• Korean Journal of Child Studies
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• v.6 no.1
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• pp.3-16
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• 1985

The purpose of this study was the application of sequential analysis to mother-infant interaction data, with particular reference to goodness of fit. The subjects of this study were 22 7- to 16-month-old infants(12 girls and 10 boys) and their mothers. Each mother-infant dyad was videotaped in a 5-min free-play session in the playroom. The videotaped data was transcribed on the behavioral checklist every 3 seconds. The recorded raw data were lagged by one time interval (3 sec.). Transitional probabilities from behavior at time t-1 to behavior at time t were gathered. The statistical analysis of frequency data and transitional probabilities consisted of Z test, t test, and sign test. It was found that regarding 1) direction of effect: the transitional probability of infant vocalization following maternal vocalization was significantly higher than the reverse; the transitional probability of a 'Coacting State' following a 'Mother Active State' was significantly higher than the reverse; the probability of a 'Mother Active State' following 'Quiescent State' was significantly higher than that of a 'Coacting State' following an 'Infant Active State'; 2) sex differences: male infants' transitional probability from an 'Infant Active State' to a 'Quiescent State' was significantly higher than that of female infants; 3) age differences: more than younger infants older infants had higher transitional probabilities from a 'Mother Active State' to a 'Coacting State', from a 'Parallel State' to a 'Coacting State', and from a 'Quiescent State' to a 'Parallel State'. These showed goodness of fit for sex and age differences, particularily for direction of effect.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2004.11a
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• pp.731-734
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• 2004

As the integrated circuit device shrinks to the smaller dimension, the chemical mechanical polishing (CMP) process was required for the global planarization of inter-metal dielectric(IMD) layer with free-defect. Polishing pads play a key role in CMP, which has been recognized as a critical step to improve the topography of wafers for semiconductor fabrication. It is investigated the performance of $SiO_2-CMP$ process using commercial silica slurry as a pad conditioning temperature increased after CMP process. This study also showed the change of SEM images in the pore geometry on the CMP pad surface after use with a different pad conditioning temperature.

• BMB Reports
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• v.48 no.11
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• pp.597-598
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• 2015

Mitochondrial respiratory defect is a key bioenergetics feature of hepatocellular carcinoma (HCC) cells. However, their involvement and roles in HCC development and progression remain unclear. Recently, we identified 10 common mitochondrial defect (CMD) signature genes that may be induced by retrograde signaling-mediated transcriptional reprogramming in response to HCC mitochondrial defects. HCC patients with enriched expression of these genes had poor prognostic outcomes, such as shorter periods of overall survival and recurrence-free survival. Nuclear protein 1 (NUPR1), a key transcription regulator, was up-regulated by Ca⁺⁺-mediated retrograde signaling. NUPR1-centric network analysis and a biochemical promoter-binding assay demonstrated that granulin (GRN) is a key downstream effector of NUPR1 for the regulation of HCC cell invasiveness; association analysis of the NUPR1-GRN pathway supported this conclusion. Mitochondrial respiratory defects and retrograde signaling thus play pivotal roles in HCC progression, highlighting the potential of the NUPR1-GRN axis as a novel diagnostic marker and therapeutic target for HCC.

• Natural Product Sciences
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• v.10 no.1
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• pp.35-39
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• 2004

Aldose reductase (AR), the key enzyme of the polyol pathway, is known to play important roles in the diabetic complications. The inhibitors of AR, therefore, would be potential agents for the prevention of diabetic complications. In order to clarify the structural requirements of flavonoids for aldose reductase inhibitory activity, thirty flavonoids were examined. Among the thirty flavonoids, flavonols such as quercetin (5), reyneutrin (7), quercitrin (9), isoquercitrin (11), and avicularin (14) were found to exhibit much stronger AR inhibition. Lonicerin (10), amentoflavone (27) and sophoraflavanone B (30) were also showed strong inhibitory activity. Especially, quercitrin and reyneutrin exhibited the most inhibitory potency on rat lens (RL) AR. The results suggested that flavonol having the 7-hydroxyl and/or catechol moiety at the B ring exhibit strong activity. In addition, flavonols having 3-O-monosaccharide also showed stronger inhibition than free flavonols at the 3-position. These results suggested that quercitrin and reyneutrin are attributed to be the promising compounds for the prevention and/or treatment of diabetic complications.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.49 no.4
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• pp.300-304
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• 2004

Gibberellic acid did not affect ethylene production, whereas gibberellin biosynthesis inhibitors triggered ethylene production in dormant tubers. Gibberellic acid did not induce sprouting of dormant tubers, however, treatment of gibberellin biosynthesis retardants enhanced sprouting rates. Sprouting rate in ancymidol-treated tubers was highest among gibberellin biosynthesis retardants. Sprouting rate of tubers treated with ancymidol increased to $91.4\%$. Batatasin-III content in $GA_3$ treated tuber was increased in the highest concentration $(30{\mu}g\;I^{-1})$. Tubers treated with mepiquat chloride, Batatasin-I was increased steadily, but contents of Batatasin-III and V showed dramatic decrease at the $ 1,000{\mu}g\;I^{-1})$ concentration. This infers that gibberellin biosynthesis retardants play key roles in promoting breaking dormancy on dormant tubers of Chinese yam.

• Preventive Nutrition and Food Science
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• v.15 no.2
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• pp.92-97
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• 2010

Luteolin and chicoric acid are the most abundant phytochemicals in dandelion (Taraxacum officinale) leaf. In this study, four kinds of extraction methods [hot water, ambient temperature (AT) water, ethanol, and methanol] were applied to analyze the contents of both phytochemicals and verify their anti-inflammatory and antioxidative activities. The methanol extract showed the most potent nitric oxide (NO) inhibitory effect. The luteolin and chicoric acid concentrations were 3.42 and $12.86\;{\mu}g/g$ dandelion leaf in the methanol extract. The NO-suppressive effect of luteolin and chicoric acid was identified in a dose-dependent manner with $IC_{50}$ values of $21.2\;{\mu}M$ and $283.6\;{\mu}M$, respectively, in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells without cytotoxicity. Malondialdehyde (MDA) concentration, as an index for free radical injury on cell membrane, was also dose-dependently inhibited by the two compounds. The suppressive effect was further examined using mRNA and protein expression levels, which were attributable to the inhibition of inducible nitric oxide synthase (iNOS). These results suggest that two phytochemicals in dandelion leaf, luteolin and chicoric acid, may play an important role in the amelioration of LPS-induced oxidative stress and inflammation.

• Journal of the Korean Home Economics Association
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• v.36 no.4
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• pp.79-94
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• 1998

The case study describes kindergarten children's reading stances and responses with relation to those of their mothers'. Rosenbaltt's theory (1978) of aesthetic and efferent stances in used to characterize the relationship between the reader and the text. mother's reading stances are examined by observing each case study child's reading experience with his/her mother at home. In most cases differences in some children's preferred stances seemed to reflect differences in their mothers' stances. As a result, children took a different type of stance from the teacher's efferent stance and were perceived by the teacher to be slower with regard to literacy development, even though they had formed their own reading worlds. Interestingly enough, children with an aesthetic reading stance were welcomed among their peers during free play time. In contrast, children who took a stance congruent with the teacher's efferent stnace were perceived by the teacher to be on the right track with regard to literacy development, although their reading worlds seened to be limited. Interestingly, the children with efferent reading stances were not engaged in collaborative meaning negotiation processes with peers. The case study children with mothers who did not take an extreme type of stance, I.e., neither a very efferent nor a very aesthetic stance, seemed to choose a type of stance depending on a context.

• Structural Engineering and Mechanics
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• v.64 no.5
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• pp.527-541
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• 2017

In this work, a new hyperbolic shear deformation beam theory is proposed based on a modified couple stress theory (MCST) to investigate the bending and free vibration responses of functionally graded (FG) micro beam made of porous material. This non-classical micro-beam model introduces the material length scale coefficient which can capture the size influence. The non-classical beam model reduces to the classical beam model when the material length scale coefficient is set to zero. The mechanical material properties of the FG micro-beam are assumed to vary in the thickness direction and are estimated through the classical rule of mixture which is modified to approximate the porous material properties with even and uneven distributions of porosities phases. Effects of several important parameters such as power-law exponents, porosity distributions, porosity volume fractions, the material length scale parameter and slenderness ratios on bending and dynamic responses of FG micro-beams are investigated and discussed in detail. It is concluded that these effects play significant role in the mechanical behavior of porous FG micro-beams.

• Journal of Distribution Science
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• v.12 no.5
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• pp.109-117
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• 2014

Purpose - The study investigates the history, production methods, market scale, and distribution of the traditional liquors of three countries: South Korean sokokju, Chinese shaoxing-chiew, and Japanese sake. These have similar production methods, being made from rice or cereal, cores of their respective food industries. Research design, data, and methodology - The study investigated the history of the three liquors, liquor classification in the three countries, and production methods. It examined the scale of the traditional liquor market and these countries' distribution structure. Results - Brand cognition of traditional liquors is affected by a focus on wellbeing and LOHAS (lifestyle of health and sustainability). Promotion and marketing strategies along with a high quality image, shelf life of draft liquor, traditional liquor identification systems, and high taxes on traditional liquor, and the need for continuous R&D and training of professionals all impacted the industry. Conclusions - These countries play important roles in world trade, seeking economic integration. By forming a free trade agreement (FTA), their traditional liquors, with a proud history, can be jointly branded in the world market.

• Asian-Australasian Journal of Animal Sciences
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• v.5 no.2
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• pp.303-308
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• 1992

Three female sheep were daily administered a pyrophosphate analogue, disodium 1-hydroxyethylidene-1, 1-bisphosphonate (HEBP) at the level of 4 mg/kg body weight. HEBP largely suppressed bone resorption, which was indicated by the reduction in plasma free hydroxyproline concentration and in calcium mobilization rate during the intravenous infusion of disodium ethylenediaminetetraacetate (EDTA). Contrary to the suppression of bone resorption, plasma total-calcium, magnesium and phosphorus concentrations were not changed by HEBP administration. These results suggest that bone mineral crystals play a meaningless role on calcium, magnesium and phosphorus homeostasis in ruminants if they are fed adequate amounts of these minerals. Plasma magnesium and phosphorus concentrations were not significantly changed after feeding. However, plasma total-calcium was decreased after feeding in both periods and the reduction seemed to be remarkable in the HEBP-treated period. Infusion of EDTA more remarkably reduced plasma ionized calcium concentration in the HEBP-treated that in the untreated period and the recovery of ionized calcium was retarded by HEBP administration. These results suggest that calcium release from bone is necessary for maintenance of plasma calcium when animals rapidly lose calcium.