• Journal of Genetic Medicine
• /
• 제6권1호
• /
• pp.81-86
• /
• 2009

다발성 골단이형성증은 임상적 및 유전학적으로 이질적인 연골이형성증으로, 골화 중심의 발달 지연, 골단만을 침범하는 사지의 변형 및 경한 저신장을 보이는 질환이다. 원인으로는 COMP 유전자의 돌연변이가 가장 흔히 발견되고 있으며, 돌연변이의 대부분은 칼모듈린 유사 반복(calmodulin-like repeats)부분과 C-말단에 위치한다. 저자들은 4대에 걸쳐 12명의 가족구성원에서 다발성 골단이형성증을 보인 한 가계에서 COMP 유전자 분석으로 새로운 돌연변이를 발견하여 보고하는 바이다. 이 가계는 젊은 나이에 퇴행성 관절염이 발생하고, 추후 관절치환술이 요구되는 상염색체 우성 유전 방식을 보이는 질환을 가지고 있었다. 방사선학적 검사상 양측 무릎 관절의 내측 대퇴돌기에 골연골 결손을 보였으며, 양측 무릎과 엉덩이 관절은 다양한 정도의 퇴행성 변화가 관찰되었다. 계보발단자 및 5명의 다른 이환된 가족들에서 시행한 COMP 유전자 분석에서, 12번째 엑손에서 현재까지 보고되지 않은 새로운 돌연변이인 c.1280G>C (p.Gly427Ala)을 확인하였다. 이 돌연변이는 다른 3명의 이환되지 않은 가족들에서는 발견되지 않았다. 상염색체 우성 방식을 보이는 다발성 골단이형성증 환자들에서 COMP 유전자의 직접 염기서열 분석법은 질병의 원인이 되는 돌연변이를 찾는데 도움이 되며, 고위험 가족들에서 보인자를 찾아낼 수 있고, 질병의 합병증이 발생하기 이전에 조기 진단 및 중재를 가능케 하는 유전 상담의 기회를 제공해 줄 수 있다.

• 농촌의학ㆍ지역보건
• /
• 제10권1호
• /
• pp.26-35
• /
• 1985

The present study was undertaken to evaluate the prevalence rate of Taenia species infection and distribution of taeniasis caused by Taenia solium among Koreans in Seoul and Cheju Do In Korea during the period from August to December 1984. A total of 4,256 stool specimens from the students of Mapo Ku and 360 stool specimens from the inhabitants of Guro-Ku in Seoul was collected and examined by cellophane thick smear technique. On the other hand 1,015 stool specimens from the students of Jocheon Myun and 265 specimens from the students of Jocheon Myun and 265 specimens from the inhabitants of Aeweol Myun and Gujwa Myun in Cheju Do were also examined. The results were summarized as follows ; Four (0.1%) out of 4.256 students were positive and 2 (0.6%) out of 360 inhabitants in Seoul were positive (Table 1, 2). Positive rates of taeniasis in Cheju Do were 1.7% (17) out of 1,015 students and 12.5% (33) out of 5 villagers (Table 3, 4). In order to observe the distribution of Taenia solium infection, the scolex or a part of Taenia spp. were collected from the stool of positive cases by anthelmintic treatment. For the species identification, expelled proglottides were examined microscopically by the number of branches of the uterus, presence of vaginal sphincter or the accessory ovarian lobe etc. Three cases were infected with Taenia solium among 6 egg positive cases in Seoul. But only 1 case was infected with Taenia solium out of 7 students taking anthelmintics voluntarily by recommendation of Korean Association for Parasite Eradication (KAFPE). On the other hand, among 32 cases of egg positive cases of this study and 26 cases of KAFPE in Cheju Do, 13 cases (22.4%) were infected with Taenia solium. But 13 cases who were not examined and complained expulsion of proglottides in their stool were infected with Taenia saginata (Table 5). Among 62 persons infected with Taenia saginata, only 4 cases did not know their infection of this worm. Rut in 17 cases with Taenia solium, 7 persons did not know their infection until stool examinations were performed (Table 6).

• 한국컴퓨터정보학회논문지
• /
• 제19권1호
• /
• pp.157-168
• /
• 2014

본 연구는 이직율의 원인 특히 기업의 종사자들이 갖고 있는 조직 내의 직무 그리고 조직과 관련된 지각 그리고 그로 인해 형성되는 태도가 그들의 이직의도 그리고 그에 따른 이직과 성과 저하에 미치는 영향을 규명하고자 한다. 이를 위해 이직의도에 영향을 미치는 근로자들의 태도 변수로는 종업원들이 지각하는 그들에 대한 그들이 근무하고 있는 조직으로부터의 후원인식과 그 조직에 대한 그들의 몰입도를 변수로 선택하였다. 본 연구에서는 이론적인 검토와 선행연구들을 기초로 하여 수립된 5개의 연구가설 중 4개의 가설이 기대했던 대로 검증되는 결과를 얻었다. 결국 조직후원인식은 정서적 몰입을 높일 수 있으며 높은 수준의 정서적 몰입은 이직의도를 낮출 수 있다는 것을 보여주는 것이라고 할 수 있다. 경기불황과 함께 이직을 고려하는 현상이 증가하는 시기에 우리나라 기업들이 조직의 유효성을 높이기 위해서는 조직후원인식 행위를 적극 권장하여 몰입의 향상방안을 모색함으로써 근로자들의 조직내 근로의 질을 향상시켜 이직의도를 줄여나가는 방향에서의 인적자원관리가 바람직할 것으로 사료된다.

• 한국보건간호학회지
• /
• 제18권2호
• /
• pp.312-329
• /
• 2004

This study was examined 718 workers who had consistent blood pressure results in 2001 and 2002 general health examinations that were held at a work places managed by a health care agency in Seoul. Significant results are found as follows by analysing SPSS 11.0 on the result of self-recorded questionnaires investigated from Mar 1, 2003 to April 30, 2003. 1. A sampled healthy group and a sampled unhealthy group had significant differences in four variables out of possible nineteens that are sex, age, marriage and occupation. The unhealthy group had more males than females, more aged (over 50 years old) than youngers (under 50 years old), more married than singles, more manufacturing workers than non-manufacturing workers. In the case of systolic blood pressure, as the healthy group had 16.52mmHg while that of the other group had 149. 58mmHg, 33.06mmHg of difference between those groups were detected. In the case of diastolic blood pressure, 74.93mmHg of the healthy group and 96.53mmHg of the unhealthy group yielded 21.60mmHg of difference between them. This result implies that a guidance of health care is required to be aware of 20-30mmHg volatility in blood pressure rate or to understand and treat properly own blood pressure. as it is difficult to detect hypertension in early stage due to no initial symptom. According to the result. an establishment of management system of workers, companies and health care agencies is required for consist health care. 2. In terms of risky habits to health, the unhealthy group had more proportion of past smokers, over-twice-a-week drinkers, people with higher obesity rate. However, in terms of excercise, the proportion of regularly exercising people is higher in the unhealthy group while that of non-exercising people is higher in the healthy group. On the other hand. the average grade of health practicing behaviour in two groups are not significantly different as the health group had 3.00 out of possible 6.00 while the other had 3.10. This result means that as workers are not interested in health practicing behaviour. health promoting programmes must be developed in such a way of various method of motivations and incentives. Particularly this implies that distortional objectives of exercises should be readjusted through health guidance. 3. Systolic blood pressure in the healthy group can be explained by sex and the obesity rate while that in the unhealthy group can be explained by subjective health awareness and the obesity. Diastolic blood pressure in the healthy group can be explained by sex and the obesity rate like the former. The obesity rate was significant variable affecting the blood pressure of both groups, and particularly the effect to the unhealthy group was remarkably higher than that to the healthy group. Therefore, this research identified that the health care on the blood pressure of workers is not only limited to hypertension patients, but also extended to all workers. In order for consistent care, an establishment of management system of workers, companies and health care agencies is required.

• 대한소아치과학회지
• /
• 제36권4호
• /
• pp.580-585
• /
• 2009

소아치과 영역에서 치아수의 이상은 흔히 관찰할 수 있으며, 그 중 대표적인 것의 하나가 과잉치이다. 과잉치의 발생원인에 대해서는 여러가지 가설이 있으며 유전적 또는 환경적 요인에 의해 치배 형성기의 정상 치판이 과도하게 증식하여 발생되는 것으로 알려져 있다. 과잉치가 가장 흔하게 발생되는 부위는 상악에서는 절치부로 그 빈도는 80-94% 정도로 보고되고 있고 그 다음으로는 구치부와 소구치부 순서로 나타난다. 상악에 비해 하악에서는 대부분 소구치 부위에서 발생되며 절치부에서는 전체 과잉치 발생빈도 중 단지 1-2% 이하로 매우 낮은 빈도로 발생되는 것으로 보고되고 있다. 이 증례는 드물게 나타나는 하악 절치부에 2개의 과잉치가 있다는 주소로 내원한 만 6세 남아에서, 임상 및 방사선학적 검사 결과 하악 절치부에 정상치와 크기와 형태가 비슷한 정상치형의 과잉치 2개를 포함하여 6개의 절치가 존재하는 것이 관찰되었다. 발치할 치아의 정확한 진단 및 결정을 위해 컴퓨터 단층 촬영을 시행하였고 발치 후 하악 전치부의 정상적인 배열을 위해 치아 맹출에 대한 주기적 정기 검진 후 교정적 평가와 치료를 진행할 예정이다.

• Asian-Australasian Journal of Animal Sciences
• /
• 제26권4호
• /
• pp.488-500
• /
• 2013

The objective of this study was to compare the effectiveness of the protocols for superstimulation of follicular growth in Thai native heifers. Heifers (n = 20) were randomly divided into four groups of five heifers/group. Heifers were given a single dose by i.m. administration of 100 mg Follicle Stimulating Hormone dissolved in polyvinylpyrrolidone (FSHp) at 24 h. Ovum pick up (OPU) occurred at 72 h ($F_{24}O_{72}$ protocol; Group 1) or 96 h ($F_{24}O_{96}$ protocol; Group 2), and at 36 h and OPU at 72 h ($F_{36}O_{72}$ protocol; Group 3) or 96 h ($F_{36}O_{96}$ protocol; Group 4) after follicular ablation. The dynamics of ovarian follicular growth were monitored by twice-daily ultrasonographic examinations. Blood sample collections were performed every 12 h after initiation of treatment for assessment of FSH, E2 and P4 profiles. All heifers were subjected to eight repeated sequential sessions of OPU. The follicular deviation commenced $24{\pm}5.32$ h after follicular ablation in all groups. The circulatory FSH surged quickly from 24 to 36 h (>0.8 ng/ml) after follicular ablation and circulatory estrogen levels steadily increased from 36 h until OPU in all groups. At the end of the OPU sessions, the mean number of aspirated follicles/heifer/session in $F_{36}O_{72}$ protocol (Group 3) and $F_{36}O_{96}$ protocol (Group 4) were higher than in the two other groups (p<0.05). The number of cumulus-oocyte complexes (COCs), cleaved and day 8 blastocysts rates in the $F_{36}O_{72}$ protocol (Group 3) were higher than in the other groups (p<0.05). It can be concluded that a single dose i.m. administration of 100 mg FSHp at 36 h and OPU at 72 h after follicular ablation ($F_{36}O_{72}$ protocol; Group 3) was the most effective protocol for superstimulation of follicular growth for repeated OPU and subsequent in vitro embryo production in Thai native heifers.

• Journal of Korean Neurosurgical Society
• /
• 제29권12호
• /
• pp.1606-1611
• /
• 2000

Objective : To obtain more reliable sample in stereotactic biopsy, authors adopted proton chemical shift imaging ($^1H$-CSI)-directed biopsy. Until now, proton single voxel spectroscopy($^1H$-SVS) technique has been reported as a technique using metabolic information in stereotactic biopsy. The authors performed $^1H$-CSI with a stereotactic headframe in place and evaluated the pathologic results obtained from local metabolic information through $^1H$-CSI. Methods : $^1H$ CSI-directed stereotactic biopsy was performed in four patients. $^1H$-CSI and conventional Gd-enhancement stereotactic MRI was done simultaneously after application of the stereotatic frame. After reconstruction of metabolic maps of NAA/Cr, Cho/Cr, and Lactate/Cr ratios, the focal areas of increased Cho/Cr ratios and decreased NAA/Cr ratios were selected for target sites in the MR images Results : There was no difficulty in performing $^1H$-CSI with the stereotactic headframe in place. In pathologic examinations, the samples taken in area of increased Cho/Cr ratios and decreased NAA/Cr ratios showed the features of increased cellularity, mitoses and cellular atypism, thus facilitated the diagnosis. The pathologic samples taken from the area of increased Lactate/Cr ratios showed prominent feature of necrosis. Conclusion : $^1H$-CSI was feasible with stereotactic head frame in place. The final pathologic results obtained in our samples were concordant with the local metabolic informations from $^1H$-CSI. Authors believe that $^1H$ CSI-directed stereotactic biopsy may provide us advantages in obtaining more reliable tissue specimen in stereotactic biopsy.

• 한국치위생학회지
• /
• 제11권5호
• /
• pp.811-822
• /
• 2011

Objectives : The purpose of this study was to examine the relationship of the self-efficacy of dental hygiene students to their stressors and ways of stress-adaptation patterns. Methods : The subjects in this study were dental hygiene juniors in four selected colleges located in the metropolitan area. Results : 1. They got a mean of 3.22 in self-efficacy. They gave the highest mark(3.50) to an item 'I can attain it if I set a primary goal.' 2. They got a mean of 3.18 in stressors. Among the stressors, task assignments(3.74) were identified as the greatest stressor, followed by the curriculum(3.25), learning environments(3.16), prospects of employment (3.07) and test anxiety(2.95). 3. They got a mean of 2.02 in stress-adaptation method. They got 2.31 and 1.72 in long-term and short-term adaptation respectively, which showed that long-term stress adaptation method were more prevailing than short-term ones. 4. As a result of analyzing whether there would be any gaps in self-efficacy according to general characteristics, statistically significant gaps were found in that regard according to experience of preparing for college admission after leaving high school, academic standing, satisfaction with the department of dental hygiene and prospects of employment(p<.05). 5. As a result of checking the relationship of their self-efficacy to their stressors and ways of stress adaptation method, there were statistically significant differences in that aspect according to examinations and prospect of employment(p<0.05). As for ways of stress adaptation method, there were statistically significant differences in long-term adaptation method (p<0.05). Conclusions : As it's found that the level of the self-efficacy of the dental hygiene students was linked to the efficiency of their ways of stress adaptation method, the development and implementation of programs geared toward boosting the self-efficacy of dental hygiene students are required to teach them to successfully cope with various kinds of stress that they are likely to face after getting a job.

• 영재교육연구
• /
• 제20권1호
• /
• pp.107-130
• /
• 2010

본 연구에서는 과학영재 학생들을 대상으로 생물 영역의 동물 발생 실험수업을 통해 나타나는 언어적 상호작용을 분석하여 과학영재성을 보여주는 특성들을 알아보고자 하였다. 연구 대상은 서울대학교 과학영재센터의 중학교 1학년 학생 20명이었으며, Creative Problem Solving (CPS) 모형을 기반으로 개발된 동물 발생 실험 프로그램으로 소집단 토의 중심의 실험 수업을 총 4회 진행하면서 학생들의 언어적 상호작용을 녹음 및 녹화, 관찰하였다. 전사된 내용으로부터 질문-응답 유형과 과학영재의 특성을 추출하여 분석하였다. 질문-응답의 유형 분석에서는 보다 높은 사고력을 요하는 사고형 질문이 기본정보형 질문보다 3~6배나 높게 나타났다. 특히, 탐구실험 I은 다른 세 탐구실험보다 기본정보형 및 사고형 질문이 40% 이상 높게 나타났다. 언어적 상호작용의 분석 결과 창의적 지필검사에서 보기 어려웠던 창의성의 세부 요인을 확인할 수 있었으며, 문제발견력 및 문제해결력, 고도의 언어능력 등을 확인하였고, 정의적 특성인 과제 집착력과 리더십도 드러나는 것을 볼 수 있었다. 본 연구 결과는 지필고사를 대신하는 영재의 판별 및 선발에서 활용할 수 있는 프로그램 개발에 실질적인 도움을 줄 수 있을 것으로 사료된다.

• Journal of Periodontal and Implant Science
• /
• 제36권3호
• /
• pp.591-600
• /
• 2006

Purpose: This study assessed the impact of self-reported periodontal health on the oral health-related quality of life among elderly Koreans. Methods: Four hundred twenty one elderly Koreans in Seoul and suburban areas were selected with a cluster (institution) sampling method, and were requested to take oral examinations and finish questionnaires on the Oral Health Impact Profile-14(OHIP-14). and self-reported periodontal health status, such as periodontal symptoms, self-rated periodontal health and periodontal treatment need. As the dependent variable, OHIP-14 showed a positive skewed distribution (skewness: 1.17), we transformed to square-root form to apply parametric analyses. Bivariate analysis by t-test and ANOVA, and multivariate analysis with the two-level regression model accounting clusters were implemented. Results: Mean age of the subjects was 74.6 years and 66.5% were women. Fourteen items of OHIP-14 were summarized to one factor explaining 78.6% of total variance and produced the Chronbach alpha coefficient of 0.92. Results from the multivariate model, adjusting for age, sex, type of institutions, ability to pay, and number of teeth present, showed significantly lower OHIP-14 with reporting less than 3 periodontal symptoms (p(O.OOO1), rating their own periodontal health as above average level (p=O.0144), and thinking they don't need any periodontal treatments in the near future (p=O.0148), than their counterparts. The intraclass-corrrelation estimated by the final model was 0.028. Conclusion: This study demonstrates a significant association between self-reported periodontal health status and the oral health-related quality of life.