• Journal of Magnetics
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• v.19 no.1
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• pp.20-27
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• 2014

This study examined the relationships between protein expression and Poly ADP ribose polymerase in brain cell death in brains damaged by thrombotic stroke and treated with the Full Wave- Cockroft Walton (FWCW) method of Transcranial Magnetic Stimulation (TMS). The two-way switching element for TMS drove a half-bridge inverter of the current resonance of direct current voltage (+) and direct current voltage (-), and the experiment was conducted by stimulating the mice with thrombotic stroke through a range of pulses. Thrombotic stroke was caused of ligation of the common carotid artery of male SD mice, and blood reperfusion was conducted five minutes later. Protein expression was examined in immune reaction cells, which reacted to an antibody to Poly ADP ribose polymerase in the cerebrum cells, and western blotting. Observations of the PARP changes after thrombotic stroke showed that the number of Poly ADP ribose polymerase reactions were significantly lower (p < 0.05) in the group treated with TMS of the FWCW than the group with thrombotic stroke 24 hours after its onset. The application of FWCW-TMS helped prevent the necrosis of nerve cells and might prevent the brain damage that occurs as a result of thrombotic stroke, and improve the function recovery and disorder of brain cells.

• Journal of Magnetics
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• v.16 no.3
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• pp.246-252
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• 2011

A high-voltage power supply has been built for activation of the brain via stimulation using a Full Wave Cockroft-Walton Circuit (FWCW). A resonant half-bridge inverter was applied (with half plus/half minus DC voltage) through a bidirectional power transistor to a magnetic stimulation device with the capability of producing a variety of pulse forms. The energy obtained from the previous stage runs the transformer and FW-CW, and the current pulse coming from the pulse-forming circuit is transmitted to a stimulation coil device. In addition, the residual energy in each circuit will again generate stimulation pulses through the transformer. In particular, the bidirectional device modifies the control mode of the stimulation coil to which the current that exceeds the rated current is applied, consequently controlling the output voltage as a constant current mode. Since a serial resonant half-bridge has less switching loss and is able to reduce parasitic capacitance, a device, which can simultaneously change the charging voltage of the energy-storage condenser and the pulse repetition rate, could be implemented. Image processing of the brain activity was implemented using a graphical user interface (GUI) through a data mining technique (data mining) after measuring the vital signs separated from the frequencies of EEG and ECG spectra obtained from the pulse stimulation using a 90S8535 chip (AMTEL Corporation).