• Ocean Systems Engineering
• /
• 제7권2호
• /
• pp.143-155
• /
• 2017

For complex flexible structures such as nets, the determination of drag forces and its deformation is a challenging task. The accurate prediction of loads on cages is one of the key steps in designing fish farm facilities. The basic physics with a simple cage, can be addressed by the use of experimental studies. However, to design more complex cage system for various environmental conditions, a reliable numerical simulation tool is essential. In this work, the current load on a cage is calculated using a Morison-force model applied at instantaneous positions of equivalent-net modeling. Variations of solidity ratio ($S_n$) of the net and current speed are considered. An equivalent array of cylinders is built to represent the physical netting. Based on the systematic comparisons between the published experimental data for Raschel nets and the current numerical simulations, carried out using the commercial software OrcaFlex, a new formulation for $C_d$ values, used in the equivalent-net model, is presented. The similar approach can also be applied to other netting materials following the same procedure. In case of high solidity ratio and current speed, the hybrid model defines $C_d$ as a function of Re (Reynolds number) and $S_n$ to better represent the corresponding weak diffraction effects. Otherwise, the conventional $C_d$ values depending only on Re can be used with including shielding effects for downstream elements. This new methodology significantly improves the agreement between numerical and experimental data.

• Computers and Concrete
• /
• 제15권4호
• /
• pp.687-707
• /
• 2015

A finite element computer code for short-term analysis of steel-concrete composite structures is extended to study long-term effects under service loads, in the present work. Long-term effects are important in engineering design because they influence stress and strain distribution of the structural system and therefore contribute to the increment of deflections in these structures. For creep analysis, a rheological model based on a Kelvin chain, with elements placed in series, was employed. The parameters of the Kelvin chain were obtained using Dirichlet series. Creep and shrinkage models, proposed by the CEB FIP 90, were used. The shear-lag phenomenon that takes place at the concrete slab is usually neglected or not properly taken into account in the formulation of beam-column finite elements. Therefore, in this work, a three-dimensional numerical model based on the assemblage of shell finite elements for representing the steel beam and the concrete slab is used. Stud shear connectors are represented for special beam-column elements to simulate the partial interaction at the slab-beam interface. The two-dimensional representation of the concrete slab permits to capture the non-uniform shear stress distribution in the horizontal plane of the slab due to shear-lag phenomenon. The model is validated with experimental results of two full-scale continuous composite beams previously studied by other authors. Results are given in terms of displacements, bending moments and cracking patterns in order to shown the influence of long-term effects in the structural response and also the potentiality of the present numerical code.

• Structural Engineering and Mechanics
• /
• 제36권6호
• /
• pp.759-783
• /
• 2010

In this paper, compressive strength of carbon fiber reinforced polymer (CFRP) confined concrete cylinders is formulated using a hybrid method coupling genetic programming (GP) and simulated annealing (SA), called GP/SA, and a robust variant of GP, namely multi expression programming (MEP). Straightforward GP/SA and MEP-based prediction equations are derived for the compressive strength of CFRP-wrapped concrete cylinders. The models are constructed using two sets of predictor variables. The first set comprises diameter of concrete cylinder, unconfined concrete strength, tensile strength of CFRP laminate, and total thickness of CFRP layer. The most widely used parameters of unconfined concrete strength and ultimate confinement pressure are included in the second set. The models are developed based on the experimental results obtained from the literature. To verify the applicability of the proposed models, they are employed to estimate the compressive strength of parts of test results that were not included in the modeling process. A sensitivity analysis is carried out to determine the contributions of the parameters affecting the compressive strength. For more verification, a parametric study is carried out and the trends of the results are confirmed via some previous studies. The GP/SA and MEP models are able to predict the ultimate compressive strength with an acceptable level of accuracy. The proposed models perform superior than several CFRP confinement models found in the literature. The derived models are particularly valuable for pre-design purposes.

• Archives of Pharmacal Research
• /
• 제28권4호
• /
• pp.488-492
• /
• 2005

The purpose of this study is to investigate the bioequivalence of two haloperidol 5 mg tablets, Myung In haloperidol (Myung In Pharm. Co., Ltd., test drug) and $Peridol^{R}$(Whanin Pharm. Co., Ltd., reference drug), and also to estimate the pharmacokinetic parameters of haloperidol in Korean volunteers. The bioavailability and pharmacokinetics of haloperidol tablets were examined on 24 healthy volunteers who received a single oral dose of each preparation in the fasting state in a randomized balanced 2 way crossover design. After an oral dosing, blood samples were collected for a period of 60 h. Plasma concentrations of haloperidol were determined using a liquid chromatographic electrospray mass spectrometric (LC-MS) method. The pharmacokinetic parameters were calculated with noncompartmental pharmacokinetic analysis. The geometric means of $AUC_{0-60h} and C_{max}$ between test and reference formulations were $17.21\pm8.26 ng\cdot/mL vs 17.31\pm13.24 ng\cdot/mL and 0.87\pm0.74 ng/mL vs 0.85\pm0.62 ng/mL$. respectively. The $90\%$ confidence intervals of mean difference of logarithmic transformed $AUC_{0-60h} and C_{max} were log0.9677{\sim}log1.1201 and log0.8208{\sim}log1.1981$, respectively. It shows that the bioavailability of test drug is equivalent with that of reference drug. The geometric means of other pharmacokinetic parameters ($AUC_{inf}. t_{1/2}, V_{d}/F, and CL/F$) between test drug and reference drug were $21.75\pm8.50 ng{\cdot}h/mL vs 21.77\pm15.63 ng{\cdot}h/mL, 29.87\pm8.25 h vs 29.60\pm7.56 h, 11.51\pm5.45 L vs 12.90\pm6.12 L and 0.26\pm0.09 L/h vs 0.31\pm0.17 L/h$, respectively. These observations indicate that the two formulation for haloperidol was bioequivalent and, thus, may be clinically interchangeable.

• 한국항공우주학회지
• /
• 제33권3호
• /
• pp.18-25
• /
• 2005

다분야 통합해석 시스템의 신뢰성 해석에 대한 기존의 연구들은 대부분 비선형 최적화 기법을 기반으로 하고 있다. 이들은 다분야 통합최적설계 프레임워크를 이용하여 신뢰성을 직접 해석하기 때문에 효율적인 AFORM기법을 적용하는 것이 불가능하다. 본 논문은 AFORM기법을 적용한 다분야 통합시스템의 순차적 신뢰성 해석기법(SARAM)을 제안한다. 이를 위해 신뢰성 해석과 다분야 통합시스템의 해석(MDA)을 분리하고, 순차적으로 배열하여, 되풀이구조를 가지는 해석구조를 구성하였다. 제안된 방법의 효율성은 계산량, 정확도, 그리고 동시 수행기능의 관점에서 평가하였다. 3개의 다분야 통합시스템 예제를 계산한 결과, 제안된 기법은 정확도를 보장하면서 기존의 방법에 비해 우수한 계산효율을 보였다.

• 폴리머
• /
• 제26권5호
• /
• pp.680-690
• /
• 2002

골 재흡수 치료를 목적으로 파미드로네이트를 지속적으로 방출하는 제형으로 제조하기 위하여 락타이드-글리콜라이드 공중합체 (PLGA, 락타이드 : 글리콜라이드 몰비 = 75 : 25, 분자량 20000 g/mole 및 90000 g/mole)를 이용하여 직접압축 성형방법으로 생분해성 웨이퍼를 제조하였다. 약물과 고분자의 함량비 웨이퍼의 두께, PLGA 분자량 등을 조절하여 PLGA 웨이퍼를 제조하였고 이들의 형태학적 특성과 방출거동 및 분해거동을 살펴보았다. 웨이퍼의 제조는 혼합된 분말을 웨이퍼 제작용 몰드에 넣은 후 프레스를 이용하여 일정 압력으로 일정시간 동안 상온에서 가압하여 제조하였다. 제조된 웨이퍼는 약물의 초기함량이 증가할수록 방출속도가 빠르게 나타났으며, 제형의 두께가 두꺼워질수록 시간이 경과함에 따라 약물의 방출속도가 증가하였다. 또한 고분자의 분자량이 큰 것이 작은 것에 비해 상대적으로 초기 약물 방출량이 적고 방출되는 속도 또한 느려져. 저분자보다 오랫동안 약물이 방출되었다. 이러한 약물전달 시스템은 압축성형방법에 의해 제조하므로 제조가 간단하고 약물방출속도를 정확하게 제어할 수 있으므로 이식을 위한 제형으로 제조시 유용하게 쓰일 것으로 예상되었다.

• Safety and Health at Work
• /
• 제7권1호
• /
• pp.12-17
• /
• 2016

Background: The mining industry is considered as one of the most dangerous and hazardous industries and the need for effective and efficient occupational health and safety management is critical to safeguard workers and the industry. Despite the dangers and hazards present in the mining industry, only few studies have focused on how occupational health and safety and turnover intentions in the mines. Method: The study suing a cross-sectional survey design collected quantitative data from the 255 mine workers that were conveniently sampled from the Ghanaian mining industry. The data collection tools were standardized questionnaires that measured occupational health and safety management and turnover intentions. These scales were also pretested before their usage in actual data collection. Results: The correlation coefficient showed that a negative relationship existed between dimensions of occupational health and safety management and turnover intention; safety leadership (r = -0.33, p < 0.01); supervision (r = -0.26, p < 0.01); safety facilities and equipment (r = -0.32, p < 0.01); safety procedure (r = -0.27, p < 0.01). Among these dimensions, safety leadership and safety facility were significant predictors of turnover intention, (${\beta}=-0.28$, p < 0.01) and (${\beta}=-0.24$, p < 0.01) respectively. The study also found that turnover intention of employees is heavily influenced by the commitment of safety leadership in ensuring the effective formulation of policies and supervision of occupational health and safety at the workplace. Conclusion: The present study demonstrates that safety leadership is crucial in the administration of occupational health and safety and reducing turnover intention in organizations.

• Nuclear Engineering and Technology
• /
• 제48권6호
• /
• pp.1360-1367
• /
• 2016

This paper introduces a boron meter with improved accuracy compared with other commercially available boron meters. Its design includes a new fitting function and a multi-detector. In pressurized water reactors (PWRs) in Korea, many boron meters have been used to continuously monitor boron concentration in reactor coolant. However, it is difficult to use the boron meters in practice because the measurement uncertainty is high. For this reason, there has been a strong demand for improvement in their accuracy. In this work, a boron meter evaluation model was developed, and two approaches were considered to improve the boron meter accuracy: the first approach uses a new fitting function and the second approach uses a multi-detector. With the new fitting function, the boron concentration error was decreased from 3.30 ppm to 0.73 ppm. With the multi-detector, the count signals were contaminated with noise such as field measurement data, and analyses were repeated 1,000 times to obtain average and standard deviations of the boron concentration errors. Finally, using the new fitting formulation and multi-detector together, the average error was decreased from 5.95 ppm to 1.83 ppm and its standard deviation was decreased from 0.64 ppm to 0.26 ppm. This result represents a great improvement of the boron meter accuracy.

• 대한한방내과학회지
• /
• 제41권3호
• /
• pp.447-456
• /
• 2020

Objectives: This review aimed to present the characteristics of hepatocellular cancer patients treated by Korean medicine. Methods: Sixty hepatocellular cancer patients in a Korean medicine hospital from July 2012 to December 2019 were studied. We evaluated the general characteristics, overall therapies, and chief complaints of the patients. Results: Of the patients, 55% were stage IV, and Korean medicine was accompanied by conventional treatments, such as chemotherapy, operation, and transarterial chemoembolization. An average number of hepatocellular cancer patients had admitted to the hospital. The patients' chief complaints were dyspnea, general weakness, abdominal discomfort, and cancer-related pain. Conclusions: This study illustrates the general characteristics of hepatocellular cancer patients on Korean medicine treatments. These findings suggest that further investigations with a rigorous study design and more participants are needed.

• 비파괴검사학회지
• /
• 제21권1호
• /
• pp.69-79
• /
• 2001

다수의 이방성 함유체를 포함하는 등방성 무한고체에서 이들 이방성 함유체에 의한 탄성파의 산란문제 해석을 효과적으로 수행할 수 있는 새로은 수치해석 방법으로 체적 적분방정식법을 제시하였다. 체적 적분방정식법에서는 등방성 무한고체에서의 Green 함수만 구할 수 있으면 이방성 함유체에서의 Green 함수를 구하지 않고서도 탄성파 산란문제 해석이 가능해지는 장점이 있다. 이 방법은 임의의 형상을 갖는 다수의 이방성 함유체가 포함된 일반적인 탄성동역학 문제 해석에도 적용이 가능하다. 한 개의 직교이방성 함유체가 등방성 무한기지에 포함된 무한고체에서 직교이방성 함유체에 의한 종과(P파) 및 횡파(SV파) 산란문제 해석을 통하여, 체적 적분방정식법이 일반적인 이방성 함유체가 포함된 무한고체에서의 탄성파 산란문제 해석에 있어 정확하고 효과적인 수치해석 방법임을 입증하였다.