• The Plant Pathology Journal
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• v.39 no.1
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• pp.75-87
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• 2023

The pine wood nematode (PWN), Bursaphelenchus xylophilus is a well-known devastating pathogen of economic importance in the Republic of Korea and other countries. In the Republic of Korea, trunk injection of nematicides is the preferred method of control. In this study, the efficacy of 16 locally produced formulations of emamectin benzoate against the PWN are compared through determining their sublethal toxicities and reproduction inhibition potentials. Nematodes were treated with varying concentrations of the tested chemicals in multi-well culture plates, and rates of paralysis and mortality were determined after 24 h. Reproduction inhibition potential was tested by inoculating pre-treated nematodes onto Botrytis cinerea, and in pine twig cuttings. Despite the uniformity in the concentration of the active ingredient, efficacy was contrastingly different among formulations. The formulations evidently conformed to three distinct groups based on similarities in sublethal activity (group 1: LC₉₅ of 0.00768-0.01443 mg/ ml; group 2: LC₉₅ of 0.03202-0.07236 mg/ml, and group 3: LC₉₅ of as high as 0.30643-0.40811 mg/ml). Nematode paralysis generally occurred at the application dose of 0.0134-0.1075 ㎍/ml, and there were significant differences in nematode paralysis rates among the products. Nematode reproduction was only evident at lower doses both on B. cinerea and pine twigs, albeit the variations among formulations. Group 1 formulations significantly reduced nematode reproduction even at a lower dose of 0.001075 ㎍/ml. The variations in efficacy might be attributed to differences in inert ingredients. Therefore, there is need to analyze the potential antagonistic effects of the large number of additives used in formulations.

• Journal of Pharmaceutical Investigation
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• v.25 no.1
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• pp.47-54
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• 1995

Transdermal patch formulations of estradiol to treat post-menopausal symptoms and prevent osteoporosis in women were developed and evaluated for the permeation characteristics through the excised hairless mouse abdorminal skin and the uterotropic effect on the ovariectomized rabbits. The design of patch formulations was optimized by varying several formulation parameters, such as type of enhancers, amount of enhancers, amount of drug loading and coating thickness. Compared to a commercially available transdermal product, several patch formulations showed the similar skin permeation profiles (following zero-order kinetics), but their skin permeation rates were lasted for the longer period (a week). In one-week uterotropic efficacy test in the ovariectimized rabbits, the selected patch formulations showed the positive effect in atrophy of the urogenital epithelium. The mean values of uterus weight in rabbits after application of patches containing estradiol were much higher than those in control group (containing no drug).

• Structural Engineering and Mechanics
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• v.61 no.5
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• pp.625-635
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• 2017

Sets of nonlinear formulations together with an energy-based damage index (DI) are proposed to model the behavior and quantify the damage of the confined and unconfined concretes under monotonic and cyclic loading. The proposed formulations and DI can be employed in numerical simulations to determine the stresses and the damages to the fibers or the layers within the sections of reinforced concrete (RC) components. To verify the proposed formulations, an adaptive finite element computer program was generated to simulate the RC structures subjected to monotonic and cyclic loading. By comparing the simulated and the experimental test results, on both the full-scale structural members and concrete cylindrical samples, the proposed uniaxial behavior modeling formulations for confined and unconfined concretes under monotonic and cyclic loading, based on an iterative process, were accordingly adjusted, and then validated. The proposed formulations have strong mathematical structures and can readily be adapted to achieve a higher degree of precision by improving the relevant coefficients based on more precise tests. To apply the proposed DI, the stress-strain data of concrete elements is required. It can easily be calculated by using the proposed nonlinear constitutive laws for confined and unconfined concretes in this paper.

• Archives of Pharmacal Research
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• v.25 no.5
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• pp.572-584
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• 2002

Rapid development in molecular biology and recent advancement in recombinant technology increase identification and commercialization of potential protein drugs. Traditional forms of administrations for the peptide and protein drugs often rely on their parenteral injection, since the bioavailability of these therapeutic agents is poor when administered nonparenterally. Tremendous efforts by numerous investigators in the world have been put to improve protein formulations and as a result, a few successful formulations have been developed including sustained-release human growth hormone. For a promising protein delivery technology, efficacy and safety are the first requirement to meet. However, these systems still require periodic injection and increase the incidence of patient compliance. The development of an oral dosage form that improves the absorption of peptide and especially protein drugs is the most desirable formulation but one of the greatest challenges in the pharmaceutical field. The major barriers to developing oral formulations for peptides and proteins are metabolic enzymes and impermeable mucosal tissues in the intestine. Furthermore, chemical and conformational instability of protein drugs is not a small issue in protein pharmaceuticals. Conventional pharmaceutical approaches to address these barriers, which have been successful with traditional organic drug molecules, have not been effective for peptide and protein formulations. It is likely that effective oral formulations for peptides and proteins will remain highly compound specific. A number of innovative oral drug delivery approaches have been recently developed, including the drug entrapment within small vesicles or their passage through the intestinal paracellular pathway. This review provides a summary of the novel approaches currently in progress in the protein oral delivery followed by factors affecting protein oral absorption.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2008.10a
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• pp.430-434
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• 2008

The group Steiner tree problem is a generalization of the Steiner tree problem that is defined as follows. Given a weighted graph with a family of subsets of nodes, called groups, the problem is to find a minimum weighted tree that contains at least one node in each group. We present some existing and some new formulations for the problem and compare the relaxations of such formulations.

• Journal of Korean Institute of Industrial Engineers
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• v.37 no.3
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• pp.191-197
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• 2011

The group Steiner tree problem is a generalization of the Steiner tree problem that is defined as follows. Given a weighted graph with a family of subsets of nodes, called groups, the problem is to find a minimum weighted tree that contains at least one node in each group. We present some existing and some new formulations for the problem and compare the relaxations of such formulations.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2000.04a
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• pp.40-43
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• 2000

This paper is concerned with development of an efficient Ρ-median approach applicable to large cell formation(CF) problems. A two-phase methodology that seeks to minimize the number of exceptional elements is proposed. In phase I, two efficient Ρ-median formulations which contain fewer binary variables than existing Ρ-median formulations are constructed. These make it possible to implement large CF problem within reasonable computer runtime with commercially available linear integer programming codes. Given the initial cell configuration found with the new p-median formulations, in phase II bottleneck machines and parts are reassigned to reduce the number of exceptional elements. This procedure has the flexibility to provide the cell designer with alternative solutions. Test results on large CF problems show a substantial efficiency of the new Ρ-median formulations.

• Structural Engineering and Mechanics
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• v.4 no.6
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• pp.655-678
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• 1996

The paper reports on alternative hybrid/mixed formulations being developed by the Structural Analysis Research Group of Institute Superior T$\acute{e}$cnico. These formulations open the scope and increase the power of the finite element method by allowing different fields to be independently approximated, within certain consistency criteria, and by enhancing the use of a wide range of approximation functions. They have been applied to the analysis of 2-D problems, laminar structures and solids, using different constitutive relations, both in quasi-static and dynamic regimes. The fundamental properties of the formulations are identified and assessed and their performance is illustrated using simple, linear applications.

• Korean Journal of Environmental Agriculture
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• v.15 no.1
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• pp.116-127
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• 1996

Recent development in Japan on jumbo formulation of pesticides for paddy application by hand throw was reviewed. In addition, the diffusion of liquid formulations in water was examined to establish the research strategy for the jumbo formulation. Research on jumbo formulation in Japan has been focused on gas-generating formulations and self-emulsifiable formulations. Although continuous efforts to minimize the problem of pesticide deposit on the treated site have been made for the gas-generating formulations, much work is still needed to establish a generally acceptable formulation method and to commercialize a herbicide formulation. The self-emulsifiable jumbo formulations have recently been investigated. These formulations could simply be processed and showed relatively high biological efficacy. The emulsifiable concentrate was more diffusible than the suspension concentrate in water. The diffusion of the emulsifiable concentrate was not greatly disturbed by floating obstacles. And the diffusion rate was high when the specific grabity was lower than one.

• Korean Journal of Weed Science
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• v.11 no.3
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• pp.159-166
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• 1991

Seven oxyfluorfen formulations were tested for control of 8 weed species and rice injury under four different water depths with various ages of rice seedlings. Among formulations tested, rice injury was slight by formulations of Elvan, Coal Slag, Chitosan and Bentonite B under 0 cm or shallow water depths, and by those of Elvan and Coal Slag under deep water conditions. Weed control was high by Bentonite A and B, and Chitosan, and was low by Elvan. Coal Slag and Sand coated oxyfluorfen, if the target weeds of oxyfluorfen are annual species, further development of Elvan, coal slag, chitosan and Bentonite A would be controlled to increase control efficacy or to decrease rice injury.