• The Journal of Korean Medicine
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• v.35 no.2
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• pp.47-59
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• 2014

Objectives: Most drug interactions are attributed to the inhibition or induction of the activity of cytochrome P450s (CYP450). Although the regulation of CYP450s by drugs has been widely reported, there have been few studies on influence of traditional herbal formulas on the drug-metabolizing enzymes. Because herbal formulas have been used traditionally to treat various diseases and because herb-drug interactions are crucial factors determining therapeutic efficacies, a systematic evaluation of the effects of herbal formulas is important. Methods: The effects of Galgeun-tang (GGT, gegen tang), Gumiganghwal-tang (GMGHT, jiuweiqianghuo tang), Insampaedok-san (ISPDS, renshenbaidu powder), Samsoeum (SSE, shensu drink), Socheongryong-tang (SCRT, xiaoqinglong-tang) and Sosiho-tang (SSHT, xiaochaihu tang) that are traditional herbal formulas used to treat common cold, on drug-metabolizing enzymes were evaluated through an in vitro CYP3A4, CYP2D6, CYP2C19 and CYP2E1 inhibition assay to assess its interaction potential with synthetic drugs. The inhibitory effects of herbal formulas were characterized with $IC_{50}$ values. Results: These six herbal formulas inhibited the activities of CYP3A4, 2C19, 2D6 and 2E1, in a concentration-dependent manner. Among the six herbal formulas, GGT critically inhibited CYP2C19, CYP2D6 and CYP2E1. GMGHT also inhibited CYP2D6 and CYP2E1 to a greater extent than the other CYP450 isozymes. Additionally, SSE and SSHT may change the effects of medicines that depend primarily on the CYP2C19 and CYP2E1 pathways. On the other hand, ISPDS and SCRT were not inhibited CYP3A4, CYP2C19, CYP2D6 and CYP2E1-mediated metabolism. Conclusions: These findings provide useful information regarding the safety and effectiveness of herbal formulas.

• Earthquakes and Structures
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• v.16 no.3
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• pp.295-310
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• 2019

This study attempts to develop new simplified approximate formulas to predict the fundamental natural periods of vibration (T) for bearing wall systems engaged with special reinforced concrete shear walls (RCSW) under seismic loads. Commonly, seismic codes suggested empirical formulas established by regression analysis of measured T for buildings during earthquake motions. These formulas depend on structure type, building height, number, height and length of SW, and ratio of SW area to base area of structure. In this study, a parametric investigation is performed for T of 110 selected models of bearing RCSW systems with varying structural height, configuration of horizontal plans including building width, number and width of bays, presence of middle corridors and core SWs. For this purpose, a 3D non-linear response time history (TH) analysis is implemented using ETABS v16.2.1. New formulas to estimate T are anticipated and compared with those obtained from formulas of IBC 2012 and ASCE/SEI 7-10. Moreover, the study examines responses of an arbitrarily two selected test model of 60 m and 80 m in height with presence of SWs having middle corridors. It is observed that the performance of the tested buildings is different through arising of considerable errors when using codes' formulas for estimating T. Accordingly, using the present proposed formulas exhibits more reasonable and safer design compared to codes' formulas. The results showed that equitable enhancement is promising to improve T formulas approaching enhanced and accurate estimation of T with reliable analysis, design, and evaluation of bearing RCSW systems.

• Preventive Nutrition and Food Science
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• v.3 no.3
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• pp.260-266
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• 1998

Selenium contents of infant formulas that were commerically available in Japan and Korean were determined by the method of atomic absorption spectrometry with hydrode generation. Total means of selenium contents were 45.2$\pm$22.1ng/g(n=34) in all the Japaneses formulas and 58.3$\pm$18.9ng/g(n=22) in all the Korean formulas. selecnium contents of milk-based formulas (54.7$\pm$23.2ng/g in Japan, n=20 and 64.8$\pm$12.6ng/g in Korean , n=18) were significantly higher than those of soy-based formulas (36.8$\pm$11.0ng/g in Japanes brands, n=11 and 36.4ng/g in Korean one , N=1). Based on selenium data of these formulas the selenium intakes of infants have been estimated to be about 6.6$\mu\textrm{g}$/day and 8.1$\mu\textrm{g}$/day in Korean by milk-based formula feeding.

• Korean Journal of Community Nutrition
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• v.1 no.1
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• pp.28-40
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• 1996

This study was conducted to evaluate the nutrition quality of the commercial infant formulas and to seek the solution to the establishment of the standard of nutrient requirements for infant formula in Korea. Nutrition informations were obtained from the labels of nineteen commercial infant formulas manufactured by 3 different companies, and the actual amounts of some nutrients were analyzed and compared to the labeled amounts. In addition, the nutrient composition of the commercial infant formulas was compared to the composition of breast milk, RDA for infants, and Codex standard for infant formula. The kind of minerals, vitamins and special components added to the commercial infant formulas were the major differences among 3 manufacturers. For some nutrients, the analyzed amounts were lower than the labeled amounts. In addition when different batches of the same kind of infant formula were analyzed, the large variations in the amounts of certain nutrients were noted. These data suggest that the nutrition labeling informations need to be validated, and nutrients added to the formulas are to be homogenized thoroughly. In order to solve these problems, therefore, like other countries, we need to establish the standard of nutrient requirements for infant formulas. Considering the available data on breast milk composition, RDA for infants and coordination with the international standard, we suggest the adoption of the Codex standard for infant formula may be the best way to manage the nutrition quality of commercial infant formulas at the present time.

• Journal of Acupuncture Research
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• v.24 no.6
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• pp.171-185
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• 2007

Objectives : This study was undertaken in order to establish the composite principles of formulas through the comparison of Saam acupuncture and Eight Constitution acupuncture theories. Methods : We compared the structural patterns of formulas between Saam and Eight Constitution acupuncture theories, and applied 'Wang Xiang Xiu Qiu Si(旺相休囚死)' to the analysis of formulas of these theories. Results : 1. There were similarities between Saam and Eight Constitution acupuncture theories in the comparisons of structural patterns of acupuncture formulas and tonifying liver formulas. 2. 'Wang Xiang Xiu Qiu Si' is applied to the constitutional strong and weak relationships of zang-fu organs in these theories. 3. In the cases of tonifying, it is possible to reinforce the family group and reduce the enemy group organs in the Eight Constitution acupuncture theory. In cases of purging, it is possible to reduce the family group and reinforce the enemy group organs. Conclusions : It is possible to establish the composite principles of formulas by the application of 'Wang Xiang Xiu Qiu Si' in Saam acupuncture and Eight Constitution acupuncture theories.

• Wind and Structures
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• v.8 no.3
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• pp.197-212
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• 2005

Tall buildings under wind action usually oscillate simultaneously in the along-wind and across-wind directions as well as in torsional modes. While several procedures have been developed for predicting wind-induced loads and responses in along-wind direction, accurate analytical methods for estimating across-wind and torsional response have not been possible yet. Simplified empirical formulas for estimation of the across-wind dynamic responses of rectangular tall buildings are presented in this paper. Unlike established empirical formulas in codifications, the formulas proposed in this paper are developed based on simultaneous pressure measurements from a series of tall building models with various side and aspect ratios in a boundary layer wind tunnel. Comparisons of the across-wind responses determined by the proposed formulas and the results obtained from the wind tunnel tests as well as those estimated by two well-known wind loading codes are made to examine the applicability and accuracy of the proposed simplified formulas. It is shown through the comparisons that the proposed simplified formulas can be served as an alternative and useful tool for the design and analysis of wind effects on rectangular tall buildings.

• The Journal of Korean Medicine
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• v.40 no.2
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• pp.94-105
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• 2019

Objectives: The correlation between medicinal herbal formulas and a risk of cardiotoxicity has been controversial. Thus, this study investigated cardiac safety assessment of 52 most commonly used medicinal herbal formulas. Methods: We evaluated the in vitro effects of medicinal herbal formulas on recombinant human embryonic kidney 293 (HEK 293) cell line expressing human ether-a-go-go-related gene (hERG) potassium channel. Results and Conclusion: Our results demonstrated that all of 52 medicinal herbal formulas did not show inhibition of hERG current in hERG-HEK 293 recombinant cells. In conclusion, these safety data suggest that 52 medicinal herbal formulas were not associated with an increased risk of cardiotoxicity in hERG-HEK 293 recombinant cells.

• Herbal Formula Science
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• v.27 no.1
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• pp.65-71
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• 2019

Objective : This study aims to diversify interpretation of formulas from "Onbyungjobyun" by analyzing various formulas from "Onbyungjobyun" as basic formulas. Method : This study found herbal communities of combination by analyzing herbal combinations based on network analysis of formulas from "Onbyungjobyun", and has analyzed each community of combination as basic formulas. Result : The results of network analysis showed a total of 3 herbal communities of combination; first was medicinal herbs from Eungyo-san(銀翹散), Jeungaek-tang(增液湯), Bokmaek-tang(復脈湯), Gyeji-tang(桂枝湯), Sogeonjung-tang (小建中湯) series; second was medicinal herbs from Angungwoohwang-hwan(安宮牛黃丸); third was medicinal herbs from Baekho-tang(白虎湯), Jaseol-dan(紫雪丹), Sayeok-tang(四逆湯) series. Conclusion : The formulas from "Onbyungjobyun" are consisted of herbal communities of combination; that treat warm-heat pathogen and supplies yin essence or yang qi; treat reverse transmission to the pericardium(逆傳心包); and treat heat in the qi phase in Onbyeong and cold-dampness in the middle energizer.

• Proceedings of the Korea Electromagnetic Engineering Society Conference
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• 2002.11a
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• pp.49-53
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• 2002

In this thesis, approximated design formulas for bandpass filters using changed coupling nodal point resonators are derived. The formulas take into account the arbitrary coupling node of lumped and distributed resonators. The advantage of this filter is its abilities to change freely the coupling structure between two resonators. Using the design formulas two filters were designed and simulated. Their responses verified the formulas.

• Journal of applied mathematics & informatics
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• v.4 no.1
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• pp.179-192
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• 1997

An algorithm to get an optimal choice for the number of symmetric quadrature points is given to find symmetric quadrature points is given to find symmetric quadrature for-mulas over a unit disk with a minimal number of points even when a high degree of polynomial precision is required. The symmetric quad-rature formulas for numerical integration over a unit disk of complete polynomial functions up to degree 19 are presented.