• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.18 no.10
• /
• pp.209-214
• /
• 2017

The purpose of this study is to identify the factors that led greenhouse grape farms to delay their heating periods after the coming into force of the Korea-Chile Free Trade Agreement (FTA). Panel data on the cropping (system) changes from 2004 through 2016 were used for the analysis. According to the panel logistic model, the estimated coefficient of the cultivation area was 0.0002, which was statistically significant at the 10% significance level, the estimated coefficient of grape imports was 1.4258, which was statistically significant at the 1% significance level, and the estimated coefficient of the regional dummy was 0.808, which was statistically significant at the 5% significance level. The results indicated that the use of wider cultivation areas, increase in grape imports, and colder climate(in the mid-northern part of Korea) increased the likelihood of delayed heating. The Korean government is offering direct payment programs and business closure support to the greenhouse grape farmers. While these actions can relieve the damage caused by the increase in grape imports, they will not provide the ultimate solution. Various support measures are needed, such as renewing the varieties to meet the changing demand of grape consumers, providing agricultural materials to reduce the heating expenses, and modernizing greenhouse facilities to improve the energy efficiency and reduce the costs.

• The Korean Journal of Physiology and Pharmacology
• /
• v.2 no.4
• /
• pp.461-469
• /
• 1998

Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethy-lamines, and many of them, especially with 6,7-disubstitution, demonstrate relatively high affinity for catecholamines. Two -OH groups at 6 and 7 positions are supposed to be essential to exert ?${\beta}-receptor$ activities. However, it is not clear whether -OH at 6,7 substitution of THIs also shows ?${\alpha}-adrenoceptor$ activities. In the present study, we investigated whether -OH or $-OCH_3$ substitutions of 6,7 position of THIs differently affect the ?1-adrenoceptor affinity. We synthesized two 1-naphthylmethyl THI alkaloids, $1-{\beta}-naphthylmethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline$ HBr (YS 51) and $1-{\beta}-naphthylmethyl-6, 7-dimethoxy-1,2,3,4-tetrahydroisoquinoline$ HCl (YS 55), and their pharmacological actions on ?${\alpha}_1-adrenoceptor$ were compared. YS 51 and YS 55, concentration-dependently relaxed endothelium-denuded rat thoracic aorta precontracted with phenylephrine (PE, 0.1 ${\mu}M$) in which $pEC_{50}$ were $5.89{\pm}0.21$ and $5.93{\pm}0.19$, respectively. Propranolol (30 nM) did not affect the relaxation-response curves to YS 51 and YS 55. Concentration-response curves to PE were shifted to right by the pretreatment with YS 51 or YS 55. The $pA_2$ values of YS 51 and YS 55 showed $6.05{\pm}0.24$ and $5.88{\pm}0.16$, respectively. Both probes relaxed KCl (65.4 mM)-contracted aorta and inhibited $CaCl_2-induced$ contraction of PE-stimulated endothelium- denuded rat thoracic aorta in $Ca^{2+}-free$ solutions. In isolated guinea pig papillary muscle, 1 and 10 ${\mu}M$ YS 51 increased contractile force about 4- and 8- fold over the control, respectively, along with the concentration-dependent increment of cytosolic $Ca^{2+}$ ions. While, 10 ${\mu}M$ YS 55 reduced the contractile force about 50 % over the control and lowered the cytosolic $Ca^{2+}$ level, in rat brain homogenates, YS 51 and YS 55 displaced $[^3H]prazosin$ binding competitively with Ki 0.15 and 0.12 ${\mu}M$, respectively. However, both probes were ineffective on $[^3H]nitrendipine$ binding. Therefore, it is concluded that two synthetic naphthylmethyl-THI alkaloids have considerable affinity to ?1-adrenenoceptors in rat aorta and brain.

• Korean Journal of Agricultural Science
• /
• v.20 no.1
• /
• pp.88-101
• /
• 1993

This study is aimed at evaluating the present management status of the rural special production area development projects and identifying managerial problems to propose new direction of the political countermeasures for the projects. In the con text of implementing the five year's economic developent plans for the past three decades, agricultural production and farm-household income have also been grown rapidly. However the income gap between rural and urbarn laborer, as an internal problem, has widened during the decades and the UR problems concerning free trade of agricultural products, as an external problems, are now agonizing the small-holder farm economy in Korea. The internal and external farm problems could be solved through improvement of agricultural structure and provision of off-farm jobs for farm household income increase. As a part of the off-farm income sources, the rural special production area development projects have propelled by the government throughout the country. The main problems to be solved for the successful implementation of the projects are as follows : 1. Present loan amount by the financial fund was estimated at 6-7% of the total installation costs required. To expand and implement the project successfully, enough financial credit support with favorable terms and conditions have to be considered by the government. 2. The operation patterns of the special production area development project should be recommended from the view point of cooperative and private operation to maximize farm household incomes including profits, marketing charges and dividens. 3. Improvement of the marketing channel of the products and marketing information through TV program and other mass communication should be implemented strongly to promote marketsales by the financial supports of the government. 4. In connection with the off-farm income increase, the population migrating to urban area in outside Chungnam province equivalent to 10-12 thousand persons with age of 20-49 years should be taken into account politically to be employed in the projects in the province. 5. Surplus farm labors should be created by means of improvement of agricultural structure including large farm management with farm mechanization and job opportunities have also to be provided in connection with the rural special production area development projects. The two imminent subjects are the prerequisites to increase off-farm incomes for the farmers living in Chungnam province. 6. Required credit supports for investment and operation costs of the projects should be taken actions by the government.

• Journal of Life Science
• /
• v.23 no.7
• /
• pp.926-932
• /
• 2013

Glutamine and serum are essential for cell survival and proliferation in vitro, yet the signaling pathways that sense glutamine and serum levels in endothelial cells remain uninvestigated. In this study, we examined the effects of glutamine deprivation and serum starvation on the fate of endothelial cells using a human umbilical vein endothelial cell (HUVEC) model. Our data indicated that glutamine deprivation and serum starvation trigger a progressive reduction in cell viability through apoptosis induction in HUVECs as determined by DAPI staining and flow cytometry analysis. Although the apoptotic effects were more predominant in the glutamine deprivation condition, both apoptotic actions were associated with an increase in the Bax/Bcl-2 (or Bcl-xL) ratio, down-regulation of the inhibitor of apoptosis protein (IAP) family proteins, activation of caspase activities, and concomitant degradation of poly (ADP-ribose) polymerases. Moreover, down-regulation of the expression of Bid or up-regulation of truncated Bid (tBid) were observed in cells grown under the same conditions, indicating that glutamine deprivation and serum starvation induce the apoptosis of HUVECs through a signaling cascade involving death-receptor-mediated extrinsic pathways, as well as mitochondria-mediated intrinsic caspase pathways. However, apoptosis was not induced in cells grown in glutamine- and serum-free media when compared with cells exposed to glutamine deprivation or serum starvation alone. Taken together, our data indicate that glutamine deprivation and serum starvation suppress cell viability without apoptosis induction in HUVECs.

• Journal of Ginseng Research
• /
• v.11 no.2
• /
• pp.145-252
• /
• 1987

Isolated rat adipocytes are well known to possess opposite pathways of lipid metabolism: lipolysis and ipogenesis. Both of the metabolism respond to various biologically active substances such as epinephrine, ACTH and insulin. Epinephrine and ACTH stimulate lipolysis and insulin accelerates lipogenesis. Recently, Korean red ginseng powder was found to contain adenosine and an acidic poptide which inhibited epinephrine-induced lipolysis and sl imulated insulin-mediated lipogenesis from added glucose. The acidic peptide is consisted mainly of glutamic acid and glucose. Ginsenosides Rb1 and Re inhibited ACTH-induced lipolysis in isolated rat adipocytes, while they did not affect insulinstimulated lipogenesis, Thus, all these substances extracted from Korean red ginseng exhibited selective modulations toward the opposite metabolic pathways in rat adipocyte; They inhibited the lipolysis but not the lipogenesis. We call these substances"selective modulators". Recently, we isolated a toxic substance named "toxohormone-L " from ascites fluid of patients with various malignant tumors. The toxohormone-L stimulated lipolysis in rat adipocytes and induced anorexia in rats. Both the lipolytic and the anorexigenic actions of toxohormone-L were found to be inhibited by ginsenoside Rb2 in Korean red ginseng. Based on these results, physiological signifi¬cances of these substances in Korean red ginseng were discussed. Pan ax ginseng is a medicinal plant long used in treatment of various pathological states including general complaints such as head ache, shoulder ache, chilly constitution and anorexia in cancer patients, There have been many pharmacological studies on Panax ginseng roots. Petkovllreported that oral administration of an aqueous alcoholic extract of ginseng roots decreased the blood sugar levtl of rabbits. Saito2lreported that Panax ginseng suppressed hyperglycemia induced by epinephrine and high carbohydrate diets. These findings suggest that Panax ginseng roots contain insulin-like substances. Previously, we demonstrated that gin¬seng roots contain an insulin-like peptide which inhibits epinephrine-induced lipolysis and stimulated insulin-mediated lipogenesis. In 1984, we suggested that such an insulin-like substance should be called a selective modulator4). Present investigation describes the details of the selective modulators in ginseng roots. During progressive weight loss in patients with various neoplastic disease, depletion of fat stores have been observed. The depletion of body fat during growth of neoplasms is associated with increase in plasma free fatty acids. Recently, we found that the ascites fluid from patients with hepatoma or ovarian tumor and the pleural fluid from patients with malignant lymphoma elicited fatty acid release in slices of rat adipose tissue in vitro. The lipolytic factor, named"toxohormone-L". was purifed from the ascites fluid of patients with hepatoma. The isolated preparation gave a single band on both disc gel electrophoresis and sodium dodecyl sulfate(SDS)-acrylamide gel electrophoresis in the presence of ${\beta}$-mercaptoethanol. Its molecular weight was determined to be 70,000-75,000 and 65,000 by SDS-acrylamide gel electrophoresis and analytical ultracentrifugation, respectively. Injection of toxohormone-L into the lateral ventricle of rats significantly suppressed food and water intakes. There was at least 5 hr delay between its injection and appearance of its suppressive effect. In the present study, we also tried to find a inhibitory substance toward toxohormone-L from root powder of ginseng.

• Korean Journal of Agricultural Science
• /
• v.22 no.1
• /
• pp.110-126
• /
• 1995

Korean economy has been developed successfully in the course of implementing the five year economic development plans since 1962. The gap of incomes and quality of life between rural and urban area has been widened and it made rural farm laborers drain to urban areas. Therefore the prevailing situation of labor shortage and wage hike in rural area has made farm management deteriorate in recent years. Under the internal and international unfavorable economic conditions, marginal farm land of 66.5 thousand ha has been idled as of end of 1993. The total area outside agricultural development zone with bad farming conditions including irrigation and drainage, and land consolidation for mechanization were estimated at 360.4thousand ha equivalent to 17.5% of the total farm land area in Korea. Considering the topographical conditions of marginal lands, the effective use of marginal lands should be studied from the view point of public interest rather than from the view point of individual economic conditions. Considering the present agricultural economic settings, such as price decrease, unfavourable benefits of farm products, labour shrotage, free trade of farm products and poor physical condition of marginal lands, the institutional and realistical measures for the effective utilization of idle and marginal land should be studied as soon as possible. Detail land use pattern should be surveyed in the areas outside agricultural development zone and have to be classified as orchard farms, grass land, fish culture farms, lawn and ornamental tree farm, sight seeing and leisure farms for urban peoples, special crops production farms and common farms to be developed for farm mechanization. According to the surveyed results, the expected utilization patterns of the idle and marginal lands could be considerd as village common use, farm land base development, leisure farm development, mutual complementary utilization between urban and rural areas, G't purchase and management, credit supply and new extension services, improvement of cropping patterns and sight seeing and leisure farm patterns. For the successful and reasonable management of the marginal lands, the actions such as institutional improvement, prohibition of idle marginal land, enforcement of activities of farm management committee members and land banking system of RDC including development and utilization systems should be included.

• Journal of Korean Elementary Science Education
• /
• v.41 no.3
• /
• pp.538-552
• /
• 2022

This study attempted to understand the characteristics of pedagogic activities performed by pre-service elementary school teachers. To this end, it applied Algodoo simulations to analyze the actions of students and obtain educational implications for optical learning. The study's participants comprised 79 first-year students enrolled in a teacher training college. Their activities could be classified as representation reproductions, verification experiments, and inquiry experiments. Students who performed representation reproduction exercises replicated renowned and authoritative exemplars, apprehending and demonstrating their principal features through simulations. Students performing verification experiments attempted to validate previously learned optical concepts by reviewing the relevant theoretical contexts. Such students primarily conducted simple experiments. Students accomplishing inquiry experiments used simulations to explore phenomena they did not know. Some of them even investigated optical phenomena beyond the domain of general physics. The above results confirmed that free optical experiments performed using Algodoo can effectively denote starting points for learners to engage in activities at varying levels. Additionally, students require assistance from instructors in addressing queries about the application of the principles and models related to optics. This study suggests ways in which instructors should help students at each level of activity. Additionally, the paper presents examples of varying levels of inquiry-related activities available on Algodoo. It also discusses the advantages and disadvantages of performing inquiry-based activities on Algodoo and suggests ways of enhancing the learning achieved through this platform.

• Proceedings of the Korean Society of Developmental Biology Conference
• /
• 2003.10a
• /
• pp.83-83
• /
• 2003

The lutropin/choriogonadotropin receptor (LHR) is a member of the rhodopsin-like subfamily of G protein coupled receptor (GPCRs), that has been shown to mediate the internalization of its two naturally occurring agonist, lutropin and choriogonadotropin (CG). The clustered agonist-receptor complex is internalized by a dynamin-dependent pathway and traverses the endosomal compartment without agonist dissociation Dissociation of the agonist-receptor complex occurs in the lysosomes, where both the agonist and receptor are degrade. Recently, constitutively activating mutations of the receptor have been identified that are associated with familial male-precocious puberty (FMPP). A FMPP is a form of sexual precocious puberty in boys in which testosterone levels are elevated independent of changes in luteinizing hormone-releasing hormone and serum luteinizing hormone levels, We have now analyzed two naturally occurring, constitutively active mutants of the human LHR. These mutations were introduced into the rat LHR (rLHR) and are designated L435R and D556Y. Cells expressing rLHR-D556Y bind human choriogonadotropin (hCG) with normal affinity, exhibit a 25-fold increase in basal cAMP and respond to hCG with a normal increase in cAMP accumulation. Cells expressing rLHR-L435R also bind hCG with normal affinity, exhibit a 47-fold increase in basal cAMP, and do not respond to hCG with a further increase in cAMP accumulation. This mutation enhances the internalization of the free and agonist-occupied receptors ~2- and ~17- fold, respectively We conclude that the state of activation of the rLHR can modulate its basal and/or agonist-stimulated internalization. Since the internalization of hCG is involved in the termination of hCG actions, we suggest that the lack of responsiveness detected in cells expressing rLHR-L435R is due to the fast rate of internalization of the bound hCG. The finding that membranes expressing rLHR-L435R respond to hCG with an increase in adenylyl cyclase activity supports this suggestion. Autonomous Leydig cell activity in FMPP is caused by a constitutively activating LH/CGR.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.30 no.6D
• /
• pp.587-597
• /
• 2010

When a car accident occurs, people who had an accident are not free from civil and criminal issues so that the accident investigator should reenact and analyze the accident situation accurately. In addition, the obtained documents through the analysis of such car accident occurrence and related factors have to be used to carry out the improvement of the areas that has numerous car accidents and complementary actions. The vehicle speed, accelerating force, braking power are currently known as the most affecting factors in accordance with many car accidents, traffic facilities, road design, etc. The vehicle's performance and rode friction coefficient road surface friction coefficient are affecting the most closely in this field. Especially, once the estimate of the speed of the accident moment relating to main eleven articles of Traffic Accident Exemption Law is very important and accuracy is required. However, currently the researches of these matters have not made exclusively yet in Korea. In this study by reflecting this current situation, until the sudden braking history is found from the car's sudden braking, it estimates accurately the transient brake time and rode friction coefficient by measuring a time of transient brake time through the precision speed detector (Vericom VC2000PC). The analysis of the experimental results calculated the transient brake time and friction coefficient to fit into the purpose of this study in the basis of different kind of various special purpose asphalt pavement and slip-prevention pavement and provided the fundamental data.

• Journal of the Computational Structural Engineering Institute of Korea
• /
• v.37 no.1
• /
• pp.49-56
• /
• 2024

An automated dynamic structural analysis module stands as a crucial element within a structural integrated mitigation system. This module must deliver prompt real-time responses to enable timely actions, such as evacuation or warnings, in response to the severity posed by the structural system. The finite element method, a widely adopted approximate structural analysis approach globally, owes its popularity in part to its user-friendly nature. However, the computational efficiency and accuracy of results depend on the user-provided finite element mesh, with the number of elements and their quality playing pivotal roles. This paper introduces a computationally efficient adaptive mesh generation scheme that optimally combines the h-method of node movement and the r-method of element division for mesh refinement. Adaptive mesh generation schemes automatically create finite element meshes, and in this case, representative strain values for a given mesh are employed for error estimates. When applied to dynamic problems analyzed in the time domain, meshes need to be modified at each time step, considering a few hundred or thousand steps. The algorithm's specifics are demonstrated through a standard cantilever beam example subjected to a concentrated load at the free end. Additionally, a portal frame example showcases the generation of various robust meshes. These examples illustrate the adaptive algorithm's capability to produce robust meshes, ensuring reasonable accuracy and efficient computing time. Moreover, the study highlights the potential for the scheme's effective application in complex structural dynamic problems, such as those subjected to seismic or erratic wind loads. It also emphasizes its suitability for general nonlinear analysis problems, establishing the versatility and reliability of the proposed adaptive mesh generation scheme.