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Antioxidant Activity of Cercis chinensis and Its Protective Effect on Skin Aging

  • Na, Min-Kyun;Bae, Ki-Hwan;Hong, Nam-Doo;Yoo, Jae-Kuk;Nobuhiko Miwa
    • Proceedings of the SCSK Conference
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    • 2003.09a
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    • pp.291-312
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    • 2003
  • Reactive oxygen species are capable of damaging biomolecules such as lipids, proteins, and DNA, which can not only lead to various diseases, but also oxidative damage resulting aging. In our previous study, Cercis chinensis (Leguminosae) showed a potent antioxidant activity. Nineteen compounds were isolated through antioxidant activity-guided fractionation. The C. chinensis extract and some of the constituents exhibited a potent antioxidant activity on the free radicals and lipid peroxidation and a notable protective effect on the t-BuOOH induced oxidative damage. In vivo test of skin damage induced by UVB irradiation, the extract of C. chinensis and a constituent, piceatannol, exhibited a significant protective effect. The life-span of the HEK-N/F cells were extended by 1.21-2.12 fold as a result of the continuous administration of 3 $\mu\textrm{g}$/ml of the C. chinensis extract and the active constituents compared to that of the control. These observations were attributed to the inhibitory effect of the C. chinensis extract and its constituents on the age-dependent shortening of the telomere. Thus, C. chinensis was demonstrated to protect the skin cells against oxidative stress and inhibit thereby the cellular aging, followed by expectation as anti-aging cosmetic ingredient.

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Management Plan for Mobile Contents Bypassing In App Billing Application (모바일 컨텐츠 인앱 결제 우회 애플리케이션에 대한 대처 방안)

  • Lee, Sang-Ho;Shin, Miyea
    • Journal of Convergence Society for SMB
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    • v.5 no.3
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    • pp.21-26
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    • 2015
  • As mobile contents grow up, In App Billing is brisk at applications including mobile contents. But some of users don't pay and use charged content for free to use cheating payment module or hacking through applications. Call this bypass payment. Applications, helping bypass, are Freedom, IAP Cracker, and DNS server suggested by the hacker named Borodin. In case of mobile game, Despite sell a lot of charged content but income is different revenue in sales log with real profits. Because of users using bypass payment application. Management plan to bypass payment are checking OrderID, encrypting public key and verifying receipt.

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Effects of Nursing Education using a TBL on Self efficacy and Self Identity among Nursing students

  • Kim, Jung-ae
    • International Journal of Advanced Culture Technology
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    • v.5 no.2
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    • pp.26-43
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    • 2017
  • This study investigated the effects of TBL nursing education(for the care of congestive heart failure patients) on self identity and self efficacy among nursing students. A one-group, pre-post design was utilized with 28 nursing students as the participants. The scenario of TBL nursing education was created based on PBL, and consisted of four states(1) Present a problem, (2) Problem Follow-Up Steps,(3) Present the results including presentation, and(4) Problem Conclusion and after resolution. And then In-depth interviews were conducted with volunteers on program experiences. The data were analyzed using descriptive statistics, Pearson's correlation coefficients and paired t-tests and Giorgi phenomenology analysis method was performed. The TBL program was effective in self - efficacy and self - identity (p<0.01) increased significantly after the education intervention and The meaning of the TBL experience is four (meaning that the learners embarrassed TBL, aggressive learning attitude change, effective collaboration for problem solving in a free learning environment, university classes imagined in high school), and 67 sub-components appeared as an element. The TBL program is an effective teaching method for nursing education and it can be used as basic data for the development of nursing education based on this research.

The Influence of Meshing Strategies on the Propeller Simulation by CFD

  • Bahatmaka, Aldias;Kim, Dong-Joon
    • Journal of Advanced Research in Ocean Engineering
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    • v.4 no.2
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    • pp.78-85
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    • 2018
  • This paper presents a study of the effects of the free surface to marine propeller including the mesh effect of the models. In the present study, we conduct the numerical simulation for propeller performance employing the openwater test. The numerical simulations compare the meshing strategies for the propeller and show the effects on both thrust and torque. OpenFOAM is applied to solve the propeller problem and then open water performances of KCS propeller (KP505) are estimated using a Reynold-averaged Navier-Stokes equations (RANS) solver and the turbulence of the $K-{\omega}$ SST model. Unstructured meshes are used in the numerical simulation employing hexahedral meshing for mesh generation. The arbitrary mesh interfacing (AMI) and multiple rotating frame (MRF) are compared to define the best meshing strategy. The meshing strategies are evaluated through 3 classifications, i.e., coarse, medium, and fine mesh. Thus, the propeller can be performed utilizing the best mesh strategy. The computational results are validated by comparison with the experimental results. The $K_T$, $K_Q$, and efficiency of the propeller are compared to an experimental result and for all of the meshing strategies. Thus, the simulations show the influence of meshing in order to perform the propeller performances.

Antioxidant Activity and Total Phenolic Content of Triphala churna

  • Jayajothi, E.;Elavarasu, T.;Hamsaveni, M.;Sridhar, S.K.
    • Natural Product Sciences
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    • v.10 no.1
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    • pp.16-19
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    • 2004
  • Triphala churna is a widely used herbal formulation that contains equal proportion of dried fruit powder of Emblica officinalis, Terminalia chebula and Terminalia belirica. In the Indian system of medicine, it is used in cleaning wounds, urinary disorders, diabetes mellitus, leprosy, constipation, eyesight promotion, piles, and as a rejuvenator. In the present study, the methanolic extract of 5 commercial Triphala was evaluated for antioxidant activity by 1,1-diphenyl-2-picryl-hydrazyl free radical scavenging method, total phenolic content by Folin-Ciocalteu method and gallic acid equivalents (GAE) by high performance thin layer chromatographic (HPTLC) method. All extracts exhibited antioxidant activity significantly. The $IC_{50}$ of the extracts ranged between $7.16\;to\;12.96\;{\mu}g/ml$. The total phenolic content of the extracts was found to be 195.3-296.4 mg of GAE/gm of GAE/gm dw. The HPTLC chromatographic data reveal that the content of GAE present in the extract was found to be $7.17-4.11\;{\mu}g/ml$. The study reveals that out of the churnas analysed, C was found to exhibit the most potent antioxidant activity. A clear correlation between $IC_{50}$ and content of GAE nor the total phenolic content could be observed. The study reveals that the consumption of Triphala would exert several beneficial effects by virtue of its antioxidant activity.

MDM2 (RS769412) G>A Polymorphism in Cigarette Smokers: a Clue for the Susceptibility to Smoking and Lung Cancer Risk

  • Ahmad, Dilshad;Bakairy, Abdul Karieem;Katheri, Abdull Malika;Tamimi, Waleed
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.9
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    • pp.4057-4060
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    • 2015
  • Cigarette smoke contains oxidants and free radicals which are carcinogens that can induce mutations in humans. Single nucleotide polymorphisms (SNPs) are the most frequent genetic alterations found in the human genome. In the present study, we have examined the ability of the murine double minute 2 (Mdm2) (rs769412) A>G polymorphism in cigarette smokers to predict risk of cancers. Our results showed that of smokers, 87% were found with AA genotype, 10% with heterozygous AG genotype, and 3% with GG genotype. The heterozygous AG genotype was observed in a lower percentage of smokers (10%) as compared to non-smokers (18%), whereas, homozygous AA genotype was observed in lower percentage of non-smokers (81%) as compared to the smokers (87%). The results from present study support the association with an allele and AG genotype in non-smokers. However, further studies are required to establish the role of Mdm2 (rs769412) C>T in cigarettes smokers and diseases.

The Effect of Imidazole and 2-Methyl Imidazole on the Corrosion of Mild Steel in Phosphoric Acid Solution

  • Chandrasekara, V.;Kannan, K.;Natesan, M.
    • Corrosion Science and Technology
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    • v.4 no.5
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    • pp.191-200
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    • 2005
  • Two azole compounds viz., Imidazole (IM) and 2-Methylimidazole (2-MIM) were studied to investigate their inhibiting action on corrosion of mild steel in phosphoric acid ($H_3PO_4$) solution by mass loss and polarization techniques at 302K-333K. It has been found that the inhibition efficiency of the all inhibitors increased with increase in inhibitor concentration and decreases with increasing temperature and also with increase in acid concentrations. The inhibition efficiency of these compounds showed very good inhibition efficiency. At 0.5% of IM and 2-MIM in 1N and 5N phosphoric acid solution at 302K to 333K for 5 hours immersion period, the inhibition efficiency of 2-Methylimidazole found to be higher than Imidazole. The adsorption of these compounds on the mild steel surface from the acids has been found to obey Tempkin's adsorption isotherm. The values of activation energy ($E{\alpha}$) and free energy of adsorption (${\Delta}G{\alpha}ds$) were also calculated. The plots of log $W_f$ against time (days) at 302K give straight line which suggested that it obeys first order kinetics and also calculate the rate constant k and half life time $t_{1/2}$. Surface was analyzed by SEM and FITR spectroscopy.

Improvement of skin barrier function using lipid mixture

  • Park, Won-Seok;Son, Eui-Dong;Nam, Gae-Won;Park, Jong-Ho
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.27 no.1
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    • pp.53-72
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    • 2001
  • Dry skin is caused mainly by the perturbation of stratum corneum lipids which affected by ageing, change of season, excess use of surfactant and the effect of disease like atopic dermatitis and psoriasis. Intercellular lipid structures in stratum corneum are responsible for the barrier function of mammalian skin. The major lipd classes that can be extracted from stratum corneum are ceramides, cholesterol and fatty acid, which make up approximately 50, 25, 10 percent of the stratum corneum lipid mass, respectively. Small amount of cholesterol sulfate, phospholipids, glycosylceramide and cholesterol esters are also present. Recent studies have shown that application of one or two these lipids to the perturbed skin delays barrier recovery; only equimolar mixtures allow normal recovery. We observed that barrier recovery rate was improved in hairless mouse by topical application of single neutral lipids (ceramide, free fatty acid, cholesterol) and lipid mixtures. Whereas the application of single lipid didn’t allows a significant enhancement comparing with normal barrier repair, the equimolar mixtures of 3 components(including synthetic pseudoceramide PC104) improved barrier repair, as assessed by the transepidermal water loss. At clinical study to the volunteers aged over sixty, skin dryness recuperated by the increase of moisture(capacitance) and the reduction of scaling. Utilization of physiologic lipid mixture containing natural ceramides or synthetic pseudoceramide could lead to new forms of topical therapy for the dryness and dermatoses(e.g., psoriasis, atopic dermatitis and irritant dermatitis).

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Hot Forging Design of Titanium Compressor Wheel for a Marine Turbocharger (선박용 과급기 타이타늄합금 압축기휠의 열간단조 공정설계)

  • Yeom, J.T.;Na, Y.S.;Lim, J.S.;Kim, J.H.;Hong, J.K.;Park, N.K.
    • Transactions of Materials Processing
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    • v.18 no.4
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    • pp.354-360
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    • 2009
  • Hot-forging process and die design were made for a large-scale compressor wheel of Ti-6Al-4V alloy by using the results of 2-D FEM simulation. The design integrated the geometry-controlled approach and the processing contour map based on the dynamic materials model and the flow stability criteria. In order to obtain the processing contour map of Ti-6Al-4V alloy, compression tests were carried out in the temperature range of $915^{\circ}C$ to $1015^{\circ}C$ and the strain rate range of $10^{-3}s^{-1}$ to $10s^{-1}$. In the die design of the compressor wheel using the rigid-plastic FEM simulation, forging dimensional accuracy, the capacity of the forging machine and defect-free forging were considered as main design factors. The microstructure of hot forged wheel using the designed die showed a typical alpha-beta structure without forging-defects.

The Wearing Conditions of Shirts and the Subjective Preferences for Shirt Fabrics (셔츠의 착용실태와 소재에 대한 주관적 선호감각)

  • Choi Jong Myoung
    • Journal of the Korean Home Economics Association
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    • v.43 no.1 s.203
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    • pp.167-176
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    • 2005
  • This study was intended to investigate the wearing conditions of shirts, and examine the preferred subjective sensation for shirt fabrics. A questionnaire survey was conducted on 469 university students (male students $45.3\%$, female students $54.7\%$) in the Cheongju area, Korea. Frequency, descriptive analysis, $\x^2$ and t-tests were used for data analysis. The results were as follows: Regardless of gender, most owned 4 shirts in the autumn, which were each worn once or twice week. Generally, patterned shirts were less favored than those with solid colors, regardless of gender, but the color of the shirts differed slightly according to gender. Most students gathered items from those displayed in the store as their source of information on shirts, and tended to purchase items worth $30,000\~50,000$ won at franchised stores with friends of the same gender. They almost always looked carefully at the size and brand, but the care label and fiber content were rather neglected during the purchase. While purchasing their shirts, the following elements were considered, in this order of importance: size; color; fitness; comfort; price; tactile sensation. Light, dense, soft, warm, wrinkle-free, dry and strong sensation of the shirt fabrics were the strongest preferences for a purchase. There were partially significant gender differences in the subjective sensation of shirt fabrics.