• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2010.05a
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• pp.369-372
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• 2010

As analyzing friability of HTPE and HTPB propellants, the following results could be derived. The friability of the tested propellants depended on its binder contents, mechanical property, and burning rate. It was decreased as burning rate was lowered and toughness was increased.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• v.y2005m4
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• pp.75-78
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• 2005

The present work has been studied to investigate the effect of formulation on friability of HTPB/AP propellants including Butacene and $Cr_{2}O_3$. The mechanical properties and burning rate of the propellants were measured using Inston tensile tester and strand burner, respectively. Friability was calculated by shot-gun and closed bomb test. The result showed that friability was higher, as the content of Butacene or AP $6{\mu}m$ in the propellant formulations was increased.

• Journal of the Korean Society of Propulsion Engineers
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• v.9 no.2
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• pp.40-45
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• 2005

In the present work, the effect of formulation on friability of HTPB/AP propellants including Betacene and $Cr_2O_3$ has been studied. The mechanical properties and burning rate of the propellants were measured using Inston tensile tester and strand burner, respectively. Friability was calculated from shot-gun and closed bomb test data. The result showed that friability was higher, as the content of Butacene or AP $6{\mu}m$ in the propellant formulations was increased.

• Journal of the Korean Society of Propulsion Engineers
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• v.15 no.1
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• pp.29-34
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• 2011

Hydroxyl terminated polyether(HTPE) propellants have been developed recently as possible replacements for HTPB/AP propellants currently used in a number of tactical rocker motor. As analyzing friability of HTPE and HTPB propellants in this study, the following results could be derived. The friability of the tested propellants depended on its binder contents, mechanical property, and burning rate. It was decreased as burning rate was lowered and toughness was increased.

• Journal of the Korea Institute of Military Science and Technology
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• v.4 no.1
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• pp.20-29
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• 2001

We recently developed a friability test procedure, which will be used as one of substance tests for Extremely Insensitive Detonating Substances(EIDSs) in Test Series 7 of the United Nations. This test was intended to assess the susceptibility of insensitive explosives to the break-up as high strain rate and subsequent ignition characteristics of the deformed material. We designed an air gun system using the hydro code simulation. The projectile velocities of the gun were in good agreement with those predicted by the hydro code with an inert material. Three different types of explosives, melt castable Comp B, castable plastic bonded explosives(PBXs), and pressable PBXs were tested during the development of the test procedure. Two tastable PBXs, i.e. DXD-09 and DXD-10, which are currently under development as candidate formulations of EIDS were classified as EIDS, since test results with these formulations were far better than the criterion of the UN Test Series 7.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.05a
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• pp.952-955
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• 2002

$WC-3%(Cr_3C_2)-2%(Mo_2C)-12%Ni$ carbides were ground with three different types of electroplated diamond wheels with respect to grain friability. The grinding ratio in the case of the highest toughness grains, A becomes the highest at the workpiece speeds of 40 and 70mm/min exhibiting larger effect with smaller workpiece speed. The grinding ratio with the medium toughness grain is higher than that of grain A at higher workpiece speeds than 100mm/min. The surface roughness becomes smaller with increasing the grain friability The increasing rate on surface roughness with the increase of workpiece speed becomes higher with using the grain of lower friability.

• Journal of Pharmaceutical Investigation
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• v.2 no.2
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• pp.18-33
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• 1972

Pharmaceutical Study on the Compressed tablets. Hardness, Friability, Disintegration time and Coefficient of Variance of Compressed tablets. Soo Uck Kim, Sung Hoon seo and Hyun Woo Lee (Department of Pharmaceutics, College of Pharmacy, Kyung Hee University) In order to know Hardness, Friability, Disintegration time and Coefficient of variance of the pharmaceutical tablets the 135 tablets sampled from market were tested in the paper. The samples tested in this paper were as follows: Antipyretics and Analgetics 41 Stomach and Digestives 22 Antituberculars 19 Vitamins 12 Sulfa drugs 9 Others (Antihistaminics etc) 32 Total 135 The results of the investigation are shown in table 1-8, Fig 1-Fig 6. Mean values of Hardness, Friability, Disintegration time and Coefficient of variance in each pharmaceutical preparation are as follows. Antipyretics and Analgetics : Hardness(kg) = 5.83 Antipyretics and Analgetics : Friabil.(%) = 0.82 Antipyretics and Analgetics : Disint.t.(min) = 5.28' Antipyretics and Analgetics : Coeff. of V.(%) = 2.90 Stomach and Digestives : Hardness(kg) = 4.11 Stomach and Digestives : Friabil.(%) = 0.71 Stomach and Digestives : Disint.t.(min) = 3.43' Stomach and Digestives : Coeff. of V.(%) = 2.76 Antituberculars : Hardness(kg) = 4.78 Antituberculars : Friabil.(%) = 0.52 Antituberculars : Disint.t.(min) = 4.32' Antituberculars : Coeff. of V.(%) = 2.99 Vitamins : Hardness(kg) = 1.60 Vitamins : Friabil.(%) = 0.43 Vitamins : Disint.t.(min) = 4.10' Vitamins : Coeff. of V.(%) = 3.19 Sulfa drugs : Hardness(kg) = 4.77 Sulfa drugs : Friabil.(%) = 0.37 Sulfa drugs : Disint.t.(min) = 3.10' Sulfa drugs : Coeff. of V.(%) = 2.09 Others : Hardness(kg) = 2.40 Others : Friabil.(%) = 0.66 Others : Disint.t.(min) = 2.19' Others : Coeff. of V.(%) = 3.10 The following summeries might be shown; 1. Ranges of Hardness, Friability, Disintegration time and Coefficient of variance are respectively 1.6 to 5.38 kg, 0.37 to 0.82%, 2 minut 19 second to 5 minut 28 second and 2.09 to 3.10%. 2. According to the results, it could be indicated that higher Hardness shows lower Friability. 3. Against the general conception between Hardness and Disintegration time, higher Hardness shows lower Disintegration time. 4. It seems that higher mean weight shows lowcr Coefficient variance.

• Journal of Life Science
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• v.33 no.3
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• pp.268-276
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• 2023

This study was conducted to optimize the formulation conditions of the immediate-release layer of carvedilol in the development of a two-layer tablet formulation for carvedilol and ivabradine. Using a 2⁴+3 full-factorial design of experiments, excipients (microcrystalline cellulose, citric acid, and crospovidone) of the carvedilol immediate-release layer (wet granulation part) and process parameters for the tablet compression process (main compression) were optimized, and seven types of each dependent variable (assay, content uniformity, hardness, friability, disintegration, and dissolution [pH 1.2 and 6.8]) were evaluated using design expert software. The analysis of variance results confirmed that the main compression has a significant effect on hardness, friability, and disintegration time and that microcrystalline cellulose has a major effect on friability and dissolution. In addition, it was confirmed that citric acid has a significant effect on friability. Crospovidone affects friability and dissolution. According to the design space from the design of the experiment results, the optimized range is microcrystalline cellulose (~18.0-32.0 mg), citric acid (~0.5-12 mg), and main compression (~615-837 kgf). Consequently, this study confirmed the availability of manufacturing the carvedilol immediate-release layer in which all risk factors evaluated in the initial risk assessment are removed.

• Journal of Pharmaceutical Investigation
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• v.4 no.4
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• pp.26-37
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• 1974

Having measured physical canstant and dissolution rate of prednisolone powder, and tablets, also particle size, particle number of powder disintegration, hardness, friability of prednisolone tablets and having also compared it's interrelationship. We obtained the results as following. 1) Dissolution rate of prednisolone powder was determinded cube root rule and: the slope $({\alpha})$ was $3.1915{\times}10^{-2}$. 2) The tablet used in this study was fourteen kind of prednisolone tablets, two kinds of which were not conformity with prednisolone dissolution rate test of U.S.P. XVIII, but the rest of them were conformity with the same test (t60% was 4.3minute in average) 3) There was no significant interrelationship between disintegration, hardness, friability and dissolution rate of prednisolone tablet used in this study but we recognized the disintegration time was greatly influenced by the dissolution rate.

• Journal of Pharmaceutical Investigation
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• v.6 no.2
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• pp.69-82
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• 1976

Tablet product design problem was structured as constrained optimization problem and subsequently solved by multiple regression analysis and Lagrangian method of optimization. We used Lagrangian method for the purpose of finding the reason of the previous results. Biodiastase and cellulase were the enzymes, chosen, $Avicel{\circledR}$ and corn starch or calcium carboxy methyl cellulose were the binder and disintegrant, respectively. The effect of the dry binder and disintegrant concentration on tablet hardness, friability, volume, disintegration time was recorded. Optimization of this parameter was studied by using the constrained optimization method. In addition to finding a optimal condition of the enzyme tablets, the application of sensitivity analysis studies to such problems was also illustrated. In order to get a stable preparations of the enzyme tablets, accelerated test of coating tablets was carried out in this study. the results are as follows. 1) The minimum disintegration time, such that the average tablet volume did not exceed 0.0154 cubic inch and the average friability value did not exceed 0.62%, was 6.6 minutes and then $Avicel{\circledR}$ and corn starch were 15.4% and 17.2%, respectively. 2) The multiple-correlation coefficients for the regression models of tablet hardness, friability, disintegration time and volume were with in the 95% confidence range. 3) According to the test results, calcium carboxymethyl cellulose can be used as a disintegrant instead of corn starch.