• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1998년도 가을 학술발표회 논문집
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• pp.201-207
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• 1998

In this study, a geometric nonlinear analysis formulation for spatial frames is developed using the 3D stability functions. For the formulation, the relationships of local and global coordinate systems in force, deformation, and the initial and current configurations of a frame are derived. The force-deformation relationship in global coordinate system is derived as well. The developed formulation is verified in each derivation by reducing the derived equations into 2D equations. The gradual plastification of connections and critical sections can be implemented effectively to this formulation for the complete second order inelastic advanced analysis of spatial frames.

• Journal of Pharmaceutical Investigation
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• 제34권5호
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• pp.407-411
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• 2004

New formulations of amlodipine maleate tablet have been investigated to enhance the stability of the drug against light and humidity. Three kinds of amlodipine maleate tablets were prepared. One is prepared by previously known formulation (formulation C), the others were by new formulations using hydrophilic polymer $(Opadry^{\circledR})$ coated granules (formulations A and B). Amlodipine maleate powder was coated with $Opadry^{\circledR}$ to produce the coated granules and it was mixed with other excipients to produce the tabletting mass of new formulations A and B. Dissolution rate of newly formulated tablets was over 80% within 10 minutes in 0.01 M HCl medium, and its dissolution pattern was similar to that of $Norvasc^{\circledR}$ tablet. After 6 months storage under accelerated conditions, residual drug contents of tested formulations (A and B) were not significantly different from formulation C, ranging from 96.2 to 100.4%. Meanwhile, dissolution amount of formulation C was significantly reduced compared to that of formulation A (p<0.05), showing formulation A was more stable than unprotected formulation C at the accelerated conditions. Results of appearance, hardness and disintegration remained unchanged during stability study. In conclusion, it showed that the new formulations had enhanced the stability characteristics and hydrophilic coating technique was an alternative and promising method to improve the stability of amlodipine maleate tablet.

• Integrative Medicine Research
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• 제3권1호
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• pp.25-33
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• 2014

Background: Green tea contains numerous polyphenols, which have health-promoting effects. The purpose of this study was to evaluate the effect of tannase-converted green tea extract (TGE) formulation on the physical stability and activities of skin-related enzymes. Methods: Physical stability was evaluated by measuring the pH, precipitation, and colors at $25{\pm}2^{\circ}C$ /ambient humidity and at $40{\pm}2^{\circ}C$ \70%${\pm}$5% relative humidity for 4 months. Activities of collagenase, elastase, and tyrosinase as skin-related enzymes were assessed on TGE formulation. Results: The concentrations of epigallocatechin-3-gallate and epicatechin-3-gallate in green tea extract were greatly decreased to the extent of negligible level when treated with tannase. The formulation containing 5% tannase-converted green tea extract showed relatively stable pH, precipitation, and color features for 16 weeks. When TGE was added to the formulation, there was a significant increase in the inhibition of elastase and tyrosinase activities (p<0.05) compared with the formulation containing 5% normal green tea extract. Conclusion: The TGE could be used in cosmetics as skin antiwrinkling or depigmenting agent.

• Earthquakes and Structures
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• 제11권2호
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• pp.297-313
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• 2016

A virtual parameter is introduced into the formulation of the previously published integration method to improve its stability properties. It seems that the numerical properties of this integration method are almost unaffected by this parameter except for the stability property. As a result, it can have second order accuracy, explicit formulation and controllable numerical dissipation in addition to the enhanced stability property. In fact, it can have unconditional stability for the system with the instantaneous degree of nonlinearity less than or equal to the specified value of the virtual parameter for the modes of interest for each time step.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book II
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• pp.286-293
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• 2003

In cosmetic formulations, texture plays a key role in ingredient choice and formulation optimization. But texture parameters are often measured by sensorial analysis in the last stages of formulation development. Rheology or texture analysis, used separately, has the benefit of characterizing the behavior of raw materials (e.g. polymers) and controlling and predicting the stability of formulations. SEPPIC has developed rheology and texture analysis protocols to obtain a better understanding of the influence of raw materials on the cosmetic texture of formulations. When used in combination, these two methodologies are complementary and provide useful data regarding the impact of raw material choice on all the development steps: manufacturing procedure, formulation stability, skin feeling.

• 공업화학
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• 제10권6호
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• pp.848-851
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• 1999

은행잎 엑스의 안정성을 증가시키기 위하여, 세 가지 다른 형태의 충진제(SBO, PEG400, PEG600 처방 형태)를 세 가지 다른 형태의 캅셀 피막제(ssmb, smb, gmb 처방 형태)에 충진하여 연질캅셀을 제조하고 이들 처방이 은행잎 엑스의 안정성에 미치는 효과를 연구하였다. 각 형태의 안정성은 $40^{\circ}C$, 75% relative humidity(RH) 조건에서 8주간 그들의 붕해시간 및 함량 측정으로 평가하였다. 시험한 충진제 및 캅셀 피막제 중, PEG600 충진처방과 ssmb 피막처방을 사용한 은행잎 엑스가 가장 좋은 안정성을 나타내었다.

• Structural Engineering and Mechanics
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• 제87권4호
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• pp.363-373
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• 2023

Since the first family of structure-dependent methods can simultaneously integrate unconditional stability and explicit formulation in addition to second order accuracy, it is very computationally efficient for solving inertial problems except for adopting auto time-stepping techniques due to no nonlinear iterations. However, an unusual stability property is first found herein since its unconditional stability interval is drastically different for zero and nonzero damping. In fact, instability might occur for solving a damped stiffness hardening system while an accurate result can be obtained for the corresponding undamped stiffness hardening system. A technique of using a stability factor is applied to overcome this difficulty. It can be applied to magnify an unconditional stability interval. After introducing this stability factor, the formulation of this family of structure-dependent methods is changed accordingly and thus its numerical properties must be re-evaluated. In summary, a large stability factor can result in a large unconditional stability interval but also lead to a large relative period error. As a consequence, a stability factor must be appropriately chosen to have a desired unconditional stability interval in addition to an acceptable period distortion.

• Journal of Microbiology and Biotechnology
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• 제15권1호
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• pp.29-34
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• 2005

W/O/W (water-in-oil-in-water) type multiple emulsion was applied to improve the storage stability of an antagonistic microorganism, Burkholderia gladioli. Encapsulation of microorganism into a W/O/W emulsion was conducted by using a two-step emulsification method. W/O/W emulsion was prepared by the incorporation of B. gladioli into rapeseed oil and the addition of polyglycerin polyriconolate (PGPR) and castor oil polyoxyethylene (COG 25) as the primary and secondary emulsifier, respectively. Microcrystalline cellulose was used as an emulsion stabilizer. To evaluate the usefulness of W/O/W emulsion formulation as a microbial pesticide for controlling the bacterial wilt pathogen (Ralstonia solanacearum), the storage stability and antagonistic activity of emulsion formulation were tested in vitro. The storage stability test revealed that the viability of formulated cells in emulsion was higher than that of unformulated cells in culture broth. At $4^{\circ}C$, the viabilities of formulated cells and unformulated cells at the end of 20 weeks decreased to about 2 and 5 log cycles, respectively. At $37^{\circ}C$, the viability of formulated cells decreased to only 2 log cycles at the end of storage. On the other hand, the viable cells in culture broth were not detected after 13 weeks. In activity test, formulated cells in emulsion were more effective in inhibiting the growth of pathogen than unformulated cells in culture broth. Unformulated cells completely lost their antagonistic activity during storage under similar conditions. The W/O/W multiple emulsion formulation was shown to be useful as the novel liquid formulation for biological control.

• Structural Engineering and Mechanics
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• 제15권2호
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• pp.199-223
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• 2003

The formulation of a non-linear shear deformable shell element is presented for the solution of stability problems of stiffened plates and shells. The formulation of the geometrical stiffness presented here is exactly defined on the midsurface and is efficient for analyzing stability problems of thick plates and shells by incorporating bending moment and transverse shear resultant force. As a result of the explicit integration of the tangent stiffness matrix, this formulation is computationally very efficient in incremental nonlinear analysis. The element is free of both membrane and shear locking behaviour by using the assumed strain method such that the element performs very well in the thin shells. By using six degrees of freedom per node, the present element can model stiffened plate and shell structures. The formulation includes large displacement effects and elasto-plastic material behaviour. The material is assumed to be isotropic and elasto-plastic obeying Von Mises's yield condition and its associated flow rules. The results showed good agreement with references and computational efficiency.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 추계학술대회 논문집 전력기술부문
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• pp.220-223
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• 2003

This paper presents VSCOPF(Votage Stability Constrained Optimal Power Flow) algorithm based on SLP(Successive Linear Programming) to interpret the large scale system. Voltage stability index used to this paper is L index to be presented by function form. The objective function consists of load shedding cost minimization. Voltage stability indicator constraint was incorporated in traditional OPF formulation. as well as the objective function and constraints are linearlized and the optimal problem is performed by SLP(Successive Linear Programming). In this paper, the effect of voltage stability limit constraint is showed in the optimal load curtailment problems. As a result, an optimal solution is calculated to minimize load shedding cost guaranteeing voltage security level. Numerical examples using IEEE 39-bus system is also presented to illustrate the capabilities of the proposed formulation.