF1, SEC61A2, N-PAC, and WIPI1 appear to be p53-independent. Overexpression of BIRC4 and TAK1 caused upregulation of p53 and accumulation of its target proteins as well as an increase in p53 mRNA levels, suggesting that these genes are involved in p53 transcription and expression of its target genes followed by p53 protein accumulation. In conclusion, apoptosis and/or autophagy mediated by BIRC4 and TAK1 may be regulated by p53 and caspase activity. These novel findings may provide valuable information that will aid in a better understanding of the roles of caspase-related genes in human cell lines and be useful for the process of drug discovery.

• The Journal of the Korea Contents Association
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• v.17 no.8
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• pp.144-151
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• 2017

The aim of this cross-sectional study was to investigate the relationship between regular interdental cleaning and periodontal condition. A total of 319 pregnant women were recruited at 21 to 24 weeks of gestation. Information on demographics, health status and health behaviors including regulary use of interdental cleaning aids, that can influence periodontal condition was collected. Full mouth periodontal probing was performed. Periodontitis was defined as CAL of 4.0 mm or greater on 2 or more sites not on the same tooth. Gingivitis was defined as 15 percent and more sites showed bleeding on probing. Gingival crevice fluid sample was collected for bacterial analysis. We studied a total of 319 subjects, comprised of 116 subjects who use interdental cleaning device regularly and 203 subjects who didn't. Subjects who do not use interdental cleaning regularly had 2.3 times higher risk of gingivitis and 2.7 times of periodontitis, 2.3 times more amount of P. gingivalis. There was a significant relationship between regular interdental cleaning and periodontal condition in Korea.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.5
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• pp.160-166
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• 2018

This paper proposes an advanced suspension system and reports its performance in the framework of the preview control algorithm based on the RPS (road profile sensing) system and MSD system with the multi-stage damping characteristics. Typical disturbance inputs that cause excessive vibration and steering instability of an automobile are irregular obstacles that protrude or sink into the road surface to be driven. The control performance can be improved if information on the existence and shape function of its obstacle is known. Based on the results of the previous study, advanced research that uses the actuating system has been processed to be commercialized practically. For this purpose, a switching algorithm between the control logic and the multi-stage damping system was developed and its connectivity is presented. To verify the applicability of an actual vehicle, the proposed control system was implemented in full vehicle models and simulations were performed. The proposed system using the 3-DS actuator system, which is applied for structural simplicity, can improve the ride comfort and steering stability. In addition, the results indicate the feasibility of the intelligently controlled suspension system.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.2
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• pp.461-468
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• 2010

This paper presents a simple digital LCD backlight inverter using a single-chip microcontroller. The proposed inverter reduces the ignition voltage and eliminates the current spikes and hence improves the ignition behavior of the cold cathode fluorescent lamp(CCFL). Thus it increases the CCFL's life span. This is achieved by implementing a digital dimming control algorithm, that contains the soft-starting algorithm, all on a single-chip microcontroller. The inverter utilizes the full-bridge resonant circuit topology. The design example along with a simple analysis for the inverter is shown, and the experimental results of the designed prototype results in close agreement with the theoretical analysis and explanation. The overall system's power efficiency is approximately 85%. Compared with conventional inverters, the ignition voltage is reduced by around 30% without any lamp current spike occurring during the dimming control operation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.11
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• pp.6565-6575
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• 2014

Hamilton's Markov-switching model [5] was extended to the simultaneous equations model. A framework for an instrumental variable interpretation of full information maximum likelihood (FIML) by Hausman [4] can be used to deal with the problem of simultaneous equations based on the Hamilton filter [5]. A comparison of the proposed FIML Markov-switching model with the LIML Markov-switching models [1,2,3] revealed the LIML Markov-switching models to be a special case of the proposed FIML Markov-switching model, where all but the first equation were just identified. Moreover, the proposed Markov-switching model is a general form in simultaneous equations and covers a broad class of models that could not be handled previously. Excess sensitivity of marginal propensity to consume with big shocks, such as housing bubble bursts in 2008, can be determined by applying the proposed model to Campbell and Mankiw's consumption function [6], and allowing for the possibility of structural breaks in the sensitivity of consumption growth to income growth.

• Journal of KIISE:Computer Systems and Theory
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• v.37 no.5
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• pp.304-313
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• 2010

There are several methods for malware analyses. However, it is difficult to detect malware exactly with existing detection methods. Especially, malware with strong anti-debugging facilities can detect analyzer and disturb their analyses. Furthermore, it takes too much time to analyze malware. In order to resolve these problems of current analyzers, more improved analysis scheme is required. This paper suggests a dynamic binary instrumentation which supports the instruction analysis and the memory access tracing. Additionally, by supporting the API call tracing with the DLL loading analysis, our system establishes the foundation for analyzing various executable codes. Based on Xen, full-virtualization environment is built using Intel's VT technology. Windows XP can be used as a guest. We analyze representative malware using several functions of our system, and show the accuracy and efficiency enhancements in binary analyses capability of our system.

• Earthquakes and Structures
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• v.8 no.5
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• pp.1069-1089
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• 2015

This paper presents average numerical results of 2128 nonlinear dynamic finite element (FE) analyses of lightweight acceleration-sensitive non-structural components (NSCs) attached to the floors of one-bay three-storey reinforced concrete (RC) primary structures (P-structures) with different eccentricity ratios. The investigated parameters include the NSC to P-structure vibration period ratio, peak ground acceleration, P-structure eccentricity ratio, and NSC damping ratio. Appropriate constitutive relationships were used to model the behaviour of the RC P-structures. The NSCs were modelled as vertical cantilevers fixed at their bases with masses on the free ends and varying lengths so as to match the vibration periods of the P-structures. Full dynamic interaction was considered between the NSCs and P-structures. A set of seven natural bi-directional ground motions were used to evaluate the seismic response of the NSCs. The numerical results show that the acceleration response of the NSCs depends on the investigated parameters. The accelerations of the NSCs attached to the flexible sides of the P-structures increased with the increase in peak ground acceleration and P-structure eccentricity ratio but decreased with the increase in NSC damping ratio. Comparison between the FE results and Eurocode 8 (EC8) predictions suggests that, under tuned conditions, EC8 provisions underestimate the seismic response of the NSCs mounted on the flexible sides of the plan-irregular RC P-structures.

• The Journal of the Acoustical Society of Korea
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• v.9 no.4
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• pp.18-32
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• 1990

Deeping on purpose, SAW device may have to function while immersed in a liquid. Those who are familiar with SAW devices would anticipate difficulty since the propagating surface waves will tend to radiate energy into the liquid and hence suffer attenuation. Thus, to design an immerable SAW device, more attention and full information about the wave properites is required to overcome the attenuation and get the highest SAW generation eficiency. Though numerical simulation, the optimal geometry of underwater SAW devices, such as optimal piezoelectric crystal cut, SAW propagation direction and nondimensional wave number(ka) is determined to get the maximum SAW excitation efficiency, the minimum attenuation in propagation and pure mode propagation for all the modes of surface wave propagation. The design technique can be appliedto an arbitrary combination of a piezoelectric layer, a substrate and a liquid medium. In this paper, PZT and PVDF layers and a steel substrate are use for the solid medium. The technique can be easily employed for the design of underwater sensors and actuators for the applications, such as sonar marine antifouling, industrial and medical uses.

• Journal of KIISE:Computer Systems and Theory
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• v.37 no.1
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• pp.19-26
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• 2010

In this paper, we adopt Storage Class Memory, which is next-generation non-volatile RAM technology, as part of main memory parallel to DRAM, and exploit the SCM+DRAM main memory system from the dependability perspective. Our system provides instant system on/off without bootstrapping, dynamic selection of process persistence or non-persistence, and fast recovery from power and/or software failure. The advantages of our system are that it does not cause the problems of checkpointing, i.e., heavy overhead and recovery delay. Furthermore, as the system enables full application transparency, our system is easily applicable to real-world environments. As proof of the concept, we implemented a system based on a commodity Linux kernel 2.6.21 operating system. We verify that the persistence enabled processes continue to execute instantly at system off-on without any state and/or data loss. Therefore, we conclude that our system can improve availability and reliability.

• The KIPS Transactions:PartD
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• v.12D no.2 s.98
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• pp.283-288
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• 2005

Test case prioritization methods schedule test cases for execution when we can not practically run all test cases for regression testing. We proposed a new prioritization method that is based on historical execution and mr detection data. And we conducted an experiment to compare the proposed method with existing Random and LRU methods using the fault age under the long run environment as criterion. The experiment shows several interesting results. First, our results show that they are complementary. Random method shows good performance for programs that have many error-detectable test cases and HED is more effective for the programs that can be detected by very small amount of test cases. But LRU is more effective for the programs that have relatively medium amount of error detectable test cases. Next, the performance of prioritization method is affected by the size of test suites. Two experiments that have different size of test suites show considerably different fault ages and performance order. And lastly, the $20\%$ of test cases shows considerably good performance compared to the execution result of the full test suite.