• Archives of Pharmacal Research
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• v.26 no.1
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• pp.53-57
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• 2003

We have found that ginsenoside Rc and Re induce c-fos in MCF-7 human breast carcinoma cells at both the mRNA and protein levels. However, neither ginsenoside activated the expression of reporter gene under the control of AP-1/TPA response elements. We have also examined the possibility that ginsenoside Rc and Re act by binding to intracellular steroid hormone receptors that act as transcriptional factors in the nucleus in inducing c-fos mRNA in MCF7 human breast carcinoma cells. However, ginsenoside Rc and Re did not bind to glucocorticoid, androgen, estrogen, or retinoic acid receptors as examined by the transcription activation of the luciferase reporter genes in CV-1 cells that were transiently transfected with the corresponding steroid hormone receptors and hormone responsive luciferase reporter plasmids. These data demonstrate that ginsenoside Rc and Re act via other transcription factors and not via estrogen receptor in c-Fos expression.

• Korean Journal of Biological Psychiatry
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• v.3 no.1
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• pp.115-120
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• 1996

To investigate characteristic drug effects on the genetic basis, the authors administered haloperidol- the $D_2$ antagonist- and clozapine -the atypical antipsychotics with few extra- pyramidal side effects- to the rats. Then, we edobtain brain specimen from the striatum, prefrontal cortex, and cortical region and compared the degree of c-fos expression. The results are 1) haloperidol was found to produce a rapid and transient induction of dos mRNA expression in striatum as compared with cortex and prefrontal area. 2) clozapine was found to produce rapid induction of c-fos mRNA in striatum and prefrontal area. From these data, we can concluded that the mechanism of action of haloperidol is different from the mechanism of clozapine in gene expression.

• Proceedings of the Korean Information Science Society Conference
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• 2006.10a
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• pp.437-442
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• 2006

임베디드 시스템은 그 용도에 따라서 다양한 기능을 수행하도록 설계된 전용 컴퓨팅 시스템으로 최근 임베디드 시스템의 보급이 많아지고 다양화됨에 따라 응용 프로그램의 재사용성 향상을 위해 운영체계의 개발 시 표준 API를 사용하여 표준화를 해야 하는 필요성이 되고 있다. 따라서 본 논문에서는 실시간 운영체계인 UbiFOS$^{TM}$에 개방형 운영체제 인터페이스인 POSIX의 API를 적용시켜 설계 및 구현하였다.

• The Journal of the Korean dental association
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• v.50 no.2
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• pp.58-63
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• 2012

The fundamental principles and the role of surgeons and orthodontists to produce successful results in orthodontic treatment combined with orthognathic surgery is not different from those of conventional procedures and FOS: surgery-first-orthodontic-treatment-later approach. The communication and cooperation between surgeon and orthodontist is of crucial importance. In FOS, the pre-surgical orthodontic preparation is not carried out in the patient's mouth, but in the mounted stone model and in addition to the simulation of tooth movement, to get a precise surgical occlusion, the entire steps of treatment should be simulated on the articulator as well. Right after the surgery, due to the instability of the occlusion, appropriate post operational care should be given according to the surgical technique applied to the mandible by use of final surgical wafer about 8 weeks.

• Proceedings of the Korean Geotechical Society Conference
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• 2000.11b
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• pp.223-232
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• 2000

Optical fibre sensors have shown a potential to serve real time health monitoring of the structures. They can be easily embedded or attached to the structures and are not affected by the electro-magnetic field. Furthermore, they have the flexibility of the sensor size and very highly sensitive. In this study, we conducted several laboratory and field tests using a novel optical sensor based on Brillouin scattering. One of the advantages of this technique is that the bare fibre itself acts as sensing element without any special fibre processing or preparation. Test results have shown that BOTDR can be a great solution for sensor systems of Civil Engineering Smart Structures.

• Proceedings of the KSR Conference
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• 2008.11b
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• pp.789-795
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• 2008

Slope stability is affected by various factors. For safety management of slopes, monitoring systems have been widely constructed along railway lines. The representative data from the systems are variations of ground profile such like ground water level and pore water pressure etc. and direct displacement measured by ground clinometer and tension wire sensor. Slopes are mainly effected by rainfall and rainfall causes the decrease of factor of safety(FOS). Because FOS varies linearly by the variation of ground water level and pore pressure, it has a weak point that could not define the time and proper warning sign to secure the safety of the train. In this study, alternative of FOS such as reliability index and probability of failure is applied to slope stability analysis introducing the reliability concept. FOS, reliability index, probability of failure and velocity of probability of failure of the slopes by variation of ground water level are investigated for setting up the specification of safety management of slopes. By executing case study of a slope(ILLO-IMSUNGLI), it is showed to be applied to specification of safety management.

• Bulletin of the Korean Chemical Society
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• v.22 no.10
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• pp.1131-1135
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• 2001

• Journal of Korean Physical Therapy Science
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• v.14 no.1_4
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• pp.11-23
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• 2007

This study was performed to evaluate the effects of low-intensity ultrasound application to the peripheral nerve injury animal model on enhancement of nerve regeneration and functional recovery. Using aseptic microsurgical techniques, the sciatic nerve of adult male Sprague-Dawley rats was crushed at the outside of right mid-thigh for 30 seconds with fine forceps. Beginning just after surgery, various continuous-wave ultrasound treatments with intensities of 0.2 W/$cm^2$, 0.5 W /$cm^2$ and 1.0 W /$cm^2$ operated at 1 MHz or sham treatment were applied to the opposite inside of the crush site for 1 minute every other day with a transducer moving speed of 2cm/sec. For evaluation of the progress of sciatic nerve regeneration, c-Fos expression in the lumbar spinal cord (L4-5) dorsal horn was investigated. c-fos expression was markedly increased at 1hour after sciatic nerve crush injury, then gradually decreased thereafter. The c-fos expressions were significantly decreased (p<0.05) in all the experimental groups in comparison with the control group until 3days post-crush, and the degrees of decrease were higher in 0.5 W/$cm^2$ and 1 W/$cm^2$ intensity ultrasound application groups. It is suggested that low-intensity ultrasound application to an animal model of sciatic crush injury may suppress pain transmission and promote nerve regeneration, and which may result in delayed progress of muscle atrophy and accelerated progress of muscle recovery and eventually may result in accelerated and improved foot function recovery.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.5
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• pp.1291-1296
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• 2007

The expressions of c-Fos and nitric oxide synthase (NOS) represent neuronal activity and play' a crucial role in the shaping of the development of brain. During the late pregnancy, stresses may influence neuronal activity of prenatal rats. In the present study, the effects of prenatal noise and music on the expressions of c-Fos and NOS in the hippocampus of rat pups were investigated. Exposure to the noise during pregnancy decreased c-Fos and NOS expressions in the hippocampus of rat pups, whereas exposure to music during pregnancy increased c-Fos and NOS expressions in the hippocampus of rat pups. The present results show that prenatal music stimulation may increase neuronal activity of rat offspring, whereas exposure to noise during pregnancy may reduce the neuronal activity of offspring. The present study suggests that prenatal stimuli including noise and music could affect the fetal brain development.

• The Journal of Internal Korean Medicine
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• v.26 no.3
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• pp.533-542
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• 2005

Objectives : In this study, aged BCAO rats were used to observe the effect of Bupleuri Radix on brain ischemic injury because aging is an important factor in storke. Methods : The brain ischemic injury was induced by temporary closing carotids on both sides in a low blood pressure state, and Bupleuri Radix was orally administered to 18 month-old BCAO rats. The ischemic damaged hippocampus and c-Fos and c-Jun expression were analyzed by the immunohistochemical staining. Result and Conclusions : Results are summarized as fellows; 1. The c-Fos expression after inducing a brain ischemic injury in the hippocampus was more inhibited in the experimental group than in the control group. 2. The normalized optical density of c-Fos expression was more reduced in cornu ammonis(CA)1, dentate gyrus(DG) areas in the experimental group than in the control group. 3. The c-Jun expression after inducing a brain ischemic injury in the hippocampus was more inhibited in the experimental group than in the control group. 4. The normalized optical density of c-Jun expression was more reduced in CA1 and DG areas in the experimental group than in the control group.