• 제목/요약/키워드: free-year system

검색결과 199건 처리시간 0.024초

Clinical and biochemical outcomes of men undergoing radical prostatectomy or radiation therapy for localized prostate cancer

  • Schreiber, David;Rineer, Justin;Weiss, Jeffrey P.;Safdieh, Joseph;Weiner, Joseph;Rotman, Marvin;Schwartz, David
    • Radiation Oncology Journal
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    • 제33권1호
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    • pp.21-28
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    • 2015
  • Purpose: We analyzed outcomes of patients with prostate cancer undergoing either radical retropubic prostatectomy (RRP) +/- salvage radiation or definitive radiation therapy (RT) +/- androgen deprivation. Materials and Methods: From 2003-2010 there were 251 patients who underwent RRP and 469 patients who received RT (${\geq}7,560cGy$) for prostate cancer. Kaplan-Meier analysis was performed with the log-rank test to compare biochemical control (bCR), distant metastatic-free survival (DMPFS), and prostate cancer-specific survival (PCSS) between the two groups. Results: The median follow-up was 70 months and 61.3% of the men were African American. For low risk disease the 6-year bCR were 90.3% for RT and 85.6% for RRP (p = 0.23) and the 6-year post-salvage bCR were 90.3% vs. 90.9%, respectively (p = 0.84). For intermediate risk disease the 6-year bCR were 82.6% for RT and 59.7% for RRP (p < 0.001) and 82.6% vs. 74.0%, respectively, after including those salvaged with RT (p = 0.06). For high risk disease, the 6-year bCR were 67.4% for RT and 41.3% for RRP (p < 0.001) and after including those salvaged with RT was 67.4% vs. 43.1%, respectively (p < 0.001). However, there were no significant differences between the two groups in regards to DMPFS or PCSS. Conclusion: Treatment approaches utilizing RRP +/- salvage radiation or RT +/- androgen deprivation yielded equivalent DMPFS and PCSS outcomes. Biochemical control rates, using their respective definitions, appeared equivalent or better in those who received treatment with RT.

부산지역 해수온도차이용 냉난방기술 (Technology of Air-Conditioning System by Ocean Thermal Energy near Busan Coast)

  • 오철;김명환;임태우;최영도
    • 대한설비공학회:학술대회논문집
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    • 대한설비공학회 2009년도 하계학술발표대회 논문집
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    • pp.350-355
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    • 2009
  • Air-conditioning system by ocean thermal energy has been developed in the areas of Europe, North America and Japan because there are abundant amount of thermal energy potential in the ocean and permanent free use for the thermal energy using the air-conditioning system. In the case of domestic ocean thermal energy resource, ocean thermal energy potential exists about 27,155Tcal/year and totally 20,285Tcal/year of possible thermal energy use by heat pump, which are reported from the survey of the 7 domestic near shore cities. Present study is aimed to survey the current development status of domestic and overseas air-conditioning system by ocean thermal energy, especially, for the air-conditioning facility technologies using sea water.

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자유 말단형 침지식 분리막을 이용한 정수장 배출수 처리 연구 - 막오염 발생 원인과 해결 방안 - (A study on the treatment of water discharge from the water treatment plant using end-free submerged membrane - Causes and solution of membrane fouling -)

  • 김준현;장정우;김진호;박광덕
    • 상하수도학회지
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    • 제34권2호
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    • pp.93-104
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    • 2020
  • As water resources are limited and legal regulations are strengthened, there is a growing need to reuse residuals in WTP(Water Treatment Plant). In this study, membrane filtration system was constructed and its operation method was studied for water quality stabilization and reuse of WTP residuals. The operation parameters were stable for 1 year and 6 months. Membrane fouling was identified as particulate pollution (activated carbon) and inorganic pollution (manganese). The membrane system was operated steadily with raw water of high concentration SS(Suspended solid) containing activated carbon because membrane fouling was reduced by the effect of End-Free type. In the case of inorganic contamination, dissolved manganese eluted by chemicals and acted as a membrane fouling source, and the operating conditions for minimizing membrane fouling. were confirmed by newly developing application methods and types of cleaning chemicals. Based on the results, design parameters for reducing manganese membrane fouling were derived.

Circulating Lymphocytes as Predictors of Sensitivity to Preoperative Chemoradiotherapy in Rectal Cancer Cases

  • Dou, Xue;Wang, Ren-Ben;Yan, Hong-Jiang;Jiang, Shu-Mei;Meng, Xiang-Jiao;Zhu, Kun-Li;Xu, Xiao-Qing;Mu, Dian-Bin
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권6호
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    • pp.3881-3885
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    • 2013
  • Objective: The objective of this study was to identify clinical predictive factors for tumor response after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC). Methods: All factors were evaluated in 88 patients with LARC treated with nCRT. After a long period of 4-8 weeks of chemoradiotherapy, 3 patients achieved clinical complete response (cCR) and thus aggressive surgery was avoided, and the remaining 85 patients underwent a curative-intent operation. The response to nCRT was evaluated by tumor regression grade (TRG) system. Results: There were 32 patients (36.4%) with good tumor regression (TRG 3-4) and 56 (63.6%) with poor tumor regression (TRG 0-2). Lymphocyte counts and ratios were higher in good response cases (P=0.01, 0.03, respectively) while neutrophil ratios and N/L ratios were higher in poor response cases (P=0.04, 0.02, respectively). High lymphocyte ratios before nCRT and good tumor regression (TRG3-4) were significantly associated with improved 5-year disease-free survival (P<0.05). Pretreatment nodal status was also significantly associated with 5-year disease-free survival and 5-year overall survival (P<0.05). Multivariate analysis confirmed that the pretreatment lymphocyte ratio and lymph nodal status were independent prognostic factors. Conclusion: Our study suggested that LARC patients with high lymphocyte ratios before nCRT would have good tumor response and high 5-year DFS and OS.

충남 학부모의 무상학교급식 만족도와 이에 영향을 미치는 요인에 대한 연구 (A Study on Satisfaction for Free Food Service of Elementary and Middle School Parents in Chungnam Province)

  • 양성범
    • 한국식품영양학회지
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    • 제30권2호
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    • pp.356-362
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    • 2017
  • The aims of this study was to investigate the satisfactions with school food service and its influencing factors for elementary and middle school parents. We surveyed parents regarding their concerns about food ingredients and dietary life, perceptions of free school food service, the necessity of food supply systems such as school food service centers, and the satisfaction about the quality and management of school food services. Compared to the last year, concerns about food ingredients and dietary life as well as perceptions about free school food services decreased. The reported necessity of supply system such as school food service centers and co-purchasing was lower than in 2015. The satisfaction about the school food service decreased, compared to 2015. More individuals had higher concerns about local food and stated the necessity for school food supply systems, as well as a higher satisfaction about the quality and management of school food services. In conclusion, it is important to emphasize characteristics of school food services such as co-purchasing local foods.

조직배양에 의한 씨마늘의 상업적 생산 (Commercial Production of Seed Garlic by Tissue Culture Technique)

  • 남상일;박주현;최종인;권기석;엄정식
    • 한국식물생명공학회:학술대회논문집
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    • 한국식물생명공학회 2002년도 추계학술대회
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    • pp.33-40
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    • 2002
  • We, Tong Yang Moolsan Co. Ltd. (TYM) set up the mass-production system for virus-free seed garlic via tissue culture technique. TYM's tissue culture technique is called as 'Multiple shoot propagation technique'. This technique can lead mass propagation of genetically homogeneous seed garlic in a short period because of its highly proliferation rate of in vitro shoots ($15^{10}$ /year). TYM researchers applied the technique to some selected garlic cultivars with superior characteristics and carried out field test of productivity in the inside and outside of the country for several years. According to the yearly results of field test with virus-free seed garlic, we ascertained that virus-free seed garlic can produce the highly yield increase (max. above $50\%$) and also can enhance the product quality. Consequently, we estimated that TYM's seed garlic will contribute to farmers with increase of income and can elevate the national position of garlic market in the world for its competitive power of technical and production cost.

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경제발전전략으로서 한국의 경제자유구역과 운영체계에 관한 연구 (Korea's Free Economic Zone as an Economic Development Strategy and Operational System)

  • 고의현
    • 유통과학연구
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    • 제12권9호
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    • pp.113-123
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    • 2014
  • Purpose - After Korea's Free Economic Zone (FEZ) system was launched in 2003, there have been many debates about upgrading it and its support systems. However, as of 2013, there were insufficient results. Further, upon the designation of the East Coast and Chungbuk as official FEZs from February 4, 2013 by the 56th the Commission, there is a concern that many people are in the area designated as FEZ 8. This study investigates Korea's new FEZ system as part of Korea's primary new economic development policy in the 21st century. Therefore, this study examines views on the weaknesses of the past ten years of FEZs so that Korea can expand its FEZ system. Research design, data, and methodology -Many countries have considered the FEZ as an economic special zone. By reviewing previous research models, this study provides an update using recent data and materials, until 2013, from the Center of Free Economic Zones. In previous studies, the lack of support systems was attributed to proposals to ensure operational autonomy and differentiation of each FEZ; however, the main cause cannot be solved through regulatory issues, as difficulties caused by the operational system are responsible for the problems. We wish to analyze the FEZ, specifically the operational system; this is the main issue of this study. Results - After the first FEZs were established, it became necessary to have basic plans, as investment results in 2013 compared to the same period this year led to lower earnings in the first half of 2014. We propose an improvement of the operational system because in the free economic zones, the operational system is the root cause of the underlying problem. The results of this research are as follows. The weak management of the FEZ system is influenced by weak investment, delayed development, foreigners' living facilities, benefits of foreign investments, the control tower's policy making decision process, quickness of the process of satisfying legal requirements, and support For the independence of FEZs. Conclusion - Local governments do not have legal rights over FEZ deregulation and investment industries. This study suggests that the local government should have more independence from the central government. Moreover, independent management committees are more effective for ensuring public rights, better employee responsibilities, and better-qualified personnel. The FEZ committee struggles to effectively manage the locations of FEZs, foreign investments, and related facilities under the control of the Ministry of Trade, Industry and Energy. Thus, the FEZ committee should be under either the Prime Minister's office or the Presidential committee, to control and effectively coordinate between the local and central governments. If the problem clearly applies to the operational system in 2013, it is necessary to provide materials and methods so that the results of the first half of 2014 can be computed despite the data limits and lack of resources, and the data can be analyzed in a more diachronic thesis.

Long-term tolerance and outcomes for dose escalation in early salvage post-prostatectomy radiation therapy

  • Safdieh, Joseph J.;Schwartz, David;Weiner, Joseph;Weiss, Jeffrey P.;Rineer, Justin;Madeb, Isaac;Rotman, Marvin;Schreiber, David
    • Radiation Oncology Journal
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    • 제32권3호
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    • pp.179-186
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    • 2014
  • Purpose: To study the long-term outcomes and tolerance in our patients who received dose escalated radiotherapy in the early salvage post-prostatectomy setting. Materials and Methods: The medical records of 54 consecutive patients who underwent radical prostatectomy subsequently followed by salvage radiation therapy (SRT) to the prostate bed between 2003-2010 were analyzed. Patients included were required to have a pre-radiation prostate specific antigen level (PSA) of 2 ng/mL or less. The median SRT dose was 70.2 Gy. Biochemical failure after salvage radiation was defined as a PSA level >0.2 ng/mL. Biochemical control and survival endpoints were analyzed using the Kaplan-Meier method. Univariate and multivariate Cox regression analysis were used to identify the potential impact of confounding factors on outcomes. Results: The median pre-SRT PSA was 0.45 ng/mL and the median follow-up time was 71 months. The 4- and 7-year actuarial biochemical control rates were 75.7% and 63.2%, respectively. The actuarial 4- and 7-year distant metastasis-free survival was 93.7% and 87.0%, respectively, and the actuarial 7-year prostate cancer specific survival was 94.9%. Grade 3 late genitourinary toxicity developed in 14 patients (25.9%), while grade 4 late genitourinary toxicity developed in 2 patients (3.7%). Grade 3 late gastrointestinal toxicity developed in 1 patient (1.9%), and grade 4 late gastrointestinal toxicity developed in 1 patient (1.9%). Conclusion: In this series with long-term follow-up, early SRT provided outcomes and toxicity profiles similar to those reported from the three major randomized trials studying adjuvant radiation therapy.

스마트교육 기반 자유선택활동 운영시스템 설계 및 구현 (Design and Implementation of Free Choice Activity Management System based on Smart Education)

  • 김경민;박현숙
    • 컴퓨터교육학회논문지
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    • 제22권3호
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    • pp.123-133
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    • 2019
  • 본 연구는 스마트교육의 한 요소인 스마트 기기를 활용하여 축적된 데이터를 기초로 유아의 개별 맞춤학습을 위한 스마트교육환경을 구축하는데 목적을 두고 있다. 이를 위해 유치원 만5세 학급에서 자유선택활동 운영을 위한 개선 방안을 제안하고, 유아 스스로 놀이 계획을 세우고 평가하는 자유선택활동 운영시스템을 구현하였다. 본 연구 참여한 유아들은 놀이계획, 놀이수행 및 수행평가등 전체 활동시간을 스스로가 적극적이며 즐겁게 참여하였다. 그 결과 유아는 스마트기기를 통한 자신의 흥미영역에 대한 활동선택에 기존교육환경보다 적극적으로 참여하는 것을 확인할 수 있었다. 본 연구에서 제안된 자유선택활동 운영시스템을 이용한 교사는 분석된 자료를 활용하여 스마트기기를 이용한 개별유아의 흥미분야와 학습수준 및 교실의 각 영역별 이용형태를 혼자서 쉽게 파악할 수 있었다.

도요타 생산방식(TPS)의 이론과 실제 (A Theoretical Study on the Toyota Production System and Practical Example)

  • 임재화;목진환
    • 한국산학경영학회:학술대회논문집
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    • 한국산학경영학회 2006년도 춘계학술발표대회 발표논문집
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    • pp.171-190
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    • 2006
  • 도요타 자동차는 2005년도 결산 보고서에서 영업이익은 6년 연속, 순이익은 4년 연속 사상 최고치를 경신한 것으로 나타났다. 순이익은 전년도 보다 11% 증가한 1조 3000억 엔(약 11조 500억 원)에 달하는 것으로 보고 있다. 최고의 이익을 계속 갱신하면서 세계의 주목을 받고 있는 도요타 자동차는 낭비제거와 개선(改善)을 골자로 하는 생산방식의 강점을 보유하고 있다. 도요타 생산방식의 기본 사상은 낭비를 철저히 제거하여 생산성을 향상시킴으로 부가가치를 통한 이익을 창출하는 것으로, 이를 뒷받침 해주는 것이 "Just-in time" 과 " 사람 인(人)변의 자동화(自動化)라는 두 가지 기둥이다. 최근 한국의 제조기업 뿐만 아니라 서비스업종까지 도요타 생산 시스템을 재조명하여 자사에 적용하기 위한 많은 시도가 이어지고 있다. 도요타 생산방식의 이론의 고찰을 통하여 도요타 생산방식을 재정립하고, 실제로 도요타 생산방식이 적용되어진 사례연구를 통하여 우리의 기업환경에 적합하도록 활용할 수 있는지를 검토하고 연구 발전시켜야 한다.

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