• 한국추진공학회:학술대회논문집
• /
• 한국추진공학회 2010년도 제34회 춘계학술대회논문집
• /
• pp.369-372
• /
• 2010

HTPE와 HTPB 추진제에 대한 friability 시험을 수행하고 그 결과를 분석하였다. 추진제의 friability는 바인더함량, 기계적 특성 및 연소속도에 의해 영향을 받았으며 연소속도가 증가할수록 toughness가 낮아질수록 friability는 증가하는 경향을 보였다.

• 한국추진공학회:학술대회논문집
• /
• 한국추진공학회 2005년도 제24회 춘계학술대회논문집
• /
• pp.75-78
• /
• 2005

본 연구에서는 연소촉매인 Butacene과 $Cr_{2}O_3$를 함유하는 HTPB/AP 추진제 조성이 추진제의 friability에 미치는 영향을 조사하였다. Inston tensile tester와 strand burner를 이용하여 HTPB/AP 추진제의 기계적 특성과 연소속도를 측정하였다. 추진제의 탄속에 따른 shot-gun과 closed bomb 시험 결과로부터 추진제의 friability를 계산하였다. 결론적으로, 추진제의 조성 중 Butacene의 함량이 많은 추진제 또는 AP $6{\mu}m$의 함량이 많은 추진제가 friability가 큼을 알 수 있었다.

• 한국추진공학회지
• /
• 제9권2호
• /
• pp.40-45
• /
• 2005

본 연구에서는 연소촉매인 Butacene과 $Cr_2O_3$를 함유하는 HTPB/AP 추진제 조성이 추진제의 friability에 미치는 영향을 조사하였다. Inston tensile tester와 strand burner를 이용하여 HTPB/AP 추진제의 기계적 특성과 연소속도를 측정하였다 추진제의 탄속에 따른 shot-gun과 closed bomb 시험 결과로부터 추진제의 friability를 계산하였다. 결론적으로, 추진제의 조성 중 Butacene의 함량이 많은 추진제 또는 AP $6{\mu}m$의 함량이 많은 추진제가 friability가 큼을 알 수 있었다.

• 한국추진공학회지
• /
• 제15권1호
• /
• pp.29-34
• /
• 2011

Hydroxyl terminated polyether(HTPE) 추진제는 전술용 모터에 현재까지도 적용되고 있는 HTPB/AP 추진제를 대체할 수 있는 추진제로서 최근에 개발되고 있다. 본 연구에서는 HTPE와 HTPB 추진제에 대한 파쇄성 시험을 수행하고 그 결과를 분석하였다. 추진제의 파쇄성은 바인더함량, 기계적 특성 및 연소속도에 의해 영향을 받았으며 연소속도가 증가할수록 기계적 인성이 낮아질수록 파쇄성은 증가하는 경향을 보였다.

• 한국군사과학기술학회지
• /
• 제4권1호
• /
• pp.20-29
• /
• 2001

We recently developed a friability test procedure, which will be used as one of substance tests for Extremely Insensitive Detonating Substances(EIDSs) in Test Series 7 of the United Nations. This test was intended to assess the susceptibility of insensitive explosives to the break-up as high strain rate and subsequent ignition characteristics of the deformed material. We designed an air gun system using the hydro code simulation. The projectile velocities of the gun were in good agreement with those predicted by the hydro code with an inert material. Three different types of explosives, melt castable Comp B, castable plastic bonded explosives(PBXs), and pressable PBXs were tested during the development of the test procedure. Two tastable PBXs, i.e. DXD-09 and DXD-10, which are currently under development as candidate formulations of EIDS were classified as EIDS, since test results with these formulations were far better than the criterion of the UN Test Series 7.

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2002년도 춘계학술대회 논문집
• /
• pp.952-955
• /
• 2002

$WC-3%(Cr_3C_2)-2%(Mo_2C)-12%Ni$ carbides were ground with three different types of electroplated diamond wheels with respect to grain friability. The grinding ratio in the case of the highest toughness grains, A becomes the highest at the workpiece speeds of 40 and 70mm/min exhibiting larger effect with smaller workpiece speed. The grinding ratio with the medium toughness grain is higher than that of grain A at higher workpiece speeds than 100mm/min. The surface roughness becomes smaller with increasing the grain friability The increasing rate on surface roughness with the increase of workpiece speed becomes higher with using the grain of lower friability.

• Journal of Pharmaceutical Investigation
• /
• 제2권2호
• /
• pp.18-33
• /
• 1972

Pharmaceutical Study on the Compressed tablets. Hardness, Friability, Disintegration time and Coefficient of Variance of Compressed tablets. Soo Uck Kim, Sung Hoon seo and Hyun Woo Lee (Department of Pharmaceutics, College of Pharmacy, Kyung Hee University) In order to know Hardness, Friability, Disintegration time and Coefficient of variance of the pharmaceutical tablets the 135 tablets sampled from market were tested in the paper. The samples tested in this paper were as follows: Antipyretics and Analgetics 41 Stomach and Digestives 22 Antituberculars 19 Vitamins 12 Sulfa drugs 9 Others (Antihistaminics etc) 32 Total 135 The results of the investigation are shown in table 1-8, Fig 1-Fig 6. Mean values of Hardness, Friability, Disintegration time and Coefficient of variance in each pharmaceutical preparation are as follows. Antipyretics and Analgetics : Hardness(kg) = 5.83 Antipyretics and Analgetics : Friabil.(%) = 0.82 Antipyretics and Analgetics : Disint.t.(min) = 5.28' Antipyretics and Analgetics : Coeff. of V.(%) = 2.90 Stomach and Digestives : Hardness(kg) = 4.11 Stomach and Digestives : Friabil.(%) = 0.71 Stomach and Digestives : Disint.t.(min) = 3.43' Stomach and Digestives : Coeff. of V.(%) = 2.76 Antituberculars : Hardness(kg) = 4.78 Antituberculars : Friabil.(%) = 0.52 Antituberculars : Disint.t.(min) = 4.32' Antituberculars : Coeff. of V.(%) = 2.99 Vitamins : Hardness(kg) = 1.60 Vitamins : Friabil.(%) = 0.43 Vitamins : Disint.t.(min) = 4.10' Vitamins : Coeff. of V.(%) = 3.19 Sulfa drugs : Hardness(kg) = 4.77 Sulfa drugs : Friabil.(%) = 0.37 Sulfa drugs : Disint.t.(min) = 3.10' Sulfa drugs : Coeff. of V.(%) = 2.09 Others : Hardness(kg) = 2.40 Others : Friabil.(%) = 0.66 Others : Disint.t.(min) = 2.19' Others : Coeff. of V.(%) = 3.10 The following summeries might be shown; 1. Ranges of Hardness, Friability, Disintegration time and Coefficient of variance are respectively 1.6 to 5.38 kg, 0.37 to 0.82%, 2 minut 19 second to 5 minut 28 second and 2.09 to 3.10%. 2. According to the results, it could be indicated that higher Hardness shows lower Friability. 3. Against the general conception between Hardness and Disintegration time, higher Hardness shows lower Disintegration time. 4. It seems that higher mean weight shows lowcr Coefficient variance.

• 생명과학회지
• /
• 제33권3호
• /
• pp.268-276
• /
• 2023

본 연구는 carvedilol과 ivabradine의 이층정 제형 개발에 있어 carvedilol 속방층의 제형조건을 최적화하기 위해 수행되었다. Full-factorial design of experiments를 사용하여 carvedilol 속방층(wet granulation part)의 첨가제(microcrystalline cellulose, citric acid, crospovidone) 및 타정 시 공정변수(main compression)를 확인하였고 각 독립변수에 대한 7가지 종속변수(함량, 함량 균일성, 경도, 마손도, 붕해, 용출(pH 1.2 및 6.8)를 design expert software를 사용하여 평가하였다. Design of experiments (DoE) 실험에서 도출된 Analysis of Variance (ANOVA) 결과를 통해 main compression은 경도, 마손도, 붕해 시간에 유의한 영향을 주었고, microcrystalline cellulose는 마손도, 용출에 주요한 영향을 주었음을 확인하였다. 또한, citric acid는 마손도, crospovidone은 마손도, 용출에 주요한 영향을 주었음을 확인하였다. DoE실험 결과를 종합하여 최종적으로 도출된 설계공간에 따라 microcrystalline cellulose (약 18.0-32.0 mg), citric acid (약 0.5-12.0 mg), main compression (약 615-837 kgf)의 최적의 범위 내에서 초기 위험평가에서 평가된 모든 위험요인이 제거된 carvedilol 속방층의 최적 제조 범위를 확인하였다.

• Journal of Pharmaceutical Investigation
• /
• 제4권4호
• /
• pp.26-37
• /
• 1974

Having measured physical canstant and dissolution rate of prednisolone powder, and tablets, also particle size, particle number of powder disintegration, hardness, friability of prednisolone tablets and having also compared it's interrelationship. We obtained the results as following. 1) Dissolution rate of prednisolone powder was determinded cube root rule and: the slope $({\alpha})$ was $3.1915{\times}10^{-2}$. 2) The tablet used in this study was fourteen kind of prednisolone tablets, two kinds of which were not conformity with prednisolone dissolution rate test of U.S.P. XVIII, but the rest of them were conformity with the same test (t60% was 4.3minute in average) 3) There was no significant interrelationship between disintegration, hardness, friability and dissolution rate of prednisolone tablet used in this study but we recognized the disintegration time was greatly influenced by the dissolution rate.

• Journal of Pharmaceutical Investigation
• /
• 제6권2호
• /
• pp.69-82
• /
• 1976

Tablet product design problem was structured as constrained optimization problem and subsequently solved by multiple regression analysis and Lagrangian method of optimization. We used Lagrangian method for the purpose of finding the reason of the previous results. Biodiastase and cellulase were the enzymes, chosen, $Avicel{\circledR}$ and corn starch or calcium carboxy methyl cellulose were the binder and disintegrant, respectively. The effect of the dry binder and disintegrant concentration on tablet hardness, friability, volume, disintegration time was recorded. Optimization of this parameter was studied by using the constrained optimization method. In addition to finding a optimal condition of the enzyme tablets, the application of sensitivity analysis studies to such problems was also illustrated. In order to get a stable preparations of the enzyme tablets, accelerated test of coating tablets was carried out in this study. the results are as follows. 1) The minimum disintegration time, such that the average tablet volume did not exceed 0.0154 cubic inch and the average friability value did not exceed 0.62%, was 6.6 minutes and then $Avicel{\circledR}$ and corn starch were 15.4% and 17.2%, respectively. 2) The multiple-correlation coefficients for the regression models of tablet hardness, friability, disintegration time and volume were with in the 95% confidence range. 3) According to the test results, calcium carboxymethyl cellulose can be used as a disintegrant instead of corn starch.