• Journal of the Speleological Society of Korea
• /
• no.66
• /
• pp.59-66
• /
• 2005

The present writer have been engaged in research the Karst topography of Korea from the 1950's. Especially, I have studiedthe hollows indicated on topographical maps(1:5,000, 1:50,000) in library side by side with field survey. As the side by side with field survey. As the result, I came to a conclusion that all the hollows in limestone area are not always dolines. Based on case study, I classified the hollow landforms into 10 groups as follow. 1) Solution hollow 2) Volcanic hollow 3) Desertic hollow 4) Structural hollow 5) Meteoric hollow 6) Limnoic hollow 7) Minal hollow 8) Artificial hollow 9) Bursted hollow 10) Compound hollow I am asking advices of you all.

• MALSORI
• /
• no.40
• /
• pp.29-49
• /
• 2000

This study has two aim: one is to clarify the restructuring of English in utterance and the other is to make use of text-setting to be applied to getting accustomed to the English rhythm and pronunciation. Clitics prove to play a crucial role on the English restructuring, and are found to be attached to their previous and to their next head or host, thus forming, respectively, an on-cliticized rhythm, trochee and a pro-cliticized rhythm, iambus. En-cliticization proves to be preferred to pro-cliticization in most types of English rhythms. Accordingly, the restructuring turn out to occur all over the levels of the Prosodic Hierarchy. That is, syllables, words and clitic groups are restructured in poetry as well as in song words, which means the necessity of restructuring throughout the levels of the Prosodic Hierarchy from the syllable to the utterance. The present study suggests a good use of a rhythmic textsetting for learners of English to get accustomed to the stress-timed rhythm as well as to such changes in pronunciation as reductions, deletions, resolutions, contractions, and rhythms in English.

• Biomolecules & Therapeutics
• /
• v.2 no.1
• /
• pp.54-58
• /
• 1994

BALB/C mice were intraperitoneally injected with methamphetamine (5 mg/kg) to observe the effect of methamphetamine on the immune system. Body weights were decreased in both acutely treated group (twice for 2 weeks with 7 days interval) and subchronically treated group (daily injection for 14 days). The relative spleen weights and the numbers of splenocytes were unexpectedly increased (p<0.05) in acutely treated group, but subchronically treated group showed the trend of decrease without significance. But there was no significant effect on antibody formation to hen egg Iysozyme which was immunized during the treatment of methamphetamine and on plaque forming cell number. The relative thymus weights of both groups were significantly decreased by the treatment of methamphetamine (acutely treated group, p<0.05; subchronically treated group, p<0.01). These results suggest that the effect of methamphetamine on the immune system may be caused by thymic dysfunction.

• Biomolecules & Therapeutics
• /
• v.21 no.6
• /
• pp.423-434
• /
• 2013

The adoption of oligonucleotide aptamer is well on the rise, serving an ever increasing demand for versatility in biomedical field. Through the SELEX (Systematic Evolution of Ligands by EXponential enrichment), aptamer that can bind to specific target with high affinity and specificity can be obtained. Aptamers are single-stranded nucleic acid molecules that can fold into complex three-dimensional structures, forming binding pockets and clefts for the specific recognition and tight binding of any given molecular target. Recently, aptamers have attracted much attention because they not only have all of the advantages of antibodies, but also have unique merits such as thermal stability, ease of synthesis, reversibility, and little immunogenicity. The advent of novel technologies is revolutionizing aptamer applications. Aptamers can be easily modified by various chemical reactions to introduce functional groups and/or nucleotide extensions. They can also be conjugated to therapeutic molecules such as drugs, drug containing carriers, toxins, or photosensitizers. Here, we discuss new SELEX strategies and stabilization methods as well as applications in drug delivery and molecular imaging.

• The Bulletin of The Korean Astronomical Society
• /
• v.35 no.1
• /
• pp.81.2-81.2
• /
• 2010

The origin of galactic angular momentum is commonly explained as a result of tidal torques of neighbouring protogalaxies on the forming galactic halo. In this context, the environment plays a preponderant role establishing the total angular momentum of present day galaxies. For the last four decades, most of the observational studies focused their attention on the spatial orientation of galaxies in filaments, groups or clusters, leaving behind the magnitude of the angular momentum. We have implemented a simple model to account for the spin of disk galaxies that allow us to obtain an estimate for any galaxy requiring a minimum of information. Applying this method to a sample of galaxies extracted from the Sloan Digital Sky Survey, we have been studying angular momentum distributions of galaxies in different environments. In this talk I will present some results for galaxies immersed in different environments, spanning three orders of magnitude in environmental density, galaxies having nearby companions and clustered galaxies.

• YAKHAK HOEJI
• /
• v.45 no.6
• /
• pp.670-676
• /
• 2001

Effect of the butanol fraction of Astragali Radix (BFAR) on the humoral immune response were investigated in ICR mice. Mice were divided into 4 groups and BFAR at doses of 5,25 and 125 mg/kg were administered orally to mice daily for 3 weeks, and the normal animals were given vehicle. The results of this study are summarized as follows; the relative weight of spleen was markedly increased by BFAR treatment, compared with that in normal mice. However, the body weight gain and the relative weight of liver were not affected. Splenic plaque forming cells and hemagglutination titers to sheep red blood cells, and the secondary IgG antibody response to bovine serum albumin were also dose-dependently enhanced by BFAR treatment. In these mice, BFAR did not increase serum alanine aminotransferase total protein, sect albumin and albumin/globulin ratio when compared with those in normal mice. Thus, these findings indicate that BFAR significantly enhances humoral immune response to antigen in concentrations that do not affected liver function.

• Bulletin of the Korean Chemical Society
• /
• v.31 no.1
• /
• pp.87-91
• /
• 2010

For the discovery of new antivirals against Severe Acute Respiratory Syndrome-coronavirus (SARS-CoV), we prepared and evaluated several benzoquinoline compounds as its 3C-like protease (3CLpro) inhibitors. Based on the computer modeling study that each of the two rigid benzoquinolinone and N-phenoltetrazole moieties of the compound 1 is bound to the S1 and S2 sites, respectively, of the SARS protease by forming H-bonds and hydrophobic interactions, we designed and synthesized alkylated benzoquinolines at both the sites of the hydroxyl groups. We found that the compound 2a showed five times higher inhibiting activity against the 3CLpro compared to the compound 1.

• Macromolecular Research
• /
• v.10 no.1
• /
• pp.18-23
• /
• 2002

We theoretically consider blends of two monodisperse one-end-functionalized homopolymers (denoted by A and B) capable of forming clusters between functional groups (stickers) using weak segregation theory. In this model system resulting molecular architectures via clustering resemble star copolymers having many A- and B-arms. Minimizing the total free energy with respect the cluster distribution, the equilibrium distribution of clusters is obtained and used for RPA (Random Phase Approximation) equations as input. For the case that polymers are functionalized by only one kind of sticker, the phase diagrams show that the associations promote the macrophase separation. When there is strong affinity between stickers belonging to the different polymer species, on the other hand, the phase diagram show a suppression of the macrophase separation at the range of high temperature regime, as well as the phase coexistence between a disordered and a mesoscopic phase at the relatively lower temperatures.

• Journal of the Korean Chemical Society
• /
• v.14 no.1
• /
• pp.123-126
• /
• 1970

The approximate crystal structure of benzidine monoperchlorate has been determined by single crystal X-Ray diffraction technique and patterson method. As the molecule has a center of symmetry in it and location of perchlorate ion is symmetrically on the mirror plane in the unit cell, perchlorate ion is forming hydrogen bond with two -$NH_2$ groups in the different molecule. Thus, one molecule of benzidine and perchloric acid combines 1:1 by mole ratio.

• Transactions of the Korean Society of Machine Tool Engineers
• /
• v.12 no.5
• /
• pp.15-23
• /
• 2003

A feature-based inspection planning system is proposed in this research to develop more efficient measuring methodology for the OMM(On-Machine Measurement) or CMM(coordinate Measuring Machine) for complicated workpiece having many primitive form features. This paper is proposed solution that optimum inspection sequence of the objective features. The sequences are determined by analyzing the feature information such as the nearest relationship and the possible probe-approach direction(PAD) of the features, and forming feature groups. A series of heuristic rules are developed to accomplish it. Also, each feature is decomposed into its constituent geometric elements for inspection process, and then the number of sampling points, location of the measuring points, optimum probing path are determined.