• BMB Reports
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• v.51 no.9
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• pp.437-443
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• 2018

Non-homologous end joining (NHEJ), and to a lesser extent, the error-free pathway known as homology-directed repair (HDR) are cellular mechanisms for recovery from double-strand DNA breaks (DSB) induced by RNA-guided programmable nuclease CRISPR/Cas. Since NHEJ is equivalent to using a duck tape to stick two pieces of metals together, the outcome of this repair mechanism is prone to error. Any out-of-frame mutations or premature stop codons resulting from NHEJ repair mechanism are extremely handy for loss-of-function studies. Substitution of a mutation on the genome with the correct exogenous repair DNA requires coordination via an error-free HDR, for targeted transgenesis. However, several practical limitations exist in harnessing the potential of HDR to replace a faulty mutation for therapeutic purposes in all cell types and more so in somatic cells. In germ cells after the DSB, copying occurs from the homologous chromosome, which increases the chances of incorporation of exogenous DNA with some degree of homology into the genome compared with somatic cells where copying from the identical sister chromatid is always preferred. This review summarizes several strategies that have been implemented to increase the frequency of HDR with a focus on somatic cells. It also highlights the limitations of this technology in gene therapy and suggests specific solutions to circumvent those barriers.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.2
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• pp.288-307
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• 2013

This paper formulates resource allocation for decode-and-forward (DF) relay assisted multi-cell orthogonal frequency division multiple (OFDM) networks as an optimization problem taking into account of inter-cell interference and users fairness. To maximize the transmit rate of system we propose a joint interference coordination, subcarrier and power allocation algorithm. To reduce the complexity, this semi-distributed algorithm divides the primal optimization into three sub-optimization problems, which transforms the mixed binary nonlinear programming problem (BNLP) into standard convex optimization problems. The first layer optimization problem is used to get the optimal subcarrier distribution index. The second is to solve the problem that how to allocate power optimally in a certain subcarrier distribution order. Based on the concept of equivalent channel gain (ECG) we transform the max-min function into standard closed expression. Subsequently, with the aid of dual decomposition, water-filling theorem and iterative power allocation algorithm the optimal solution of the original problem can be got with acceptable complexity. The third sub-problem considers dynamic co-channel interference caused by adjacent cells and redistributes resources to achieve the goal of maximizing system throughput. Finally, simulation results are provided to corroborate the proposed algorithm.

• The Research Journal of the Costume Culture
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• v.17 no.6
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• pp.1021-1033
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• 2009

This study aimed to analyze the expression of Hybrid in Contemporary Hair Design that is one kind of total fashion. In this research, by background of the hybrid characteristics of the messes culture art, the hybrid characteristics of the hair design has been defined as characters which is the mixture of timeless spaces, styles, sexes, unsuitable elements and cultures. The results of analysis by the expression of the hybrid hair design after 2000 is like this. As the researching, the hybrid characteristics of the hair design by the mixture of unsuitable elements and styles have been presented the highest. The result of the frequency of the apparition in the hair design molding elements according to the expression of the hybrid hair design, the hybrid characteristics of the unsuitable elements and style has been presented ideological form and the artificial form was the highest. The case of the hybrid of the activated texture, the unsuitable elements, style and timeless space has been presented excellently one after another. In the color tone, the mixture of the style, the unsuitable elements and timeless space has been presented one by one. The case of the hybrid of the image, the unsuitable elements that is the highest the frequency of the apparition was presented the image of the avant-garde, the fantastic and humor one after another.

• Proceedings of the KIEE Conference
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• 2004.05b
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• pp.227-230
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• 2004

The Co-Gen System which maximize energy efficiency was installed at the industrial plants at the initial stage. However Small Scale Co-Gen System was expanded even to the general end-users such as housing and building owing to ESCO business recently. For this SSC, inter-connected operation to the utility is desirable due to voltage and frequency fluctuation following to unbalance between power output and load. Then voltage unbalance with utility system, frequency, increase of short circuit capacity, reclosing, and ALTS etc. should be fully considered for the inter-connected operation. Voltage variation, protection coordination, Co-Generators single running, and short circuit capacity should also be solved. For Con-Gen users, the several protection relays are recommended to install at the user's main incoming panel by the guide lines and/or instructions of the interconnected utility Then user's main CB(Circuit Breaker) have the chance to be tripped by some of this recommended relays and users have to undergo the unexpected blackout. So the circuit breaker trip schemes targeted to trip with these protection relays are reconsidered and the study result is hereunder proposed.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.3
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• pp.886-900
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• 2015

Small cells are deployed in Heterogeneous Networks (HetNet) to improve overall performance. These access points can provide high-rate mobile services at hotspots to users. In a Small Cell Network (SCN), the good deployment of small cells can guarantee the performance of users on the basis of average and cell edge spectrum efficiency. In this paper, the performance of small cell deployment is analyzed by using system-level simulations. The positions of small cells can be adjusted according to the deployment radius and angle. Moreover, different Inter-Cell Interference Coordination (ICIC) techniques are also studied, which can be implemented either in time domain or in frequency domain. The network performances are evaluated under different ICIC techniques when the locations of Small evolved Nodes (SeNBs) vary. Simulation results show that the average throughput and cell edge throughput can be greatly improved when small cells are properly deployed with the certain deployment radius and angle. Meanwhile, how to optimally configure the parameters to achieve the potential of the deployment is discussed when applying different ICIC techniques.

• Journal of Fashion Business
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• v.10 no.5
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• pp.15-27
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• 2006

The purpose of this study is to evaluate the differences of visual image by variations in the location of the waistline and the width of the round belt of the basic pants. The stimuli are 21 samples: 7 variations of the location of the waistline and 3 variations of the width of the belt. The data has been obtained from 35 fashion design majors. The data has analyzed by frequency, factor analysis, anova, scheffe's test and the MCA method. The visual image by the location of waistline and the width of belt are composed of 3 factors : modernity, comfort and attraction factor. In these factors, modernity factor is estimated as the most important factor. The visual image is modern and attractive as the location of waist line goes down. And when the location of waist line is in the position of natural waist belt, belt of 3.2cm width is visually effective. Belt of 4.2cm width is effective except the position of natural waist belt. The interaction effects between the location of the waistline and the width of the belt have significant differences in comfort and attraction factors. As the main effect, significant differences were observed in all of the three factors according to the location of waistline and the width of belt.

• Journal of the Korea Fashion and Costume Design Association
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• v.9 no.2
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• pp.69-83
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• 2007

The purpose of this study was to investigate the differences in the hairdo involvement and hairdo attitude influenced by clothing involvement. In addition, actual conditions of hairdo were investigated. The questionnaires were given to female residents in Seoul and Gyeong-gi province during September to October 2006. Four hundred and six questionnaires were used for data analysis. The collected data were analyzed by using SPSS 12.0 software with various techniques such as factor analysis, Cronbach's alpha, cluster analysis, ANOVA test, Duncan test, frequency analysis and $X^2-test$. The results of this study were as follows; 1. The factors for clothing involvement were found to be interests and pleasure in clothes, coordination of clothes, symbolic representation, fashionableness, and risk awareness. The hairdo involvement factors were found to be interests and pleasure in hairdo, fashionableness, symbolic representation, risk awareness, and coordination of hairdo. The factors for attitude toward hairdo were found to be orientations toward leader's fashion conformity, distinct individuality, constancy, and consciousness of others. 2. According to the level of clothing involvement, three types of group were defined. When difference in the hairdo involvement was analyzed, all factors showed significant differences. When difference in the hairdo attitude was analyzed, significant differences were found in orientations toward leader's fashion conformity, distinct individuality and consciousness of others. 3. Reason for choosing hair style is 'it's because they wanted the hair style', 'it's easy to groom', 'it's what they usually choose'. Average hair grooming time is less than 5 minute had higher rate, and then less than 10 minute came second. The money spend on buying consumption goods for hair treatment per month had the highest rate on spending 10,000 to 20,000won and the source of information on hairdo had the highest rate on hairdresser. The reason for choosing hair saloon had the highest rate on hairdressing skill, which shows that people choose hair saloons which they can trust on hair saloon's hairdressing skill.

• Fashion & Textile Research Journal
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• v.20 no.4
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• pp.400-409
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• 2018

The purpose of this study was to identify the appearance-oriented, appearance-related consumption behavior according to appearance instrumentality. Questionnaires were administered to 460 males and females of 20 to 30 living in Daegu. The SPSS 20.0 package was utilized for data analysis which included frequency analysis, factor analysis, cronbach's ${\alpha}$, t-test, regression analysis. Three factors of appearance instrumentality (social achievement, sexual attractiveness, social relationship formation), two factors of appearance-oriented and five factors of appearance-related consumption behavior were utilized for the problem analysis of the study. The results of this study were: First, there was significant differences in the appearance coordination oriented and appearance management oriented according to group of social achievement (high, low) and group of sexual attractiveness (high, low). But social relationship formation(high, low) had not significant differences in appearance oriented. Second, group of social achievement (high, low) were significant differences in cosmetic surgery behavior and fashion behavior, group of sexual attractiveness (high, low) showed a significant differences in cosmetic surgery behavior, hair management behavior and fashion behavior. But group of social relationship formation (high, low) had not significant differences on all of appearance management behavior. Third, appearance coordination oriented was a influences on beauty management behavior, cosmetic surgery behavior, hair style management behavior, fashion behavior. And appearance management oriented was influences on body management behavior, hair style management behavior, fashion behavior.

• The Journal of the Petrological Society of Korea
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• v.10 no.3
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• pp.233-245
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• 2001

With the advent of super-conducting magnet, NMR spectroscopy becomes a very important tool in geology as well as in chemistry. $^{29}Si$ and $^{27}Al$ which are the main components of minerals and contain structural informations, are useful major targets for the NMR study in geology, but some other elements including alkali cations such as $^{23}Na$ are also one of them. NMR can be applied to many different fields. For example, it can be applied to study smaller range of structure (in molecular level) than XRD and TEM. NMR provides us with structural informations such as order-disorder in Al and Si distribution, oxygen coordination number, and distribution of other cations. Another important information that we can obtain from NMR is not only the static structural informations, but also the molecular dynamics. This dynamic informations of molecules also enable us to figure out the frequency of molecular motion and activation energy. Structure of amorphous minerals and chemistry and structure of natural organic materials are also studied by NMR.

• The Journal of Korean Physical Therapy
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• v.24 no.2
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• pp.151-156
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• 2012

Purpose: The purpose of this study was to investigate the adverse effects of sensorimotor function at the shoulder joint according to long-term cane usage in stroke patients without apraxic behavior, in terms of the presence of shoulder joint pain, accuracy of tracking task, proprioceptive joint position sense, and nine-hole pegboard. Methods: Nineteen stroke patients with long-term cane usage (cane usage group) and nineteen stroke patients without cane usage (non-cane usage group) were recruited. All subjects were tested in pain presence, a tracking task for visuomotor function, joint reposition, and nine-hole pegboard in the shoulder joint regarding the non-affected side. Results: In the accuracy index for tracking task and the nine-hole pegboard test, significant differences were observed between the cane usage group and the non-cane usage group. However, although a higher emergence of shoulder pain and a lower accuracy for joint reposition sense were detected in the cane usage group in comparison to the non-cane usage group, there were no significant differences between the two groups. Conclusion: Our findings suggest that long-term cane usage could induce to decrease in delicate movement and coordination in the non-affected upper arm in stroke patients. In addition, they could experience high frequency of shoulder pain and poor joint reposition sense. Therefore, careful evaluation and observation will be required concerning stroke patients with long-term cane usage.